Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05-19

AUTHORS

Hironori Tsujimoto, Yuji Morimoto, Risa Takahata, Shinsuke Nomura, Kazumichi Yoshida, Shuichi Hiraki, Hiroyuki Horiguchi, Hiromi Miyazaki, Satoshi Ono, Daizo Saito, Isao Hara, Eiichi Ozeki, Junji Yamamoto, Kazuo Hase

ABSTRACT

BackgroundPreoperative and intraoperative diagnoses of lymph node (LN) metastasis in patients with gastric cancer is essential to determine the extent of LN dissection in order to establish individualized treatment strategies. We investigated the theranostic value of a newly developed drug delivery system employing nanoparticles loaded with the indocyanine green (ICG) derivative ICG-loaded lactosome (ICGm) using a murine draining LN metastasis model of gastric cancer.MethodsIn the experimental draining LN metastasis model of human gastric cancer, the right hind footpads of nude mice were injected with cancer cells. Three weeks later, either ICGm or ICG solution was injected through the tail vein. Forty-eight hours after the administration of a photosensitizer, in vivo and ex vivo imaging and photodynamic therapy (PDT) were performed, and size of the LNs was measured.ResultsIn vivo imaging revealed metastatic LNs in the ICGm-treated mice but not in the ICG-treated mice. PDT using ICGm induced apoptosis and significantly inhibited the growth of metastatic LNs.ConclusionsICGm presents a novel theranostic nanodevice for LN metastasis of gastric cancer. More... »

PAGES

923-928

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-015-4594-0

DOI

http://dx.doi.org/10.1245/s10434-015-4594-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047227466

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25986868


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coloring Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Delivery Systems", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indocyanine Green", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanoparticles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Photochemotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Photosensitizing Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Theranostic Nanomedicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsujimoto", 
        "givenName": "Hironori", 
        "id": "sg:person.01022371461.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022371461.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morimoto", 
        "givenName": "Yuji", 
        "id": "sg:person.016515614461.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016515614461.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahata", 
        "givenName": "Risa", 
        "id": "sg:person.01111262557.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111262557.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nomura", 
        "givenName": "Shinsuke", 
        "id": "sg:person.01345075153.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345075153.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Kazumichi", 
        "id": "sg:person.01322710516.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322710516.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hiraki", 
        "givenName": "Shuichi", 
        "id": "sg:person.0752534414.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752534414.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horiguchi", 
        "givenName": "Hiroyuki", 
        "id": "sg:person.01052146053.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052146053.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Traumatology, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Division of Traumatology, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyazaki", 
        "givenName": "Hiromi", 
        "id": "sg:person.01102355343.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102355343.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Traumatology, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Division of Traumatology, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ono", 
        "givenName": "Satoshi", 
        "id": "sg:person.01070504661.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070504661.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Traumatology, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Division of Traumatology, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saito", 
        "givenName": "Daizo", 
        "id": "sg:person.01064126175.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064126175.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technology Research Laboratory, Shimadzu Corporation, Soraku-gun, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Technology Research Laboratory, Shimadzu Corporation, Soraku-gun, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hara", 
        "givenName": "Isao", 
        "id": "sg:person.0747643165.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747643165.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technology Research Laboratory, Shimadzu Corporation, Soraku-gun, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Technology Research Laboratory, Shimadzu Corporation, Soraku-gun, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ozeki", 
        "givenName": "Eiichi", 
        "id": "sg:person.01031350526.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031350526.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Junji", 
        "id": "sg:person.0760422621.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760422621.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hase", 
        "givenName": "Kazuo", 
        "id": "sg:person.01251324614.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251324614.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10120-011-0085-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045810678", 
          "https://doi.org/10.1007/s10120-011-0085-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00011720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026415252", 
          "https://doi.org/10.1007/pl00011720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s101200200000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044679233", 
          "https://doi.org/10.1007/s101200200000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-006-9132-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029273543", 
          "https://doi.org/10.1007/s11095-006-9132-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-010-0587-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000386000", 
          "https://doi.org/10.1007/s00268-010-0587-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-010-0568-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028038438", 
          "https://doi.org/10.1007/s10120-010-0568-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-05-19", 
    "datePublishedReg": "2015-05-19", 
    "description": "BackgroundPreoperative and intraoperative diagnoses of lymph node (LN) metastasis in patients with gastric cancer is essential to determine the extent of LN dissection in order to establish individualized treatment strategies. We investigated the theranostic value of a newly developed drug delivery system employing nanoparticles loaded with the indocyanine green (ICG) derivative ICG-loaded lactosome (ICGm) using a murine draining LN metastasis model of gastric cancer.MethodsIn the experimental draining LN metastasis model of human gastric cancer, the right hind footpads of nude mice were injected with cancer cells. Three weeks later, either ICGm or ICG solution was injected through the tail vein. Forty-eight hours after the administration of a photosensitizer, in vivo and ex vivo imaging and photodynamic therapy (PDT) were performed, and size of the LNs was measured.ResultsIn vivo imaging revealed metastatic LNs in the ICGm-treated mice but not in the ICG-treated mice. PDT using ICGm induced apoptosis and significantly inhibited the growth of metastatic LNs.ConclusionsICGm presents a novel theranostic nanodevice for LN metastasis of gastric cancer.", 
    "genre": "article", 
    "id": "sg:pub.10.1245/s10434-015-4594-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5873728", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6144596", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "Suppl 3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "keywords": [
      "lymph node metastasis", 
      "gastric cancer", 
      "metastatic LNs", 
      "node metastasis", 
      "metastasis model", 
      "photodynamic therapy", 
      "human gastric cancer", 
      "LN dissection", 
      "right hind", 
      "LN metastasis", 
      "treatment strategies", 
      "tail vein", 
      "intraoperative diagnosis", 
      "nude mice", 
      "ex vivo", 
      "cancer", 
      "metastasis", 
      "theranostic value", 
      "mice", 
      "cancer cells", 
      "ICG solution", 
      "vivo", 
      "patients", 
      "therapy", 
      "MethodsIn", 
      "delivery system", 
      "diagnosis", 
      "administration", 
      "dissection", 
      "weeks", 
      "hind", 
      "vein", 
      "drug delivery systems", 
      "murine", 
      "apoptosis", 
      "hours", 
      "Lactosome", 
      "theranostic nanodevices", 
      "cells", 
      "Ln", 
      "extent", 
      "strategies", 
      "photosensitizer", 
      "growth", 
      "model", 
      "values", 
      "size", 
      "system", 
      "order", 
      "photosensitive nanoparticles", 
      "solution", 
      "nanoparticles", 
      "nanodevices", 
      "BackgroundPreoperative", 
      "ICGm", 
      "green (ICG) derivative ICG-loaded lactosome", 
      "derivative ICG-loaded lactosome", 
      "ICG-loaded lactosome", 
      "LN metastasis model", 
      "experimental draining LN metastasis model", 
      "draining LN metastasis model", 
      "ResultsIn vivo", 
      "ICGm-treated mice", 
      "ICG-treated mice", 
      "ConclusionsICGm", 
      "novel theranostic nanodevice", 
      "Theranostic Photosensitive Nanoparticles"
    ], 
    "name": "Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer", 
    "pagination": "923-928", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047227466"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-015-4594-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25986868"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-015-4594-0", 
      "https://app.dimensions.ai/details/publication/pub.1047227466"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_679.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1245/s10434-015-4594-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4594-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4594-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4594-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4594-0'


 

This table displays all metadata directly associated to this object as RDF triples.

347 TRIPLES      22 PREDICATES      122 URIs      108 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-015-4594-0 schema:about N005644f5f5fb47c180c037aca0fa8486
2 N078d63185940423aba8f8b5dfcd325b9
3 N146130c55748463a9e9706fc42530a92
4 N188622c6d10f4993932e06b6cd0057f9
5 N19676e5bbbc44f8abdc31ffa3776d8e7
6 N1c701ffdaf344e7b96e9edc8cc6f61a1
7 N22ef5ce2fed44e4aa4c129c4615f674f
8 N29fc6aad1b9745019369711de74f745b
9 N3295d1dc4c8c43adb4f958f5419d4af0
10 N3b660b3546014d9083c6aa4c41341963
11 N3e240614d64d496999f8693140824412
12 N41e5200cd4d4488ba598d8572919b21c
13 N43a956d2ffd44aa6beeb7954a03bb568
14 N4714dd49f15f40f9b3b3d7a146ab5dbf
15 N4ec65f00f4934407b74d445da7f16c5c
16 N5bcee674f66b47f79461dbb4c0b21446
17 N61ac2a69256648539679daf661e9f6c0
18 N7c5ad06bbdb345a99f6ae75c4d7f0ad0
19 N84816e086cec4f14ac3d1d6c2155b95c
20 N92d45e9fcc6a41bda1c686c9512096db
21 Nd011efa138e5482e9aec8b84cbdcaa20
22 Ndc040f5c07a444c5926840f9643b082f
23 Nf6ab864ee1b140f6badab78967e2723f
24 anzsrc-for:11
25 anzsrc-for:1112
26 schema:author Na3f8d2897a24469ea3f4d4094f3caf81
27 schema:citation sg:pub.10.1007/pl00011720
28 sg:pub.10.1007/s00268-010-0587-0
29 sg:pub.10.1007/s10120-010-0568-x
30 sg:pub.10.1007/s10120-011-0085-6
31 sg:pub.10.1007/s101200200000
32 sg:pub.10.1007/s11095-006-9132-0
33 schema:datePublished 2015-05-19
34 schema:datePublishedReg 2015-05-19
35 schema:description BackgroundPreoperative and intraoperative diagnoses of lymph node (LN) metastasis in patients with gastric cancer is essential to determine the extent of LN dissection in order to establish individualized treatment strategies. We investigated the theranostic value of a newly developed drug delivery system employing nanoparticles loaded with the indocyanine green (ICG) derivative ICG-loaded lactosome (ICGm) using a murine draining LN metastasis model of gastric cancer.MethodsIn the experimental draining LN metastasis model of human gastric cancer, the right hind footpads of nude mice were injected with cancer cells. Three weeks later, either ICGm or ICG solution was injected through the tail vein. Forty-eight hours after the administration of a photosensitizer, in vivo and ex vivo imaging and photodynamic therapy (PDT) were performed, and size of the LNs was measured.ResultsIn vivo imaging revealed metastatic LNs in the ICGm-treated mice but not in the ICG-treated mice. PDT using ICGm induced apoptosis and significantly inhibited the growth of metastatic LNs.ConclusionsICGm presents a novel theranostic nanodevice for LN metastasis of gastric cancer.
36 schema:genre article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N9fd38ca478fc483bbf81494f0a3b2032
40 Nd0eeb8572667457e832b732ca96fca19
41 sg:journal.1105545
42 schema:keywords BackgroundPreoperative
43 ConclusionsICGm
44 ICG solution
45 ICG-loaded lactosome
46 ICG-treated mice
47 ICGm
48 ICGm-treated mice
49 LN dissection
50 LN metastasis
51 LN metastasis model
52 Lactosome
53 Ln
54 MethodsIn
55 ResultsIn vivo
56 Theranostic Photosensitive Nanoparticles
57 administration
58 apoptosis
59 cancer
60 cancer cells
61 cells
62 delivery system
63 derivative ICG-loaded lactosome
64 diagnosis
65 dissection
66 draining LN metastasis model
67 drug delivery systems
68 ex vivo
69 experimental draining LN metastasis model
70 extent
71 gastric cancer
72 green (ICG) derivative ICG-loaded lactosome
73 growth
74 hind
75 hours
76 human gastric cancer
77 intraoperative diagnosis
78 lymph node metastasis
79 metastasis
80 metastasis model
81 metastatic LNs
82 mice
83 model
84 murine
85 nanodevices
86 nanoparticles
87 node metastasis
88 novel theranostic nanodevice
89 nude mice
90 order
91 patients
92 photodynamic therapy
93 photosensitive nanoparticles
94 photosensitizer
95 right hind
96 size
97 solution
98 strategies
99 system
100 tail vein
101 theranostic nanodevices
102 theranostic value
103 therapy
104 treatment strategies
105 values
106 vein
107 vivo
108 weeks
109 schema:name Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer
110 schema:pagination 923-928
111 schema:productId N2594b0630942485e8efe08f5034490fa
112 Naf54ceb1c39d442ca7ec8f51b6a7b031
113 Nef230ed7598f4738ad602f580d886310
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047227466
115 https://doi.org/10.1245/s10434-015-4594-0
116 schema:sdDatePublished 2022-01-01T18:38
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher N1b39ad33aa6c41fa8c9f821b4cee3227
119 schema:url https://doi.org/10.1245/s10434-015-4594-0
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N005644f5f5fb47c180c037aca0fa8486 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Fluorescence
125 rdf:type schema:DefinedTerm
126 N03d4e8677c5c4db1b70b6873c18ae40b rdf:first sg:person.01052146053.07
127 rdf:rest N8bb98063b6584cab9bf4e094bb75ff63
128 N078d63185940423aba8f8b5dfcd325b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Photochemotherapy
130 rdf:type schema:DefinedTerm
131 N146130c55748463a9e9706fc42530a92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mice, Inbred BALB C
133 rdf:type schema:DefinedTerm
134 N188622c6d10f4993932e06b6cd0057f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Nanoparticles
136 rdf:type schema:DefinedTerm
137 N19676e5bbbc44f8abdc31ffa3776d8e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Male
139 rdf:type schema:DefinedTerm
140 N1b39ad33aa6c41fa8c9f821b4cee3227 schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 N1c701ffdaf344e7b96e9edc8cc6f61a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Lymphatic Metastasis
144 rdf:type schema:DefinedTerm
145 N1e5bfff3df9a4754a319a2d9f7e5cb76 rdf:first sg:person.01322710516.06
146 rdf:rest Nbd093a2d9ac74d4089ef0cba5126a4ec
147 N22ef5ce2fed44e4aa4c129c4615f674f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Mice
149 rdf:type schema:DefinedTerm
150 N2594b0630942485e8efe08f5034490fa schema:name dimensions_id
151 schema:value pub.1047227466
152 rdf:type schema:PropertyValue
153 N29fc6aad1b9745019369711de74f745b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Mice, Nude
155 rdf:type schema:DefinedTerm
156 N3295d1dc4c8c43adb4f958f5419d4af0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Cell Proliferation
158 rdf:type schema:DefinedTerm
159 N3610982cfa58484794128d8f88876bae rdf:first sg:person.01345075153.13
160 rdf:rest N1e5bfff3df9a4754a319a2d9f7e5cb76
161 N3b660b3546014d9083c6aa4c41341963 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Indocyanine Green
163 rdf:type schema:DefinedTerm
164 N3e240614d64d496999f8693140824412 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 N41e5200cd4d4488ba598d8572919b21c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Photosensitizing Agents
169 rdf:type schema:DefinedTerm
170 N43a956d2ffd44aa6beeb7954a03bb568 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Xenograft Model Antitumor Assays
172 rdf:type schema:DefinedTerm
173 N4714dd49f15f40f9b3b3d7a146ab5dbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Adenocarcinoma
175 rdf:type schema:DefinedTerm
176 N4ec65f00f4934407b74d445da7f16c5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Stomach Neoplasms
178 rdf:type schema:DefinedTerm
179 N51da8e99feac4d4096832975bca75f38 rdf:first sg:person.01064126175.61
180 rdf:rest N886c86c1c9b44b309ec3205568a7e4d8
181 N5bcee674f66b47f79461dbb4c0b21446 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Lymph Nodes
183 rdf:type schema:DefinedTerm
184 N5e5528b8fcd6479e8e55a3c049d061bf rdf:first sg:person.01251324614.42
185 rdf:rest rdf:nil
186 N61ac2a69256648539679daf661e9f6c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Theranostic Nanomedicine
188 rdf:type schema:DefinedTerm
189 N7c5ad06bbdb345a99f6ae75c4d7f0ad0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Drug Delivery Systems
191 rdf:type schema:DefinedTerm
192 N82e2b137cdd34fc99e70a32d2f5d2fb9 rdf:first sg:person.01111262557.97
193 rdf:rest N3610982cfa58484794128d8f88876bae
194 N84816e086cec4f14ac3d1d6c2155b95c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Tumor Cells, Cultured
196 rdf:type schema:DefinedTerm
197 N886c86c1c9b44b309ec3205568a7e4d8 rdf:first sg:person.0747643165.16
198 rdf:rest Ne17dd52d9d0c4fea9b35ecfa16bfba77
199 N8bb98063b6584cab9bf4e094bb75ff63 rdf:first sg:person.01102355343.75
200 rdf:rest Nd3e0b8aefa274e1d8dc75d0f6936375c
201 N8f6e000f5d4a4986bc00334a3d852487 rdf:first sg:person.016515614461.54
202 rdf:rest N82e2b137cdd34fc99e70a32d2f5d2fb9
203 N92d45e9fcc6a41bda1c686c9512096db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Animals
205 rdf:type schema:DefinedTerm
206 N9fd38ca478fc483bbf81494f0a3b2032 schema:issueNumber Suppl 3
207 rdf:type schema:PublicationIssue
208 Na3f8d2897a24469ea3f4d4094f3caf81 rdf:first sg:person.01022371461.19
209 rdf:rest N8f6e000f5d4a4986bc00334a3d852487
210 Naf54ceb1c39d442ca7ec8f51b6a7b031 schema:name pubmed_id
211 schema:value 25986868
212 rdf:type schema:PropertyValue
213 Nb03217b7bcf143238ad4c2ad83212324 rdf:first sg:person.0760422621.80
214 rdf:rest N5e5528b8fcd6479e8e55a3c049d061bf
215 Nbd093a2d9ac74d4089ef0cba5126a4ec rdf:first sg:person.0752534414.59
216 rdf:rest N03d4e8677c5c4db1b70b6873c18ae40b
217 Nd011efa138e5482e9aec8b84cbdcaa20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Lactic Acid
219 rdf:type schema:DefinedTerm
220 Nd0eeb8572667457e832b732ca96fca19 schema:volumeNumber 22
221 rdf:type schema:PublicationVolume
222 Nd3e0b8aefa274e1d8dc75d0f6936375c rdf:first sg:person.01070504661.01
223 rdf:rest N51da8e99feac4d4096832975bca75f38
224 Ndc040f5c07a444c5926840f9643b082f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Coloring Agents
226 rdf:type schema:DefinedTerm
227 Ne17dd52d9d0c4fea9b35ecfa16bfba77 rdf:first sg:person.01031350526.51
228 rdf:rest Nb03217b7bcf143238ad4c2ad83212324
229 Nef230ed7598f4738ad602f580d886310 schema:name doi
230 schema:value 10.1245/s10434-015-4594-0
231 rdf:type schema:PropertyValue
232 Nf6ab864ee1b140f6badab78967e2723f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Apoptosis
234 rdf:type schema:DefinedTerm
235 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
236 schema:name Medical and Health Sciences
237 rdf:type schema:DefinedTerm
238 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
239 schema:name Oncology and Carcinogenesis
240 rdf:type schema:DefinedTerm
241 sg:grant.5873728 http://pending.schema.org/fundedItem sg:pub.10.1245/s10434-015-4594-0
242 rdf:type schema:MonetaryGrant
243 sg:grant.6144596 http://pending.schema.org/fundedItem sg:pub.10.1245/s10434-015-4594-0
244 rdf:type schema:MonetaryGrant
245 sg:journal.1105545 schema:issn 1068-9265
246 1534-4681
247 schema:name Annals of Surgical Oncology
248 schema:publisher Springer Nature
249 rdf:type schema:Periodical
250 sg:person.01022371461.19 schema:affiliation grid-institutes:grid.416614.0
251 schema:familyName Tsujimoto
252 schema:givenName Hironori
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022371461.19
254 rdf:type schema:Person
255 sg:person.01031350526.51 schema:affiliation grid-institutes:None
256 schema:familyName Ozeki
257 schema:givenName Eiichi
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031350526.51
259 rdf:type schema:Person
260 sg:person.01052146053.07 schema:affiliation grid-institutes:grid.416614.0
261 schema:familyName Horiguchi
262 schema:givenName Hiroyuki
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052146053.07
264 rdf:type schema:Person
265 sg:person.01064126175.61 schema:affiliation grid-institutes:grid.416614.0
266 schema:familyName Saito
267 schema:givenName Daizo
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064126175.61
269 rdf:type schema:Person
270 sg:person.01070504661.01 schema:affiliation grid-institutes:grid.416614.0
271 schema:familyName Ono
272 schema:givenName Satoshi
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070504661.01
274 rdf:type schema:Person
275 sg:person.01102355343.75 schema:affiliation grid-institutes:grid.416614.0
276 schema:familyName Miyazaki
277 schema:givenName Hiromi
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102355343.75
279 rdf:type schema:Person
280 sg:person.01111262557.97 schema:affiliation grid-institutes:grid.416614.0
281 schema:familyName Takahata
282 schema:givenName Risa
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111262557.97
284 rdf:type schema:Person
285 sg:person.01251324614.42 schema:affiliation grid-institutes:grid.416614.0
286 schema:familyName Hase
287 schema:givenName Kazuo
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251324614.42
289 rdf:type schema:Person
290 sg:person.01322710516.06 schema:affiliation grid-institutes:grid.416614.0
291 schema:familyName Yoshida
292 schema:givenName Kazumichi
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322710516.06
294 rdf:type schema:Person
295 sg:person.01345075153.13 schema:affiliation grid-institutes:grid.416614.0
296 schema:familyName Nomura
297 schema:givenName Shinsuke
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345075153.13
299 rdf:type schema:Person
300 sg:person.016515614461.54 schema:affiliation grid-institutes:grid.416614.0
301 schema:familyName Morimoto
302 schema:givenName Yuji
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016515614461.54
304 rdf:type schema:Person
305 sg:person.0747643165.16 schema:affiliation grid-institutes:None
306 schema:familyName Hara
307 schema:givenName Isao
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747643165.16
309 rdf:type schema:Person
310 sg:person.0752534414.59 schema:affiliation grid-institutes:grid.416614.0
311 schema:familyName Hiraki
312 schema:givenName Shuichi
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752534414.59
314 rdf:type schema:Person
315 sg:person.0760422621.80 schema:affiliation grid-institutes:grid.416614.0
316 schema:familyName Yamamoto
317 schema:givenName Junji
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760422621.80
319 rdf:type schema:Person
320 sg:pub.10.1007/pl00011720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026415252
321 https://doi.org/10.1007/pl00011720
322 rdf:type schema:CreativeWork
323 sg:pub.10.1007/s00268-010-0587-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000386000
324 https://doi.org/10.1007/s00268-010-0587-0
325 rdf:type schema:CreativeWork
326 sg:pub.10.1007/s10120-010-0568-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028038438
327 https://doi.org/10.1007/s10120-010-0568-x
328 rdf:type schema:CreativeWork
329 sg:pub.10.1007/s10120-011-0085-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045810678
330 https://doi.org/10.1007/s10120-011-0085-6
331 rdf:type schema:CreativeWork
332 sg:pub.10.1007/s101200200000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044679233
333 https://doi.org/10.1007/s101200200000
334 rdf:type schema:CreativeWork
335 sg:pub.10.1007/s11095-006-9132-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029273543
336 https://doi.org/10.1007/s11095-006-9132-0
337 rdf:type schema:CreativeWork
338 grid-institutes:None schema:alternateName Technology Research Laboratory, Shimadzu Corporation, Soraku-gun, Kyoto, Japan
339 schema:name Technology Research Laboratory, Shimadzu Corporation, Soraku-gun, Kyoto, Japan
340 rdf:type schema:Organization
341 grid-institutes:grid.416614.0 schema:alternateName Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
342 Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
343 Division of Traumatology, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan
344 schema:name Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
345 Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
346 Division of Traumatology, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan
347 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...