Molecular Genomic Testing for Breast Cancer: Utility for Surgeons View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02

AUTHORS

Oluwadamilola M. Fayanju, Ko Un Park, Anthony Lucci

ABSTRACT

Molecular genomic testing provides clinicians with both prognostic and (sometimes) predictive information that can help individualize treatment and decrease the risk of over- or under-treatment. We review the genomic tests that are currently available for clinical use in management of breast cancer, discuss ongoing research related to validating and expanding their utility in different patient populations, and explain why it is important for surgeons to know how to incorporate these tools into their clinical practice in order to individualize patient treatment, reduce unnecessary morbidity, and, accordingly, improve outcomes. More... »

PAGES

512-519

References to SciGraph publications

  • 2015-11. A phase II trial of ixabepilone and cyclophosphamide as neoadjuvant therapy for patients with HER2-negative breast cancer: correlation of pathologic complete response with the 21-gene recurrence score in BREAST CANCER RESEARCH AND TREATMENT
  • 2014-04. Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer in BRITISH JOURNAL OF CANCER
  • 2015-12. Multigene prognostic tests in breast cancer: past, present, future in BREAST CANCER RESEARCH
  • 2014-09. Diagnostic tests based on gene expression profile in breast cancer: from background to clinical use in TUMOR BIOLOGY
  • 1982-03. A prognostic index in primary breast cancer in BRITISH JOURNAL OF CANCER
  • 2014-12. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition in BMC CANCER
  • 2013-06. BreastPRS is a gene expression assay that stratifies intermediate-risk Oncotype DX patients into high- or low-risk for disease recurrence in BREAST CANCER RESEARCH AND TREATMENT
  • 2015-07. A population-based validation study of the DCIS Score predicting recurrence risk in individuals treated by breast-conserving surgery alone in BREAST CANCER RESEARCH AND TREATMENT
  • 2008-12. Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature in BMC CANCER
  • 2014-12. Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens in BMC CANCER
  • 2010-08. Mammostrat®as a tool to stratify breast cancer patients at risk of recurrence during endocrine therapy in BREAST CANCER RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1245/s10434-017-6254-z

    DOI

    http://dx.doi.org/10.1245/s10434-017-6254-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092823116

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29159748


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