Skeletal Muscle Attenuation (Sarcopenia) Predicts Reduced Overall Survival in Patients with Advanced Epithelial Ovarian Cancer Undergoing Primary Debulking Surgery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08-01

AUTHORS

Beyhan Ataseven, Teresa González Luengo, Andreas du Bois, Kai-Uwe Waltering, Alexander Traut, Florian Heitz, Pier Francesco Alesina, Sonia Prader, Beate Meier, Stephanie Schneider, Jens-Albrecht Koch, Martin Walz, Harald-Thomas Groeben, Pauly Nina, Violeta Brunkhorst, Sebastian Heikaus, Philipp Harter

ABSTRACT

BackgroundSarcopenia was reported as a prognostic factor in cancer patients. Using computed tomography (CT), we analyzed the impact of sarcopenia on overall survival (OS) in patients with advanced epithelial ovarian cancer (EOC) after primary debulking surgery (PDS).MethodsPreoperative CT scans of consecutive EOC patients (n = 323) were retrospectively assessed for skeletal muscle index (SMI) and muscle attenuation (MA; Hounsfield units [HU]). The optimal cut-off point for MA (32 HU) was calculated using the Martingale residuals method, and previously reported cut-offs for SMI were used. Logistic regression was used to determine univariate and multivariate factors associated with OS.ResultsSarcopenia defined as SMI < 38.5, < 39, and 41 cm2/m2 was detected in 29.4, 33.7, and 47.1% of patients, respectively; however, none of these SMI cut-off levels were associated with OS. MA < 32 HU was present in 21.1% (68/323) of the total cohort. Significant differences between patients with MA < 32 and ≥ 32 HU were detected for median age (67 vs. 57 years), Eastern Cooperative Oncology Group (ECOG) > 0 (13.2 vs. 3.1%), comorbidity (age-adjusted Charlson Comorbidity Index [ACCI] ≥ 4; 36.8 vs. 13.3%), median body mass index (BMI; 27 vs. 24 kg/m2), International Federation of Gynecology and Obstetrics (FIGO) stage, histology (high-grade serous 95.6 vs. 84.7%), and complete resection (38.2 vs. 68.2%). MA < 32 HU remained a significant prognostic factor for OS in multivariate Cox regression analysis (hazard ratio 1.79, p = 0.003). Median OS in patients with MA < 32 HU versus MA ≥ 32 HU was 28 versus 56 months (p < 0.001). Furthermore, MA < 32 HU was significantly associated with OS in the prognostically poor population of patients with residual tumor (p = 0.015).ConclusionsLow MA was significantly associated with poor survival, especially in patients with residual tumor after PDS. MA assessment could be used for risk stratification after PDS. More... »

PAGES

3372-3379

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-018-6683-3

DOI

http://dx.doi.org/10.1245/s10434-018-6683-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105951493

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30069659


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Mass Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Ovarian Epithelial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoreduction Surgical Procedures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcopenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411095.8", 
          "name": [
            "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany", 
            "Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ataseven", 
        "givenName": "Beyhan", 
        "id": "sg:person.01055774132.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055774132.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Kliniken Essen-Mitte, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Radiology, Kliniken Essen-Mitte, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luengo", 
        "givenName": "Teresa Gonz\u00e1lez", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "du Bois", 
        "givenName": "Andreas", 
        "id": "sg:person.01300434727.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300434727.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Kliniken Essen-Mitte, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Radiology, Kliniken Essen-Mitte, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waltering", 
        "givenName": "Kai-Uwe", 
        "id": "sg:person.011231725606.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011231725606.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Traut", 
        "givenName": "Alexander", 
        "id": "sg:person.01100262661.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100262661.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heitz", 
        "givenName": "Florian", 
        "id": "sg:person.0643043273.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643043273.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Visceral Surgery, Kliniken Essen-Mitte, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Visceral Surgery, Kliniken Essen-Mitte, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alesina", 
        "givenName": "Pier Francesco", 
        "id": "sg:person.01053047413.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053047413.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prader", 
        "givenName": "Sonia", 
        "id": "sg:person.0762633757.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762633757.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Visceral Surgery, Kliniken Essen-Mitte, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Visceral Surgery, Kliniken Essen-Mitte, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meier", 
        "givenName": "Beate", 
        "id": "sg:person.0730466067.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730466067.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schneider", 
        "givenName": "Stephanie", 
        "id": "sg:person.01172510545.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172510545.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Kliniken Essen-Mitte, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Radiology, Kliniken Essen-Mitte, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koch", 
        "givenName": "Jens-Albrecht", 
        "id": "sg:person.01230075746.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230075746.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Visceral Surgery, Kliniken Essen-Mitte, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Visceral Surgery, Kliniken Essen-Mitte, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walz", 
        "givenName": "Martin", 
        "id": "sg:person.0761166456.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761166456.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Intensive Care, Kliniken Essen-Mitte, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Anesthesiology and Intensive Care, Kliniken Essen-Mitte, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Groeben", 
        "givenName": "Harald-Thomas", 
        "id": "sg:person.01351104275.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351104275.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nina", 
        "givenName": "Pauly", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Intensive Care, Kliniken Essen-Mitte, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Anesthesiology and Intensive Care, Kliniken Essen-Mitte, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brunkhorst", 
        "givenName": "Violeta", 
        "id": "sg:person.0666562733.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666562733.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Pathology, Kliniken Essen-Mitte, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Center for Pathology, Kliniken Essen-Mitte, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heikaus", 
        "givenName": "Sebastian", 
        "id": "sg:person.01314572015.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314572015.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harter", 
        "givenName": "Philipp", 
        "id": "sg:person.01001147210.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001147210.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1245/s10434-014-4285-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014572189", 
          "https://doi.org/10.1245/s10434-014-4285-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-017-6079-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091482223", 
          "https://doi.org/10.1245/s10434-017-6079-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-014-4040-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053187502", 
          "https://doi.org/10.1245/s10434-014-4040-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-014-4281-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020151524", 
          "https://doi.org/10.1245/s10434-014-4281-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-012-1923-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020456159", 
          "https://doi.org/10.1007/s11605-012-1923-5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08-01", 
    "datePublishedReg": "2018-08-01", 
    "description": "BackgroundSarcopenia was reported as a prognostic factor in cancer patients. Using computed tomography (CT), we analyzed the impact of sarcopenia on overall survival (OS) in patients with advanced epithelial ovarian cancer (EOC) after primary debulking surgery (PDS).MethodsPreoperative CT scans of consecutive EOC patients (n\u2009=\u2009323) were retrospectively assessed for skeletal muscle index (SMI) and muscle attenuation (MA; Hounsfield units [HU]). The optimal cut-off point for MA (32\u00a0HU) was calculated using the Martingale residuals method, and previously reported cut-offs for SMI were used. Logistic regression was used to determine univariate and multivariate factors associated with OS.ResultsSarcopenia defined as SMI\u2009<\u200938.5,\u2009<\u200939, and 41\u00a0cm2/m2 was detected in 29.4, 33.7, and 47.1% of patients, respectively; however, none of these SMI cut-off levels were associated with OS. MA\u2009<\u200932\u00a0HU was present in 21.1% (68/323) of the total cohort. Significant differences between patients with MA\u2009<\u200932 and \u2265\u200932\u00a0HU were detected for median age (67 vs. 57\u00a0years), Eastern Cooperative Oncology Group (ECOG)\u2009>\u20090 (13.2 vs. 3.1%), comorbidity (age-adjusted Charlson Comorbidity Index [ACCI] \u2265\u20094; 36.8 vs. 13.3%), median body mass index (BMI; 27 vs. 24\u00a0kg/m2), International Federation of Gynecology and Obstetrics (FIGO) stage, histology (high-grade serous 95.6 vs. 84.7%), and complete resection (38.2 vs. 68.2%). MA\u2009<\u200932\u00a0HU remained a significant prognostic factor for OS in multivariate Cox regression analysis (hazard ratio 1.79, p\u2009=\u20090.003). Median OS in patients with MA\u2009<\u200932\u00a0HU versus MA \u2265\u200932\u00a0HU was 28 versus 56\u00a0months (p\u2009<\u20090.001). Furthermore, MA\u2009<\u200932\u00a0HU was significantly associated with OS in the prognostically poor population of patients with residual tumor (p\u2009=\u20090.015).ConclusionsLow MA was significantly associated with poor survival, especially in patients with residual tumor after PDS. MA assessment could be used for risk stratification after PDS.", 
    "genre": "article", 
    "id": "sg:pub.10.1245/s10434-018-6683-3", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "keywords": [
      "skeletal muscle index", 
      "epithelial ovarian cancer", 
      "advanced epithelial ovarian cancer", 
      "Eastern Cooperative Oncology Group", 
      "overall survival", 
      "prognostic factors", 
      "muscle attenuation", 
      "residual tumor", 
      "ovarian cancer", 
      "median body mass index", 
      "multivariate Cox regression analysis", 
      "MethodsPreoperative CT scans", 
      "consecutive EOC patients", 
      "skeletal muscle attenuation", 
      "Primary Debulking Surgery", 
      "impact of sarcopenia", 
      "median overall survival", 
      "significant prognostic factors", 
      "Cooperative Oncology Group", 
      "Cox regression analysis", 
      "cm2/m2", 
      "body mass index", 
      "Obstetrics stage", 
      "Debulking Surgery", 
      "total cohort", 
      "Oncology Group", 
      "muscle index", 
      "median age", 
      "complete resection", 
      "EOC patients", 
      "mass index", 
      "risk stratification", 
      "cancer patients", 
      "poor survival", 
      "CT scan", 
      "MA assessment", 
      "patients", 
      "logistic regression", 
      "International Federation", 
      "significant differences", 
      "surgery", 
      "regression analysis", 
      "survival", 
      "tumors", 
      "cancer", 
      "multivariate factors", 
      "ResultsSarcopenia", 
      "BackgroundSarcopenia", 
      "comorbidities", 
      "resection", 
      "sarcopenia", 
      "HU", 
      "poor population", 
      "Gynecology", 
      "cohort", 
      "histology", 
      "factors", 
      "univariate", 
      "months", 
      "index", 
      "tomography", 
      "age", 
      "scans", 
      "PDS", 
      "group", 
      "regression", 
      "attenuation", 
      "population", 
      "stratification", 
      "assessment", 
      "levels", 
      "differences", 
      "m2", 
      "stage", 
      "impact", 
      "analysis", 
      "cut", 
      "Federation", 
      "point", 
      "method", 
      "Ma", 
      "residual method"
    ], 
    "name": "Skeletal Muscle Attenuation (Sarcopenia) Predicts Reduced Overall Survival in Patients with Advanced Epithelial Ovarian Cancer Undergoing Primary Debulking Surgery", 
    "pagination": "3372-3379", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105951493"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-018-6683-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30069659"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-018-6683-3", 
      "https://app.dimensions.ai/details/publication/pub.1105951493"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_776.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1245/s10434-018-6683-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-018-6683-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-018-6683-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-018-6683-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-018-6683-3'


 

This table displays all metadata directly associated to this object as RDF triples.

350 TRIPLES      22 PREDICATES      129 URIs      116 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-018-6683-3 schema:about N160c1cb892af4dfa943ff72072a4f68d
2 N17815da75fce4d5f878f660e93a67961
3 N3bb78df6ce4444de8bbd6e7264e5e728
4 N49a3a71ca2884d2bba8d6e709db079ae
5 N4cd8c6f68b8e42a4a6da336a428b45a0
6 N4e245b56ffb74da99dc801fb7e6256f6
7 N50058ce70fef4ae6a7e8928993867191
8 N5c177a4944f347a2afbf756cddaa7902
9 N5c673a04e23a46289e54f30c6f9603a9
10 N874e951a5b4f4e279b810f9ddd7ab3e4
11 N8ed9603091aa4ca6940d13568d8c58ec
12 Na083d8b51bb9421e9c73e1b0d5b4b77f
13 Nbf988dc804d3443db4c4d0c5f56899b1
14 Nc1dcd8aa13be44b9927372a004450edd
15 Nf25e2f0539b04e75a90f5dde6963100a
16 Nfcdfe22676fb4042928b5216b7545a43
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N132a1ba0729e486886c7647ef65674d5
20 schema:citation sg:pub.10.1007/s11605-012-1923-5
21 sg:pub.10.1245/s10434-014-4040-8
22 sg:pub.10.1245/s10434-014-4281-6
23 sg:pub.10.1245/s10434-014-4285-2
24 sg:pub.10.1245/s10434-017-6079-9
25 schema:datePublished 2018-08-01
26 schema:datePublishedReg 2018-08-01
27 schema:description BackgroundSarcopenia was reported as a prognostic factor in cancer patients. Using computed tomography (CT), we analyzed the impact of sarcopenia on overall survival (OS) in patients with advanced epithelial ovarian cancer (EOC) after primary debulking surgery (PDS).MethodsPreoperative CT scans of consecutive EOC patients (n = 323) were retrospectively assessed for skeletal muscle index (SMI) and muscle attenuation (MA; Hounsfield units [HU]). The optimal cut-off point for MA (32 HU) was calculated using the Martingale residuals method, and previously reported cut-offs for SMI were used. Logistic regression was used to determine univariate and multivariate factors associated with OS.ResultsSarcopenia defined as SMI < 38.5, < 39, and 41 cm2/m2 was detected in 29.4, 33.7, and 47.1% of patients, respectively; however, none of these SMI cut-off levels were associated with OS. MA < 32 HU was present in 21.1% (68/323) of the total cohort. Significant differences between patients with MA < 32 and ≥ 32 HU were detected for median age (67 vs. 57 years), Eastern Cooperative Oncology Group (ECOG) > 0 (13.2 vs. 3.1%), comorbidity (age-adjusted Charlson Comorbidity Index [ACCI] ≥ 4; 36.8 vs. 13.3%), median body mass index (BMI; 27 vs. 24 kg/m2), International Federation of Gynecology and Obstetrics (FIGO) stage, histology (high-grade serous 95.6 vs. 84.7%), and complete resection (38.2 vs. 68.2%). MA < 32 HU remained a significant prognostic factor for OS in multivariate Cox regression analysis (hazard ratio 1.79, p = 0.003). Median OS in patients with MA < 32 HU versus MA ≥ 32 HU was 28 versus 56 months (p < 0.001). Furthermore, MA < 32 HU was significantly associated with OS in the prognostically poor population of patients with residual tumor (p = 0.015).ConclusionsLow MA was significantly associated with poor survival, especially in patients with residual tumor after PDS. MA assessment could be used for risk stratification after PDS.
28 schema:genre article
29 schema:inLanguage en
30 schema:isAccessibleForFree false
31 schema:isPartOf N40b36197fda940dab98590dd88fa26b0
32 N6ab84e15f0254851abe8535925e9735f
33 sg:journal.1105545
34 schema:keywords BackgroundSarcopenia
35 CT scan
36 Cooperative Oncology Group
37 Cox regression analysis
38 Debulking Surgery
39 EOC patients
40 Eastern Cooperative Oncology Group
41 Federation
42 Gynecology
43 HU
44 International Federation
45 MA assessment
46 Ma
47 MethodsPreoperative CT scans
48 Obstetrics stage
49 Oncology Group
50 PDS
51 Primary Debulking Surgery
52 ResultsSarcopenia
53 advanced epithelial ovarian cancer
54 age
55 analysis
56 assessment
57 attenuation
58 body mass index
59 cancer
60 cancer patients
61 cm2/m2
62 cohort
63 comorbidities
64 complete resection
65 consecutive EOC patients
66 cut
67 differences
68 epithelial ovarian cancer
69 factors
70 group
71 histology
72 impact
73 impact of sarcopenia
74 index
75 levels
76 logistic regression
77 m2
78 mass index
79 median age
80 median body mass index
81 median overall survival
82 method
83 months
84 multivariate Cox regression analysis
85 multivariate factors
86 muscle attenuation
87 muscle index
88 ovarian cancer
89 overall survival
90 patients
91 point
92 poor population
93 poor survival
94 population
95 prognostic factors
96 regression
97 regression analysis
98 resection
99 residual method
100 residual tumor
101 risk stratification
102 sarcopenia
103 scans
104 significant differences
105 significant prognostic factors
106 skeletal muscle attenuation
107 skeletal muscle index
108 stage
109 stratification
110 surgery
111 survival
112 tomography
113 total cohort
114 tumors
115 univariate
116 schema:name Skeletal Muscle Attenuation (Sarcopenia) Predicts Reduced Overall Survival in Patients with Advanced Epithelial Ovarian Cancer Undergoing Primary Debulking Surgery
117 schema:pagination 3372-3379
118 schema:productId N056d5a9587d94e60b692fe18929539a1
119 N5d54ee156207403e802ec83d69fe05a3
120 Nde04372ff2c04256b46e09f6a99fff45
121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105951493
122 https://doi.org/10.1245/s10434-018-6683-3
123 schema:sdDatePublished 2022-05-20T07:34
124 schema:sdLicense https://scigraph.springernature.com/explorer/license/
125 schema:sdPublisher N0f10dfed27f647a395100eccfac56ff5
126 schema:url https://doi.org/10.1245/s10434-018-6683-3
127 sgo:license sg:explorer/license/
128 sgo:sdDataset articles
129 rdf:type schema:ScholarlyArticle
130 N056d5a9587d94e60b692fe18929539a1 schema:name dimensions_id
131 schema:value pub.1105951493
132 rdf:type schema:PropertyValue
133 N07974b6323fd46a1b01deb828ede708c rdf:first sg:person.01351104275.76
134 rdf:rest N947e6bdc76054d138ee60a7cf125dd1a
135 N0e7177f740d948968e5496641c4a9fa9 rdf:first sg:person.01230075746.29
136 rdf:rest N7ef0c533186c47e1bcb4db6948c68126
137 N0f10dfed27f647a395100eccfac56ff5 schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 N132a1ba0729e486886c7647ef65674d5 rdf:first sg:person.01055774132.85
140 rdf:rest Nd70b1b58aa8d4c5494d0246645c3a424
141 N160c1cb892af4dfa943ff72072a4f68d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Adult
143 rdf:type schema:DefinedTerm
144 N17815da75fce4d5f878f660e93a67961 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Middle Aged
146 rdf:type schema:DefinedTerm
147 N1869d92c4ef244bfa8fd8d3592b13ce4 rdf:first sg:person.01001147210.98
148 rdf:rest rdf:nil
149 N1ae6670be94645988cef089a5b87eabf rdf:first sg:person.01172510545.70
150 rdf:rest N0e7177f740d948968e5496641c4a9fa9
151 N2a83877e4342493a89805783c6c49535 rdf:first sg:person.01300434727.46
152 rdf:rest N6c59ded75ec44d6ba8be8e7514c5c372
153 N379bca7fc8a141629985406f0e9c15bb rdf:first sg:person.0666562733.98
154 rdf:rest Ne697a64a9bea4b5ca50976e463fdbdeb
155 N39c23730db7744f5aa76c74e1a5573f7 schema:affiliation grid-institutes:grid.461714.1
156 schema:familyName Luengo
157 schema:givenName Teresa González
158 rdf:type schema:Person
159 N3bb78df6ce4444de8bbd6e7264e5e728 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Young Adult
161 rdf:type schema:DefinedTerm
162 N40b36197fda940dab98590dd88fa26b0 schema:issueNumber 11
163 rdf:type schema:PublicationIssue
164 N49a3a71ca2884d2bba8d6e709db079ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 N4cd8c6f68b8e42a4a6da336a428b45a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Cytoreduction Surgical Procedures
169 rdf:type schema:DefinedTerm
170 N4e245b56ffb74da99dc801fb7e6256f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Retrospective Studies
172 rdf:type schema:DefinedTerm
173 N50058ce70fef4ae6a7e8928993867191 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Sarcopenia
175 rdf:type schema:DefinedTerm
176 N587709e085e449d79eb8bf8d01b6639c rdf:first sg:person.0762633757.90
177 rdf:rest N87e88696456242bda8c9083dd65e6f47
178 N5c177a4944f347a2afbf756cddaa7902 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Female
180 rdf:type schema:DefinedTerm
181 N5c673a04e23a46289e54f30c6f9603a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Follow-Up Studies
183 rdf:type schema:DefinedTerm
184 N5d54ee156207403e802ec83d69fe05a3 schema:name pubmed_id
185 schema:value 30069659
186 rdf:type schema:PropertyValue
187 N6ab84e15f0254851abe8535925e9735f schema:volumeNumber 25
188 rdf:type schema:PublicationVolume
189 N6c59ded75ec44d6ba8be8e7514c5c372 rdf:first sg:person.011231725606.89
190 rdf:rest Na945f5cb42a548d6ba7b13f2402fe2af
191 N7ef0c533186c47e1bcb4db6948c68126 rdf:first sg:person.0761166456.21
192 rdf:rest N07974b6323fd46a1b01deb828ede708c
193 N874e951a5b4f4e279b810f9ddd7ab3e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Muscle, Skeletal
195 rdf:type schema:DefinedTerm
196 N87e88696456242bda8c9083dd65e6f47 rdf:first sg:person.0730466067.17
197 rdf:rest N1ae6670be94645988cef089a5b87eabf
198 N8ed9603091aa4ca6940d13568d8c58ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Body Mass Index
200 rdf:type schema:DefinedTerm
201 N947e6bdc76054d138ee60a7cf125dd1a rdf:first N950bf2dcd7db4214b67914d14fcb13fd
202 rdf:rest N379bca7fc8a141629985406f0e9c15bb
203 N950bf2dcd7db4214b67914d14fcb13fd schema:affiliation grid-institutes:grid.461714.1
204 schema:familyName Nina
205 schema:givenName Pauly
206 rdf:type schema:Person
207 Na083d8b51bb9421e9c73e1b0d5b4b77f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Survival Rate
209 rdf:type schema:DefinedTerm
210 Na945f5cb42a548d6ba7b13f2402fe2af rdf:first sg:person.01100262661.18
211 rdf:rest Nfc4cdb1472ec47dabc27d16044865dab
212 Nbaff2ca584ae48708a75667b09eef799 rdf:first sg:person.01053047413.74
213 rdf:rest N587709e085e449d79eb8bf8d01b6639c
214 Nbf988dc804d3443db4c4d0c5f56899b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Carcinoma, Ovarian Epithelial
216 rdf:type schema:DefinedTerm
217 Nc1dcd8aa13be44b9927372a004450edd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Aged
219 rdf:type schema:DefinedTerm
220 Nd70b1b58aa8d4c5494d0246645c3a424 rdf:first N39c23730db7744f5aa76c74e1a5573f7
221 rdf:rest N2a83877e4342493a89805783c6c49535
222 Nde04372ff2c04256b46e09f6a99fff45 schema:name doi
223 schema:value 10.1245/s10434-018-6683-3
224 rdf:type schema:PropertyValue
225 Ne697a64a9bea4b5ca50976e463fdbdeb rdf:first sg:person.01314572015.43
226 rdf:rest N1869d92c4ef244bfa8fd8d3592b13ce4
227 Nf25e2f0539b04e75a90f5dde6963100a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
228 schema:name Aged, 80 and over
229 rdf:type schema:DefinedTerm
230 Nfc4cdb1472ec47dabc27d16044865dab rdf:first sg:person.0643043273.53
231 rdf:rest Nbaff2ca584ae48708a75667b09eef799
232 Nfcdfe22676fb4042928b5216b7545a43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Prognosis
234 rdf:type schema:DefinedTerm
235 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
236 schema:name Medical and Health Sciences
237 rdf:type schema:DefinedTerm
238 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
239 schema:name Oncology and Carcinogenesis
240 rdf:type schema:DefinedTerm
241 sg:journal.1105545 schema:issn 1068-9265
242 1534-4681
243 schema:name Annals of Surgical Oncology
244 schema:publisher Springer Nature
245 rdf:type schema:Periodical
246 sg:person.01001147210.98 schema:affiliation grid-institutes:grid.461714.1
247 schema:familyName Harter
248 schema:givenName Philipp
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001147210.98
250 rdf:type schema:Person
251 sg:person.01053047413.74 schema:affiliation grid-institutes:grid.461714.1
252 schema:familyName Alesina
253 schema:givenName Pier Francesco
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053047413.74
255 rdf:type schema:Person
256 sg:person.01055774132.85 schema:affiliation grid-institutes:grid.411095.8
257 schema:familyName Ataseven
258 schema:givenName Beyhan
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055774132.85
260 rdf:type schema:Person
261 sg:person.01100262661.18 schema:affiliation grid-institutes:grid.461714.1
262 schema:familyName Traut
263 schema:givenName Alexander
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100262661.18
265 rdf:type schema:Person
266 sg:person.011231725606.89 schema:affiliation grid-institutes:grid.461714.1
267 schema:familyName Waltering
268 schema:givenName Kai-Uwe
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011231725606.89
270 rdf:type schema:Person
271 sg:person.01172510545.70 schema:affiliation grid-institutes:grid.461714.1
272 schema:familyName Schneider
273 schema:givenName Stephanie
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172510545.70
275 rdf:type schema:Person
276 sg:person.01230075746.29 schema:affiliation grid-institutes:grid.461714.1
277 schema:familyName Koch
278 schema:givenName Jens-Albrecht
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230075746.29
280 rdf:type schema:Person
281 sg:person.01300434727.46 schema:affiliation grid-institutes:grid.461714.1
282 schema:familyName du Bois
283 schema:givenName Andreas
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300434727.46
285 rdf:type schema:Person
286 sg:person.01314572015.43 schema:affiliation grid-institutes:grid.461714.1
287 schema:familyName Heikaus
288 schema:givenName Sebastian
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314572015.43
290 rdf:type schema:Person
291 sg:person.01351104275.76 schema:affiliation grid-institutes:grid.461714.1
292 schema:familyName Groeben
293 schema:givenName Harald-Thomas
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351104275.76
295 rdf:type schema:Person
296 sg:person.0643043273.53 schema:affiliation grid-institutes:grid.461714.1
297 schema:familyName Heitz
298 schema:givenName Florian
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643043273.53
300 rdf:type schema:Person
301 sg:person.0666562733.98 schema:affiliation grid-institutes:grid.461714.1
302 schema:familyName Brunkhorst
303 schema:givenName Violeta
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666562733.98
305 rdf:type schema:Person
306 sg:person.0730466067.17 schema:affiliation grid-institutes:grid.461714.1
307 schema:familyName Meier
308 schema:givenName Beate
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730466067.17
310 rdf:type schema:Person
311 sg:person.0761166456.21 schema:affiliation grid-institutes:grid.461714.1
312 schema:familyName Walz
313 schema:givenName Martin
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761166456.21
315 rdf:type schema:Person
316 sg:person.0762633757.90 schema:affiliation grid-institutes:grid.461714.1
317 schema:familyName Prader
318 schema:givenName Sonia
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762633757.90
320 rdf:type schema:Person
321 sg:pub.10.1007/s11605-012-1923-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020456159
322 https://doi.org/10.1007/s11605-012-1923-5
323 rdf:type schema:CreativeWork
324 sg:pub.10.1245/s10434-014-4040-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053187502
325 https://doi.org/10.1245/s10434-014-4040-8
326 rdf:type schema:CreativeWork
327 sg:pub.10.1245/s10434-014-4281-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020151524
328 https://doi.org/10.1245/s10434-014-4281-6
329 rdf:type schema:CreativeWork
330 sg:pub.10.1245/s10434-014-4285-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014572189
331 https://doi.org/10.1245/s10434-014-4285-2
332 rdf:type schema:CreativeWork
333 sg:pub.10.1245/s10434-017-6079-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091482223
334 https://doi.org/10.1245/s10434-017-6079-9
335 rdf:type schema:CreativeWork
336 grid-institutes:grid.411095.8 schema:alternateName Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
337 schema:name Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany
338 Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
339 rdf:type schema:Organization
340 grid-institutes:grid.461714.1 schema:alternateName Center for Pathology, Kliniken Essen-Mitte, Essen, Germany
341 Department of Anesthesiology and Intensive Care, Kliniken Essen-Mitte, Essen, Germany
342 Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany
343 Department of Radiology, Kliniken Essen-Mitte, Essen, Germany
344 Department of Visceral Surgery, Kliniken Essen-Mitte, Essen, Germany
345 schema:name Center for Pathology, Kliniken Essen-Mitte, Essen, Germany
346 Department of Anesthesiology and Intensive Care, Kliniken Essen-Mitte, Essen, Germany
347 Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany
348 Department of Radiology, Kliniken Essen-Mitte, Essen, Germany
349 Department of Visceral Surgery, Kliniken Essen-Mitte, Essen, Germany
350 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...