Hepatic Arterial Infusion in Combination with Modern Systemic Chemotherapy is Associated with Improved Survival Compared with Modern Systemic Chemotherapy Alone ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01

AUTHORS

Mashaal Dhir, Heather L. Jones, Yongli Shuai, Amber K. Clifford, Samantha Perkins, Jennifer Steve, Melissa E. Hogg, M. Haroon A. Choudry, James F. Pingpank, Matthew P. Holtzman, Herbert J. Zeh, Nathan Bahary, David L. Bartlett, Amer H. Zureikat

ABSTRACT

BACKGROUND: In the era of effective modern systemic chemotherapy (CT), the role of hepatic arterial infusion of fluoxuridine (HAI-FUDR) in the treatment of isolated unresectable colorectal liver metastasis (IU-CRCLM) remains controversial. This study aimed to compare the overall survival (OS) of HAI-FUDR in combination with modern systemic CT versus modern systemic CT alone in patients with IU-CRCLM. METHODS: This was a case-control study of IU-CRCLM patients who underwent HAI + modern systemic CT or modern systemic CT alone. Modern systemic CT was defined as the use of multidrug regimens containing oxaliplatin and/or irinotecan ± biologics. RESULTS: Overall, 86 patients met the inclusion criteria (n = 40 for the HAI + CT group, and n = 46 for the CT-alone group). Both groups were similar in demographics, primary and stage IV tumor characteristics, and treatment-related variables (carcinoembryonic antigen, use of biologic agents, total number of lines of systemic CT administered) (all p > 0.05). Additionally, both groups were comparable with respect to liver tumor burden [median number of lesions (13.5 vs. 15), percentage of liver tumor replacement (37.5 vs. 40 %), and size of largest lesion] (all p > 0.05). Median OS in the HAI + CT group was 32.8 months compared with 15.3 months in the CT-alone group (p < 0.0001). Multivariate analysis revealed HAI + CT (hazard ratio 0.4, 95 % confidence interval 0.21-0.72; p = 0.003), Eastern Cooperative Oncology Group status, and receipt of increasing number of lines of systemic CT to be independent predictors of survival. CONCLUSIONS: In this case-control study of patients with IU-CRCLM, HAI in combination with CT was associated with improved OS when compared with modern systemic CT alone. More... »

PAGES

150-158

References to SciGraph publications

  • 2013-02. Chance of Cure Following Liver Resection for Initially Unresectable Colorectal Metastases: Analysis of Actual 5-Year Survival in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2014-12. The CAIRO4 study: the role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer – a randomized phase III study of the Dutch Colorectal Cancer Group (DCCG) in BMC CANCER
  • 2007-10. Final analysis of colorectal cancer patients treated with irinotecan and 5-fluorouracil plus folinic acid neoadjuvant chemotherapy for unresectable liver metastases in BRITISH JOURNAL OF CANCER
  • 2012-12. A randomised controlled trial of a theory-based intervention to improve sun protective behaviour in adolescents ('you can still be HOT in the shade'): study protocol in BMC CANCER
  • 2009-12. Capecitabine plus Irinotecan (XELIRI regimen) compared to 5-FU/LV plus Irinotecan (FOLFIRI regimen) as neoadjuvant treatment for patients with unresectable liver-only metastases of metastatic colorectal cancer: a randomised prospective phase II trial in BMC CANCER
  • 2014-11. Association Between Palliative Resection of the Primary Tumor and Overall Survival in a Population-Based Cohort of Metastatic Colorectal Cancer Patients in ANNALS OF SURGICAL ONCOLOGY
  • 2011-04. Effect on Outcome of Recurrence Patterns After Hepatectomy for Colorectal Metastases in ANNALS OF SURGICAL ONCOLOGY
  • 2015-03. A Multicenter Phase II Trial of mFOLFOX6 Plus Bevacizumab to Treat Liver-Only Metastases of Colorectal Cancer that are Unsuitable for Upfront Resection (TRICC0808) in ANNALS OF SURGICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1245/s10434-016-5418-6

    DOI

    http://dx.doi.org/10.1245/s10434-016-5418-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016706571

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27431415


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies, Monoclonal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Camptothecin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Case-Control Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Floxuridine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hepatic Artery", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infusions, Intra-Arterial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Irinotecan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organoplatinum Compounds", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxaliplatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dhir", 
            "givenName": "Mashaal", 
            "id": "sg:person.01205114144.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205114144.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jones", 
            "givenName": "Heather L.", 
            "id": "sg:person.0714612140.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714612140.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh", 
              "id": "https://www.grid.ac/institutes/grid.21925.3d", 
              "name": [
                "Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shuai", 
            "givenName": "Yongli", 
            "id": "sg:person.01174250635.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174250635.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clifford", 
            "givenName": "Amber K.", 
            "id": "sg:person.0603401475.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603401475.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perkins", 
            "givenName": "Samantha", 
            "id": "sg:person.010724046655.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010724046655.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Steve", 
            "givenName": "Jennifer", 
            "id": "sg:person.010534076645.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010534076645.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hogg", 
            "givenName": "Melissa E.", 
            "id": "sg:person.01120171750.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120171750.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choudry", 
            "givenName": "M. Haroon A.", 
            "id": "sg:person.01247102013.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247102013.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pingpank", 
            "givenName": "James F.", 
            "id": "sg:person.011151263607.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011151263607.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holtzman", 
            "givenName": "Matthew P.", 
            "id": "sg:person.0702146346.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702146346.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zeh", 
            "givenName": "Herbert J.", 
            "id": "sg:person.01132623346.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132623346.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Department of Medical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bahary", 
            "givenName": "Nathan", 
            "id": "sg:person.0756325003.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756325003.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bartlett", 
            "givenName": "David L.", 
            "id": "sg:person.01200736546.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200736546.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412689.0", 
              "name": [
                "Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zureikat", 
            "givenName": "Amer H.", 
            "id": "sg:person.01215507274.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215507274.03"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.bjc.6603988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000295738", 
              "https://doi.org/10.1038/sj.bjc.6603988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-014-3797-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004339895", 
              "https://doi.org/10.1245/s10434-014-3797-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000217629.94941.cf", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008912065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000217629.94941.cf", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008912065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1463-1318.2011.02817.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010419996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011682275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2012.42.8201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012907743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014250067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2013.53.2473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014382035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31819a0486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016002497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31819a0486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016002497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31819a0486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016002497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.27.6055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018118954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-12-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019716785", 
              "https://doi.org/10.1186/1471-2407-12-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)61900-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020430219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000000614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026316538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000000614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026316538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.20.1301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027887204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11605-012-2103-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028262614", 
              "https://doi.org/10.1007/s11605-012-2103-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-014-4094-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028460460", 
              "https://doi.org/10.1245/s10434-014-4094-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-9-120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030864199", 
              "https://doi.org/10.1186/1471-2407-9-120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(14)70330-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032780345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.soc.2014.09.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035479385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.07.100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039342053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.07.740", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040572481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.36.1980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040911839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000000860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043154871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000000860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043154871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-010-1409-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044879140", 
              "https://doi.org/10.1245/s10434-010-1409-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.33.5091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045522021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.19.9273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047377641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdq714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048274008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdu088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048953923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(09)70330-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050539676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.29.5436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051337190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-14-741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052962070", 
              "https://doi.org/10.1186/1471-2407-14-741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000141198.92114.f6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060331907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000141198.92114.f6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060331907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000141198.92114.f6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060331907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000141198.92114.f6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060331907"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-01", 
        "datePublishedReg": "2017-01-01", 
        "description": "BACKGROUND: In the era of effective modern systemic chemotherapy (CT), the role of hepatic arterial infusion of fluoxuridine (HAI-FUDR) in the treatment of isolated unresectable colorectal liver metastasis (IU-CRCLM) remains controversial. This study aimed to compare the overall survival (OS) of HAI-FUDR in combination with modern systemic CT versus modern systemic CT alone in patients with IU-CRCLM.\nMETHODS: This was a case-control study of IU-CRCLM patients who underwent HAI\u00a0+\u00a0modern systemic CT or modern systemic CT alone. Modern systemic CT was defined as the use of multidrug regimens containing oxaliplatin and/or irinotecan\u00a0\u00b1\u00a0biologics.\nRESULTS: Overall, 86 patients met the inclusion criteria (n\u00a0=\u00a040 for the HAI\u00a0+\u00a0CT group, and n\u00a0=\u00a046 for the CT-alone group). Both groups were similar in demographics, primary and stage IV tumor characteristics, and treatment-related variables (carcinoembryonic antigen, use of biologic agents, total number of lines of systemic CT administered) (all p\u00a0>\u00a00.05). Additionally, both groups were comparable with respect to liver tumor burden [median number of lesions (13.5 vs. 15), percentage of liver tumor replacement (37.5 vs. 40\u00a0%), and size of largest lesion] (all p\u00a0>\u00a00.05). Median OS in the HAI\u00a0+\u00a0CT group was 32.8\u00a0months compared with 15.3\u00a0months in the CT-alone group (p\u00a0<\u00a00.0001). Multivariate analysis revealed HAI\u00a0+\u00a0CT (hazard ratio 0.4, 95\u00a0% confidence interval 0.21-0.72; p\u00a0=\u00a00.003), Eastern Cooperative Oncology Group status, and receipt of increasing number of lines of systemic CT to be independent predictors of survival.\nCONCLUSIONS: In this case-control study of patients with IU-CRCLM, HAI in combination with CT was associated with improved OS when compared with modern systemic CT alone.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1245/s10434-016-5418-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1105545", 
            "issn": [
              "1068-9265", 
              "1534-4681"
            ], 
            "name": "Annals of Surgical Oncology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "24"
          }
        ], 
        "name": "Hepatic Arterial Infusion in Combination with Modern Systemic Chemotherapy is Associated with Improved Survival Compared with Modern Systemic Chemotherapy Alone in Patients with Isolated Unresectable Colorectal Liver Metastases: A Case\u2013Control Study", 
        "pagination": "150-158", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "4f99aa6cb09a5f6a232d0226811dd3017b1126b37d7cadeca78231c82b89f029"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27431415"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9420840"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1245/s10434-016-5418-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1016706571"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1245/s10434-016-5418-6", 
          "https://app.dimensions.ai/details/publication/pub.1016706571"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:36", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70031_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1245%2Fs10434-016-5418-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-016-5418-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-016-5418-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-016-5418-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-016-5418-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    344 TRIPLES      21 PREDICATES      80 URIs      40 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1245/s10434-016-5418-6 schema:about N0326bfb9521c4878bdf9de810b2e29d6
    2 N0e56e4e9f64845ad84b44e77bd69f30f
    3 N43d1dac935a3468fb85c23ffcc30159a
    4 N4c44ec54d9ad4d1f8a06fec2353f885b
    5 N50c5b7e32cd840ae9d4fed57694a2db5
    6 N5634c96cbc1844388384677792708987
    7 N5d75053e242a45c5a9731b39bdd81325
    8 N60ad29175ae64d618502b89ea3abff6d
    9 N675e59f4e9224c89940269f4c77023d0
    10 N6be90a45bbdc4668a22705353163acfb
    11 N7b97cbd46d924b8eb4e03d3fd1d423b7
    12 N89e5a54873314fbdabed671fbc8a7d64
    13 N92115007d2bb408380b370d2941bf71d
    14 Na3383921af944ab58fb91c77f91aa543
    15 Naff2d596db7b4e74988bfe1522cabedc
    16 Nb79063db23e24157ad2be581cf713db9
    17 Nbf27a62551f74f5ab466790d41c9e937
    18 Nbfabfe50990547e982de861cb2d5959c
    19 Nf3d02f3e97924162abc76b316182326d
    20 anzsrc-for:11
    21 anzsrc-for:1112
    22 schema:author Nbafd9d2a41b6418dacba9144e1589811
    23 schema:citation sg:pub.10.1007/s11605-012-2103-3
    24 sg:pub.10.1038/sj.bjc.6603988
    25 sg:pub.10.1186/1471-2407-12-1
    26 sg:pub.10.1186/1471-2407-14-741
    27 sg:pub.10.1186/1471-2407-9-120
    28 sg:pub.10.1245/s10434-010-1409-1
    29 sg:pub.10.1245/s10434-014-3797-0
    30 sg:pub.10.1245/s10434-014-4094-7
    31 https://doi.org/10.1016/j.soc.2014.09.005
    32 https://doi.org/10.1016/s0140-6736(12)61900-x
    33 https://doi.org/10.1016/s1470-2045(09)70330-4
    34 https://doi.org/10.1016/s1470-2045(14)70330-4
    35 https://doi.org/10.1093/annonc/mdq714
    36 https://doi.org/10.1093/annonc/mdu088
    37 https://doi.org/10.1097/01.sla.0000141198.92114.f6
    38 https://doi.org/10.1097/01.sla.0000217629.94941.cf
    39 https://doi.org/10.1097/sla.0000000000000614
    40 https://doi.org/10.1097/sla.0000000000000860
    41 https://doi.org/10.1097/sla.0b013e31819a0486
    42 https://doi.org/10.1111/j.1463-1318.2011.02817.x
    43 https://doi.org/10.1200/jco.2005.07.100
    44 https://doi.org/10.1200/jco.2005.07.740
    45 https://doi.org/10.1200/jco.2008.19.9273
    46 https://doi.org/10.1200/jco.2008.20.1301
    47 https://doi.org/10.1200/jco.2009.27.6055
    48 https://doi.org/10.1200/jco.2010.29.5436
    49 https://doi.org/10.1200/jco.2010.33.5091
    50 https://doi.org/10.1200/jco.2011.36.1980
    51 https://doi.org/10.1200/jco.2012.42.8201
    52 https://doi.org/10.1200/jco.2013.53.2473
    53 https://doi.org/10.3322/caac.21220
    54 https://doi.org/10.3322/caac.21254
    55 schema:datePublished 2017-01
    56 schema:datePublishedReg 2017-01-01
    57 schema:description BACKGROUND: In the era of effective modern systemic chemotherapy (CT), the role of hepatic arterial infusion of fluoxuridine (HAI-FUDR) in the treatment of isolated unresectable colorectal liver metastasis (IU-CRCLM) remains controversial. This study aimed to compare the overall survival (OS) of HAI-FUDR in combination with modern systemic CT versus modern systemic CT alone in patients with IU-CRCLM. METHODS: This was a case-control study of IU-CRCLM patients who underwent HAI + modern systemic CT or modern systemic CT alone. Modern systemic CT was defined as the use of multidrug regimens containing oxaliplatin and/or irinotecan ± biologics. RESULTS: Overall, 86 patients met the inclusion criteria (n = 40 for the HAI + CT group, and n = 46 for the CT-alone group). Both groups were similar in demographics, primary and stage IV tumor characteristics, and treatment-related variables (carcinoembryonic antigen, use of biologic agents, total number of lines of systemic CT administered) (all p > 0.05). Additionally, both groups were comparable with respect to liver tumor burden [median number of lesions (13.5 vs. 15), percentage of liver tumor replacement (37.5 vs. 40 %), and size of largest lesion] (all p > 0.05). Median OS in the HAI + CT group was 32.8 months compared with 15.3 months in the CT-alone group (p < 0.0001). Multivariate analysis revealed HAI + CT (hazard ratio 0.4, 95 % confidence interval 0.21-0.72; p = 0.003), Eastern Cooperative Oncology Group status, and receipt of increasing number of lines of systemic CT to be independent predictors of survival. CONCLUSIONS: In this case-control study of patients with IU-CRCLM, HAI in combination with CT was associated with improved OS when compared with modern systemic CT alone.
    58 schema:genre research_article
    59 schema:inLanguage en
    60 schema:isAccessibleForFree false
    61 schema:isPartOf N29c593070da648d0893579ca0b75ec0c
    62 Nab5ba49791e14d80a71b125e43a0d03c
    63 sg:journal.1105545
    64 schema:name Hepatic Arterial Infusion in Combination with Modern Systemic Chemotherapy is Associated with Improved Survival Compared with Modern Systemic Chemotherapy Alone in Patients with Isolated Unresectable Colorectal Liver Metastases: A Case–Control Study
    65 schema:pagination 150-158
    66 schema:productId N26cd123890c54a7c9f4a4739e3583f22
    67 N74a429dc031445b4b49d1143f4cfc515
    68 N8b0889a35a57409595c310d8369641e9
    69 N90bcf316fd1a4794b8e93cbabb2e8c96
    70 Ne60b3991a3b74937821adbce91ab6d2b
    71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016706571
    72 https://doi.org/10.1245/s10434-016-5418-6
    73 schema:sdDatePublished 2019-04-11T12:36
    74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    75 schema:sdPublisher Nb387ebc859d046e4a10351c977056953
    76 schema:url https://link.springer.com/10.1245%2Fs10434-016-5418-6
    77 sgo:license sg:explorer/license/
    78 sgo:sdDataset articles
    79 rdf:type schema:ScholarlyArticle
    80 N0326bfb9521c4878bdf9de810b2e29d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    81 schema:name Camptothecin
    82 rdf:type schema:DefinedTerm
    83 N0e56e4e9f64845ad84b44e77bd69f30f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    84 schema:name Middle Aged
    85 rdf:type schema:DefinedTerm
    86 N1a4f334056ea466090de49210474bf4f rdf:first sg:person.011151263607.01
    87 rdf:rest Ncd2c75bbb69b419fa92ae6e61bce8100
    88 N26cd123890c54a7c9f4a4739e3583f22 schema:name nlm_unique_id
    89 schema:value 9420840
    90 rdf:type schema:PropertyValue
    91 N29c593070da648d0893579ca0b75ec0c schema:volumeNumber 24
    92 rdf:type schema:PublicationVolume
    93 N2bdc4ce9e8914a2d92f865ae7f0d20a4 rdf:first sg:person.010724046655.99
    94 rdf:rest N99f2ef50dae54c90a0504d993dadfbe6
    95 N2d49f16bd1884b999daa52e2199f1a6d rdf:first sg:person.01200736546.31
    96 rdf:rest Nb13423262cea4a08b8c32312ef9868f6
    97 N43d1dac935a3468fb85c23ffcc30159a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Female
    99 rdf:type schema:DefinedTerm
    100 N4c44ec54d9ad4d1f8a06fec2353f885b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Organoplatinum Compounds
    102 rdf:type schema:DefinedTerm
    103 N50c5b7e32cd840ae9d4fed57694a2db5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Antineoplastic Combined Chemotherapy Protocols
    105 rdf:type schema:DefinedTerm
    106 N518c09c46c654d0e9e2fa9d331e29eb3 rdf:first sg:person.0714612140.04
    107 rdf:rest N5497c70932d04f598a9e7588a6233ca7
    108 N5497c70932d04f598a9e7588a6233ca7 rdf:first sg:person.01174250635.34
    109 rdf:rest Na7fd435a08f649998bc871c71baf4d72
    110 N5634c96cbc1844388384677792708987 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Infusions, Intra-Arterial
    112 rdf:type schema:DefinedTerm
    113 N5d75053e242a45c5a9731b39bdd81325 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Hepatic Artery
    115 rdf:type schema:DefinedTerm
    116 N60ad29175ae64d618502b89ea3abff6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Survival Rate
    118 rdf:type schema:DefinedTerm
    119 N675e59f4e9224c89940269f4c77023d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Male
    121 rdf:type schema:DefinedTerm
    122 N6be90a45bbdc4668a22705353163acfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Floxuridine
    124 rdf:type schema:DefinedTerm
    125 N74a429dc031445b4b49d1143f4cfc515 schema:name doi
    126 schema:value 10.1245/s10434-016-5418-6
    127 rdf:type schema:PropertyValue
    128 N7b97cbd46d924b8eb4e03d3fd1d423b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Colorectal Neoplasms
    130 rdf:type schema:DefinedTerm
    131 N89e5a54873314fbdabed671fbc8a7d64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Humans
    133 rdf:type schema:DefinedTerm
    134 N8b0889a35a57409595c310d8369641e9 schema:name dimensions_id
    135 schema:value pub.1016706571
    136 rdf:type schema:PropertyValue
    137 N90bcf316fd1a4794b8e93cbabb2e8c96 schema:name pubmed_id
    138 schema:value 27431415
    139 rdf:type schema:PropertyValue
    140 N92115007d2bb408380b370d2941bf71d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Irinotecan
    142 rdf:type schema:DefinedTerm
    143 N945e981261654dc5872134068c6e5019 rdf:first sg:person.0756325003.92
    144 rdf:rest N2d49f16bd1884b999daa52e2199f1a6d
    145 N99f2ef50dae54c90a0504d993dadfbe6 rdf:first sg:person.010534076645.11
    146 rdf:rest Ne9dcc7e4ae0a4adba297e2a59e01abd5
    147 Na3383921af944ab58fb91c77f91aa543 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Aged
    149 rdf:type schema:DefinedTerm
    150 Na7fd435a08f649998bc871c71baf4d72 rdf:first sg:person.0603401475.30
    151 rdf:rest N2bdc4ce9e8914a2d92f865ae7f0d20a4
    152 Nab5ba49791e14d80a71b125e43a0d03c schema:issueNumber 1
    153 rdf:type schema:PublicationIssue
    154 Naff2d596db7b4e74988bfe1522cabedc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Liver Neoplasms
    156 rdf:type schema:DefinedTerm
    157 Nb13423262cea4a08b8c32312ef9868f6 rdf:first sg:person.01215507274.03
    158 rdf:rest rdf:nil
    159 Nb387ebc859d046e4a10351c977056953 schema:name Springer Nature - SN SciGraph project
    160 rdf:type schema:Organization
    161 Nb79063db23e24157ad2be581cf713db9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Treatment Outcome
    163 rdf:type schema:DefinedTerm
    164 Nbafd9d2a41b6418dacba9144e1589811 rdf:first sg:person.01205114144.30
    165 rdf:rest N518c09c46c654d0e9e2fa9d331e29eb3
    166 Nbf27a62551f74f5ab466790d41c9e937 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Oxaliplatin
    168 rdf:type schema:DefinedTerm
    169 Nbf33d95fd84242c0b9bb97e7142c7d3d rdf:first sg:person.01132623346.71
    170 rdf:rest N945e981261654dc5872134068c6e5019
    171 Nbfabfe50990547e982de861cb2d5959c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Antibodies, Monoclonal
    173 rdf:type schema:DefinedTerm
    174 Ncd2c75bbb69b419fa92ae6e61bce8100 rdf:first sg:person.0702146346.81
    175 rdf:rest Nbf33d95fd84242c0b9bb97e7142c7d3d
    176 Ne607a9dddd1a4a8d93e8e5b03e9cc5be rdf:first sg:person.01247102013.55
    177 rdf:rest N1a4f334056ea466090de49210474bf4f
    178 Ne60b3991a3b74937821adbce91ab6d2b schema:name readcube_id
    179 schema:value 4f99aa6cb09a5f6a232d0226811dd3017b1126b37d7cadeca78231c82b89f029
    180 rdf:type schema:PropertyValue
    181 Ne9dcc7e4ae0a4adba297e2a59e01abd5 rdf:first sg:person.01120171750.96
    182 rdf:rest Ne607a9dddd1a4a8d93e8e5b03e9cc5be
    183 Nf3d02f3e97924162abc76b316182326d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Case-Control Studies
    185 rdf:type schema:DefinedTerm
    186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    187 schema:name Medical and Health Sciences
    188 rdf:type schema:DefinedTerm
    189 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    190 schema:name Oncology and Carcinogenesis
    191 rdf:type schema:DefinedTerm
    192 sg:journal.1105545 schema:issn 1068-9265
    193 1534-4681
    194 schema:name Annals of Surgical Oncology
    195 rdf:type schema:Periodical
    196 sg:person.010534076645.11 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    197 schema:familyName Steve
    198 schema:givenName Jennifer
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010534076645.11
    200 rdf:type schema:Person
    201 sg:person.010724046655.99 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    202 schema:familyName Perkins
    203 schema:givenName Samantha
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010724046655.99
    205 rdf:type schema:Person
    206 sg:person.011151263607.01 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    207 schema:familyName Pingpank
    208 schema:givenName James F.
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011151263607.01
    210 rdf:type schema:Person
    211 sg:person.01120171750.96 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    212 schema:familyName Hogg
    213 schema:givenName Melissa E.
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120171750.96
    215 rdf:type schema:Person
    216 sg:person.01132623346.71 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    217 schema:familyName Zeh
    218 schema:givenName Herbert J.
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132623346.71
    220 rdf:type schema:Person
    221 sg:person.01174250635.34 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
    222 schema:familyName Shuai
    223 schema:givenName Yongli
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174250635.34
    225 rdf:type schema:Person
    226 sg:person.01200736546.31 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    227 schema:familyName Bartlett
    228 schema:givenName David L.
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200736546.31
    230 rdf:type schema:Person
    231 sg:person.01205114144.30 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    232 schema:familyName Dhir
    233 schema:givenName Mashaal
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205114144.30
    235 rdf:type schema:Person
    236 sg:person.01215507274.03 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    237 schema:familyName Zureikat
    238 schema:givenName Amer H.
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215507274.03
    240 rdf:type schema:Person
    241 sg:person.01247102013.55 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    242 schema:familyName Choudry
    243 schema:givenName M. Haroon A.
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247102013.55
    245 rdf:type schema:Person
    246 sg:person.0603401475.30 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    247 schema:familyName Clifford
    248 schema:givenName Amber K.
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603401475.30
    250 rdf:type schema:Person
    251 sg:person.0702146346.81 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    252 schema:familyName Holtzman
    253 schema:givenName Matthew P.
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702146346.81
    255 rdf:type schema:Person
    256 sg:person.0714612140.04 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    257 schema:familyName Jones
    258 schema:givenName Heather L.
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714612140.04
    260 rdf:type schema:Person
    261 sg:person.0756325003.92 schema:affiliation https://www.grid.ac/institutes/grid.412689.0
    262 schema:familyName Bahary
    263 schema:givenName Nathan
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756325003.92
    265 rdf:type schema:Person
    266 sg:pub.10.1007/s11605-012-2103-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028262614
    267 https://doi.org/10.1007/s11605-012-2103-3
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/sj.bjc.6603988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000295738
    270 https://doi.org/10.1038/sj.bjc.6603988
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1186/1471-2407-12-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019716785
    273 https://doi.org/10.1186/1471-2407-12-1
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1186/1471-2407-14-741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052962070
    276 https://doi.org/10.1186/1471-2407-14-741
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1186/1471-2407-9-120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030864199
    279 https://doi.org/10.1186/1471-2407-9-120
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1245/s10434-010-1409-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044879140
    282 https://doi.org/10.1245/s10434-010-1409-1
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1245/s10434-014-3797-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004339895
    285 https://doi.org/10.1245/s10434-014-3797-0
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1245/s10434-014-4094-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028460460
    288 https://doi.org/10.1245/s10434-014-4094-7
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.soc.2014.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035479385
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/s0140-6736(12)61900-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020430219
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/s1470-2045(09)70330-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050539676
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/s1470-2045(14)70330-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032780345
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1093/annonc/mdq714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048274008
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1093/annonc/mdu088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048953923
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1097/01.sla.0000141198.92114.f6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060331907
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1097/01.sla.0000217629.94941.cf schema:sameAs https://app.dimensions.ai/details/publication/pub.1008912065
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1097/sla.0000000000000614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026316538
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1097/sla.0000000000000860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043154871
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1097/sla.0b013e31819a0486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016002497
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1111/j.1463-1318.2011.02817.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010419996
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1200/jco.2005.07.100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039342053
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1200/jco.2005.07.740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040572481
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1200/jco.2008.19.9273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047377641
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1200/jco.2008.20.1301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027887204
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1200/jco.2009.27.6055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018118954
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1200/jco.2010.29.5436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051337190
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1200/jco.2010.33.5091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045522021
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1200/jco.2011.36.1980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040911839
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1200/jco.2012.42.8201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012907743
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1200/jco.2013.53.2473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014382035
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.3322/caac.21220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014250067
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.3322/caac.21254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011682275
    337 rdf:type schema:CreativeWork
    338 https://www.grid.ac/institutes/grid.21925.3d schema:alternateName University of Pittsburgh
    339 schema:name Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA
    340 rdf:type schema:Organization
    341 https://www.grid.ac/institutes/grid.412689.0 schema:alternateName University of Pittsburgh Medical Center
    342 schema:name Department of Medical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    343 Division of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    344 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...