Ontology type: schema:ScholarlyArticle
2018-01
AUTHORSBo Young Oh, Yoon Ah Park, Jung Wook Huh, Seong Hyeon Yun, Hee Cheol Kim, Ho-Kyung Chun, Seok Hyung Kim, Sang Yun Ha, Woo Yong Lee, Yong Beom Cho
ABSTRACTBACKGROUND: Tumor budding is associated with adverse histology and is a predictor of lymph node metastasis. However, it remains unclear whether tumor budding is predictive of a poor prognosis for colon cancer patients. This study sought to investigate the prognostic significance of tumor budding in colon cancer. METHODS: This study evaluated 4196 colon cancer patients who underwent radical surgery from 2007 to 2013 at a single institution. The patients were categorized according to tumor-budding status. Adjustment was made for using propensity score-matched analysis, and both disease-free survival (DFS) and overall survival (OS) were compared between the groups. RESULTS: Among the 4196 patients, 2269 had low budding (< 5 buds), 1312 had intermediate budding (5-9 buds), and 615 had high budding (≥ 10 buds). High budding was associated with adverse histologic features such as elevated levels of preoperative carcinoembryonic antigen, advanced stage, poor histology, and the presence of lymphatic/vascular/perineural invasion. Before matching, DFS and OS decreased significantly with increasing tumor budding. After matching, the difference in survival between the low- and intermediate-budding groups disappeared. However, the OS and DFS rates for the high-budding group were significantly lower than for the other two groups. In the multivariate analysis of prognostic factors, high budding was an independent poor prognostic factor in DFS and OS, whereas tumor-budding positivity itself was not an independent prognostic factor. CONCLUSION: Tumor-budding grade rather than tumor-budding positivity was an independent prognostic factor in colon cancer. More... »
PAGES204-211
http://scigraph.springernature.com/pub.10.1245/s10434-017-6135-5
DOIhttp://dx.doi.org/10.1245/s10434-017-6135-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1092450342
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29086140
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blood Vessels",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoembryonic Antigen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colonic Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease-Free Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphatic Vessels",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Invasiveness",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Staging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Propensity Score",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Ewha Womans University",
"id": "https://www.grid.ac/institutes/grid.255649.9",
"name": [
"Department of Surgery, College of Medicine, Ewha Womans University, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Oh",
"givenName": "Bo Young",
"id": "sg:person.01353425521.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353425521.26"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Yoon Ah",
"id": "sg:person.01073733706.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073733706.95"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Huh",
"givenName": "Jung Wook",
"id": "sg:person.01310235260.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310235260.89"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Yun",
"givenName": "Seong Hyeon",
"id": "sg:person.01036042356.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036042356.80"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Hee Cheol",
"id": "sg:person.0727305260.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727305260.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sungkyunkwan University",
"id": "https://www.grid.ac/institutes/grid.264381.a",
"name": [
"Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Chun",
"givenName": "Ho-Kyung",
"id": "sg:person.01244247364.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244247364.49"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Seok Hyung",
"id": "sg:person.0631172351.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631172351.05"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Ha",
"givenName": "Sang Yun",
"id": "sg:person.0623270054.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623270054.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sungkyunkwan University",
"id": "https://www.grid.ac/institutes/grid.264381.a",
"name": [
"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea",
"Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Woo Yong",
"id": "sg:person.01246232354.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246232354.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sungkyunkwan University",
"id": "https://www.grid.ac/institutes/grid.264381.a",
"name": [
"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea",
"Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea",
"Department of Medical Device Management & Research, SAIHST, Sungkyunkwan University, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Cho",
"givenName": "Yong Beom",
"id": "sg:person.01316440011.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316440011.46"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/modpathol.2013.124",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000425774",
"https://doi.org/10.1038/modpathol.2013.124"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-012-2426-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003634868",
"https://doi.org/10.1245/s10434-012-2426-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/codi.12454",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004432355"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1463-1318.2009.02119.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007515922"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10350-005-0060-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008834614",
"https://doi.org/10.1007/s10350-005-0060-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1007/s10350-005-0060-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008834614"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1007/s10350-005-0060-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008834614"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10350-008-9192-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011036595",
"https://doi.org/10.1007/s10350-008-9192-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1007/s10350-008-9192-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011036595"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e318184cd55",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016146482"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/pas.0b013e318184cd55",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016146482"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10350-006-0595-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023460672",
"https://doi.org/10.1007/s10350-006-0595-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1007/s10350-006-0595-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023460672"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1463-1318.2007.01240.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024327669"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19890201)63:3<539::aid-cncr2820630323>3.0.co;2-s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025080304"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2559.2002.01324.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025809082"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2004.04.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026025014"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ctrv.2014.12.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027753425"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/his.13164",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030633894"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.humpath.2012.07.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031591523"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.thorsurg.2014.12.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032347522"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1007/dcr.0b013e3181c3ed05",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034008522"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1007/dcr.0b013e3181c3ed05",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034008522"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02238588",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035318561",
"https://doi.org/10.1007/bf02238588"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1007/bf02238588",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035318561"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1007/bf02238588",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035318561"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.humpath.2015.08.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039950468"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.humpath.2011.02.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050729342"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.2016.173",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050753615",
"https://doi.org/10.1038/bjc.2016.173"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4143/crt.2005.37.3.177",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072255620"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4143/crt.2005.37.3.177",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072255620"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077675891",
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.2017.46",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085592506",
"https://doi.org/10.1038/modpathol.2017.46"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-01",
"datePublishedReg": "2018-01-01",
"description": "BACKGROUND: Tumor budding is associated with adverse histology and is a predictor of lymph node metastasis. However, it remains unclear whether tumor budding is predictive of a poor prognosis for colon cancer patients. This study sought to investigate the prognostic significance of tumor budding in colon cancer.\nMETHODS: This study evaluated 4196 colon cancer patients who underwent radical surgery from 2007 to 2013 at a single institution. The patients were categorized according to tumor-budding status. Adjustment was made for using propensity score-matched analysis, and both disease-free survival (DFS) and overall survival (OS) were compared between the groups.\nRESULTS: Among the 4196 patients, 2269 had low budding (<\u00a05 buds), 1312 had intermediate budding (5-9 buds), and 615 had high budding (\u2265\u00a010 buds). High budding was associated with adverse histologic features such as elevated levels of preoperative carcinoembryonic antigen, advanced stage, poor histology, and the presence of lymphatic/vascular/perineural invasion. Before matching, DFS and OS decreased significantly with increasing tumor budding. After matching, the difference in survival between the low- and intermediate-budding groups disappeared. However, the OS and DFS rates for the high-budding group were significantly lower than for the other two groups. In the multivariate analysis of prognostic factors, high budding was an independent poor prognostic factor in DFS and OS, whereas tumor-budding positivity itself was not an independent prognostic factor.\nCONCLUSION: Tumor-budding grade rather than tumor-budding positivity was an independent prognostic factor in colon cancer.",
"genre": "research_article",
"id": "sg:pub.10.1245/s10434-017-6135-5",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.7496722",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1105545",
"issn": [
"1068-9265",
"1534-4681"
],
"name": "Annals of Surgical Oncology",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "25"
}
],
"name": "Prognostic Impact of Tumor-Budding Grade in Stages 1\u20133 Colon Cancer: A Retrospective Cohort Study",
"pagination": "204-211",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"dc7071c3fedd36b6901340bb0901db53df86750a78c9f6683a641f411c2d21d4"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29086140"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9420840"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1245/s10434-017-6135-5"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1092450342"
]
}
],
"sameAs": [
"https://doi.org/10.1245/s10434-017-6135-5",
"https://app.dimensions.ai/details/publication/pub.1092450342"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:06",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60372_00000003.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1245%2Fs10434-017-6135-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-017-6135-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-017-6135-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-017-6135-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-017-6135-5'
This table displays all metadata directly associated to this object as RDF triples.
307 TRIPLES
21 PREDICATES
73 URIs
37 LITERALS
25 BLANK NODES