Expressional STAT3/STAT5 Ratio is an Independent Prognostic Marker in Colon Carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12

AUTHORS

Fee Klupp, Johannes Diers, Christoph Kahlert, Lena Neumann, Niels Halama, Clemens Franz, Thomas Schmidt, Felix Lasitschka, Arne Warth, Juergen Weitz, Moritz Koch, Martin Schneider, Alexis Ulrich

ABSTRACT

BACKGROUND: Signal transducer and activator of transcription proteins (STATs) are crucial regulators of cell growth and differentiation; however, their specific prognostic impact in human colon cancer has only been studied to limited extent. We aimed to assess the prognostic significance of specific STAT expression patterns in colon carcinoma. METHODS: Protein expression patterns of activated STAT1, STAT3, STAT4, and STAT5 in human colon carcinoma tissue and corresponding healthy mucosa (n = 104) were assessed using multiplex bead-based immunoassay technologies. Expression patterns were correlated with clinical and survival data. Immunohistochemistry was performed to assess spatial expression of STAT3 and STAT5. RESULTS: STAT3 was underexpressed whereas STAT4 and STAT5 were overexpressed in colon carcinoma tissue. Primary tumors from patients with distant metastases (M1) displayed significantly increased expression of STAT1 and STAT3 but decreased expression of STAT4 and STAT5. Increased tumor expression of STAT1 or STAT3 was associated with impaired patient survival, whereas increased expression of STAT4 or STAT5 correlated with improved survival. Multivariate analysis identified an increased STAT3/STAT5 expressional ratio as an adverse prognostic marker in colon cancer patients. CONCLUSIONS: The tumor progression-associated transcription factors STAT3, STAT4, and STAT5 are differently expressed in colon carcinoma tissue and colon mucosa. Moreover, the STAT3/STAT5 expression ratio is an independent prognostic marker in colon cancer patients. More... »

PAGES

1548-1555

References to SciGraph publications

  • 2011-01. Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2005-12. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity in NATURE MEDICINE
  • 2006-04. Regulatory T cells, tumour immunity and immunotherapy in NATURE REVIEWS IMMUNOLOGY
  • 2009-09. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses in NATURE MEDICINE
  • 2006-04. Surgical resection of hepatic metastases from colorectal cancer: A systematic review of published studies in BRITISH JOURNAL OF CANCER
  • 2007-01. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment in NATURE REVIEWS IMMUNOLOGY
  • 2013-07. Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma in BRITISH JOURNAL OF CANCER
  • 2013-07. Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer in BRITISH JOURNAL OF CANCER
  • 2009-11. STATs in cancer inflammation and immunity: a leading role for STAT3 in NATURE REVIEWS CANCER
  • 2008-12. Role of Cancer Microenvironment in Metastasis: Focus on Colon Cancer in CANCER MICROENVIRONMENT
  • 2013-12. IL-22 is related to development of human colon cancer by activation of STAT3 in BMC CANCER
  • 2004-04. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis in ONCOGENE
  • 2009-01. Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas in BRITISH JOURNAL OF CANCER
  • 2002-06. Epithelial–mesenchymal transitions in tumour progression in NATURE REVIEWS CANCER
  • 2007-12. Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells in BMC CANCER
  • 2006-10. Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1245/s10434-015-4485-4

    DOI

    http://dx.doi.org/10.1245/s10434-015-4485-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015219703

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25773877


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blotting, Western", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colonic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoenzyme Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphatic Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "STAT3 Transcription Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "STAT5 Transcription Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Klupp", 
            "givenName": "Fee", 
            "id": "sg:person.01364752534.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364752534.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Diers", 
            "givenName": "Johannes", 
            "id": "sg:person.01045313115.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045313115.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kahlert", 
            "givenName": "Christoph", 
            "id": "sg:person.01216400054.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216400054.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Neumann", 
            "givenName": "Lena", 
            "id": "sg:person.01161541515.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161541515.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "National Center for Tumor Diseases, Medical Oncology, and Internal Medicine VI, Tissue Imaging and Analysis Center, Bioquant, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Halama", 
            "givenName": "Niels", 
            "id": "sg:person.01040326116.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040326116.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Franz", 
            "givenName": "Clemens", 
            "id": "sg:person.0737166606.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737166606.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schmidt", 
            "givenName": "Thomas", 
            "id": "sg:person.0605741476.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605741476.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Institute of Pathology, University of Heidelberg, Heidelberg, Germany", 
                "Tissue Bank of the National Center for Tumor Diseases (NCT), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lasitschka", 
            "givenName": "Felix", 
            "id": "sg:person.0607222354.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607222354.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Institute of Pathology, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Warth", 
            "givenName": "Arne", 
            "id": "sg:person.01364412735.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364412735.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "TU Dresden", 
              "id": "https://www.grid.ac/institutes/grid.4488.0", 
              "name": [
                "Department of Visceral, Thoracic, and Vascular Surgery, University of Dresden, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weitz", 
            "givenName": "Juergen", 
            "id": "sg:person.01336467554.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336467554.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "TU Dresden", 
              "id": "https://www.grid.ac/institutes/grid.4488.0", 
              "name": [
                "Department of Visceral, Thoracic, and Vascular Surgery, University of Dresden, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koch", 
            "givenName": "Moritz", 
            "id": "sg:person.01270354354.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270354354.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schneider", 
            "givenName": "Martin", 
            "id": "sg:person.01176531455.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176531455.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ulrich", 
            "givenName": "Alexis", 
            "id": "sg:person.01017021755.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017021755.83"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.0509808103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000576508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1055-3207(02)00091-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000904609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002607732", 
              "https://doi.org/10.1038/sj.onc.1207383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002607732", 
              "https://doi.org/10.1038/sj.onc.1207383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cccn.2005.06.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004018481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cccn.2005.06.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004018481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004289511", 
              "https://doi.org/10.1038/nri1806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004289511", 
              "https://doi.org/10.1038/nri1806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007240913", 
              "https://doi.org/10.1038/nm.2015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007240913", 
              "https://doi.org/10.1038/nm.2015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2008.05.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008314667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12307-008-0007-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008521202", 
              "https://doi.org/10.1007/s12307-008-0007-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009280775", 
              "https://doi.org/10.1038/nm1325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009280775", 
              "https://doi.org/10.1038/nm1325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009293249", 
              "https://doi.org/10.1038/sj.bjc.6604794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-2488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011430825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-1308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011632011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0301-472x(02)00922-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013202003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0301-472x(02)00922-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013202003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.r700016200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015184745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2009.194472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015842871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2006.06.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018499531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020528453", 
              "https://doi.org/10.1038/nrc822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020528453", 
              "https://doi.org/10.1038/nrc822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022123078", 
              "https://doi.org/10.1038/nrc2734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022556392", 
              "https://doi.org/10.1038/bjc.2013.274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2007.00550.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023634454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci39104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026879393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci39104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026879393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028771627", 
              "https://doi.org/10.1038/sj.onc.1209942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028771627", 
              "https://doi.org/10.1038/sj.onc.1209942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15216540410001668064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029256955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/canjclin.50.1.7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029345645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jjco/hyf068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029663691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1593/neo.07971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029807292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1593/neo.06820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031212995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1221243110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031762119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200601018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032841661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.2004.023416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033025204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.27975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035793101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.5278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036508017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.5278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036508017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virusres.2013.12.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036746402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mc.22076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037275569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1593/neo.04571", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038861647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-7-111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039286059", 
              "https://doi.org/10.1186/1471-2407-7-111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039301272", 
              "https://doi.org/10.1038/bjc.2013.305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-11-055756", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039421946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/00365521.2012.640824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039661642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1746.2011.06883.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040032122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-200206000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041943148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-200206000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041943148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20080003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042543400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mc.21841", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042646973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.31.8907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042970868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mimet.2013.10.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043830687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.02.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045384677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellsig.2006.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045818441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-2694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047218875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0094226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047639328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-13-59", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047860698", 
              "https://doi.org/10.1186/1471-2407-13-59"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.22977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050386495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051210499", 
              "https://doi.org/10.1038/sj.bjc.6603033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051210499", 
              "https://doi.org/10.1038/sj.bjc.6603033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(94)92529-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051430862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(94)92529-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051430862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1995", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052092567", 
              "https://doi.org/10.1038/nri1995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1995", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052092567", 
              "https://doi.org/10.1038/nri1995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-0575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053443939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-010-1090-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053535169", 
              "https://doi.org/10.1007/s00384-010-1090-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-010-1090-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053535169", 
              "https://doi.org/10.1007/s00384-010-1090-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v18.i7.601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071369002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.2013.2049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071513216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.2013.2049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071513216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.15.6.1445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071530024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076997366", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077688788", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e31827ea79e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078691158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e31827ea79e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078691158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e31827ea79e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078691158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082482595", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-12", 
        "datePublishedReg": "2015-12-01", 
        "description": "BACKGROUND: Signal transducer and activator of transcription proteins (STATs) are crucial regulators of cell growth and differentiation; however, their specific prognostic impact in human colon cancer has only been studied to limited extent. We aimed to assess the prognostic significance of specific STAT expression patterns in colon carcinoma.\nMETHODS: Protein expression patterns of activated STAT1, STAT3, STAT4, and STAT5 in human colon carcinoma tissue and corresponding healthy mucosa (n = 104) were assessed using multiplex bead-based immunoassay technologies. Expression patterns were correlated with clinical and survival data. Immunohistochemistry was performed to assess spatial expression of STAT3 and STAT5.\nRESULTS: STAT3 was underexpressed whereas STAT4 and STAT5 were overexpressed in colon carcinoma tissue. Primary tumors from patients with distant metastases (M1) displayed significantly increased expression of STAT1 and STAT3 but decreased expression of STAT4 and STAT5. Increased tumor expression of STAT1 or STAT3 was associated with impaired patient survival, whereas increased expression of STAT4 or STAT5 correlated with improved survival. Multivariate analysis identified an increased STAT3/STAT5 expressional ratio as an adverse prognostic marker in colon cancer patients.\nCONCLUSIONS: The tumor progression-associated transcription factors STAT3, STAT4, and STAT5 are differently expressed in colon carcinoma tissue and colon mucosa. Moreover, the STAT3/STAT5 expression ratio is an independent prognostic marker in colon cancer patients.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1245/s10434-015-4485-4", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1105545", 
            "issn": [
              "1068-9265", 
              "1534-4681"
            ], 
            "name": "Annals of Surgical Oncology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "Suppl 3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "22"
          }
        ], 
        "name": "Expressional STAT3/STAT5 Ratio is an Independent Prognostic Marker in Colon Carcinoma", 
        "pagination": "1548-1555", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "48831b32c84e658bc895a8a11076cc4cffee58ebd297351e2407eaa1dd1a3c80"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25773877"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9420840"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1245/s10434-015-4485-4"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1015219703"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1245/s10434-015-4485-4", 
          "https://app.dimensions.ai/details/publication/pub.1015219703"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T14:06", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000499.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1245/s10434-015-4485-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4485-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4485-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4485-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4485-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    433 TRIPLES      21 PREDICATES      109 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1245/s10434-015-4485-4 schema:about N18866ad244c8472cbf5e9f7b849167b3
    2 N19c4ccf7acd541a4adc88ddad194ebd3
    3 N2098aa737d824491b5e7c24bcda6fae8
    4 N2a25aa475c4a488eb57227e0eabc26e0
    5 N434165d8f4a64d54aa063cef76a7fefd
    6 N6193891c021f4881b5735dfad7cbeb59
    7 N657c37ca20b54d11a78b93f3fa9a6c1e
    8 N681c016fa2db4d05abb74706d422a1f1
    9 N68ef2daff9594c72bcf38ad6ff0c113f
    10 N70d223a94f1b4d5eb0960da5cbc65f0c
    11 N7b56c946feb6468cba348474775b267a
    12 N8d1075861fa94b2fab8609efb4b41e99
    13 N954b1b36dc0f47ab90c077a8d2c061a0
    14 Na9be8d7bf1e641ef880f379f25936f6c
    15 Naf9a1dfeb1ef4c5e9af4f75a612d7788
    16 Nb116634ec5704e39b67514904632d12d
    17 Ndd4be490d6a449b6bc5a99fea89b535e
    18 anzsrc-for:11
    19 anzsrc-for:1112
    20 schema:author N9a9bbb7b692e40b29d0572fd62716cab
    21 schema:citation sg:pub.10.1007/s00384-010-1090-7
    22 sg:pub.10.1007/s12307-008-0007-2
    23 sg:pub.10.1038/bjc.2013.274
    24 sg:pub.10.1038/bjc.2013.305
    25 sg:pub.10.1038/nm.2015
    26 sg:pub.10.1038/nm1325
    27 sg:pub.10.1038/nrc2734
    28 sg:pub.10.1038/nrc822
    29 sg:pub.10.1038/nri1806
    30 sg:pub.10.1038/nri1995
    31 sg:pub.10.1038/sj.bjc.6603033
    32 sg:pub.10.1038/sj.bjc.6604794
    33 sg:pub.10.1038/sj.onc.1207383
    34 sg:pub.10.1038/sj.onc.1209942
    35 sg:pub.10.1186/1471-2407-13-59
    36 sg:pub.10.1186/1471-2407-7-111
    37 https://app.dimensions.ai/details/publication/pub.1076997366
    38 https://app.dimensions.ai/details/publication/pub.1077688788
    39 https://app.dimensions.ai/details/publication/pub.1082482595
    40 https://doi.org/10.1002/bjs.5278
    41 https://doi.org/10.1002/ijc.27975
    42 https://doi.org/10.1002/jcp.22977
    43 https://doi.org/10.1002/mc.21841
    44 https://doi.org/10.1002/mc.22076
    45 https://doi.org/10.1016/j.cccn.2005.06.023
    46 https://doi.org/10.1016/j.ccr.2009.02.015
    47 https://doi.org/10.1016/j.cellsig.2006.09.003
    48 https://doi.org/10.1016/j.devcel.2008.05.009
    49 https://doi.org/10.1016/j.mimet.2013.10.004
    50 https://doi.org/10.1016/j.virusres.2013.12.037
    51 https://doi.org/10.1016/s0140-6736(94)92529-1
    52 https://doi.org/10.1016/s0301-472x(02)00922-0
    53 https://doi.org/10.1016/s1055-3207(02)00091-1
    54 https://doi.org/10.1053/j.gastro.2006.06.016
    55 https://doi.org/10.1073/pnas.0509808103
    56 https://doi.org/10.1073/pnas.1221243110
    57 https://doi.org/10.1074/jbc.r700016200
    58 https://doi.org/10.1080/15216540410001668064
    59 https://doi.org/10.1083/jcb.200601018
    60 https://doi.org/10.1084/jem.20080003
    61 https://doi.org/10.1093/jjco/hyf068
    62 https://doi.org/10.1097/00000658-200206000-00002
    63 https://doi.org/10.1097/pai.0b013e31827ea79e
    64 https://doi.org/10.1111/j.1349-7006.2007.00550.x
    65 https://doi.org/10.1111/j.1440-1746.2011.06883.x
    66 https://doi.org/10.1136/gut.2009.194472
    67 https://doi.org/10.1136/jcp.2004.023416
    68 https://doi.org/10.1158/0008-5472.can-04-2488
    69 https://doi.org/10.1158/0008-5472.can-06-1308
    70 https://doi.org/10.1158/0008-5472.can-07-0575
    71 https://doi.org/10.1158/1078-0432.ccr-10-2694
    72 https://doi.org/10.1172/jci39104
    73 https://doi.org/10.1182/blood-2006-11-055756
    74 https://doi.org/10.1200/jco.2010.31.8907
    75 https://doi.org/10.1371/journal.pone.0094226
    76 https://doi.org/10.1593/neo.04571
    77 https://doi.org/10.1593/neo.06820
    78 https://doi.org/10.1593/neo.07971
    79 https://doi.org/10.3109/00365521.2012.640824
    80 https://doi.org/10.3322/canjclin.50.1.7
    81 https://doi.org/10.3748/wjg.v18.i7.601
    82 https://doi.org/10.3892/ijo.2013.2049
    83 https://doi.org/10.3892/or.15.6.1445
    84 schema:datePublished 2015-12
    85 schema:datePublishedReg 2015-12-01
    86 schema:description BACKGROUND: Signal transducer and activator of transcription proteins (STATs) are crucial regulators of cell growth and differentiation; however, their specific prognostic impact in human colon cancer has only been studied to limited extent. We aimed to assess the prognostic significance of specific STAT expression patterns in colon carcinoma. METHODS: Protein expression patterns of activated STAT1, STAT3, STAT4, and STAT5 in human colon carcinoma tissue and corresponding healthy mucosa (n = 104) were assessed using multiplex bead-based immunoassay technologies. Expression patterns were correlated with clinical and survival data. Immunohistochemistry was performed to assess spatial expression of STAT3 and STAT5. RESULTS: STAT3 was underexpressed whereas STAT4 and STAT5 were overexpressed in colon carcinoma tissue. Primary tumors from patients with distant metastases (M1) displayed significantly increased expression of STAT1 and STAT3 but decreased expression of STAT4 and STAT5. Increased tumor expression of STAT1 or STAT3 was associated with impaired patient survival, whereas increased expression of STAT4 or STAT5 correlated with improved survival. Multivariate analysis identified an increased STAT3/STAT5 expressional ratio as an adverse prognostic marker in colon cancer patients. CONCLUSIONS: The tumor progression-associated transcription factors STAT3, STAT4, and STAT5 are differently expressed in colon carcinoma tissue and colon mucosa. Moreover, the STAT3/STAT5 expression ratio is an independent prognostic marker in colon cancer patients.
    87 schema:genre research_article
    88 schema:inLanguage en
    89 schema:isAccessibleForFree false
    90 schema:isPartOf N7a6bcee83bb746c1add55c7fedad28ef
    91 Naf05f154931448428bf72123109e8400
    92 sg:journal.1105545
    93 schema:name Expressional STAT3/STAT5 Ratio is an Independent Prognostic Marker in Colon Carcinoma
    94 schema:pagination 1548-1555
    95 schema:productId N3a2e683f450a4b2bb31b399a34f65e47
    96 N500d511e6f7d44c4ba7308917d62de0a
    97 N5733358be89342f9b1c1927c143293c5
    98 N9b4be214231f4efdb9ec8e98fa8a1b0e
    99 Nbfae372779ec4d7cb460010763911491
    100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015219703
    101 https://doi.org/10.1245/s10434-015-4485-4
    102 schema:sdDatePublished 2019-04-10T14:06
    103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    104 schema:sdPublisher N8ad563f973b74b0e8a0a4a875c106dff
    105 schema:url http://link.springer.com/10.1245/s10434-015-4485-4
    106 sgo:license sg:explorer/license/
    107 sgo:sdDataset articles
    108 rdf:type schema:ScholarlyArticle
    109 N089acc3362eb4827a202a7323bbf3fba rdf:first sg:person.01216400054.70
    110 rdf:rest N691b48980918420886df27cae0a52a50
    111 N18866ad244c8472cbf5e9f7b849167b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Liver Neoplasms
    113 rdf:type schema:DefinedTerm
    114 N19c4ccf7acd541a4adc88ddad194ebd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Colonic Neoplasms
    116 rdf:type schema:DefinedTerm
    117 N2098aa737d824491b5e7c24bcda6fae8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Female
    119 rdf:type schema:DefinedTerm
    120 N2a25aa475c4a488eb57227e0eabc26e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Survival Rate
    122 rdf:type schema:DefinedTerm
    123 N3a2e683f450a4b2bb31b399a34f65e47 schema:name doi
    124 schema:value 10.1245/s10434-015-4485-4
    125 rdf:type schema:PropertyValue
    126 N415c2f748a3f4e2ca423eeb126da054d rdf:first sg:person.01045313115.46
    127 rdf:rest N089acc3362eb4827a202a7323bbf3fba
    128 N434165d8f4a64d54aa063cef76a7fefd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name STAT3 Transcription Factor
    130 rdf:type schema:DefinedTerm
    131 N500d511e6f7d44c4ba7308917d62de0a schema:name dimensions_id
    132 schema:value pub.1015219703
    133 rdf:type schema:PropertyValue
    134 N5148ebdf76f24bafa05b6869c563abca rdf:first sg:person.01336467554.88
    135 rdf:rest Nd594307ac2ca4a37af4b7011e43dd69a
    136 N5733358be89342f9b1c1927c143293c5 schema:name nlm_unique_id
    137 schema:value 9420840
    138 rdf:type schema:PropertyValue
    139 N58d9f197f5834b4188dd731fd1f7b3e0 rdf:first sg:person.01364412735.49
    140 rdf:rest N5148ebdf76f24bafa05b6869c563abca
    141 N5a59b454eb5f4e259a90785f1aecddfc rdf:first sg:person.01176531455.34
    142 rdf:rest Nf303171ab51b4fe59f8c2e20e4b304fb
    143 N6193891c021f4881b5735dfad7cbeb59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Male
    145 rdf:type schema:DefinedTerm
    146 N657c37ca20b54d11a78b93f3fa9a6c1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name STAT5 Transcription Factor
    148 rdf:type schema:DefinedTerm
    149 N681c016fa2db4d05abb74706d422a1f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Biomarkers, Tumor
    151 rdf:type schema:DefinedTerm
    152 N68ef2daff9594c72bcf38ad6ff0c113f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Humans
    154 rdf:type schema:DefinedTerm
    155 N691b48980918420886df27cae0a52a50 rdf:first sg:person.01161541515.70
    156 rdf:rest Nf2b8ff8f9f9a46c0bd49903784f76e02
    157 N70d223a94f1b4d5eb0960da5cbc65f0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Immunoenzyme Techniques
    159 rdf:type schema:DefinedTerm
    160 N7a6bcee83bb746c1add55c7fedad28ef schema:issueNumber Suppl 3
    161 rdf:type schema:PublicationIssue
    162 N7b56c946feb6468cba348474775b267a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Prognosis
    164 rdf:type schema:DefinedTerm
    165 N8ad563f973b74b0e8a0a4a875c106dff schema:name Springer Nature - SN SciGraph project
    166 rdf:type schema:Organization
    167 N8d1075861fa94b2fab8609efb4b41e99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Tumor Suppressor Proteins
    169 rdf:type schema:DefinedTerm
    170 N93590373ff86471094165eae043106f1 schema:name National Center for Tumor Diseases, Medical Oncology, and Internal Medicine VI, Tissue Imaging and Analysis Center, Bioquant, University of Heidelberg, Heidelberg, Germany
    171 rdf:type schema:Organization
    172 N954b1b36dc0f47ab90c077a8d2c061a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Aged
    174 rdf:type schema:DefinedTerm
    175 N9a9bbb7b692e40b29d0572fd62716cab rdf:first sg:person.01364752534.48
    176 rdf:rest N415c2f748a3f4e2ca423eeb126da054d
    177 N9b4be214231f4efdb9ec8e98fa8a1b0e schema:name readcube_id
    178 schema:value 48831b32c84e658bc895a8a11076cc4cffee58ebd297351e2407eaa1dd1a3c80
    179 rdf:type schema:PropertyValue
    180 Na9be8d7bf1e641ef880f379f25936f6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Follow-Up Studies
    182 rdf:type schema:DefinedTerm
    183 Naf05f154931448428bf72123109e8400 schema:volumeNumber 22
    184 rdf:type schema:PublicationVolume
    185 Naf9a1dfeb1ef4c5e9af4f75a612d7788 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Lymphatic Metastasis
    187 rdf:type schema:DefinedTerm
    188 Nb116634ec5704e39b67514904632d12d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Blotting, Western
    190 rdf:type schema:DefinedTerm
    191 Nb2bdc17a58cf4a42923870b42ddd1dc7 rdf:first sg:person.0737166606.65
    192 rdf:rest Nc4c21beb6102444aac6fe503cd061dd3
    193 Nb79e6be70c724a76a96abce9b037a9e9 rdf:first sg:person.0607222354.52
    194 rdf:rest N58d9f197f5834b4188dd731fd1f7b3e0
    195 Nbfae372779ec4d7cb460010763911491 schema:name pubmed_id
    196 schema:value 25773877
    197 rdf:type schema:PropertyValue
    198 Nc4c21beb6102444aac6fe503cd061dd3 rdf:first sg:person.0605741476.97
    199 rdf:rest Nb79e6be70c724a76a96abce9b037a9e9
    200 Nd594307ac2ca4a37af4b7011e43dd69a rdf:first sg:person.01270354354.14
    201 rdf:rest N5a59b454eb5f4e259a90785f1aecddfc
    202 Ndd4be490d6a449b6bc5a99fea89b535e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Neoplasm Staging
    204 rdf:type schema:DefinedTerm
    205 Nf2b8ff8f9f9a46c0bd49903784f76e02 rdf:first sg:person.01040326116.86
    206 rdf:rest Nb2bdc17a58cf4a42923870b42ddd1dc7
    207 Nf303171ab51b4fe59f8c2e20e4b304fb rdf:first sg:person.01017021755.83
    208 rdf:rest rdf:nil
    209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Medical and Health Sciences
    211 rdf:type schema:DefinedTerm
    212 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Oncology and Carcinogenesis
    214 rdf:type schema:DefinedTerm
    215 sg:journal.1105545 schema:issn 1068-9265
    216 1534-4681
    217 schema:name Annals of Surgical Oncology
    218 rdf:type schema:Periodical
    219 sg:person.01017021755.83 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    220 schema:familyName Ulrich
    221 schema:givenName Alexis
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017021755.83
    223 rdf:type schema:Person
    224 sg:person.01040326116.86 schema:affiliation N93590373ff86471094165eae043106f1
    225 schema:familyName Halama
    226 schema:givenName Niels
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040326116.86
    228 rdf:type schema:Person
    229 sg:person.01045313115.46 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    230 schema:familyName Diers
    231 schema:givenName Johannes
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045313115.46
    233 rdf:type schema:Person
    234 sg:person.01161541515.70 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    235 schema:familyName Neumann
    236 schema:givenName Lena
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161541515.70
    238 rdf:type schema:Person
    239 sg:person.01176531455.34 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    240 schema:familyName Schneider
    241 schema:givenName Martin
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176531455.34
    243 rdf:type schema:Person
    244 sg:person.01216400054.70 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    245 schema:familyName Kahlert
    246 schema:givenName Christoph
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216400054.70
    248 rdf:type schema:Person
    249 sg:person.01270354354.14 schema:affiliation https://www.grid.ac/institutes/grid.4488.0
    250 schema:familyName Koch
    251 schema:givenName Moritz
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270354354.14
    253 rdf:type schema:Person
    254 sg:person.01336467554.88 schema:affiliation https://www.grid.ac/institutes/grid.4488.0
    255 schema:familyName Weitz
    256 schema:givenName Juergen
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336467554.88
    258 rdf:type schema:Person
    259 sg:person.01364412735.49 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    260 schema:familyName Warth
    261 schema:givenName Arne
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364412735.49
    263 rdf:type schema:Person
    264 sg:person.01364752534.48 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    265 schema:familyName Klupp
    266 schema:givenName Fee
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364752534.48
    268 rdf:type schema:Person
    269 sg:person.0605741476.97 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    270 schema:familyName Schmidt
    271 schema:givenName Thomas
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605741476.97
    273 rdf:type schema:Person
    274 sg:person.0607222354.52 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    275 schema:familyName Lasitschka
    276 schema:givenName Felix
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607222354.52
    278 rdf:type schema:Person
    279 sg:person.0737166606.65 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    280 schema:familyName Franz
    281 schema:givenName Clemens
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737166606.65
    283 rdf:type schema:Person
    284 sg:pub.10.1007/s00384-010-1090-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053535169
    285 https://doi.org/10.1007/s00384-010-1090-7
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1007/s12307-008-0007-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008521202
    288 https://doi.org/10.1007/s12307-008-0007-2
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/bjc.2013.274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022556392
    291 https://doi.org/10.1038/bjc.2013.274
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/bjc.2013.305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039301272
    294 https://doi.org/10.1038/bjc.2013.305
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nm.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007240913
    297 https://doi.org/10.1038/nm.2015
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nm1325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009280775
    300 https://doi.org/10.1038/nm1325
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/nrc2734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022123078
    303 https://doi.org/10.1038/nrc2734
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/nrc822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020528453
    306 https://doi.org/10.1038/nrc822
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/nri1806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004289511
    309 https://doi.org/10.1038/nri1806
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/nri1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052092567
    312 https://doi.org/10.1038/nri1995
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/sj.bjc.6603033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051210499
    315 https://doi.org/10.1038/sj.bjc.6603033
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/sj.bjc.6604794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009293249
    318 https://doi.org/10.1038/sj.bjc.6604794
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/sj.onc.1207383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002607732
    321 https://doi.org/10.1038/sj.onc.1207383
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/sj.onc.1209942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028771627
    324 https://doi.org/10.1038/sj.onc.1209942
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1186/1471-2407-13-59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047860698
    327 https://doi.org/10.1186/1471-2407-13-59
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1186/1471-2407-7-111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039286059
    330 https://doi.org/10.1186/1471-2407-7-111
    331 rdf:type schema:CreativeWork
    332 https://app.dimensions.ai/details/publication/pub.1076997366 schema:CreativeWork
    333 https://app.dimensions.ai/details/publication/pub.1077688788 schema:CreativeWork
    334 https://app.dimensions.ai/details/publication/pub.1082482595 schema:CreativeWork
    335 https://doi.org/10.1002/bjs.5278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036508017
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1002/ijc.27975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035793101
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1002/jcp.22977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050386495
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1002/mc.21841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042646973
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1002/mc.22076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037275569
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/j.cccn.2005.06.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004018481
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/j.ccr.2009.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045384677
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/j.cellsig.2006.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045818441
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1016/j.devcel.2008.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008314667
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1016/j.mimet.2013.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043830687
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/j.virusres.2013.12.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036746402
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/s0140-6736(94)92529-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051430862
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/s0301-472x(02)00922-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013202003
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/s1055-3207(02)00091-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000904609
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1053/j.gastro.2006.06.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018499531
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1073/pnas.0509808103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000576508
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1073/pnas.1221243110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031762119
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1074/jbc.r700016200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015184745
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1080/15216540410001668064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029256955
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1083/jcb.200601018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032841661
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1084/jem.20080003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042543400
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1093/jjco/hyf068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029663691
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1097/00000658-200206000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041943148
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1097/pai.0b013e31827ea79e schema:sameAs https://app.dimensions.ai/details/publication/pub.1078691158
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1111/j.1349-7006.2007.00550.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023634454
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1111/j.1440-1746.2011.06883.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040032122
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1136/gut.2009.194472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015842871
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1136/jcp.2004.023416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033025204
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1158/0008-5472.can-04-2488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011430825
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1158/0008-5472.can-06-1308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011632011
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1158/0008-5472.can-07-0575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053443939
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1158/1078-0432.ccr-10-2694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047218875
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1172/jci39104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026879393
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1182/blood-2006-11-055756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039421946
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1200/jco.2010.31.8907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042970868
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1371/journal.pone.0094226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047639328
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1593/neo.04571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038861647
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1593/neo.06820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031212995
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1593/neo.07971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029807292
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.3109/00365521.2012.640824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039661642
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.3322/canjclin.50.1.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029345645
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.3748/wjg.v18.i7.601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071369002
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.3892/ijo.2013.2049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071513216
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.3892/or.15.6.1445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071530024
    422 rdf:type schema:CreativeWork
    423 https://www.grid.ac/institutes/grid.4488.0 schema:alternateName TU Dresden
    424 schema:name Department of Visceral, Thoracic, and Vascular Surgery, University of Dresden, Dresden, Germany
    425 rdf:type schema:Organization
    426 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
    427 schema:name Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    428 Tissue Bank of the National Center for Tumor Diseases (NCT), Heidelberg, Germany
    429 rdf:type schema:Organization
    430 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
    431 schema:name Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    432 Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    433 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...