Electrochemotherapy: Animal Model Work Review View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000-02-18

AUTHORS

Mark J. Jaroszeski , Richard Heller , Richard Gilbert , Gregor Serša

ABSTRACT

The major disadvantage of clinically established chemotherapeutic agents is their lack of selectivity for tumor cells. Therefore, for a pronounced antitumor effect, high doses of the chemotherapeutic drugs are needed, which often cause systemic toxicity and severe side effects. Some chemotherapeutic drugs do not exert their antitumor effects because they have hampered transport through the plasma membrane, but once inside the cell, they can be very potent. To overcome membrane restriction, much effort has been put into the development of drug delivery systems. These systems are aimed at facilitating the delivery of a chemotherapeutic drug into tumor cells at concentrations that are sufficient for effective cell killing and, at the same time, to minimize the drug concentration in normal tissue. More... »

PAGES

119-36

Book

TITLE

Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery

ISBN

1-59259-080-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-080-2:119

DOI

http://dx.doi.org/10.1385/1-59259-080-2:119

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003705776

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21445732


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