Prognostic Value of Preoperative Systemic Immunoinflammatory Measures in Patients with Esophageal Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07-17

AUTHORS

Yusuke Ishibashi, Hironori Tsujimoto, Shuichi Hiraki, Isao Kumano, Yoshihisa Yaguchi, Hiroyuki Horiguchi, Shinsuke Nomura, Nozomi Ito, Eiji Shinto, Suefumi Aosasa, Junji Yamamoto, Hideki Ueno

ABSTRACT

BackgroundIt is reported that several systemic immunoinflammatory measures, including systemic immune-inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, and C-reactive protein (CRP)-to-albumin ratio (CAR), are associated with survival in patients with various types of cancer.ObjectiveThe aim of the present study was to clear which systemic immunoinflammatory measures had the greatest prognostic values. In addition, we examined which component had the greatest prognostic power in patients with esophageal cancer.MethodsPreoperative systemic immunoinflammatory measures were evaluated in 143 patients undergoing esophageal resection for esophageal cancer from 2009 to 2014. Univariate and multivariate analyses were performed to determine the prognostic significance of these markers. Receiver operating characteristic (ROC) curves were plotted, and the area under the ROC curves (AUROCs) were compared to verify the accuracy of each measure in predicting overall survival (OS).ResultsIn univariate analysis, preoperative SII, NLR, and CAR were the predictors of OS in patients who underwent esophagectomy for esophageal cancer (p < 0.05, respectively), whereas in multivariate analysis, CAR and pathological tumor depth were the significant predictors of OS (hazard ratio [HR] 1.994, p = 0.03 vs. HR 1.967, p = 0.02, respectively). According to AUROC, the CRP (0.66) and albumin levels (0.66) were more important systemic immunoinflammatory measures than neutrophil (0.58), lymphocyte (0.63), and platelet (0.56) levels.ConclusionAmong systemic immunoinflammatory measures, CAR was the most significant predictor of OS in patients with esophageal cancer. CRP and albumin levels were more important components of systemic immunoinflammatory measures. More... »

PAGES

3288-3299

References to SciGraph publications

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    http://scigraph.springernature.com/pub.10.1245/s10434-018-6651-y

    DOI

    http://dx.doi.org/10.1245/s10434-018-6651-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105641025

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30019304


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