Ontology type: schema:ScholarlyArticle
2020-06-02
AUTHORSTakuji Noro, Makoto Nishikawa, Mayumi Hoshikawa, Takahiro Einama, Suefumi Aosasa, Yoshiki Kajiwara, Yoshihisa Yaguchi, Koichi Okamoto, Eiji Shinto, Hironori Tsujimoto, Kazuo Hase, Hideki Ueno, Junji Yamamoto
ABSTRACTBackgroundMany patients undergoing hepatectomy for colorectal liver metastases (CRLM) experience recurrence. However, no criteria for screening candidates to undergo repeat hepatectomy (RH) for CRLM have been established. Budding, one form by which colorectal carcinoma malignancies are expressed, is a new pathologic index. This study aimed to analyze prognostic factors, including budding, and to provide criteria for screening candidates to undergo RH for recurrent CRLM.MethodsData of 186 consecutive patients who underwent hepatectomy for CRLM between April 2008 and December 2015 were collected. Survival was calculated using the Kaplan–Meier method. Uni- and multivariate analyses were performed to determine factors significantly affecting mortality.ResultsOf 186 patients, 131 experienced recurrence after hepatectomy, with 83 of the 131 patients showing recurrence in the liver, and 52 of these 83 patients undergoing primary surgery at the authors’ institution and having information on budding grade. In the univariate analysis, preoperative chemotherapy, budding grade, extrahepatic metastases, and number of liver metastases at the time of recurrence were associated with overall survival (OS) for the 52 patients. In the multivariate analysis, budding grade and number of liver metastases at the time of recurrence were associated with OS.ConclusionThe study examined simple prognostic factors that could help to screen patients better for RH. Repeat hepatectomy improved the prognosis for patients with recurrent CRLM. The independent prognostic factors for OS were number of liver metastases at recurrence as a conventional factor and budding grade as a new pathologic factor. With budding used as an index, patients who could benefit from hepatectomy can be screened more precisely. More... »
PAGES5200-5207
http://scigraph.springernature.com/pub.10.1245/s10434-020-08684-3
DOIhttp://dx.doi.org/10.1245/s10434-020-08684-3
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/32488517
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