Recurrence Patterns After Anatomic or Parenchyma-Sparing Liver Resection for Hepatocarcinoma in a Western Population of Cirrhotic Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09-22

AUTHORS

Simone Famularo, Stefano Di Sandro, Alessandro Giani, Andrea Lauterio, Marta Sandini, Riccardo De Carlis, Vincenzo Buscemi, Fabio Uggeri, Fabrizio Romano, Luca Gianotti, Luciano De Carlis

ABSTRACT

BackgroundThe optimal surgical strategy to lessen the risk of hepatocarcinoma (HCC) recurrence is debated. This study aimed to investigate the role of anatomic resection (AR) and parenchyma-sparing resection (PSR) in HCC recurrence patterns.MethodsThe study analyzed 384 cirrhotic patients with a first diagnosis of HCC. Of these patients, 142 underwent AR, and 242 underwent PSR. The two groups were unbalanced at the univariate analysis. To minimize this bias, a 1:1 propensity score-matching analysis (PSA) was used. Disease-free survival (DFS) curves were analyzed by the Kaplan-Maier method.ResultsThe PSA allowed pairing of 200 patients (100 for AR and 100 for PSR). In this study, 59 patients (62.8%) had recurrence after AR compared with 58 patients (63.7%) after PSR (p = 0.891). The rates of local recurrence were respectively 15.3% and 15.5% (p = 0.968). When microvascular invasion was considered, the median DFS was 10.7 months for AR and 9.4 months for PSR (p = 0.607). In comparisons of AR and PSR, DFS did not differ significantly between subgroups with high histologic grading (p = 0.520), multiple nodules (p = 0.307), and Child–Pugh B (p = 0.679).ConclusionExcision of the anatomic segment did not seem to reduce the rate of relapse or recurrence patterns significantly, even in high-risk subgroups. More... »

PAGES

3974-3981

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-018-6730-0

DOI

http://dx.doi.org/10.1245/s10434-018-6730-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107186471

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30244421


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