Abdominal Infection Suppresses the Number and Activity of Intrahepatic Natural Killer Cells and Promotes Tumor Growth in a Murine Liver ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-03-10

AUTHORS

Yusuke Matsumoto, Hironori Tsujimoto, Satoshi Ono, Nariyoshi Shinomiya, Hiromi Miyazaki, Shuichi Hiraki, Risa Takahata, Kazumichi Yoshida, Daizoh Saitoh, Takao Yamori, Junji Yamamoto, Kazuo Hase

ABSTRACT

BackgroundIncreasing evidence suggests that postoperative infection is associated with poorer long-term outcome in various malignancies. However, the mechanism of poor prognosis induced by postoperative infection has not been clearly explained. We sought to determine whether abdominal infection promotes cancer metastases in a murine liver metastasis model, and to investigate the role of liver natural killer (NK) cells on antitumor immunity during abdominal infection. MethodsFemale BALB/c (8–10 weeks old) mice were inoculated with NL-17 colon cancer cells into the spleen and then subjected to abdominal infection induced by cecal ligation and puncture (CLP) or sham treatment. The extent of liver metastases and cytokine production in the serum and liver were investigated. Cell fraction and cytotoxic activities of liver mononuclear cells (MNCs) were elucidated.ResultsCLP mice had poorer survival and their serum levels of IL-6, -10, and -12p70 were significantly elevated on day 1 compared with sham-treated and control mice. No obvious differences in cytokine levels of the liver homogenates were identified among the three groups, except IL-12p70 levels in CLP mice on day 7 significantly decreased. The cytotoxic activities of liver MNCs were significantly suppressed in CLP mice soon after tumor inoculation. Flow cytometry revealed a decrease in NK cells in the liver and perforin and granzyme B expression levels.ConclusionsAbdominal infection promoted liver metastases in a murine liver metastasis model, which may be partially caused by a decrease in the number and activity of NK cells during abdominal infection. More... »

PAGES

257-265

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-015-4466-7

DOI

http://dx.doi.org/10.1245/s10434-015-4466-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048687547

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25752891


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intraabdominal Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Killer Cells, Natural", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocytes, Mononuclear", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peritonitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Yusuke", 
        "id": "sg:person.01203211414.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203211414.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsujimoto", 
        "givenName": "Hironori", 
        "id": "sg:person.01022371461.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022371461.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Traumatology, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Division of Traumatology, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ono", 
        "givenName": "Satoshi", 
        "id": "sg:person.01070504661.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070504661.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shinomiya", 
        "givenName": "Nariyoshi", 
        "id": "sg:person.0736166676.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736166676.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Traumatology, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Division of Traumatology, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyazaki", 
        "givenName": "Hiromi", 
        "id": "sg:person.01102355343.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102355343.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hiraki", 
        "givenName": "Shuichi", 
        "id": "sg:person.0752534414.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752534414.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahata", 
        "givenName": "Risa", 
        "id": "sg:person.01111262557.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111262557.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Kazumichi", 
        "id": "sg:person.01322710516.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322710516.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Traumatology, National Defense Medical College, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Division of Traumatology, National Defense Medical College, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saitoh", 
        "givenName": "Daizoh", 
        "id": "sg:person.0620720327.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620720327.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamori", 
        "givenName": "Takao", 
        "id": "sg:person.01276775426.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276775426.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Junji", 
        "id": "sg:person.0760422621.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760422621.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hase", 
        "givenName": "Kazuo", 
        "id": "sg:person.01251324614.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251324614.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00341385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009329257", 
          "https://doi.org/10.1007/bf00341385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-008-0249-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035174921", 
          "https://doi.org/10.1245/s10434-008-0249-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-014-1535-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049619302", 
          "https://doi.org/10.1007/s00262-014-1535-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s005950050187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019621188", 
          "https://doi.org/10.1007/s005950050187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-005-0315-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018699035", 
          "https://doi.org/10.1007/s10120-005-0315-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-03-10", 
    "datePublishedReg": "2015-03-10", 
    "description": "BackgroundIncreasing evidence suggests that postoperative infection is associated with poorer long-term outcome in various malignancies. However, the mechanism of poor prognosis induced by postoperative infection has not been clearly explained. We sought to determine whether abdominal infection promotes cancer metastases in a murine liver metastasis model, and to investigate the role of liver natural killer (NK) cells on antitumor immunity during abdominal infection.\nMethodsFemale BALB/c (8\u201310\u00a0weeks old) mice were inoculated with NL-17 colon cancer cells into the spleen and then subjected to abdominal infection induced by cecal ligation and puncture (CLP) or sham treatment. The extent of liver metastases and cytokine production in the serum and liver were investigated. Cell fraction and cytotoxic activities of liver mononuclear cells (MNCs) were elucidated.ResultsCLP mice had poorer survival and their serum levels of IL-6, -10, and -12p70 were significantly elevated on day 1 compared with sham-treated and control mice. No obvious differences in cytokine levels of the liver homogenates were identified among the three groups, except IL-12p70 levels in CLP mice on day 7 significantly decreased. The cytotoxic activities of liver MNCs were significantly suppressed in CLP mice soon after tumor inoculation. Flow cytometry revealed a decrease in NK cells in the liver and perforin and granzyme B expression levels.ConclusionsAbdominal infection promoted liver metastases in a murine liver metastasis model, which may be partially caused by a decrease in the number and activity of NK cells during abdominal infection.", 
    "genre": "article", 
    "id": "sg:pub.10.1245/s10434-015-4466-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5858484", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5897191", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "Suppl 2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "murine liver metastasis model", 
      "liver metastasis model", 
      "liver mononuclear cells", 
      "abdominal infection", 
      "natural killer cells", 
      "mononuclear cells", 
      "metastasis model", 
      "CLP mice", 
      "postoperative infection", 
      "killer cells", 
      "liver metastases", 
      "NK cells", 
      "poor long-term outcome", 
      "liver natural killer cells", 
      "granzyme B expression levels", 
      "Intrahepatic Natural Killer Cells", 
      "long-term outcomes", 
      "BALB/c mice", 
      "Promotes Tumor Growth", 
      "cytotoxic activity", 
      "IL-12p70 levels", 
      "tumor inoculation", 
      "antitumor immunity", 
      "cecal ligation", 
      "cytokine levels", 
      "sham treatment", 
      "serum levels", 
      "control mice", 
      "poor prognosis", 
      "cytokine production", 
      "poor survival", 
      "day 1", 
      "day 7", 
      "tumor growth", 
      "infection", 
      "cancer metastasis", 
      "flow cytometry", 
      "colon cancer cells", 
      "mice", 
      "metastasis", 
      "liver homogenates", 
      "cancer cells", 
      "expression levels", 
      "cell fraction", 
      "liver", 
      "cells", 
      "prognosis", 
      "levels", 
      "IL-6", 
      "malignancy", 
      "perforin", 
      "spleen", 
      "puncture", 
      "activity", 
      "immunity", 
      "serum", 
      "cytometry", 
      "ligation", 
      "survival", 
      "outcomes", 
      "decrease", 
      "treatment", 
      "homogenates", 
      "obvious differences", 
      "group", 
      "inoculation", 
      "evidence", 
      "differences", 
      "role", 
      "number", 
      "mechanism", 
      "extent", 
      "fraction", 
      "model", 
      "production", 
      "growth", 
      "BackgroundIncreasing evidence", 
      "MethodsFemale BALB/c (8\u201310\u00a0weeks old) mice", 
      "c (8\u201310\u00a0weeks old) mice", 
      "NL-17 colon cancer cells", 
      "ResultsCLP mice", 
      "B expression levels", 
      "ConclusionsAbdominal infection"
    ], 
    "name": "Abdominal Infection Suppresses the Number and Activity of Intrahepatic Natural Killer Cells and Promotes Tumor Growth in a Murine Liver Metastasis Model", 
    "pagination": "257-265", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048687547"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-015-4466-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25752891"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-015-4466-7", 
      "https://app.dimensions.ai/details/publication/pub.1048687547"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_657.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1245/s10434-015-4466-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4466-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4466-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4466-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-015-4466-7'


 

This table displays all metadata directly associated to this object as RDF triples.

329 TRIPLES      22 PREDICATES      133 URIs      119 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-015-4466-7 schema:about N16fb3ba9bd4d4b02b6e403778fb41a45
2 N176198cab81541d8874c05f1c5526e78
3 N30a3e194e2b34e66a8883face8c384a2
4 N3655aad7eff346359da6462b79df007e
5 N4208c5f2d6664486b732cfd3c9dbec8b
6 N43379455aaa348f3a5de8a9dd4e2d6ac
7 N446a21968e23466cb604db91a8340525
8 N4a7299e3f6614b039260ccdad8bd85d6
9 N5c37290aa499411eb01496012abfd7fa
10 N671b1066da4b4d3691453396e798fede
11 N8bd5a98d8fda407c9ac716926bc8f4d6
12 N8fd80b4d75da4b1a8ee863c3415fcb4b
13 Na72eb6df7d60472296b3406efd5370ea
14 Na88dcd1cc21c41cba91003e7867f6d5a
15 Nb17f11f079f24588b1390b154d6206e9
16 Ne24a20434d0549f4a651f66ead3a184d
17 Ne2b4837b970e488baff84313a04e522c
18 Nf71ec26f49d842c4af6be4bc76683a29
19 anzsrc-for:11
20 anzsrc-for:1103
21 anzsrc-for:1107
22 schema:author N99994b538f5e4123971e848276e33e52
23 schema:citation sg:pub.10.1007/bf00341385
24 sg:pub.10.1007/s00262-014-1535-x
25 sg:pub.10.1007/s005950050187
26 sg:pub.10.1007/s10120-005-0315-x
27 sg:pub.10.1245/s10434-008-0249-8
28 schema:datePublished 2015-03-10
29 schema:datePublishedReg 2015-03-10
30 schema:description BackgroundIncreasing evidence suggests that postoperative infection is associated with poorer long-term outcome in various malignancies. However, the mechanism of poor prognosis induced by postoperative infection has not been clearly explained. We sought to determine whether abdominal infection promotes cancer metastases in a murine liver metastasis model, and to investigate the role of liver natural killer (NK) cells on antitumor immunity during abdominal infection. MethodsFemale BALB/c (8–10 weeks old) mice were inoculated with NL-17 colon cancer cells into the spleen and then subjected to abdominal infection induced by cecal ligation and puncture (CLP) or sham treatment. The extent of liver metastases and cytokine production in the serum and liver were investigated. Cell fraction and cytotoxic activities of liver mononuclear cells (MNCs) were elucidated.ResultsCLP mice had poorer survival and their serum levels of IL-6, -10, and -12p70 were significantly elevated on day 1 compared with sham-treated and control mice. No obvious differences in cytokine levels of the liver homogenates were identified among the three groups, except IL-12p70 levels in CLP mice on day 7 significantly decreased. The cytotoxic activities of liver MNCs were significantly suppressed in CLP mice soon after tumor inoculation. Flow cytometry revealed a decrease in NK cells in the liver and perforin and granzyme B expression levels.ConclusionsAbdominal infection promoted liver metastases in a murine liver metastasis model, which may be partially caused by a decrease in the number and activity of NK cells during abdominal infection.
31 schema:genre article
32 schema:inLanguage en
33 schema:isAccessibleForFree false
34 schema:isPartOf N5a7e717bf30b42df9e3786ccec4e3cb1
35 N67b41dfbfa724dfb92881fb27b207553
36 sg:journal.1105545
37 schema:keywords B expression levels
38 BALB/c mice
39 BackgroundIncreasing evidence
40 CLP mice
41 ConclusionsAbdominal infection
42 IL-12p70 levels
43 IL-6
44 Intrahepatic Natural Killer Cells
45 MethodsFemale BALB/c (8–10 weeks old) mice
46 NK cells
47 NL-17 colon cancer cells
48 Promotes Tumor Growth
49 ResultsCLP mice
50 abdominal infection
51 activity
52 antitumor immunity
53 c (8–10 weeks old) mice
54 cancer cells
55 cancer metastasis
56 cecal ligation
57 cell fraction
58 cells
59 colon cancer cells
60 control mice
61 cytokine levels
62 cytokine production
63 cytometry
64 cytotoxic activity
65 day 1
66 day 7
67 decrease
68 differences
69 evidence
70 expression levels
71 extent
72 flow cytometry
73 fraction
74 granzyme B expression levels
75 group
76 growth
77 homogenates
78 immunity
79 infection
80 inoculation
81 killer cells
82 levels
83 ligation
84 liver
85 liver homogenates
86 liver metastases
87 liver metastasis model
88 liver mononuclear cells
89 liver natural killer cells
90 long-term outcomes
91 malignancy
92 mechanism
93 metastasis
94 metastasis model
95 mice
96 model
97 mononuclear cells
98 murine liver metastasis model
99 natural killer cells
100 number
101 obvious differences
102 outcomes
103 perforin
104 poor long-term outcome
105 poor prognosis
106 poor survival
107 postoperative infection
108 production
109 prognosis
110 puncture
111 role
112 serum
113 serum levels
114 sham treatment
115 spleen
116 survival
117 treatment
118 tumor growth
119 tumor inoculation
120 schema:name Abdominal Infection Suppresses the Number and Activity of Intrahepatic Natural Killer Cells and Promotes Tumor Growth in a Murine Liver Metastasis Model
121 schema:pagination 257-265
122 schema:productId N3fe19169481e4d3db599b4c17da6be97
123 N8b8ae3b238de4bb4a9469108248d121e
124 Nd73e05f5823645e2ba9f99e098d01d59
125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048687547
126 https://doi.org/10.1245/s10434-015-4466-7
127 schema:sdDatePublished 2021-12-01T19:33
128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
129 schema:sdPublisher N020bfcbe968a4c67834b95393ae8e495
130 schema:url https://doi.org/10.1245/s10434-015-4466-7
131 sgo:license sg:explorer/license/
132 sgo:sdDataset articles
133 rdf:type schema:ScholarlyArticle
134 N020bfcbe968a4c67834b95393ae8e495 schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 N0df581e175e747288ea334d4c88eec4a rdf:first sg:person.01251324614.42
137 rdf:rest rdf:nil
138 N16fb3ba9bd4d4b02b6e403778fb41a45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Leukocytes, Mononuclear
140 rdf:type schema:DefinedTerm
141 N176198cab81541d8874c05f1c5526e78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Colonic Neoplasms
143 rdf:type schema:DefinedTerm
144 N30a3e194e2b34e66a8883face8c384a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Survival Rate
146 rdf:type schema:DefinedTerm
147 N3655aad7eff346359da6462b79df007e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Tumor Cells, Cultured
149 rdf:type schema:DefinedTerm
150 N3fe19169481e4d3db599b4c17da6be97 schema:name dimensions_id
151 schema:value pub.1048687547
152 rdf:type schema:PropertyValue
153 N4208c5f2d6664486b732cfd3c9dbec8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Killer Cells, Natural
155 rdf:type schema:DefinedTerm
156 N43379455aaa348f3a5de8a9dd4e2d6ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Flow Cytometry
158 rdf:type schema:DefinedTerm
159 N446a21968e23466cb604db91a8340525 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Mice
161 rdf:type schema:DefinedTerm
162 N4a7299e3f6614b039260ccdad8bd85d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Intraabdominal Infections
164 rdf:type schema:DefinedTerm
165 N5a7e717bf30b42df9e3786ccec4e3cb1 schema:volumeNumber 23
166 rdf:type schema:PublicationVolume
167 N5c37290aa499411eb01496012abfd7fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Female
169 rdf:type schema:DefinedTerm
170 N64a4ac759b0a406ab99dd0e4ebe52b9c rdf:first sg:person.01022371461.19
171 rdf:rest Nc1a9e6994a524b22b51f35ea8f07e04c
172 N671b1066da4b4d3691453396e798fede schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Mice, Inbred BALB C
174 rdf:type schema:DefinedTerm
175 N67b41dfbfa724dfb92881fb27b207553 schema:issueNumber Suppl 2
176 rdf:type schema:PublicationIssue
177 N691b49adc1c548a69c6fb80d71f8fa50 rdf:first sg:person.0760422621.80
178 rdf:rest N0df581e175e747288ea334d4c88eec4a
179 N8b8ae3b238de4bb4a9469108248d121e schema:name doi
180 schema:value 10.1245/s10434-015-4466-7
181 rdf:type schema:PropertyValue
182 N8bd5a98d8fda407c9ac716926bc8f4d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Peritonitis
184 rdf:type schema:DefinedTerm
185 N8fd80b4d75da4b1a8ee863c3415fcb4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Immunoenzyme Techniques
187 rdf:type schema:DefinedTerm
188 N99994b538f5e4123971e848276e33e52 rdf:first sg:person.01203211414.85
189 rdf:rest N64a4ac759b0a406ab99dd0e4ebe52b9c
190 N9f44c5de85bd45b4a4ce34a423030295 rdf:first sg:person.01322710516.06
191 rdf:rest Nf0cf3ba7bc494b95ab2b325b42d2d9d9
192 Na72eb6df7d60472296b3406efd5370ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Apoptosis
194 rdf:type schema:DefinedTerm
195 Na88dcd1cc21c41cba91003e7867f6d5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Animals
197 rdf:type schema:DefinedTerm
198 Nb17f11f079f24588b1390b154d6206e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Cytokines
200 rdf:type schema:DefinedTerm
201 Nb19aabfd77c44f8e807580c2a01dfcd5 rdf:first sg:person.01102355343.75
202 rdf:rest Ndb42ae0112ca4d5c89516ea241a1d2fa
203 Nc1a9e6994a524b22b51f35ea8f07e04c rdf:first sg:person.01070504661.01
204 rdf:rest Nc2136b7487a04063aad202637840aa41
205 Nc2136b7487a04063aad202637840aa41 rdf:first sg:person.0736166676.13
206 rdf:rest Nb19aabfd77c44f8e807580c2a01dfcd5
207 Nd63c2b2258da4870a855a12692273f88 rdf:first sg:person.01111262557.97
208 rdf:rest N9f44c5de85bd45b4a4ce34a423030295
209 Nd73e05f5823645e2ba9f99e098d01d59 schema:name pubmed_id
210 schema:value 25752891
211 rdf:type schema:PropertyValue
212 Ndb42ae0112ca4d5c89516ea241a1d2fa rdf:first sg:person.0752534414.59
213 rdf:rest Nd63c2b2258da4870a855a12692273f88
214 Ne24a20434d0549f4a651f66ead3a184d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Humans
216 rdf:type schema:DefinedTerm
217 Ne2b4837b970e488baff84313a04e522c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Liver Neoplasms
219 rdf:type schema:DefinedTerm
220 Nf0cf3ba7bc494b95ab2b325b42d2d9d9 rdf:first sg:person.0620720327.86
221 rdf:rest Nf34003a45c9c4559bda7601afb7e9c26
222 Nf34003a45c9c4559bda7601afb7e9c26 rdf:first sg:person.01276775426.37
223 rdf:rest N691b49adc1c548a69c6fb80d71f8fa50
224 Nf71ec26f49d842c4af6be4bc76683a29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Disease Models, Animal
226 rdf:type schema:DefinedTerm
227 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
228 schema:name Medical and Health Sciences
229 rdf:type schema:DefinedTerm
230 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
231 schema:name Clinical Sciences
232 rdf:type schema:DefinedTerm
233 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
234 schema:name Immunology
235 rdf:type schema:DefinedTerm
236 sg:grant.5858484 http://pending.schema.org/fundedItem sg:pub.10.1245/s10434-015-4466-7
237 rdf:type schema:MonetaryGrant
238 sg:grant.5897191 http://pending.schema.org/fundedItem sg:pub.10.1245/s10434-015-4466-7
239 rdf:type schema:MonetaryGrant
240 sg:journal.1105545 schema:issn 1068-9265
241 1534-4681
242 schema:name Annals of Surgical Oncology
243 schema:publisher Springer Nature
244 rdf:type schema:Periodical
245 sg:person.01022371461.19 schema:affiliation grid-institutes:grid.416614.0
246 schema:familyName Tsujimoto
247 schema:givenName Hironori
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022371461.19
249 rdf:type schema:Person
250 sg:person.01070504661.01 schema:affiliation grid-institutes:grid.416614.0
251 schema:familyName Ono
252 schema:givenName Satoshi
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070504661.01
254 rdf:type schema:Person
255 sg:person.01102355343.75 schema:affiliation grid-institutes:grid.416614.0
256 schema:familyName Miyazaki
257 schema:givenName Hiromi
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102355343.75
259 rdf:type schema:Person
260 sg:person.01111262557.97 schema:affiliation grid-institutes:grid.416614.0
261 schema:familyName Takahata
262 schema:givenName Risa
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111262557.97
264 rdf:type schema:Person
265 sg:person.01203211414.85 schema:affiliation grid-institutes:grid.416614.0
266 schema:familyName Matsumoto
267 schema:givenName Yusuke
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203211414.85
269 rdf:type schema:Person
270 sg:person.01251324614.42 schema:affiliation grid-institutes:grid.416614.0
271 schema:familyName Hase
272 schema:givenName Kazuo
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251324614.42
274 rdf:type schema:Person
275 sg:person.01276775426.37 schema:affiliation grid-institutes:grid.410807.a
276 schema:familyName Yamori
277 schema:givenName Takao
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276775426.37
279 rdf:type schema:Person
280 sg:person.01322710516.06 schema:affiliation grid-institutes:grid.416614.0
281 schema:familyName Yoshida
282 schema:givenName Kazumichi
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322710516.06
284 rdf:type schema:Person
285 sg:person.0620720327.86 schema:affiliation grid-institutes:grid.416614.0
286 schema:familyName Saitoh
287 schema:givenName Daizoh
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620720327.86
289 rdf:type schema:Person
290 sg:person.0736166676.13 schema:affiliation grid-institutes:grid.416614.0
291 schema:familyName Shinomiya
292 schema:givenName Nariyoshi
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736166676.13
294 rdf:type schema:Person
295 sg:person.0752534414.59 schema:affiliation grid-institutes:grid.416614.0
296 schema:familyName Hiraki
297 schema:givenName Shuichi
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752534414.59
299 rdf:type schema:Person
300 sg:person.0760422621.80 schema:affiliation grid-institutes:grid.416614.0
301 schema:familyName Yamamoto
302 schema:givenName Junji
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760422621.80
304 rdf:type schema:Person
305 sg:pub.10.1007/bf00341385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009329257
306 https://doi.org/10.1007/bf00341385
307 rdf:type schema:CreativeWork
308 sg:pub.10.1007/s00262-014-1535-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049619302
309 https://doi.org/10.1007/s00262-014-1535-x
310 rdf:type schema:CreativeWork
311 sg:pub.10.1007/s005950050187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019621188
312 https://doi.org/10.1007/s005950050187
313 rdf:type schema:CreativeWork
314 sg:pub.10.1007/s10120-005-0315-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018699035
315 https://doi.org/10.1007/s10120-005-0315-x
316 rdf:type schema:CreativeWork
317 sg:pub.10.1245/s10434-008-0249-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035174921
318 https://doi.org/10.1245/s10434-008-0249-8
319 rdf:type schema:CreativeWork
320 grid-institutes:grid.410807.a schema:alternateName Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan
321 schema:name Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan
322 rdf:type schema:Organization
323 grid-institutes:grid.416614.0 schema:alternateName Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
324 Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan
325 Division of Traumatology, National Defense Medical College, Tokorozawa, Saitama, Japan
326 schema:name Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
327 Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan
328 Division of Traumatology, National Defense Medical College, Tokorozawa, Saitama, Japan
329 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...