Pathogenesis and Animal Models View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000-01-17

AUTHORS

James Gray , Ulrich Desselberger , Linda J. Saif , Lucy A. Ward

ABSTRACT

Because of the limitations in studying human rotavirus (HRV) pathogenesis and mucosal immunity in the natural host (infants and children), various animal models have been utilized to investigate rotavirus (RV) disease pathogenesis and immunity. Mice and rabbits serve as useful models to evaluate and dissect immune responses to RV (see Chapter 9 ). However, because older mice (>14 d) and rabbits are not susceptible to diarrhea after inoculation with either homologous (murine or lapine, respectively) or heterologous (human) RVs, assessment of protective immunity is restricted to prevention of virus shedding only (1-3). More... »

PAGES

101-17

Book

TITLE

Rotaviruses

ISBN

1-59259-078-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-078-0:101

DOI

http://dx.doi.org/10.1385/1-59259-078-0:101

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011183619

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21318857


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