The Prognostic Index Independently Predicts Survival in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Resection View Full Text


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Article Info

DATE

2020-01-03

AUTHORS

Elisabeth S. Gruber, Gerd Jomrich, Alexandra Kaider, Michael Gnant, Klaus Sahora, Martin Schindl

ABSTRACT

BackgroundCancer-related inflammation is associated with tumour proliferation, maintenance and dissemination. It therefore impacts pancreatic cancer survival. The goal of this study was to examine the Prognostic Index (PI) as a prognostic biomarker for survival in patients with pancreatic ductal adenocarcinoma (PDAC). In addition, we explored factors known to interact with the immune and inflammation cascade that might interfere with the PI’s strength for prognostication.MethodsPatients with PDAC undergoing resection were analysed retrospectively. The PI was calculated from preoperatively derived C-reactive protein levels and white blood count. Data were subject to correlation and survival analysis.ResultsOf 357 patients, 235 (65.8%) patients had a PI 0, 108 (30.3%) PI 1, and 14 (3.9%) PI 2. Median (quartiles) survival with a high PI (group 1 + 2) was 13.2 months (7.7–27.0), compared with 18.7 months (10.2–35.4) with a low PI (group 0; p = 0.012). The PI proved to be an independent prognostic factor for cancer-specific survival (p = 0.003) adjusted for conventional prognostic factors. Prognostic strength was influenced by the presence of a bile stent (p = 0.032).ConclusionsThe PI is a strong and solid independent prognostic tool for survival in patients with PDAC undergoing resection. Preoperative survey of inflammatory activity as provided by the use of a biomarker like the PI may help to identify those patients at risk of a poor prognosis. More... »

PAGES

2017-2024

References to SciGraph publications

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    http://scigraph.springernature.com/pub.10.1245/s10434-019-08161-6

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    DIMENSIONS

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    37 schema:description BackgroundCancer-related inflammation is associated with tumour proliferation, maintenance and dissemination. It therefore impacts pancreatic cancer survival. The goal of this study was to examine the Prognostic Index (PI) as a prognostic biomarker for survival in patients with pancreatic ductal adenocarcinoma (PDAC). In addition, we explored factors known to interact with the immune and inflammation cascade that might interfere with the PI’s strength for prognostication.MethodsPatients with PDAC undergoing resection were analysed retrospectively. The PI was calculated from preoperatively derived C-reactive protein levels and white blood count. Data were subject to correlation and survival analysis.ResultsOf 357 patients, 235 (65.8%) patients had a PI 0, 108 (30.3%) PI 1, and 14 (3.9%) PI 2. Median (quartiles) survival with a high PI (group 1 + 2) was 13.2 months (7.7–27.0), compared with 18.7 months (10.2–35.4) with a low PI (group 0; p = 0.012). The PI proved to be an independent prognostic factor for cancer-specific survival (p = 0.003) adjusted for conventional prognostic factors. Prognostic strength was influenced by the presence of a bile stent (p = 0.032).ConclusionsThe PI is a strong and solid independent prognostic tool for survival in patients with PDAC undergoing resection. Preoperative survey of inflammatory activity as provided by the use of a biomarker like the PI may help to identify those patients at risk of a poor prognosis.
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    45 C-reactive protein levels
    46 MethodsPatients
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    48 Pi 2
    49 activity
    50 addition
    51 adenocarcinoma
    52 analysis
    53 bile
    54 biomarkers
    55 blood count
    56 cancer survival
    57 cancer-specific survival
    58 cascade
    59 conventional prognostic factors
    60 correlation
    61 count
    62 data
    63 dissemination
    64 ductal adenocarcinoma
    65 factors
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    67 high prognostic index
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    69 independent prognostic tool
    70 index
    71 inflammation
    72 inflammation cascade
    73 inflammatory activity
    74 levels
    75 low prognostic index
    76 maintenance
    77 median survival
    78 months
    79 pancreatic cancer survival
    80 pancreatic ductal adenocarcinoma
    81 patients
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    83 poor prognosis
    84 preoperative survey
    85 presence
    86 prognosis
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    88 prognostic factors
    89 prognostic index
    90 prognostic strength
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    92 prognostication
    93 proliferation
    94 protein levels
    95 resection
    96 risk
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