RAS Mutation Predicts Positive Resection Margins and Narrower Resection Margins in Patients Undergoing Resection of Colorectal Liver Metastases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-03-25

AUTHORS

Kristoffer Watten Brudvik, Yoshihiro Mise, Michael Hsiang Chung, Yun Shin Chun, Scott E. Kopetz, Guillaume Passot, Claudius Conrad, Dipen M. Maru, Thomas A. Aloia, Jean-Nicolas Vauthey

ABSTRACT

BackgroundIn patients undergoing resection of colorectal liver metastases (CLM), resection margin status is a significant predictor of survival, particularly in patients with suboptimal response to preoperative therapy. RAS mutations have been linked to more invasive and migratory tumor biology and poor response to modern chemotherapy.ObjectiveThe aim of this study was to evaluate the relationship between RAS mutation and resection margin status in patients undergoing resection of CLM.MethodsPatients who underwent curative resection of CLM from 2005 to 2013 with known RAS mutation status were identified from a prospectively maintained database. A positive margin was defined as tumor cells <1 mm from the parenchymal transection line.ResultsThe study included 633 patients, of whom 229 (36.2 %) had mutant RAS. The positive margin rate was 11.4 % (26/229) for mutant RAS and 5.4 % (22/404) for wild-type RAS (p = 0.007). In multivariate analysis, the only factors associated with a positive margin were RAS mutation (hazard ratio [HR] 2.439; p = 0.005) and carcinoembryonic antigen level 4.5 ng/mL or greater (HR 2.060; p = 0.026). Among patients presenting with liver-first recurrence during follow-up, those with mutant RAS had narrower margins at initial CLM resection (median 4 mm vs. 7 mm; p = 0.031). A positive margin (HR 3.360; p < 0.001) and RAS mutation (HR 1.629; p = 0.044) were independently associated with worse overall survival.ConclusionRAS mutations are associated with positive margins in patients undergoing resection of CLM. Tumors with RAS mutation should prompt careful efforts to achieve negative resection margins. More... »

PAGES

2635-2643

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-016-5187-2

DOI

http://dx.doi.org/10.1245/s10434-016-5187-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050206513

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27016292


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Margins of Excision", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ras Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brudvik", 
        "givenName": "Kristoffer Watten", 
        "id": "sg:person.0631060551.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631060551.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mise", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.0626665021.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626665021.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Michael Hsiang", 
        "id": "sg:person.014730366531.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014730366531.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chun", 
        "givenName": "Yun Shin", 
        "id": "sg:person.01127474651.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127474651.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kopetz", 
        "givenName": "Scott E.", 
        "id": "sg:person.01320500077.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320500077.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Passot", 
        "givenName": "Guillaume", 
        "id": "sg:person.01130704511.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130704511.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Conrad", 
        "givenName": "Claudius", 
        "id": "sg:person.07430101017.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07430101017.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maru", 
        "givenName": "Dipen M.", 
        "id": "sg:person.01232724076.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232724076.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aloia", 
        "givenName": "Thomas A.", 
        "id": "sg:person.0762234740.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762234740.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vauthey", 
        "givenName": "Jean-Nicolas", 
        "id": "sg:person.07742537757.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07742537757.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1477-7819-12-127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028337829", 
          "https://doi.org/10.1186/1477-7819-12-127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.1999.00945.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024282263", 
          "https://doi.org/10.1111/j.1572-0241.1999.00945.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-002-6267-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037410368", 
          "https://doi.org/10.1007/s00268-002-6267-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0605-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048935334", 
          "https://doi.org/10.1245/s10434-009-0605-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2014.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013862887", 
          "https://doi.org/10.1038/modpathol.2014.4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-014-4042-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028729249", 
          "https://doi.org/10.1245/s10434-014-4042-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025871106", 
          "https://doi.org/10.1038/nm.3511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00316981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038122014", 
          "https://doi.org/10.1007/bf00316981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-011-2114-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022367853", 
          "https://doi.org/10.1245/s10434-011-2114-4"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-03-25", 
    "datePublishedReg": "2016-03-25", 
    "description": "BackgroundIn patients undergoing resection of colorectal liver metastases (CLM), resection margin status is a significant predictor of survival, particularly in patients with suboptimal response to preoperative therapy. RAS mutations have been linked to more invasive and migratory tumor biology and poor response to modern chemotherapy.ObjectiveThe aim of this study was to evaluate the relationship between RAS mutation and resection margin status in patients undergoing resection of CLM.MethodsPatients who underwent curative resection of CLM from 2005 to 2013 with known RAS mutation status were identified from a prospectively maintained database. A positive margin was defined as tumor cells <1\u00a0mm from the parenchymal transection line.ResultsThe study included 633 patients, of whom 229 (36.2\u00a0%) had mutant RAS. The positive margin rate was 11.4\u00a0% (26/229) for mutant RAS and 5.4\u00a0% (22/404) for wild-type RAS (p\u00a0=\u00a00.007). In multivariate analysis, the only factors associated with a positive margin were RAS mutation (hazard ratio [HR] 2.439; p\u00a0=\u00a00.005) and carcinoembryonic antigen level 4.5\u00a0ng/mL or greater (HR 2.060; p\u00a0=\u00a00.026). Among patients presenting with liver-first recurrence during follow-up, those with mutant RAS had narrower margins at initial CLM resection (median 4\u00a0mm vs. 7\u00a0mm; p\u00a0=\u00a00.031). A positive margin (HR 3.360; p\u00a0<\u00a00.001) and RAS mutation (HR 1.629; p\u00a0=\u00a00.044) were independently associated with worse overall survival.ConclusionRAS mutations are associated with positive margins in patients undergoing resection of CLM. Tumors with RAS mutation should prompt careful efforts to achieve negative resection margins.", 
    "genre": "article", 
    "id": "sg:pub.10.1245/s10434-016-5187-2", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "colorectal liver metastases", 
      "resection of CRLM", 
      "resection margin status", 
      "positive margins", 
      "resection margins", 
      "RAS mutations", 
      "liver metastases", 
      "margin status", 
      "Patients Undergoing Resection", 
      "negative resection margins", 
      "positive resection margins", 
      "worse overall survival", 
      "RAS mutation status", 
      "positive margin rate", 
      "mutant RAS", 
      "parenchymal transection line", 
      "CLM resection", 
      "undergoing resection", 
      "preoperative therapy", 
      "curative resection", 
      "BackgroundIn patients", 
      "suboptimal response", 
      "overall survival", 
      "transection line", 
      "poor response", 
      "modern chemotherapy", 
      "margin rate", 
      "ResultsThe study", 
      "resection", 
      "patients", 
      "mutation status", 
      "tumor biology", 
      "multivariate analysis", 
      "tumor cells", 
      "levels 4.5", 
      "only factor", 
      "significant predictors", 
      "metastasis", 
      "wild-type Ras", 
      "survival", 
      "status", 
      "mutations", 
      "narrow margin", 
      "MethodsPatients", 
      "chemotherapy", 
      "RAS", 
      "recurrence", 
      "therapy", 
      "tumors", 
      "response", 
      "predictors", 
      "study", 
      "cells", 
      "margin", 
      "aim", 
      "RA", 
      "factors", 
      "database", 
      "rate", 
      "careful efforts", 
      "biology", 
      "relationship", 
      "lines", 
      "analysis", 
      "efforts"
    ], 
    "name": "RAS Mutation Predicts Positive Resection Margins and Narrower Resection Margins in Patients Undergoing Resection of Colorectal Liver Metastases", 
    "pagination": "2635-2643", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050206513"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-016-5187-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27016292"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-016-5187-2", 
      "https://app.dimensions.ai/details/publication/pub.1050206513"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_704.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1245/s10434-016-5187-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-016-5187-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-016-5187-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-016-5187-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-016-5187-2'


 

This table displays all metadata directly associated to this object as RDF triples.

307 TRIPLES      21 PREDICATES      118 URIs      101 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-016-5187-2 schema:about N09fa3f97880a4beeb681a13f0f773b6c
2 N1c19cb53ae8c4e078375ff6fdd271ec7
3 N249ff91d29b94cff90e7a4d401f69f72
4 N58a451137ec84bc8ac82d854b1215798
5 N5a94d68cde5b46bc850b186dd77c76c2
6 N5c283f8f01d145a4ab54213ca8ec8b15
7 N610f529f3f454b86806dbbead3ae6884
8 N7fc69d9ccf3544f9972e38abe397bca2
9 N81373a83206842e5ad5ba269907e487b
10 N8ef97b05870947dcbbb480757c678612
11 Nb027c1c8c23f41ef9e4d9fa86f510e63
12 Nb033269ea75344238f58eed9bfca6de6
13 Nb9abf3052c68422d95a4303ab2591ef9
14 Nc36b6c78dcff42f5ae83a86b64d7fa63
15 Nc7c78ad08f294aafaa8685482e407870
16 Nc89659cf77a14f109d840362829719f7
17 Ne1622032603f4c4f825064a23c3027da
18 Ne38e350bb30340a3a343746bf42ad847
19 Nf222cecd31a843709a740fd5044153fd
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N2e68a4de757d44c193b09bb3819ffaaf
23 schema:citation sg:pub.10.1007/bf00316981
24 sg:pub.10.1007/s00268-002-6267-y
25 sg:pub.10.1038/modpathol.2014.4
26 sg:pub.10.1038/nm.3511
27 sg:pub.10.1111/j.1572-0241.1999.00945.x
28 sg:pub.10.1186/1477-7819-12-127
29 sg:pub.10.1245/s10434-009-0605-3
30 sg:pub.10.1245/s10434-011-2114-4
31 sg:pub.10.1245/s10434-014-4042-6
32 schema:datePublished 2016-03-25
33 schema:datePublishedReg 2016-03-25
34 schema:description BackgroundIn patients undergoing resection of colorectal liver metastases (CLM), resection margin status is a significant predictor of survival, particularly in patients with suboptimal response to preoperative therapy. RAS mutations have been linked to more invasive and migratory tumor biology and poor response to modern chemotherapy.ObjectiveThe aim of this study was to evaluate the relationship between RAS mutation and resection margin status in patients undergoing resection of CLM.MethodsPatients who underwent curative resection of CLM from 2005 to 2013 with known RAS mutation status were identified from a prospectively maintained database. A positive margin was defined as tumor cells <1 mm from the parenchymal transection line.ResultsThe study included 633 patients, of whom 229 (36.2 %) had mutant RAS. The positive margin rate was 11.4 % (26/229) for mutant RAS and 5.4 % (22/404) for wild-type RAS (p = 0.007). In multivariate analysis, the only factors associated with a positive margin were RAS mutation (hazard ratio [HR] 2.439; p = 0.005) and carcinoembryonic antigen level 4.5 ng/mL or greater (HR 2.060; p = 0.026). Among patients presenting with liver-first recurrence during follow-up, those with mutant RAS had narrower margins at initial CLM resection (median 4 mm vs. 7 mm; p = 0.031). A positive margin (HR 3.360; p < 0.001) and RAS mutation (HR 1.629; p = 0.044) were independently associated with worse overall survival.ConclusionRAS mutations are associated with positive margins in patients undergoing resection of CLM. Tumors with RAS mutation should prompt careful efforts to achieve negative resection margins.
35 schema:genre article
36 schema:isAccessibleForFree true
37 schema:isPartOf Nc4386277fa7b4f5f899009fcbbafef61
38 Nd66dcecc73f3460888e3be062e027b2f
39 sg:journal.1105545
40 schema:keywords BackgroundIn patients
41 CLM resection
42 MethodsPatients
43 Patients Undergoing Resection
44 RA
45 RAS
46 RAS mutation status
47 RAS mutations
48 ResultsThe study
49 aim
50 analysis
51 biology
52 careful efforts
53 cells
54 chemotherapy
55 colorectal liver metastases
56 curative resection
57 database
58 efforts
59 factors
60 levels 4.5
61 lines
62 liver metastases
63 margin
64 margin rate
65 margin status
66 metastasis
67 modern chemotherapy
68 multivariate analysis
69 mutant RAS
70 mutation status
71 mutations
72 narrow margin
73 negative resection margins
74 only factor
75 overall survival
76 parenchymal transection line
77 patients
78 poor response
79 positive margin rate
80 positive margins
81 positive resection margins
82 predictors
83 preoperative therapy
84 rate
85 recurrence
86 relationship
87 resection
88 resection margin status
89 resection margins
90 resection of CRLM
91 response
92 significant predictors
93 status
94 study
95 suboptimal response
96 survival
97 therapy
98 transection line
99 tumor biology
100 tumor cells
101 tumors
102 undergoing resection
103 wild-type Ras
104 worse overall survival
105 schema:name RAS Mutation Predicts Positive Resection Margins and Narrower Resection Margins in Patients Undergoing Resection of Colorectal Liver Metastases
106 schema:pagination 2635-2643
107 schema:productId N5169e2e56a8c43f1bd069c6d10f252e9
108 N6a795e4718bb4e8ea1923a1d6a6abdaa
109 Nfb11d6bb0dc84ee3b8d34a82023a08b4
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050206513
111 https://doi.org/10.1245/s10434-016-5187-2
112 schema:sdDatePublished 2022-08-04T17:04
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher Nd5c4dc406d0e4816814dee1334e6ebad
115 schema:url https://doi.org/10.1245/s10434-016-5187-2
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N09fa3f97880a4beeb681a13f0f773b6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Follow-Up Studies
121 rdf:type schema:DefinedTerm
122 N0ed07a5c414c4e099191042b9885728b rdf:first sg:person.07430101017.47
123 rdf:rest Nc2b14d2553ab43f1b2b8b2dd7f65a934
124 N1c19cb53ae8c4e078375ff6fdd271ec7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Mutation
126 rdf:type schema:DefinedTerm
127 N249ff91d29b94cff90e7a4d401f69f72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Male
129 rdf:type schema:DefinedTerm
130 N2e68a4de757d44c193b09bb3819ffaaf rdf:first sg:person.0631060551.45
131 rdf:rest N32b64c2cae46415e9ceecc808a9eade2
132 N32b64c2cae46415e9ceecc808a9eade2 rdf:first sg:person.0626665021.66
133 rdf:rest Nd1c3680cd0944b71a2d63cf5c15249a0
134 N5169e2e56a8c43f1bd069c6d10f252e9 schema:name doi
135 schema:value 10.1245/s10434-016-5187-2
136 rdf:type schema:PropertyValue
137 N58a451137ec84bc8ac82d854b1215798 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name ras Proteins
139 rdf:type schema:DefinedTerm
140 N5a94d68cde5b46bc850b186dd77c76c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Female
142 rdf:type schema:DefinedTerm
143 N5c283f8f01d145a4ab54213ca8ec8b15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Aged, 80 and over
145 rdf:type schema:DefinedTerm
146 N610f529f3f454b86806dbbead3ae6884 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Colorectal Neoplasms
148 rdf:type schema:DefinedTerm
149 N6a795e4718bb4e8ea1923a1d6a6abdaa schema:name pubmed_id
150 schema:value 27016292
151 rdf:type schema:PropertyValue
152 N773e67895df04badbd4ae12dbd555e83 rdf:first sg:person.01320500077.48
153 rdf:rest N79bd729f2d2f44e9a773efe6f70c1e85
154 N79bd729f2d2f44e9a773efe6f70c1e85 rdf:first sg:person.01130704511.97
155 rdf:rest N0ed07a5c414c4e099191042b9885728b
156 N7fc69d9ccf3544f9972e38abe397bca2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Survival Rate
158 rdf:type schema:DefinedTerm
159 N81373a83206842e5ad5ba269907e487b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Neoplasm Recurrence, Local
161 rdf:type schema:DefinedTerm
162 N8ef97b05870947dcbbb480757c678612 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Humans
164 rdf:type schema:DefinedTerm
165 Naa15f7b971a645e4838c32d7bba9f3c6 rdf:first sg:person.0762234740.61
166 rdf:rest Nc0d7b744eebc48ffa818359d1cf6cc0c
167 Nb027c1c8c23f41ef9e4d9fa86f510e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Prognosis
169 rdf:type schema:DefinedTerm
170 Nb033269ea75344238f58eed9bfca6de6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Liver Neoplasms
172 rdf:type schema:DefinedTerm
173 Nb9abf3052c68422d95a4303ab2591ef9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Adult
175 rdf:type schema:DefinedTerm
176 Nc0d7b744eebc48ffa818359d1cf6cc0c rdf:first sg:person.07742537757.29
177 rdf:rest rdf:nil
178 Nc2b14d2553ab43f1b2b8b2dd7f65a934 rdf:first sg:person.01232724076.44
179 rdf:rest Naa15f7b971a645e4838c32d7bba9f3c6
180 Nc36b6c78dcff42f5ae83a86b64d7fa63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Middle Aged
182 rdf:type schema:DefinedTerm
183 Nc4386277fa7b4f5f899009fcbbafef61 schema:volumeNumber 23
184 rdf:type schema:PublicationVolume
185 Nc7c78ad08f294aafaa8685482e407870 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Hepatectomy
187 rdf:type schema:DefinedTerm
188 Nc89659cf77a14f109d840362829719f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Young Adult
190 rdf:type schema:DefinedTerm
191 Nd1c3680cd0944b71a2d63cf5c15249a0 rdf:first sg:person.014730366531.75
192 rdf:rest Nf562f38d5fc74135bfa3a7822979d3ae
193 Nd5c4dc406d0e4816814dee1334e6ebad schema:name Springer Nature - SN SciGraph project
194 rdf:type schema:Organization
195 Nd66dcecc73f3460888e3be062e027b2f schema:issueNumber 8
196 rdf:type schema:PublicationIssue
197 Ne1622032603f4c4f825064a23c3027da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Prospective Studies
199 rdf:type schema:DefinedTerm
200 Ne38e350bb30340a3a343746bf42ad847 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Margins of Excision
202 rdf:type schema:DefinedTerm
203 Nf222cecd31a843709a740fd5044153fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Aged
205 rdf:type schema:DefinedTerm
206 Nf562f38d5fc74135bfa3a7822979d3ae rdf:first sg:person.01127474651.06
207 rdf:rest N773e67895df04badbd4ae12dbd555e83
208 Nfb11d6bb0dc84ee3b8d34a82023a08b4 schema:name dimensions_id
209 schema:value pub.1050206513
210 rdf:type schema:PropertyValue
211 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
212 schema:name Medical and Health Sciences
213 rdf:type schema:DefinedTerm
214 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
215 schema:name Oncology and Carcinogenesis
216 rdf:type schema:DefinedTerm
217 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1245/s10434-016-5187-2
218 rdf:type schema:MonetaryGrant
219 sg:journal.1105545 schema:issn 1068-9265
220 1534-4681
221 schema:name Annals of Surgical Oncology
222 schema:publisher Springer Nature
223 rdf:type schema:Periodical
224 sg:person.01127474651.06 schema:affiliation grid-institutes:grid.240145.6
225 schema:familyName Chun
226 schema:givenName Yun Shin
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127474651.06
228 rdf:type schema:Person
229 sg:person.01130704511.97 schema:affiliation grid-institutes:grid.240145.6
230 schema:familyName Passot
231 schema:givenName Guillaume
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130704511.97
233 rdf:type schema:Person
234 sg:person.01232724076.44 schema:affiliation grid-institutes:grid.240145.6
235 schema:familyName Maru
236 schema:givenName Dipen M.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232724076.44
238 rdf:type schema:Person
239 sg:person.01320500077.48 schema:affiliation grid-institutes:grid.240145.6
240 schema:familyName Kopetz
241 schema:givenName Scott E.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320500077.48
243 rdf:type schema:Person
244 sg:person.014730366531.75 schema:affiliation grid-institutes:grid.240145.6
245 schema:familyName Chung
246 schema:givenName Michael Hsiang
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014730366531.75
248 rdf:type schema:Person
249 sg:person.0626665021.66 schema:affiliation grid-institutes:grid.240145.6
250 schema:familyName Mise
251 schema:givenName Yoshihiro
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626665021.66
253 rdf:type schema:Person
254 sg:person.0631060551.45 schema:affiliation grid-institutes:grid.240145.6
255 schema:familyName Brudvik
256 schema:givenName Kristoffer Watten
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631060551.45
258 rdf:type schema:Person
259 sg:person.07430101017.47 schema:affiliation grid-institutes:grid.240145.6
260 schema:familyName Conrad
261 schema:givenName Claudius
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07430101017.47
263 rdf:type schema:Person
264 sg:person.0762234740.61 schema:affiliation grid-institutes:grid.240145.6
265 schema:familyName Aloia
266 schema:givenName Thomas A.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762234740.61
268 rdf:type schema:Person
269 sg:person.07742537757.29 schema:affiliation grid-institutes:grid.240145.6
270 schema:familyName Vauthey
271 schema:givenName Jean-Nicolas
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07742537757.29
273 rdf:type schema:Person
274 sg:pub.10.1007/bf00316981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038122014
275 https://doi.org/10.1007/bf00316981
276 rdf:type schema:CreativeWork
277 sg:pub.10.1007/s00268-002-6267-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1037410368
278 https://doi.org/10.1007/s00268-002-6267-y
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/modpathol.2014.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013862887
281 https://doi.org/10.1038/modpathol.2014.4
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/nm.3511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025871106
284 https://doi.org/10.1038/nm.3511
285 rdf:type schema:CreativeWork
286 sg:pub.10.1111/j.1572-0241.1999.00945.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024282263
287 https://doi.org/10.1111/j.1572-0241.1999.00945.x
288 rdf:type schema:CreativeWork
289 sg:pub.10.1186/1477-7819-12-127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028337829
290 https://doi.org/10.1186/1477-7819-12-127
291 rdf:type schema:CreativeWork
292 sg:pub.10.1245/s10434-009-0605-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048935334
293 https://doi.org/10.1245/s10434-009-0605-3
294 rdf:type schema:CreativeWork
295 sg:pub.10.1245/s10434-011-2114-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022367853
296 https://doi.org/10.1245/s10434-011-2114-4
297 rdf:type schema:CreativeWork
298 sg:pub.10.1245/s10434-014-4042-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028729249
299 https://doi.org/10.1245/s10434-014-4042-6
300 rdf:type schema:CreativeWork
301 grid-institutes:grid.240145.6 schema:alternateName Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
302 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
303 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
304 schema:name Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
305 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
306 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
307 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...