Electrochemotherapy of Murine Melanoma Using Intratumor Drug Administration View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000-02-18

AUTHORS

Mark J. Jaroszeski , Richard Heller , Richard Gilbert

ABSTRACT

Administering a chemotherapeutic agent in combination with electric fields (electrochemotherapy; ECT) has been shown to be an effective localized treatment for solid tumors (1). The drug used most often in this combination treatment has been bleomycin. ECT has been used successfully in both animal studies and clinical trials (1-3). The treatment was initially performed by exposing tumor cells to electrical fields following intravenous injection of the chemotherapeutic agent. Although ECT using intravenous bleomycin was successful, the procedure was limited by the existence of a narrow but optimal time window for effective treatment as well as the fact that a systemic drug dose was being administered for a localized therapy. In addition, the use of intravenous administration also precludes the treatment of patients with poor circulation. More... »

PAGES

253-7

References to SciGraph publications

Book

TITLE

Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery

ISBN

1-59259-080-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-080-2:253

DOI

http://dx.doi.org/10.1385/1-59259-080-2:253

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028947786

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21445739


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