Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05-19

AUTHORS

Hironori Tsujimoto, Yuji Morimoto, Risa Takahata, Shinsuke Nomura, Kazumichi Yoshida, Shuichi Hiraki, Hiroyuki Horiguchi, Hiromi Miyazaki, Satoshi Ono, Daizo Saito, Isao Hara, Eiichi Ozeki, Junji Yamamoto, Kazuo Hase

ABSTRACT

BackgroundPreoperative and intraoperative diagnoses of lymph node (LN) metastasis in patients with gastric cancer is essential to determine the extent of LN dissection in order to establish individualized treatment strategies. We investigated the theranostic value of a newly developed drug delivery system employing nanoparticles loaded with the indocyanine green (ICG) derivative ICG-loaded lactosome (ICGm) using a murine draining LN metastasis model of gastric cancer.MethodsIn the experimental draining LN metastasis model of human gastric cancer, the right hind footpads of nude mice were injected with cancer cells. Three weeks later, either ICGm or ICG solution was injected through the tail vein. Forty-eight hours after the administration of a photosensitizer, in vivo and ex vivo imaging and photodynamic therapy (PDT) were performed, and size of the LNs was measured.ResultsIn vivo imaging revealed metastatic LNs in the ICGm-treated mice but not in the ICG-treated mice. PDT using ICGm induced apoptosis and significantly inhibited the growth of metastatic LNs.ConclusionsICGm presents a novel theranostic nanodevice for LN metastasis of gastric cancer. More... »

PAGES

923-928

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-015-4594-0

DOI

http://dx.doi.org/10.1245/s10434-015-4594-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047227466

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25986868


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35 schema:description BackgroundPreoperative and intraoperative diagnoses of lymph node (LN) metastasis in patients with gastric cancer is essential to determine the extent of LN dissection in order to establish individualized treatment strategies. We investigated the theranostic value of a newly developed drug delivery system employing nanoparticles loaded with the indocyanine green (ICG) derivative ICG-loaded lactosome (ICGm) using a murine draining LN metastasis model of gastric cancer.MethodsIn the experimental draining LN metastasis model of human gastric cancer, the right hind footpads of nude mice were injected with cancer cells. Three weeks later, either ICGm or ICG solution was injected through the tail vein. Forty-eight hours after the administration of a photosensitizer, in vivo and ex vivo imaging and photodynamic therapy (PDT) were performed, and size of the LNs was measured.ResultsIn vivo imaging revealed metastatic LNs in the ICGm-treated mice but not in the ICG-treated mice. PDT using ICGm induced apoptosis and significantly inhibited the growth of metastatic LNs.ConclusionsICGm presents a novel theranostic nanodevice for LN metastasis of gastric cancer.
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42 schema:keywords BackgroundPreoperative
43 ConclusionsICGm
44 ICG solution
45 ICG-loaded lactosome
46 ICG-treated mice
47 ICGm
48 ICGm-treated mice
49 LN dissection
50 LN metastasis
51 LN metastasis model
52 Lactosome
53 Ln
54 MethodsIn
55 ResultsIn vivo
56 Theranostic Photosensitive Nanoparticles
57 administration
58 apoptosis
59 cancer
60 cancer cells
61 cells
62 delivery system
63 derivative ICG-loaded lactosome
64 diagnosis
65 dissection
66 draining LN metastasis model
67 drug delivery systems
68 ex vivo
69 experimental draining LN metastasis model
70 extent
71 gastric cancer
72 green (ICG) derivative ICG-loaded lactosome
73 growth
74 hind
75 hours
76 human gastric cancer
77 intraoperative diagnosis
78 lymph node metastasis
79 metastasis
80 metastasis model
81 metastatic LNs
82 mice
83 model
84 murine
85 nanodevices
86 nanoparticles
87 node metastasis
88 novel theranostic nanodevice
89 nude mice
90 order
91 patients
92 photodynamic therapy
93 photosensitive nanoparticles
94 photosensitizer
95 right hind
96 size
97 solution
98 strategies
99 system
100 tail vein
101 theranostic nanodevices
102 theranostic value
103 therapy
104 treatment strategies
105 values
106 vein
107 vivo
108 weeks
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