Ontology type: schema:ScholarlyArticle
2015-12
AUTHORSVladimir Neychev, Seth M. Steinberg, Lily Yang, Amit Mehta, Naris Nilubol, Margaret F. Keil, Lynnette Nieman, Constantine A. Stratakis, Electron Kebebew
ABSTRACTBACKGROUND: Laparoscopic bilateral adrenalectomy (LBA) is recommended for patients with bilateral adrenal disease and occult or unresectable ectopic Cushing's syndrome (CS). There are limited data on long-term outcomes after LBA, partly due to the lack of disease-specific tools for the measurement of impact on patients' health and quality of life. METHODS: We used a disease-specific questionnaire covering all major clinicopathologic characteristics of CS. We compared the outcome from LBA to a control group of 60 patients who had thyroidectomy (matched for age, gender, and time of surgery, 2:1 control-to-CS). RESULTS: Twenty-eight patients (20 women and 8 men) underwent LBA for CS. Of them, 24 patients (86 %) provided responses to our questionnaire. Ninety-two percent of patients' responses indicated a significant improvement of general Cushing's physical features with complete resolution reported in 59 % of responses. Significant improvement of associated biochemical abnormalities and comorbidities was reported in 83 % of patients' responses including complete reversal in 58 %. Significant improvement in emotional-behavioral symptoms was reported in 84 % of patients' responses with complete recovery in 53 %. All patients expressed satisfaction with LBA and significant improvement in their general health and self-reported quality of life. All of the improvements after LBA were statistically significant compared with the control group. CONCLUSIONS: Our disease-specific questionnaire enables a clearer understanding of the association between the clinical, metabolic, and emotional-behavioral features of CS, its treatment with LBA, and long-term impact on patient-reported quality of life. This disease-specific questionnaire may be useful for future studies in patients with CS. More... »
PAGES699-706
http://scigraph.springernature.com/pub.10.1245/s10434-015-4605-1
DOIhttp://dx.doi.org/10.1245/s10434-015-4605-1
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1051269060
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25968622
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