Amelioration of Hypertensive Heart Failure by Amlodipine May Occur via Antioxidative Effects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-09

AUTHORS

Hiroshi Hasegawa, Hiroyuki Takano, Takahide Kohro, Kazutaka Ueda, Yuriko Niitsuma, Hiroyuki Aburatani, Issei Komuro

ABSTRACT

Although recent clinical studies have suggested that long-acting calcium channel blockers (CCBs) have beneficial effects on heart failure, the precise mechanism is unknown. In this study, Dahl salt-sensitive rats fed a high salt diet were treated with the long-acting CCB amlodipine, the low–molecular-weight membrane permeable superoxide dismutase mimetic 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (Tempol), or saline from 11 weeks after birth. The cardiac geometry and function, and gene expression profiles were determined at 17 weeks. Dahl salt-sensitive rats fed a high salt diet followed by saline as a non-treatment control (HS group) showed a marked increase in blood pressure and developed concentric hypertrophy at 11 weeks, followed by left ventricular (LV) dilation and congestive heart failure by 17 weeks. The treatment with amlodipine (AMLO group) or Tempol (TEMP group) significantly inhibited the development of LV hypertrophy and cardiac dysfunction. Analysis using an Affymetrix GeneChip U34 revealed that the expression levels of 195 genes were changed by the treatment with amlodipine. Among these 195 genes, 110 genes were increased in HS rats and decreased in AMLO rats. And of these 110 genes, 54 genes were also decreased in TEMP rats. In contrast, 85 genes were decreased in HS rats and increased in AMLO rats. Of these 85 genes, 38 genes were also increased in TEMP rats. Approximately 48% of the genes were changed in similar fashion in AMLO and TEMP rats, suggesting that amlodipine shows beneficial effects on heart failure mainly via antioxidative mechanisms. More... »

PAGES

719-729

Identifiers

URI

http://scigraph.springernature.com/pub.10.1291/hypres.29.719

DOI

http://dx.doi.org/10.1291/hypres.29.719

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012502782

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17249528


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