Mouse Aortic Ring Assay: A New Approach of the Molecular Genetics of Angiogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-06

AUTHORS

Véronique Masson, Laetitia Devy, Christine Grignet-Debrus, Sarah Bernt, Khalid Bajou, Silvia Blacher, Guy Roland, Yawen Chang, Timothy Fong, Peter Carmeliet, Jean-Michel Foidart, Agnès Noël

ABSTRACT

Angiogenesis, a key step in many physiological and pathological processes, involves proteolysis of the extracellular matrix. To study the role of two enzymatic families, serine-proteases and matrix metalloproteases in angiogenesis, we have adapted to the mouse, the aortic ring assay initially developed in the rat. The use of deficient mice allowed us to demonstrate that PAI-1 is essential for angiogenesis while the absence of an MMP, MMP-11, did not affect vessel sprouting. We report here that this model is attractive to elucidate the cellular and molecular mechanisms of angiogenesis, to identify, characterise or screen "pro- or anti-angiogenic agents that could be used for the treatment of angiogenesis-dependent diseases. Approaches include using recombinant proteins, synthetic molecules and adenovirus-mediated gene transfer. More... »

PAGES

24-31

Identifiers

URI

http://scigraph.springernature.com/pub.10.1251/bpo30

DOI

http://dx.doi.org/10.1251/bpo30

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051116835

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12734572


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