Appendiceal Cancer Patient-Specific Tumor Organoid Model for Predicting Chemotherapy Efficacy Prior to Initiation of Treatment: A Feasibility Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

Konstantinos I. Votanopoulos, Andrea Mazzocchi, Hemamylammal Sivakumar, Steven Forsythe, Julio Aleman, Edward A. Levine, Aleksander Skardal

ABSTRACT

INTRODUCTION: We have hypothesized that biofabrication of appendiceal tumor organoids allows for a more personalized clinical approach and facilitates research in a rare disease. METHODS: Appendiceal cancer specimens obtained during cytoreduction with hyperthermic intraperitoneal chemotherapy procedures (CRS/HIPEC) were dissociated and incorporated into an extracellular matrix-based hydrogel system as three-dimensional (3D), patient-specific tumor organoids. Cells were not sorted, preserving tumor heterogeneity, including stroma and immune cell components. Following establishment of organoid sets, chemotherapy drugs were screened in parallel. Live/dead staining and quantitative metabolism assays recorded which chemotherapies were most effective in killing cancer cells for a specific patient. Maintenance of cancer phenotypes were confirmed by using immunohistochemistry. RESULTS: Biospecimens from 12 patients were applied for organoid development between November 2016 and May 2018. Successful establishment rate of viable organoid sets was 75% (9/12). Average time from organoid development to chemotherapy testing was 7 days. These tumors included three high-grade appendiceal (HGA) and nine low-grade appendiceal (LGA) primaries obtained from sites of peritoneal metastasis. All tumor organoids were tested with chemotherapeutic agents exhibited responses that were either similar to the patient response or within the variability of the expected clinical response. More specifically, HGA tumor organoids derived from different patients demonstrated variable chemotherapy tumor-killing responses, whereas LGA organoids tested with the same regimens showed no response to chemotherapy. One LGA set of organoids was immune-enhanced with cells from a patient-matched lymph node to demonstrate feasibility of a symbiotic 3D reconstruction of a patient matched tumor and immune system component. CONCLUSIONS: Development of 3D appendiceal tumor organoids is feasible even in low cellularity LGA tumors, allowing for individual patient tumors to remain viable for research and personalized drug screening. More... »

PAGES

1-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-018-7008-2

DOI

http://dx.doi.org/10.1245/s10434-018-7008-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1109801247

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30414038


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Wake Forest Baptist Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412860.9", 
          "name": [
            "Department of Surgery \u2013 Oncology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA", 
            "Comprehensive Cancer Center at Wake Forest Baptist Medical, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Votanopoulos", 
        "givenName": "Konstantinos I.", 
        "id": "sg:person.01155643513.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155643513.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest University", 
          "id": "https://www.grid.ac/institutes/grid.241167.7", 
          "name": [
            "Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA", 
            "Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazzocchi", 
        "givenName": "Andrea", 
        "id": "sg:person.07672654660.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07672654660.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest University", 
          "id": "https://www.grid.ac/institutes/grid.241167.7", 
          "name": [
            "Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sivakumar", 
        "givenName": "Hemamylammal", 
        "id": "sg:person.015675637356.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015675637356.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest University", 
          "id": "https://www.grid.ac/institutes/grid.241167.7", 
          "name": [
            "Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA", 
            "Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forsythe", 
        "givenName": "Steven", 
        "id": "sg:person.01270761777.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270761777.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest University", 
          "id": "https://www.grid.ac/institutes/grid.241167.7", 
          "name": [
            "Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aleman", 
        "givenName": "Julio", 
        "id": "sg:person.01072531465.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072531465.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest Baptist Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412860.9", 
          "name": [
            "Department of Surgery \u2013 Oncology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA", 
            "Comprehensive Cancer Center at Wake Forest Baptist Medical, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levine", 
        "givenName": "Edward A.", 
        "id": "sg:person.01362075400.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362075400.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest University", 
          "id": "https://www.grid.ac/institutes/grid.241167.7", 
          "name": [
            "Comprehensive Cancer Center at Wake Forest Baptist Medical, Winston-Salem, NC, USA", 
            "Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA", 
            "Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA", 
            "Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Skardal", 
        "givenName": "Aleksander", 
        "id": "sg:person.01033434737.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033434737.72"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-14-0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000404010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-014-4147-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000934407", 
          "https://doi.org/10.1245/s10434-014-4147-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2012.03.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001413490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2015.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001763644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2011.12.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010225928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-13-0087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017991650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.b.33736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018279418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/9781782622055-00191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021110935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/1758-5090/7/3/031001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027066739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2010.04.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036020632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.25950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053492530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2009.0798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059315534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-08879-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091232024", 
          "https://doi.org/10.1038/s41598-017-08879-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-08879-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091232024", 
          "https://doi.org/10.1038/s41598-017-08879-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-08879-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091232024", 
          "https://doi.org/10.1038/s41598-017-08879-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2017.0397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091847991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-319-60511-1_4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092361205", 
          "https://doi.org/10.1007/978-3-319-60511-1_4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-319-60511-1_4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092361205", 
          "https://doi.org/10.1007/978-3-319-60511-1_4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-21200-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100901821", 
          "https://doi.org/10.1038/s41598-018-21200-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aao2774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101186518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aao2774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101186518"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01", 
    "datePublishedReg": "2019-01-01", 
    "description": "INTRODUCTION: We have hypothesized that biofabrication of appendiceal tumor organoids allows for a more personalized clinical approach and facilitates research in a rare disease.\nMETHODS: Appendiceal cancer specimens obtained during cytoreduction with hyperthermic intraperitoneal chemotherapy procedures (CRS/HIPEC) were dissociated and incorporated into an extracellular matrix-based hydrogel system as three-dimensional (3D), patient-specific tumor organoids. Cells were not sorted, preserving tumor heterogeneity, including stroma and immune cell components. Following establishment of organoid sets, chemotherapy drugs were screened in parallel. Live/dead staining and quantitative metabolism assays recorded which chemotherapies were most effective in killing cancer cells for a specific patient. Maintenance of cancer phenotypes were confirmed by using immunohistochemistry.\nRESULTS: Biospecimens from 12 patients were applied for organoid development between November 2016 and May 2018. Successful establishment rate of viable organoid sets was 75% (9/12). Average time from organoid development to chemotherapy testing was 7\u00a0days. These tumors included three high-grade appendiceal (HGA) and nine low-grade appendiceal (LGA) primaries obtained from sites of peritoneal metastasis. All tumor organoids were tested with chemotherapeutic agents exhibited responses that were either similar to the patient response or within the variability of the expected clinical response. More specifically, HGA tumor organoids derived from different patients demonstrated variable chemotherapy tumor-killing responses, whereas LGA organoids tested with the same regimens showed no response to chemotherapy. One LGA set of organoids was immune-enhanced with cells from a patient-matched lymph node to demonstrate feasibility of a symbiotic 3D reconstruction of a patient matched tumor and immune system component.\nCONCLUSIONS: Development of 3D appendiceal tumor organoids is feasible even in low cellularity LGA tumors, allowing for individual patient tumors to remain viable for research and personalized drug screening.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-018-7008-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }
    ], 
    "name": "Appendiceal Cancer Patient-Specific Tumor Organoid Model for Predicting Chemotherapy Efficacy Prior to Initiation of Treatment: A Feasibility Study", 
    "pagination": "1-9", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d76ddcb5cd3be8defc0058a21f38707256804b7d995a69424a07ac64020babe7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30414038"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-018-7008-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1109801247"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-018-7008-2", 
      "https://app.dimensions.ai/details/publication/pub.1109801247"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000610.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1245%2Fs10434-018-7008-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-018-7008-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-018-7008-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-018-7008-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-018-7008-2'


 

This table displays all metadata directly associated to this object as RDF triples.

167 TRIPLES      21 PREDICATES      44 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-018-7008-2 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N7c623be903d842e9b6f5647a57ab48f7
4 schema:citation sg:pub.10.1007/978-3-319-60511-1_4
5 sg:pub.10.1038/s41598-017-08879-x
6 sg:pub.10.1038/s41598-018-21200-8
7 sg:pub.10.1245/s10434-014-4147-y
8 https://doi.org/10.1002/bit.25950
9 https://doi.org/10.1002/jbm.b.33736
10 https://doi.org/10.1016/j.actbio.2015.07.030
11 https://doi.org/10.1016/j.biomaterials.2010.04.045
12 https://doi.org/10.1016/j.biomaterials.2012.03.034
13 https://doi.org/10.1016/j.jamcollsurg.2011.12.028
14 https://doi.org/10.1039/9781782622055-00191
15 https://doi.org/10.1088/1758-5090/7/3/031001
16 https://doi.org/10.1089/ten.tea.2009.0798
17 https://doi.org/10.1089/ten.tea.2017.0397
18 https://doi.org/10.1126/science.aao2774
19 https://doi.org/10.1158/0008-5472.can-13-0087
20 https://doi.org/10.1158/2159-8290.cd-14-0001
21 schema:datePublished 2019-01
22 schema:datePublishedReg 2019-01-01
23 schema:description INTRODUCTION: We have hypothesized that biofabrication of appendiceal tumor organoids allows for a more personalized clinical approach and facilitates research in a rare disease. METHODS: Appendiceal cancer specimens obtained during cytoreduction with hyperthermic intraperitoneal chemotherapy procedures (CRS/HIPEC) were dissociated and incorporated into an extracellular matrix-based hydrogel system as three-dimensional (3D), patient-specific tumor organoids. Cells were not sorted, preserving tumor heterogeneity, including stroma and immune cell components. Following establishment of organoid sets, chemotherapy drugs were screened in parallel. Live/dead staining and quantitative metabolism assays recorded which chemotherapies were most effective in killing cancer cells for a specific patient. Maintenance of cancer phenotypes were confirmed by using immunohistochemistry. RESULTS: Biospecimens from 12 patients were applied for organoid development between November 2016 and May 2018. Successful establishment rate of viable organoid sets was 75% (9/12). Average time from organoid development to chemotherapy testing was 7 days. These tumors included three high-grade appendiceal (HGA) and nine low-grade appendiceal (LGA) primaries obtained from sites of peritoneal metastasis. All tumor organoids were tested with chemotherapeutic agents exhibited responses that were either similar to the patient response or within the variability of the expected clinical response. More specifically, HGA tumor organoids derived from different patients demonstrated variable chemotherapy tumor-killing responses, whereas LGA organoids tested with the same regimens showed no response to chemotherapy. One LGA set of organoids was immune-enhanced with cells from a patient-matched lymph node to demonstrate feasibility of a symbiotic 3D reconstruction of a patient matched tumor and immune system component. CONCLUSIONS: Development of 3D appendiceal tumor organoids is feasible even in low cellularity LGA tumors, allowing for individual patient tumors to remain viable for research and personalized drug screening.
24 schema:genre research_article
25 schema:inLanguage en
26 schema:isAccessibleForFree false
27 schema:isPartOf sg:journal.1105545
28 schema:name Appendiceal Cancer Patient-Specific Tumor Organoid Model for Predicting Chemotherapy Efficacy Prior to Initiation of Treatment: A Feasibility Study
29 schema:pagination 1-9
30 schema:productId N24f4954d4b164adfabfbcae67d71d28f
31 N623a4fa2aa5746bbb01ebec0e7543c61
32 N7feb51e1459f40a79d54364051a6cc76
33 Nf32eca57c79e4ed8acdd7c6d0b0a4cab
34 Nf68f95603f944a93997ef5f20cb1219b
35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109801247
36 https://doi.org/10.1245/s10434-018-7008-2
37 schema:sdDatePublished 2019-04-10T14:24
38 schema:sdLicense https://scigraph.springernature.com/explorer/license/
39 schema:sdPublisher Ne38a09d4c93f43b7b046484613703ef1
40 schema:url https://link.springer.com/10.1245%2Fs10434-018-7008-2
41 sgo:license sg:explorer/license/
42 sgo:sdDataset articles
43 rdf:type schema:ScholarlyArticle
44 N0734e9367ef14e8bb6fb27ac1c24f4cf rdf:first sg:person.01270761777.91
45 rdf:rest N93aa07eaec8a415f846336da412aa94d
46 N24f4954d4b164adfabfbcae67d71d28f schema:name readcube_id
47 schema:value d76ddcb5cd3be8defc0058a21f38707256804b7d995a69424a07ac64020babe7
48 rdf:type schema:PropertyValue
49 N36883368877e4e08845d41df51acd295 rdf:first sg:person.01362075400.37
50 rdf:rest Nc0f40052bb9a4d079f6837219fa1e803
51 N54fe5accf43d4a8dbd2e588db8466d19 rdf:first sg:person.015675637356.06
52 rdf:rest N0734e9367ef14e8bb6fb27ac1c24f4cf
53 N623a4fa2aa5746bbb01ebec0e7543c61 schema:name pubmed_id
54 schema:value 30414038
55 rdf:type schema:PropertyValue
56 N7c623be903d842e9b6f5647a57ab48f7 rdf:first sg:person.01155643513.53
57 rdf:rest Nbcc21b22c7a94a65a642232876687edf
58 N7feb51e1459f40a79d54364051a6cc76 schema:name doi
59 schema:value 10.1245/s10434-018-7008-2
60 rdf:type schema:PropertyValue
61 N93aa07eaec8a415f846336da412aa94d rdf:first sg:person.01072531465.05
62 rdf:rest N36883368877e4e08845d41df51acd295
63 Nbcc21b22c7a94a65a642232876687edf rdf:first sg:person.07672654660.06
64 rdf:rest N54fe5accf43d4a8dbd2e588db8466d19
65 Nc0f40052bb9a4d079f6837219fa1e803 rdf:first sg:person.01033434737.72
66 rdf:rest rdf:nil
67 Ne38a09d4c93f43b7b046484613703ef1 schema:name Springer Nature - SN SciGraph project
68 rdf:type schema:Organization
69 Nf32eca57c79e4ed8acdd7c6d0b0a4cab schema:name nlm_unique_id
70 schema:value 9420840
71 rdf:type schema:PropertyValue
72 Nf68f95603f944a93997ef5f20cb1219b schema:name dimensions_id
73 schema:value pub.1109801247
74 rdf:type schema:PropertyValue
75 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
76 schema:name Medical and Health Sciences
77 rdf:type schema:DefinedTerm
78 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
79 schema:name Oncology and Carcinogenesis
80 rdf:type schema:DefinedTerm
81 sg:journal.1105545 schema:issn 1068-9265
82 1534-4681
83 schema:name Annals of Surgical Oncology
84 rdf:type schema:Periodical
85 sg:person.01033434737.72 schema:affiliation https://www.grid.ac/institutes/grid.241167.7
86 schema:familyName Skardal
87 schema:givenName Aleksander
88 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033434737.72
89 rdf:type schema:Person
90 sg:person.01072531465.05 schema:affiliation https://www.grid.ac/institutes/grid.241167.7
91 schema:familyName Aleman
92 schema:givenName Julio
93 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072531465.05
94 rdf:type schema:Person
95 sg:person.01155643513.53 schema:affiliation https://www.grid.ac/institutes/grid.412860.9
96 schema:familyName Votanopoulos
97 schema:givenName Konstantinos I.
98 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155643513.53
99 rdf:type schema:Person
100 sg:person.01270761777.91 schema:affiliation https://www.grid.ac/institutes/grid.241167.7
101 schema:familyName Forsythe
102 schema:givenName Steven
103 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270761777.91
104 rdf:type schema:Person
105 sg:person.01362075400.37 schema:affiliation https://www.grid.ac/institutes/grid.412860.9
106 schema:familyName Levine
107 schema:givenName Edward A.
108 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362075400.37
109 rdf:type schema:Person
110 sg:person.015675637356.06 schema:affiliation https://www.grid.ac/institutes/grid.241167.7
111 schema:familyName Sivakumar
112 schema:givenName Hemamylammal
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015675637356.06
114 rdf:type schema:Person
115 sg:person.07672654660.06 schema:affiliation https://www.grid.ac/institutes/grid.241167.7
116 schema:familyName Mazzocchi
117 schema:givenName Andrea
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07672654660.06
119 rdf:type schema:Person
120 sg:pub.10.1007/978-3-319-60511-1_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092361205
121 https://doi.org/10.1007/978-3-319-60511-1_4
122 rdf:type schema:CreativeWork
123 sg:pub.10.1038/s41598-017-08879-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1091232024
124 https://doi.org/10.1038/s41598-017-08879-x
125 rdf:type schema:CreativeWork
126 sg:pub.10.1038/s41598-018-21200-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100901821
127 https://doi.org/10.1038/s41598-018-21200-8
128 rdf:type schema:CreativeWork
129 sg:pub.10.1245/s10434-014-4147-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1000934407
130 https://doi.org/10.1245/s10434-014-4147-y
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1002/bit.25950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053492530
133 rdf:type schema:CreativeWork
134 https://doi.org/10.1002/jbm.b.33736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018279418
135 rdf:type schema:CreativeWork
136 https://doi.org/10.1016/j.actbio.2015.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001763644
137 rdf:type schema:CreativeWork
138 https://doi.org/10.1016/j.biomaterials.2010.04.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036020632
139 rdf:type schema:CreativeWork
140 https://doi.org/10.1016/j.biomaterials.2012.03.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001413490
141 rdf:type schema:CreativeWork
142 https://doi.org/10.1016/j.jamcollsurg.2011.12.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010225928
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1039/9781782622055-00191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021110935
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1088/1758-5090/7/3/031001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027066739
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1089/ten.tea.2009.0798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059315534
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1089/ten.tea.2017.0397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091847991
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1126/science.aao2774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101186518
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1158/0008-5472.can-13-0087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017991650
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1158/2159-8290.cd-14-0001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000404010
157 rdf:type schema:CreativeWork
158 https://www.grid.ac/institutes/grid.241167.7 schema:alternateName Wake Forest University
159 schema:name Comprehensive Cancer Center at Wake Forest Baptist Medical, Winston-Salem, NC, USA
160 Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA
161 Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
162 Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA
163 rdf:type schema:Organization
164 https://www.grid.ac/institutes/grid.412860.9 schema:alternateName Wake Forest Baptist Medical Center
165 schema:name Comprehensive Cancer Center at Wake Forest Baptist Medical, Winston-Salem, NC, USA
166 Department of Surgery – Oncology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA
167 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...