Is Additional Surgery Always Sufficient for Preventing Recurrence After Endoscopic Submucosal Dissection with Curability C-2 for Early Gastric Cancer? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-07-24

AUTHORS

Waku Hatta, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Shiro Oka, Shu Hoteya, Masahiro Nakagawa, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Ryo Shimoda, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Hiroyuki Aoyagi, Tomohiro Nakamura, Naoki Nakaya, Tooru Shimosegawa, Atsushi Masamune

ABSTRACT

BackgroundWhen a lesion does not meet the curative criteria of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC), referred to as non-curative resection or curability C-2 in the guidelines, an additional surgery is the standard therapy because of the risk of lymph node metastasis (LNM).ObjectiveThis study aimed to identify high-risk patients for recurrence after additional surgery for curability C-2 ESD of EGC.MethodsThis multicenter retrospective cohort study enrolled 1064 patients who underwent additional surgery after curability C-2 ESD for EGC. We evaluated the recurrence rate and the risk factors for recurrence after additional surgery in these patients.ResultsThe 5-year recurrence rate after additional surgery was 1.3%. Multivariate Cox analysis revealed that the independent risk factors for recurrence after additional surgery were LNM (hazard ratio [HR] 32.47; p < 0.001) and vascular invasion (HR 4.75; p = 0.014). Moreover, patients with both LNM and vascular invasion had a high rate of recurrence after additional surgery (24.6% in 5 years), with a high HR (119.32) compared with those with neither LNM nor vascular invasion. Among patients with no vascular invasion, a high rate of recurrence was observed in those with N2/N3 disease according to the American Joint Committee on Cancer TNM staging system (27.3% in 5 years), in contrast with no recurrence in those with N1 disease.ConclusionsPatients with both LNM (N1–N3) and vascular invasion, as well as those with N2/N3 disease but no vascular invasion, would be candidates for adjuvant chemotherapy after additional surgery for curability C-2 ESD of EGC. More... »

PAGES

3636-3643

References to SciGraph publications

  • 2006-05. Gastric cancer treated in 1991 in Japan: data analysis of nationwide registry in GASTRIC CANCER
  • 2017-10-05. Is the eCura system useful for selecting patients who require radical surgery after noncurative endoscopic submucosal dissection for early gastric cancer? A comparative study in GASTRIC CANCER
  • 2018-03-22. Adjuvant Chemotherapy Versus Chemoradiotherapy Versus Surgery Alone for Early Gastric Cancer with One or Two Lymph Node Metastasis in ANNALS OF SURGICAL ONCOLOGY
  • 2016-10-08. Clinical outcomes of early gastric cancer patients after noncurative endoscopic submucosal dissection in a large consecutive patient series in GASTRIC CANCER
  • 2012-06-23. Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry in GASTRIC CANCER
  • 2016-08-05. Risk factors for lymph node metastasis and long-term outcomes of patients with early gastric cancer after non-curative endoscopic submucosal dissection in SURGICAL ENDOSCOPY
  • 2016-06-24. Japanese gastric cancer treatment guidelines 2014 (ver. 4) in GASTRIC CANCER
  • 2016-04-20. Is radical surgery necessary in all patients who do not meet the curative criteria for endoscopic submucosal dissection in early gastric cancer? A multi-center retrospective study in Japan in JOURNAL OF GASTROENTEROLOGY
  • 2009-11-11. Recurrence After Curative Resection of Early Gastric Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2008-12. Recurrence in early gastric cancer with lymph node metastasis in GASTRIC CANCER
  • 2017-08-09. Survival Benefit of Additional Surgery After Non-curative Endoscopic Submucosal Dissection for Early Gastric Cancer: A Propensity Score Matching Analysis in ANNALS OF SURGICAL ONCOLOGY
  • 2011-09-07. Gastric cancer treatment in Japan: 2008 annual report of the JGCA nationwide registry in GASTRIC CANCER
  • 2011-12-10. Metachronous Liver Metastasis from Early Gastric Cancer in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2011-05-15. Japanese classification of gastric carcinoma: 3rd English edition in GASTRIC CANCER
  • 2014-08-30. Predictors of lymph node metastasis in patients with non-curative endoscopic resection of early gastric cancer in SURGICAL ENDOSCOPY
  • 2015-10-13. Optimal management for patients not meeting the inclusion criteria after endoscopic submucosal dissection for gastric cancer in SURGICAL ENDOSCOPY
  • 2017-06-20. Management of early gastric cancer that meet the indication for radical lymph node dissection following endoscopic resection: a retrospective cohort analysis in BMC SURGERY
  • 2017-04-11. A Scoring System to Stratify Curability after Endoscopic Submucosal Dissection for Early Gastric Cancer: “eCura system” in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • Journal

    TITLE

    Annals of Surgical Oncology

    ISSUE

    11

    VOLUME

    26

    Author Affiliations

  • Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
  • Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Division of Endoscopy, Saku Central Hospital Advanced Care Center, Saku, Japan
  • Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan
  • Department of Gastroenterology and Metabolism, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
  • Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
  • Department of Endoscopy, Hiroshima City Hospital, Hiroshima, Japan
  • Department of Internal Medicine, Niigata Prefectural Central Hospital, Joetsu, Japan
  • Department of Gastroenterology, Kitakyushu Municipal Medical Center, Kitakyushu, Japan
  • Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan
  • Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan
  • Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Saga, Japan
  • Department of Gastroenterology and Endocrinology and Metabolism, Nara Medical University, Nara, Japan
  • Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan
  • Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
  • Department of Gastroenterology and Hepatology, Japanese Red Cross Society Kyoto Daiichi Hospital, Kyoto, Japan
  • Department of Gastroenterology, Akita City Hospital, Akita, Japan
  • Department of Gastroenterology, Osaki Citizen Hospital, Osaki, Japan
  • Division of Gastroenterology, Fukui Prefectural Hospital, Fukui, Japan
  • Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Sendai, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1245/s10434-019-07579-2

    DOI

    http://dx.doi.org/10.1245/s10434-019-07579-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1119796464

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31342376


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