Is Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy Justified for Biphasic Variants of Peritoneal Mesothelioma? Outcomes from the Peritoneal Surface Oncology ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03

AUTHORS

Konstantinos I. Votanopoulos, Paul Sugarbaker, Marcello Deraco, David Morris, Olivier Glehen, Dominique Elias, Michele De Simone, Manuela Robella, Bruno Heyd, Shigeki Kusamura, Dario Baratti, Konstantinos Chouliaras, Greg Russell, Perry Shen, Edward A. Levine, RENAPE Working Group

ABSTRACT

BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has dramatically improved the survival of patients with epithelioid peritoneal mesothelioma. It is unknown if CRS/HIPEC is indicated for the more aggressive biphasic mesothelioma variant. METHODS: A retrospective analysis of the Peritoneal Surface Oncology Group International (PSOGI) registry including data from 33 centers was performed. Survival was reviewed based on mesothelioma type, completion of cytoreduction, and volume of disease. RESULTS: Overall, 484 of 1165 (41.5%) CRS/HIPEC procedures with complete CC0 and CC1 cytoreductions were analyzed; 450 (93%) procedures were performed for epithelioid mesotheliomas, while 34 (7%) were performed for biphasic mesotheliomas. For patients with CC0 resection, 5-year survival was 64.5 and 50.2% (median 7.8 and 6.8 years; p = 0.015) for epithelioid and biphasic mesotheliomas, respectively, while inclusion of CC1 resections in the analysis resulted in inferior 5-year survival of 62.9% and 41.6% (median 7.8 and 2.8 years; p = 0.0012), respectively. Incomplete CC2 resections for biphasic primaries resulted in a median survival of 4.3 months. Univariate analysis of the biphasic cohort indicated Peritoneal Cancer Index (PCI; p = 0.015), CC status of resection (p < 0.0001), and Ki67 (p = 0.04) as predictors of survival. Systemic chemotherapy before (p = 0.55) or after (p = 0.7) CRS/HIPEC did not influence survival. In multivariate analysis, only PCI (p = 0.03) and CC (p = 0.04) remained significant. CONCLUSIONS: Long-term survival is achievable in patients with low-volume biphasic mesothelioma after complete macroscopic cytoreduction. Biphasic peritoneal mesotheliomas should not be considered as an absolute contraindication for CRS/HIPEC if there is low-volume disease and if complete cytoreduction can be achieved. More... »

PAGES

667-673

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-017-6293-5

DOI

http://dx.doi.org/10.1245/s10434-017-6293-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099723374

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29260418


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Cancer, Regional Perfusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoreduction Surgical Procedures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperthermia, Induced", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesothelioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peritoneal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Registries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Wake Forest University", 
          "id": "https://www.grid.ac/institutes/grid.241167.7", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "Wake Forest School of Medicine, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Votanopoulos", 
        "givenName": "Konstantinos I.", 
        "id": "sg:person.01155643513.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155643513.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MedStar Washington Hospital Center", 
          "id": "https://www.grid.ac/institutes/grid.415235.4", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "MedStar Washington Hospital Center, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugarbaker", 
        "givenName": "Paul", 
        "id": "sg:person.014474321717.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014474321717.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "IRCCS Instituto Nazionale Tumori, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deraco", 
        "givenName": "Marcello", 
        "id": "sg:person.0752112530.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752112530.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest Baptist Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412860.9", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "St. George Hospital, University of New South Wales, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morris", 
        "givenName": "David", 
        "id": "sg:person.01026500154.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026500154.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Lyon Sud", 
          "id": "https://www.grid.ac/institutes/grid.411430.3", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "Centre Hospitalier Lyon-Sud, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Glehen", 
        "givenName": "Olivier", 
        "id": "sg:person.0620604712.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620604712.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "Department of Oncologic Surgery, Institut Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elias", 
        "givenName": "Dominique", 
        "id": "sg:person.01260460625.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260460625.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Candiolo Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.419555.9", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "Unit of Surgical Oncology, Candiolo Cancer Institute, Turin, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Simone", 
        "givenName": "Michele", 
        "id": "sg:person.01354444415.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354444415.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Candiolo Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.419555.9", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "Unit of Surgical Oncology, Candiolo Cancer Institute, Turin, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robella", 
        "givenName": "Manuela", 
        "id": "sg:person.01057022435.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057022435.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Besan\u00e7on", 
          "id": "https://www.grid.ac/institutes/grid.411158.8", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "Surgery Department, CHU Besan\u00e7on, Besan\u00e7on, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heyd", 
        "givenName": "Bruno", 
        "id": "sg:person.01247424224.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247424224.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "IRCCS Instituto Nazionale Tumori, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kusamura", 
        "givenName": "Shigeki", 
        "id": "sg:person.01053067111.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053067111.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "IRCCS Instituto Nazionale Tumori, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baratti", 
        "givenName": "Dario", 
        "id": "sg:person.0652340040.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652340040.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest University", 
          "id": "https://www.grid.ac/institutes/grid.241167.7", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "Wake Forest School of Medicine, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chouliaras", 
        "givenName": "Konstantinos", 
        "id": "sg:person.01214635353.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214635353.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest University", 
          "id": "https://www.grid.ac/institutes/grid.241167.7", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "Wake Forest School of Medicine, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russell", 
        "givenName": "Greg", 
        "id": "sg:person.010655424252.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010655424252.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest University", 
          "id": "https://www.grid.ac/institutes/grid.241167.7", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "Wake Forest School of Medicine, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Perry", 
        "id": "sg:person.01261074562.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261074562.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest University", 
          "id": "https://www.grid.ac/institutes/grid.241167.7", 
          "name": [
            "Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA", 
            "Wake Forest School of Medicine, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levine", 
        "givenName": "Edward A.", 
        "id": "sg:person.01362075400.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362075400.37"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "RENAPE Working Group", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1245/s10434-015-4962-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002915947", 
          "https://doi.org/10.1245/s10434-015-4962-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0344-0338(11)80700-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006076367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.suronc.2014.12.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009215435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/aso.2006.05.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012661544", 
          "https://doi.org/10.1245/aso.2006.05.041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/aso.2006.05.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012661544", 
          "https://doi.org/10.1245/aso.2006.05.041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-014-3978-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013947803", 
          "https://doi.org/10.1245/s10434-014-3978-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.9640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019587384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4613-1247-5_23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025625790", 
          "https://doi.org/10.1007/978-1-4613-1247-5_23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4613-1247-5_23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025625790", 
          "https://doi.org/10.1007/978-1-4613-1247-5_23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.04.150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203550"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-03", 
    "datePublishedReg": "2018-03-01", 
    "description": "BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has dramatically improved the survival of patients with epithelioid peritoneal mesothelioma. It is unknown if CRS/HIPEC is indicated for the more aggressive biphasic mesothelioma variant.\nMETHODS: A retrospective analysis of the Peritoneal Surface Oncology Group International (PSOGI) registry including data from 33 centers was performed. Survival was reviewed based on mesothelioma type, completion of cytoreduction, and volume of disease.\nRESULTS: Overall, 484 of 1165 (41.5%) CRS/HIPEC procedures with complete CC0 and CC1 cytoreductions were analyzed; 450 (93%) procedures were performed for epithelioid mesotheliomas, while 34 (7%) were performed for biphasic mesotheliomas. For patients with CC0 resection, 5-year survival was 64.5 and 50.2% (median 7.8 and 6.8\u00a0years; p\u00a0=\u00a00.015) for epithelioid and biphasic mesotheliomas, respectively, while inclusion of CC1 resections in the analysis resulted in inferior 5-year survival of 62.9% and 41.6% (median 7.8 and 2.8\u00a0years; p\u00a0=\u00a00.0012), respectively. Incomplete CC2 resections for biphasic primaries resulted in a median survival of 4.3\u00a0months. Univariate analysis of the biphasic cohort indicated Peritoneal Cancer Index (PCI; p\u00a0=\u00a00.015), CC status of resection (p\u00a0<\u00a00.0001), and Ki67 (p\u00a0=\u00a00.04) as predictors of survival. Systemic chemotherapy before (p\u00a0=\u00a00.55) or after (p\u00a0=\u00a00.7) CRS/HIPEC did not influence survival. In multivariate analysis, only PCI (p\u00a0=\u00a00.03) and CC (p\u00a0=\u00a00.04) remained significant.\nCONCLUSIONS: Long-term survival is achievable in patients with low-volume biphasic mesothelioma after complete macroscopic cytoreduction. Biphasic peritoneal mesotheliomas should not be considered as an absolute contraindication for CRS/HIPEC if there is low-volume disease and if complete cytoreduction can be achieved.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-017-6293-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "name": "Is Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy Justified for Biphasic Variants of Peritoneal Mesothelioma? Outcomes from the Peritoneal Surface Oncology Group International Registry", 
    "pagination": "667-673", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "982dc8be1882d6b16ccc9d0266b8cfb3fc0d671be0bf5e5bd5935e1254c3089c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29260418"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-017-6293-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1099723374"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-017-6293-5", 
      "https://app.dimensions.ai/details/publication/pub.1099723374"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29207_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1245%2Fs10434-017-6293-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-017-6293-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-017-6293-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-017-6293-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-017-6293-5'


 

This table displays all metadata directly associated to this object as RDF triples.

295 TRIPLES      21 PREDICATES      54 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-017-6293-5 schema:about N04bac7c50f354a2991f40f28539ed685
2 N20c1772aa2644e5c90ee50f104c2aaa5
3 N218dad92db134b309879145bf5212d33
4 N46d549962012410eb19e2a7276438217
5 N516ce0d4297e4aa095c820139df7b60b
6 N5fa7259cd9e24736ae43e38f3aa7d585
7 N76a935391f1e418d86ce95d22b02fc05
8 N7803748cd12d450ba5377a0c97655037
9 N7f4960a0db054845beaf6884f06a6d7e
10 Na6862560b2fb4f04a284cd121bffdef4
11 Ncf293e912ac5474a9d59737ed85fd16c
12 Nd22a1e59f4114aa989d5539d029af55a
13 Nd730d6596ebe46d886ae018622a380cd
14 Ndaf0e47408754df882886ddd5a7547a5
15 Ndebdd32a00474ccebfb49feb5944844e
16 Nf1f7bf1dd5e9402992db622e73ef4187
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author Nc031cb861ed1464682a5df0af777a71e
20 schema:citation sg:pub.10.1007/978-1-4613-1247-5_23
21 sg:pub.10.1245/aso.2006.05.041
22 sg:pub.10.1245/s10434-014-3978-x
23 sg:pub.10.1245/s10434-015-4962-9
24 https://doi.org/10.1016/j.suronc.2014.12.002
25 https://doi.org/10.1016/s0344-0338(11)80700-4
26 https://doi.org/10.1097/01.sla.0000133083.54934.ae
27 https://doi.org/10.1200/jco.2003.04.150
28 https://doi.org/10.1200/jco.2009.23.9640
29 schema:datePublished 2018-03
30 schema:datePublishedReg 2018-03-01
31 schema:description BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has dramatically improved the survival of patients with epithelioid peritoneal mesothelioma. It is unknown if CRS/HIPEC is indicated for the more aggressive biphasic mesothelioma variant. METHODS: A retrospective analysis of the Peritoneal Surface Oncology Group International (PSOGI) registry including data from 33 centers was performed. Survival was reviewed based on mesothelioma type, completion of cytoreduction, and volume of disease. RESULTS: Overall, 484 of 1165 (41.5%) CRS/HIPEC procedures with complete CC0 and CC1 cytoreductions were analyzed; 450 (93%) procedures were performed for epithelioid mesotheliomas, while 34 (7%) were performed for biphasic mesotheliomas. For patients with CC0 resection, 5-year survival was 64.5 and 50.2% (median 7.8 and 6.8 years; p = 0.015) for epithelioid and biphasic mesotheliomas, respectively, while inclusion of CC1 resections in the analysis resulted in inferior 5-year survival of 62.9% and 41.6% (median 7.8 and 2.8 years; p = 0.0012), respectively. Incomplete CC2 resections for biphasic primaries resulted in a median survival of 4.3 months. Univariate analysis of the biphasic cohort indicated Peritoneal Cancer Index (PCI; p = 0.015), CC status of resection (p < 0.0001), and Ki67 (p = 0.04) as predictors of survival. Systemic chemotherapy before (p = 0.55) or after (p = 0.7) CRS/HIPEC did not influence survival. In multivariate analysis, only PCI (p = 0.03) and CC (p = 0.04) remained significant. CONCLUSIONS: Long-term survival is achievable in patients with low-volume biphasic mesothelioma after complete macroscopic cytoreduction. Biphasic peritoneal mesotheliomas should not be considered as an absolute contraindication for CRS/HIPEC if there is low-volume disease and if complete cytoreduction can be achieved.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N2c61d550122943888c707642ae34cb6e
36 Ne408a131b0d942289a7020df64d27e65
37 sg:journal.1105545
38 schema:name Is Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy Justified for Biphasic Variants of Peritoneal Mesothelioma? Outcomes from the Peritoneal Surface Oncology Group International Registry
39 schema:pagination 667-673
40 schema:productId N0ba8cee00961457d95ad04b29cecf3b1
41 N16fd9ed3b1404b19a83f4e64a863bf62
42 N2fa57743e37f4b3180cffd790b2a03a0
43 N82b8c30987794b28911f39e560e86a01
44 Ne83c0d18f6e74ac1b3498e7fb428682d
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099723374
46 https://doi.org/10.1245/s10434-017-6293-5
47 schema:sdDatePublished 2019-04-11T11:55
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N2c18c8c975a342d89f4e08663c701702
50 schema:url https://link.springer.com/10.1245%2Fs10434-017-6293-5
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N033aad9c73a041d198af03272f4e2f08 rdf:first sg:person.010655424252.42
55 rdf:rest N70b3bc9402ef403bb371f290d4b08d5b
56 N04bac7c50f354a2991f40f28539ed685 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Peritoneal Neoplasms
58 rdf:type schema:DefinedTerm
59 N0ba8cee00961457d95ad04b29cecf3b1 schema:name nlm_unique_id
60 schema:value 9420840
61 rdf:type schema:PropertyValue
62 N1395c5fde6074118a9ed3bb42f6c6ee0 rdf:first sg:person.0620604712.70
63 rdf:rest N72a3d62aaab645369bcfc223129825bc
64 N16fd9ed3b1404b19a83f4e64a863bf62 schema:name pubmed_id
65 schema:value 29260418
66 rdf:type schema:PropertyValue
67 N1c79aef30b3944229bca5ae76a20bcef rdf:first sg:person.01362075400.37
68 rdf:rest Nbde82089da694c399b5f3966f99e8c23
69 N20c1772aa2644e5c90ee50f104c2aaa5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Humans
71 rdf:type schema:DefinedTerm
72 N218dad92db134b309879145bf5212d33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Middle Aged
74 rdf:type schema:DefinedTerm
75 N2c18c8c975a342d89f4e08663c701702 schema:name Springer Nature - SN SciGraph project
76 rdf:type schema:Organization
77 N2c61d550122943888c707642ae34cb6e schema:volumeNumber 25
78 rdf:type schema:PublicationVolume
79 N2fa57743e37f4b3180cffd790b2a03a0 schema:name readcube_id
80 schema:value 982dc8be1882d6b16ccc9d0266b8cfb3fc0d671be0bf5e5bd5935e1254c3089c
81 rdf:type schema:PropertyValue
82 N46d549962012410eb19e2a7276438217 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Retrospective Studies
84 rdf:type schema:DefinedTerm
85 N516ce0d4297e4aa095c820139df7b60b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Combined Modality Therapy
87 rdf:type schema:DefinedTerm
88 N597f8c36cab541f6ab25a19478cbe455 rdf:first sg:person.01214635353.38
89 rdf:rest N033aad9c73a041d198af03272f4e2f08
90 N5fa7259cd9e24736ae43e38f3aa7d585 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Male
92 rdf:type schema:DefinedTerm
93 N63f5c3ac6bff4cb0bb38639cd04eda80 rdf:first sg:person.014474321717.64
94 rdf:rest N99e7ac14a1444a598686b6fcfae34610
95 N6972f9944d5c49c6b8908a4279f0a9ee schema:familyName RENAPE Working Group
96 rdf:type schema:Person
97 N70b3bc9402ef403bb371f290d4b08d5b rdf:first sg:person.01261074562.24
98 rdf:rest N1c79aef30b3944229bca5ae76a20bcef
99 N72a3d62aaab645369bcfc223129825bc rdf:first sg:person.01260460625.42
100 rdf:rest N8f1b5e016fb74b668f425e013cfabe25
101 N76a935391f1e418d86ce95d22b02fc05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Mesothelioma
103 rdf:type schema:DefinedTerm
104 N7803748cd12d450ba5377a0c97655037 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Cytoreduction Surgical Procedures
106 rdf:type schema:DefinedTerm
107 N7f4960a0db054845beaf6884f06a6d7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Female
109 rdf:type schema:DefinedTerm
110 N82b8c30987794b28911f39e560e86a01 schema:name doi
111 schema:value 10.1245/s10434-017-6293-5
112 rdf:type schema:PropertyValue
113 N86ecea0d4bb94cacac67ebef2f51fdc1 rdf:first sg:person.01026500154.51
114 rdf:rest N1395c5fde6074118a9ed3bb42f6c6ee0
115 N890b07ba900740778f516898d131b51a rdf:first sg:person.01053067111.88
116 rdf:rest Nde13ab74e5624e309801e5fc864fc0c1
117 N8f1b5e016fb74b668f425e013cfabe25 rdf:first sg:person.01354444415.46
118 rdf:rest Ndab5c26797d74971b9aac9b5bebb6094
119 N99e7ac14a1444a598686b6fcfae34610 rdf:first sg:person.0752112530.81
120 rdf:rest N86ecea0d4bb94cacac67ebef2f51fdc1
121 Na0a824f0bd7c438a93d4c7cd2c707a63 rdf:first sg:person.01247424224.14
122 rdf:rest N890b07ba900740778f516898d131b51a
123 Na6862560b2fb4f04a284cd121bffdef4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Follow-Up Studies
125 rdf:type schema:DefinedTerm
126 Nbde82089da694c399b5f3966f99e8c23 rdf:first N6972f9944d5c49c6b8908a4279f0a9ee
127 rdf:rest rdf:nil
128 Nc031cb861ed1464682a5df0af777a71e rdf:first sg:person.01155643513.53
129 rdf:rest N63f5c3ac6bff4cb0bb38639cd04eda80
130 Ncf293e912ac5474a9d59737ed85fd16c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Survival Rate
132 rdf:type schema:DefinedTerm
133 Nd22a1e59f4114aa989d5539d029af55a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Hyperthermia, Induced
135 rdf:type schema:DefinedTerm
136 Nd730d6596ebe46d886ae018622a380cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Prognosis
138 rdf:type schema:DefinedTerm
139 Ndab5c26797d74971b9aac9b5bebb6094 rdf:first sg:person.01057022435.45
140 rdf:rest Na0a824f0bd7c438a93d4c7cd2c707a63
141 Ndaf0e47408754df882886ddd5a7547a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Chemotherapy, Adjuvant
143 rdf:type schema:DefinedTerm
144 Nde13ab74e5624e309801e5fc864fc0c1 rdf:first sg:person.0652340040.51
145 rdf:rest N597f8c36cab541f6ab25a19478cbe455
146 Ndebdd32a00474ccebfb49feb5944844e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Registries
148 rdf:type schema:DefinedTerm
149 Ne408a131b0d942289a7020df64d27e65 schema:issueNumber 3
150 rdf:type schema:PublicationIssue
151 Ne83c0d18f6e74ac1b3498e7fb428682d schema:name dimensions_id
152 schema:value pub.1099723374
153 rdf:type schema:PropertyValue
154 Nf1f7bf1dd5e9402992db622e73ef4187 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Chemotherapy, Cancer, Regional Perfusion
156 rdf:type schema:DefinedTerm
157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
158 schema:name Medical and Health Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
161 schema:name Oncology and Carcinogenesis
162 rdf:type schema:DefinedTerm
163 sg:journal.1105545 schema:issn 1068-9265
164 1534-4681
165 schema:name Annals of Surgical Oncology
166 rdf:type schema:Periodical
167 sg:person.01026500154.51 schema:affiliation https://www.grid.ac/institutes/grid.412860.9
168 schema:familyName Morris
169 schema:givenName David
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026500154.51
171 rdf:type schema:Person
172 sg:person.01053067111.88 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
173 schema:familyName Kusamura
174 schema:givenName Shigeki
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053067111.88
176 rdf:type schema:Person
177 sg:person.01057022435.45 schema:affiliation https://www.grid.ac/institutes/grid.419555.9
178 schema:familyName Robella
179 schema:givenName Manuela
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057022435.45
181 rdf:type schema:Person
182 sg:person.010655424252.42 schema:affiliation https://www.grid.ac/institutes/grid.241167.7
183 schema:familyName Russell
184 schema:givenName Greg
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010655424252.42
186 rdf:type schema:Person
187 sg:person.01155643513.53 schema:affiliation https://www.grid.ac/institutes/grid.241167.7
188 schema:familyName Votanopoulos
189 schema:givenName Konstantinos I.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155643513.53
191 rdf:type schema:Person
192 sg:person.01214635353.38 schema:affiliation https://www.grid.ac/institutes/grid.241167.7
193 schema:familyName Chouliaras
194 schema:givenName Konstantinos
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214635353.38
196 rdf:type schema:Person
197 sg:person.01247424224.14 schema:affiliation https://www.grid.ac/institutes/grid.411158.8
198 schema:familyName Heyd
199 schema:givenName Bruno
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247424224.14
201 rdf:type schema:Person
202 sg:person.01260460625.42 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
203 schema:familyName Elias
204 schema:givenName Dominique
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260460625.42
206 rdf:type schema:Person
207 sg:person.01261074562.24 schema:affiliation https://www.grid.ac/institutes/grid.241167.7
208 schema:familyName Shen
209 schema:givenName Perry
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261074562.24
211 rdf:type schema:Person
212 sg:person.01354444415.46 schema:affiliation https://www.grid.ac/institutes/grid.419555.9
213 schema:familyName De Simone
214 schema:givenName Michele
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354444415.46
216 rdf:type schema:Person
217 sg:person.01362075400.37 schema:affiliation https://www.grid.ac/institutes/grid.241167.7
218 schema:familyName Levine
219 schema:givenName Edward A.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362075400.37
221 rdf:type schema:Person
222 sg:person.014474321717.64 schema:affiliation https://www.grid.ac/institutes/grid.415235.4
223 schema:familyName Sugarbaker
224 schema:givenName Paul
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014474321717.64
226 rdf:type schema:Person
227 sg:person.0620604712.70 schema:affiliation https://www.grid.ac/institutes/grid.411430.3
228 schema:familyName Glehen
229 schema:givenName Olivier
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620604712.70
231 rdf:type schema:Person
232 sg:person.0652340040.51 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
233 schema:familyName Baratti
234 schema:givenName Dario
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652340040.51
236 rdf:type schema:Person
237 sg:person.0752112530.81 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
238 schema:familyName Deraco
239 schema:givenName Marcello
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752112530.81
241 rdf:type schema:Person
242 sg:pub.10.1007/978-1-4613-1247-5_23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025625790
243 https://doi.org/10.1007/978-1-4613-1247-5_23
244 rdf:type schema:CreativeWork
245 sg:pub.10.1245/aso.2006.05.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012661544
246 https://doi.org/10.1245/aso.2006.05.041
247 rdf:type schema:CreativeWork
248 sg:pub.10.1245/s10434-014-3978-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013947803
249 https://doi.org/10.1245/s10434-014-3978-x
250 rdf:type schema:CreativeWork
251 sg:pub.10.1245/s10434-015-4962-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002915947
252 https://doi.org/10.1245/s10434-015-4962-9
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.suronc.2014.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009215435
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s0344-0338(11)80700-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006076367
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1097/01.sla.0000133083.54934.ae schema:sameAs https://app.dimensions.ai/details/publication/pub.1024049438
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1200/jco.2003.04.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203550
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1200/jco.2009.23.9640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019587384
263 rdf:type schema:CreativeWork
264 https://www.grid.ac/institutes/grid.14925.3b schema:alternateName Institut Gustave Roussy
265 schema:name Department of Oncologic Surgery, Institut Gustave Roussy, Villejuif, France
266 Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.241167.7 schema:alternateName Wake Forest University
269 schema:name Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA
270 Wake Forest School of Medicine, Winston-Salem, NC, USA
271 rdf:type schema:Organization
272 https://www.grid.ac/institutes/grid.411158.8 schema:alternateName Centre Hospitalier Universitaire de Besançon
273 schema:name Surgery Department, CHU Besançon, Besançon, France
274 Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA
275 rdf:type schema:Organization
276 https://www.grid.ac/institutes/grid.411430.3 schema:alternateName Centre Hospitalier Lyon Sud
277 schema:name Centre Hospitalier Lyon-Sud, Lyon, France
278 Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.412860.9 schema:alternateName Wake Forest Baptist Medical Center
281 schema:name St. George Hospital, University of New South Wales, Sydney, NSW, Australia
282 Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.415235.4 schema:alternateName MedStar Washington Hospital Center
285 schema:name MedStar Washington Hospital Center, Washington, DC, USA
286 Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA
287 rdf:type schema:Organization
288 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
289 schema:name IRCCS Instituto Nazionale Tumori, Milan, Italy
290 Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA
291 rdf:type schema:Organization
292 https://www.grid.ac/institutes/grid.419555.9 schema:alternateName Candiolo Cancer Institute
293 schema:name Surgical Oncology Service, Department of General Surgery, Wake Forest Baptist Health, Winston-Salem, NC, USA
294 Unit of Surgical Oncology, Candiolo Cancer Institute, Turin, Italy
295 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...