Correlation Between Immunoinflammatory Measures and Periostin Expression in Esophageal Squamous Cell Carcinoma: A Single-Center, Retrospective Cohort Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-07-01

AUTHORS

Yusuke Ishibashi, Hironori Tsujimoto, Takahiro Einama, Satsuki Mochizuki, Keita Kouzu, Shinsuke Nomura, Nozomi Ito, Manabu Harada, Hidekazu Sugasawa, Eiji Shinto, Yoji Kishi, Hideki Ueno

ABSTRACT

BackgroundImmunoinflammatory measures such as the neutrophil–lymphocyte ratio (NLR), the platelet–lymphocyte ratio (PLR), and the C-reactive protein (CRP)–albumin ratio (CAR) are useful prognostic measures in various malignancies. However, no study has investigated the correlation of these measures with microenvironmental inflammation. Periostin (POSTN), a small extracellular matrix protein, strongly associates with cancer microenvironmental inflammation. The current study investigated the correlation of NLR, PLR, and CAR with periostin expression in esophageal squamous cell carcinoma (ESCC).MethodsThe study retrospectively evaluated preoperative NLR, PLR, and CAR hematologically and POSTN immunohistochemically in 171 patients. The correlation of immunoinflammatory measures, POSTN expression, and survival outcomes was measured.ResultsThe study showed a significant correlation of POSTN-positive expression with poor overall survival (OS) (P < 0.0001) and recurrence-free survival (RFS) (P = 0.03). The POSTN-positive group had higher PLR (189.6 ± 8 vs. 159.3 ± 12; P = 0.04) and CAR (0.36 ± 0.06 vs. 0.14 ± 0.09; P < 0.05) than the POSTN-negative group, whereas NLR did not differ between the two groups (3.27 ± 0.19 vs. 2.65 ± 0.28; P = 0.07). The uni- and multivariate analyses showed that POSTN-positive expression (hazard ratio [HR], 1.595; 95% confidence interval [CI], 0.770–3.031; P = 0.03), CAR (HR, 1.663; 95% CI, 1.016–2.764; P = 0.03), gender (HR, 2.303; 95% CI, 1.067–6.019; P = 0.03), and tumor depth (HR, 1.957; 95% CI, 1.122–3.526; P = 0.01) were independent prognostic factors.ConclusionsBecause POSTN-positive expression strongly correlates with immunoinflammatory measures, especially PLR and CAR, it is an independent prognostic factor in ESCC. More... »

PAGES

1228-1237

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-020-08765-3

DOI

http://dx.doi.org/10.1245/s10434-020-08765-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1128915361

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32613365


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27 schema:description BackgroundImmunoinflammatory measures such as the neutrophil–lymphocyte ratio (NLR), the platelet–lymphocyte ratio (PLR), and the C-reactive protein (CRP)–albumin ratio (CAR) are useful prognostic measures in various malignancies. However, no study has investigated the correlation of these measures with microenvironmental inflammation. Periostin (POSTN), a small extracellular matrix protein, strongly associates with cancer microenvironmental inflammation. The current study investigated the correlation of NLR, PLR, and CAR with periostin expression in esophageal squamous cell carcinoma (ESCC).MethodsThe study retrospectively evaluated preoperative NLR, PLR, and CAR hematologically and POSTN immunohistochemically in 171 patients. The correlation of immunoinflammatory measures, POSTN expression, and survival outcomes was measured.ResultsThe study showed a significant correlation of POSTN-positive expression with poor overall survival (OS) (P < 0.0001) and recurrence-free survival (RFS) (P = 0.03). The POSTN-positive group had higher PLR (189.6 ± 8 vs. 159.3 ± 12; P = 0.04) and CAR (0.36 ± 0.06 vs. 0.14 ± 0.09; P < 0.05) than the POSTN-negative group, whereas NLR did not differ between the two groups (3.27 ± 0.19 vs. 2.65 ± 0.28; P = 0.07). The uni- and multivariate analyses showed that POSTN-positive expression (hazard ratio [HR], 1.595; 95% confidence interval [CI], 0.770–3.031; P = 0.03), CAR (HR, 1.663; 95% CI, 1.016–2.764; P = 0.03), gender (HR, 2.303; 95% CI, 1.067–6.019; P = 0.03), and tumor depth (HR, 1.957; 95% CI, 1.122–3.526; P = 0.01) were independent prognostic factors.ConclusionsBecause POSTN-positive expression strongly correlates with immunoinflammatory measures, especially PLR and CAR, it is an independent prognostic factor in ESCC.
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35 ConclusionsBecause POSTN-positive expression
36 MethodsThe study
37 POSTN expression
38 POSTN-negative group
39 POSTN-positive expression
40 POSTN-positive group
41 ResultsThe study
42 albumin ratio
43 analysis
44 cancer microenvironmental inflammation
45 car
46 carcinoma
47 cell carcinoma
48 cohort study
49 correlation
50 correlation of NLR
51 current study
52 depth
53 esophageal squamous cell carcinoma
54 expression
55 extracellular matrix proteins
56 factors
57 gender
58 group
59 high platelet-lymphocyte ratio
60 immunoinflammatory measures
61 independent prognostic factor
62 inflammation
63 malignancy
64 matrix proteins
65 measures
66 microenvironmental inflammation
67 multivariate analysis
68 neutrophil-lymphocyte ratio
69 outcomes
70 overall survival
71 patients
72 periostin
73 periostin expression
74 platelet-lymphocyte ratio
75 poor overall survival
76 preoperative neutrophil-lymphocyte ratio
77 prognostic factors
78 prognostic measures
79 protein
80 ratio
81 reactive protein
82 recurrence-free survival
83 retrospective cohort study
84 significant correlation
85 single center
86 small extracellular matrix protein
87 squamous cell carcinoma
88 study
89 survival
90 survival outcomes
91 tumor depth
92 useful prognostic measure
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