Rescue of Pulmonary Hypertension with an Oral Sulfonamide Antibiotic Sulfisoxazole by Endothelin Receptor Antagonistic Actions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008

AUTHORS

Katsushige Ono, Motoko Yamabe, Satoshi Takebayashi, Shamarendra N Sanyal, Takayuki Noguchi, Tatsuo Shimada, Tomoko Uchino, Toru Shimaoka, Toshihiko Kaku

ABSTRACT

Pulmonary hypertension (PH) is a disease of unknown etiology that ultimately causes right ventricle heart failure with a lethal outcome. An increase in circulating endothelin (ET)-1 levels may contribute to disease progression. This study aimed to examine the possible effects of an orally active ET receptor antagonist, sulfisoxazole (SFX), for the rescue of PH, right ventricular hypertrophy, and eventual right ventricular failure. PH rats (single injection of monocrotaline [MCT]) were treated with an ET antagonist, SFX, an orally active sulfonamide antibody. Effects of SFX on PH rats were assessed in terms of survival rate, pulmonary artery blood pressure (PABP), autonomic nerve activity, and atrial natriuretic peptide (ANP) concentration in right ventricular myocytes and plasma. SFX did not change systemic blood pressure, however, it significantly suppressed the elevation of PABP. SFX maintained the derangement of autonomic nerve control, blunted an increase in ANP in myocytes and plasma, and significantly improved survival in right heart failure and/or related organs dysfunction in PH rats. The ET antagonistic action of the antimicrobial agent, SFX, was experimentally confirmed for treatment of PH in rats. More... »

PAGES

1781

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1291/hypres.31.1781

DOI

http://dx.doi.org/10.1291/hypres.31.1781

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011453128

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18971557


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