Chromatographic Behavior of Uric Acid and Methyl Uric Acids on a Diol Column in HILIC View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-04

AUTHORS

Noel S. Quiming, Nerissa L. Denola, Yoshihiro Saito, Alicia P. Catabay, Kiyokatsu Jinno

ABSTRACT

The retention behavior of uric acid (UA) and methyl uric acids (MUAs) on a diol column in hydrophilic interaction chromatography (HILIC) is presented. The effects of chromatographic parameters such as organic solvent content and salt concentration in the mobile phase, and column temperature were systematically investigated using a design of experiment (DOE). The results of the DOE revealed that the content of organic solvent, acetonitrile (ACN), had the most influence on the retention of the analytes. The effect of salt concentration indicated the possibility of electrostatic repulsion between the negatively charged analytes and the deprotonized residual silanol groups on the surface of the stationary phase. Van’t Hoff plots were constructed to further study the effects of column temperature on the retention of the compounds on the diol phase. Nonlinear van’t Hoff plots were observed for all the analytes in the studied temperature range (0–50 °C) signifying that the retention of UAs and MUAs on the diol column is governed by mixed retention mechanisms. Retention prediction models derived by multiple linear regression (MLR) showed that the retention of the analytes is dependent on the percentage of ACN in the mobile phase and two solute-related descriptors namely ovality (Ov) and the lowest unoccupied molecular orbital (LUMO). The incorporation of Ov, a shape parameter, in the MLR equation signified the importance of the shape/size of the compounds on the observed retention on the diol phase. More... »

PAGES

507-515

Identifiers

URI

http://scigraph.springernature.com/pub.10.1365/s10337-008-0559-9

DOI

http://dx.doi.org/10.1365/s10337-008-0559-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041576422


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Chemistry (incl. Structural)", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of the Philippines Manila", 
          "id": "https://www.grid.ac/institutes/grid.11159.3d", 
          "name": [
            "School of Materials Science, Toyohashi University of Technology, 441-8580, Toyohashi, Japan", 
            "Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila, Philippines"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quiming", 
        "givenName": "Noel S.", 
        "id": "sg:person.01362320024.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362320024.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Philippines Manila", 
          "id": "https://www.grid.ac/institutes/grid.11159.3d", 
          "name": [
            "School of Materials Science, Toyohashi University of Technology, 441-8580, Toyohashi, Japan", 
            "Department of Pharmaceutical Chemistry, College of Pharmacy, University of the Philippines Manila, Manila, Philippines"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Denola", 
        "givenName": "Nerissa L.", 
        "id": "sg:person.0705027124.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705027124.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyohashi University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.412804.b", 
          "name": [
            "School of Materials Science, Toyohashi University of Technology, 441-8580, Toyohashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saito", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.01161207721.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161207721.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kuwait University", 
          "id": "https://www.grid.ac/institutes/grid.411196.a", 
          "name": [
            "Faculty of Pharmacy, Kuwait University, Safat, Kuwait"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Catabay", 
        "givenName": "Alicia P.", 
        "id": "sg:person.0756316675.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756316675.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyohashi University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.412804.b", 
          "name": [
            "School of Materials Science, Toyohashi University of Technology, 441-8580, Toyohashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jinno", 
        "givenName": "Kiyokatsu", 
        "id": "sg:person.01033057312.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033057312.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1570-0232(02)00850-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000595107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1570-0232(02)00850-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000595107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0021-9673(00)80281-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002634238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chroma.2005.03.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002884725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxicon.2005.10.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003952806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0021-9673(01)01328-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003970126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1365/s10337-007-0264-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006876035", 
          "https://doi.org/10.1365/s10337-007-0264-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jssc.200600199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007567469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9673(93)80812-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008003174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1201/9780203912812.ch25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011472024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpba.2006.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014823804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.2000.4790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016446745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9673(94)00689-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016610110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chroma.2004.08.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018537012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chroma.2005.05.056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020950001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jssc.200500253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022124492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jssc.200500253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022124492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0021-9673(00)85602-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023596740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1365/s10337-007-0200-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024869326", 
          "https://doi.org/10.1365/s10337-007-0200-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/rcm.2171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025500079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/rcm.2171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025500079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/a801532e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026862006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chroma.2005.05.082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029315485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-007-1554-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033301653", 
          "https://doi.org/10.1007/s00216-007-1554-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-007-1554-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033301653", 
          "https://doi.org/10.1007/s00216-007-1554-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chroma.2005.06.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034308718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chroma.2006.05.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035033007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0021-9673(00)85601-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038602416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jssc.200301591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040186294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1208/ps030430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040612465", 
          "https://doi.org/10.1208/ps030430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-2670(00)80671-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045893607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.aca.2007.07.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046610172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/rcm.1890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046658652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-4347(01)00021-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046751193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-007-1415-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046908356", 
          "https://doi.org/10.1007/s00216-007-1415-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-007-1415-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046908356", 
          "https://doi.org/10.1007/s00216-007-1415-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpba.2006.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049294187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jchromb.2003.08.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049511680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jchromb.2003.08.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049511680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(99)00260-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050432644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jchromb.2004.11.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051427094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac026313p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054994424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac026313p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054994424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac990862m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055077325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac990862m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055077325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00193a003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055713047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp9638503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056123777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp9638503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056123777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077713347", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000473018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079598433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082793724", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1365/s10337-003-0117-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106241510", 
          "https://doi.org/10.1365/s10337-003-0117-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1365/s10337-003-0117-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106241510", 
          "https://doi.org/10.1365/s10337-003-0117-4"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-04", 
    "datePublishedReg": "2008-04-01", 
    "description": "The retention behavior of uric acid (UA) and methyl uric acids (MUAs) on a diol column in hydrophilic interaction chromatography (HILIC) is presented. The effects of chromatographic parameters such as organic solvent content and salt concentration in the mobile phase, and column temperature were systematically investigated using a design of experiment (DOE). The results of the DOE revealed that the content of organic solvent, acetonitrile (ACN), had the most influence on the retention of the analytes. The effect of salt concentration indicated the possibility of electrostatic repulsion between the negatively charged analytes and the deprotonized residual silanol groups on the surface of the stationary phase. Van\u2019t Hoff plots were constructed to further study the effects of column temperature on the retention of the compounds on the diol phase. Nonlinear van\u2019t Hoff plots were observed for all the analytes in the studied temperature range (0\u201350 \u00b0C) signifying that the retention of UAs and MUAs on the diol column is governed by mixed retention mechanisms. Retention prediction models derived by multiple linear regression (MLR) showed that the retention of the analytes is dependent on the percentage of ACN in the mobile phase and two solute-related descriptors namely ovality (Ov) and the lowest unoccupied molecular orbital (LUMO). The incorporation of Ov, a shape parameter, in the MLR equation signified the importance of the shape/size of the compounds on the observed retention on the diol phase.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1365/s10337-008-0559-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1015080", 
        "issn": [
          "0009-5893", 
          "1612-1112"
        ], 
        "name": "Chromatographia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7-8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "67"
      }
    ], 
    "name": "Chromatographic Behavior of Uric Acid and Methyl Uric Acids on a Diol Column in HILIC", 
    "pagination": "507-515", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c60e7da9dc263ddd0a2826d03d0d88d161daacf9bfb9cb31008170637239a896"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1365/s10337-008-0559-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041576422"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1365/s10337-008-0559-9", 
      "https://app.dimensions.ai/details/publication/pub.1041576422"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000592.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1365/s10337-008-0559-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1365/s10337-008-0559-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1365/s10337-008-0559-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1365/s10337-008-0559-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1365/s10337-008-0559-9'


 

This table displays all metadata directly associated to this object as RDF triples.

230 TRIPLES      21 PREDICATES      70 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1365/s10337-008-0559-9 schema:about anzsrc-for:03
2 anzsrc-for:0306
3 schema:author N9eb0337413c04f4aa6053c757cd866e1
4 schema:citation sg:pub.10.1007/s00216-007-1415-8
5 sg:pub.10.1007/s00216-007-1554-y
6 sg:pub.10.1208/ps030430
7 sg:pub.10.1365/s10337-003-0117-4
8 sg:pub.10.1365/s10337-007-0200-3
9 sg:pub.10.1365/s10337-007-0264-0
10 https://app.dimensions.ai/details/publication/pub.1077713347
11 https://app.dimensions.ai/details/publication/pub.1082793724
12 https://doi.org/10.1002/jssc.200301591
13 https://doi.org/10.1002/jssc.200500253
14 https://doi.org/10.1002/jssc.200600199
15 https://doi.org/10.1002/rcm.1890
16 https://doi.org/10.1002/rcm.2171
17 https://doi.org/10.1006/abio.2000.4790
18 https://doi.org/10.1016/0021-9673(93)80812-m
19 https://doi.org/10.1016/0021-9673(94)00689-7
20 https://doi.org/10.1016/j.aca.2007.07.039
21 https://doi.org/10.1016/j.chroma.2004.08.113
22 https://doi.org/10.1016/j.chroma.2005.03.058
23 https://doi.org/10.1016/j.chroma.2005.05.056
24 https://doi.org/10.1016/j.chroma.2005.05.082
25 https://doi.org/10.1016/j.chroma.2005.06.048
26 https://doi.org/10.1016/j.chroma.2006.05.019
27 https://doi.org/10.1016/j.jchromb.2003.08.026
28 https://doi.org/10.1016/j.jchromb.2004.11.013
29 https://doi.org/10.1016/j.jpba.2006.02.006
30 https://doi.org/10.1016/j.jpba.2006.03.013
31 https://doi.org/10.1016/j.toxicon.2005.10.012
32 https://doi.org/10.1016/s0003-2670(00)80671-6
33 https://doi.org/10.1016/s0021-9673(00)80281-2
34 https://doi.org/10.1016/s0021-9673(00)85601-0
35 https://doi.org/10.1016/s0021-9673(00)85602-2
36 https://doi.org/10.1016/s0021-9673(01)01328-0
37 https://doi.org/10.1016/s0140-6736(99)00260-3
38 https://doi.org/10.1016/s0378-4347(01)00021-4
39 https://doi.org/10.1016/s1570-0232(02)00850-4
40 https://doi.org/10.1021/ac026313p
41 https://doi.org/10.1021/ac990862m
42 https://doi.org/10.1021/ja00193a003
43 https://doi.org/10.1021/jp9638503
44 https://doi.org/10.1039/a801532e
45 https://doi.org/10.1159/000473018
46 https://doi.org/10.1201/9780203912812.ch25
47 schema:datePublished 2008-04
48 schema:datePublishedReg 2008-04-01
49 schema:description The retention behavior of uric acid (UA) and methyl uric acids (MUAs) on a diol column in hydrophilic interaction chromatography (HILIC) is presented. The effects of chromatographic parameters such as organic solvent content and salt concentration in the mobile phase, and column temperature were systematically investigated using a design of experiment (DOE). The results of the DOE revealed that the content of organic solvent, acetonitrile (ACN), had the most influence on the retention of the analytes. The effect of salt concentration indicated the possibility of electrostatic repulsion between the negatively charged analytes and the deprotonized residual silanol groups on the surface of the stationary phase. Van’t Hoff plots were constructed to further study the effects of column temperature on the retention of the compounds on the diol phase. Nonlinear van’t Hoff plots were observed for all the analytes in the studied temperature range (0–50 °C) signifying that the retention of UAs and MUAs on the diol column is governed by mixed retention mechanisms. Retention prediction models derived by multiple linear regression (MLR) showed that the retention of the analytes is dependent on the percentage of ACN in the mobile phase and two solute-related descriptors namely ovality (Ov) and the lowest unoccupied molecular orbital (LUMO). The incorporation of Ov, a shape parameter, in the MLR equation signified the importance of the shape/size of the compounds on the observed retention on the diol phase.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf N83857e62363c44799f3df02560eb196d
54 Nc964410be50a46368b66e3958ab27085
55 sg:journal.1015080
56 schema:name Chromatographic Behavior of Uric Acid and Methyl Uric Acids on a Diol Column in HILIC
57 schema:pagination 507-515
58 schema:productId N46a2275e2a38471ea25df113d7ab8b75
59 Nb3177addb86e47be97a4a678cd9e80f5
60 Nefada5d755e4425c8f3c6f41203976bf
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041576422
62 https://doi.org/10.1365/s10337-008-0559-9
63 schema:sdDatePublished 2019-04-10T18:31
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nd518a34e646543a59dfc1bee04e08f01
66 schema:url http://link.springer.com/10.1365/s10337-008-0559-9
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N46a2275e2a38471ea25df113d7ab8b75 schema:name doi
71 schema:value 10.1365/s10337-008-0559-9
72 rdf:type schema:PropertyValue
73 N62cd6a6700c640eba7b601ab5b65bd34 rdf:first sg:person.0756316675.50
74 rdf:rest Ncc41ecf0dd85440fa97707700d43eecd
75 N83857e62363c44799f3df02560eb196d schema:volumeNumber 67
76 rdf:type schema:PublicationVolume
77 N9eb0337413c04f4aa6053c757cd866e1 rdf:first sg:person.01362320024.38
78 rdf:rest Nabf3cf6561474c6d809a23812b13b30e
79 Nabf3cf6561474c6d809a23812b13b30e rdf:first sg:person.0705027124.96
80 rdf:rest Nf5c9b0aa890d4f18aad10e3e7bb26b93
81 Nb3177addb86e47be97a4a678cd9e80f5 schema:name readcube_id
82 schema:value c60e7da9dc263ddd0a2826d03d0d88d161daacf9bfb9cb31008170637239a896
83 rdf:type schema:PropertyValue
84 Nc964410be50a46368b66e3958ab27085 schema:issueNumber 7-8
85 rdf:type schema:PublicationIssue
86 Ncc41ecf0dd85440fa97707700d43eecd rdf:first sg:person.01033057312.59
87 rdf:rest rdf:nil
88 Nd518a34e646543a59dfc1bee04e08f01 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 Nefada5d755e4425c8f3c6f41203976bf schema:name dimensions_id
91 schema:value pub.1041576422
92 rdf:type schema:PropertyValue
93 Nf5c9b0aa890d4f18aad10e3e7bb26b93 rdf:first sg:person.01161207721.65
94 rdf:rest N62cd6a6700c640eba7b601ab5b65bd34
95 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
96 schema:name Chemical Sciences
97 rdf:type schema:DefinedTerm
98 anzsrc-for:0306 schema:inDefinedTermSet anzsrc-for:
99 schema:name Physical Chemistry (incl. Structural)
100 rdf:type schema:DefinedTerm
101 sg:journal.1015080 schema:issn 0009-5893
102 1612-1112
103 schema:name Chromatographia
104 rdf:type schema:Periodical
105 sg:person.01033057312.59 schema:affiliation https://www.grid.ac/institutes/grid.412804.b
106 schema:familyName Jinno
107 schema:givenName Kiyokatsu
108 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033057312.59
109 rdf:type schema:Person
110 sg:person.01161207721.65 schema:affiliation https://www.grid.ac/institutes/grid.412804.b
111 schema:familyName Saito
112 schema:givenName Yoshihiro
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161207721.65
114 rdf:type schema:Person
115 sg:person.01362320024.38 schema:affiliation https://www.grid.ac/institutes/grid.11159.3d
116 schema:familyName Quiming
117 schema:givenName Noel S.
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362320024.38
119 rdf:type schema:Person
120 sg:person.0705027124.96 schema:affiliation https://www.grid.ac/institutes/grid.11159.3d
121 schema:familyName Denola
122 schema:givenName Nerissa L.
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705027124.96
124 rdf:type schema:Person
125 sg:person.0756316675.50 schema:affiliation https://www.grid.ac/institutes/grid.411196.a
126 schema:familyName Catabay
127 schema:givenName Alicia P.
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756316675.50
129 rdf:type schema:Person
130 sg:pub.10.1007/s00216-007-1415-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046908356
131 https://doi.org/10.1007/s00216-007-1415-8
132 rdf:type schema:CreativeWork
133 sg:pub.10.1007/s00216-007-1554-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1033301653
134 https://doi.org/10.1007/s00216-007-1554-y
135 rdf:type schema:CreativeWork
136 sg:pub.10.1208/ps030430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040612465
137 https://doi.org/10.1208/ps030430
138 rdf:type schema:CreativeWork
139 sg:pub.10.1365/s10337-003-0117-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106241510
140 https://doi.org/10.1365/s10337-003-0117-4
141 rdf:type schema:CreativeWork
142 sg:pub.10.1365/s10337-007-0200-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024869326
143 https://doi.org/10.1365/s10337-007-0200-3
144 rdf:type schema:CreativeWork
145 sg:pub.10.1365/s10337-007-0264-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006876035
146 https://doi.org/10.1365/s10337-007-0264-0
147 rdf:type schema:CreativeWork
148 https://app.dimensions.ai/details/publication/pub.1077713347 schema:CreativeWork
149 https://app.dimensions.ai/details/publication/pub.1082793724 schema:CreativeWork
150 https://doi.org/10.1002/jssc.200301591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040186294
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1002/jssc.200500253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022124492
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1002/jssc.200600199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007567469
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1002/rcm.1890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046658652
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1002/rcm.2171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025500079
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1006/abio.2000.4790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016446745
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/0021-9673(93)80812-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1008003174
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/0021-9673(94)00689-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016610110
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.aca.2007.07.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046610172
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.chroma.2004.08.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018537012
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.chroma.2005.03.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002884725
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.chroma.2005.05.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020950001
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.chroma.2005.05.082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029315485
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.chroma.2005.06.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034308718
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.chroma.2006.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035033007
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.jchromb.2003.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049511680
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.jchromb.2004.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051427094
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.jpba.2006.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049294187
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.jpba.2006.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014823804
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.toxicon.2005.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003952806
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s0003-2670(00)80671-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045893607
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0021-9673(00)80281-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002634238
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0021-9673(00)85601-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038602416
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0021-9673(00)85602-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023596740
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s0021-9673(01)01328-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003970126
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/s0140-6736(99)00260-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050432644
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/s0378-4347(01)00021-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046751193
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/s1570-0232(02)00850-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000595107
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1021/ac026313p schema:sameAs https://app.dimensions.ai/details/publication/pub.1054994424
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1021/ac990862m schema:sameAs https://app.dimensions.ai/details/publication/pub.1055077325
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1021/ja00193a003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055713047
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1021/jp9638503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056123777
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1039/a801532e schema:sameAs https://app.dimensions.ai/details/publication/pub.1026862006
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1159/000473018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079598433
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1201/9780203912812.ch25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011472024
219 rdf:type schema:CreativeWork
220 https://www.grid.ac/institutes/grid.11159.3d schema:alternateName University of the Philippines Manila
221 schema:name Department of Pharmaceutical Chemistry, College of Pharmacy, University of the Philippines Manila, Manila, Philippines
222 Department of Physical Sciences and Mathematics, College of Arts and Sciences, University of the Philippines Manila, Manila, Philippines
223 School of Materials Science, Toyohashi University of Technology, 441-8580, Toyohashi, Japan
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.411196.a schema:alternateName Kuwait University
226 schema:name Faculty of Pharmacy, Kuwait University, Safat, Kuwait
227 rdf:type schema:Organization
228 https://www.grid.ac/institutes/grid.412804.b schema:alternateName Toyohashi University of Technology
229 schema:name School of Materials Science, Toyohashi University of Technology, 441-8580, Toyohashi, Japan
230 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...