Validation of Hepatectomy for Elderly Patients with Hepatocellular Carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-09

AUTHORS

Norihiro Kishida, Taizo Hibi, Osamu Itano, Koji Okabayashi, Masahiro Shinoda, Minoru Kitago, Yuta Abe, Hiroshi Yagi, Yuko Kitagawa

ABSTRACT

BACKGROUND: The safety and feasibility of hepatectomy for hepatocellular carcinoma (HCC) in the elderly population have not been defined to date. METHODS: A single-center, retrospective cohort study was conducted with 104 patients who underwent hepatectomy for HCC from 2005 to 2010. The patients were divided into two groups, the elderly group (age, ≥75 years; n = 22) and the nonelderly group (age, <75 years; n = 82), for comparison of short- and long-term outcomes. RESULTS: More patients were categorized as preoperative Eastern Cooperative Oncology Group (ECOG) performance status 1 in the elderly group (32 %) than in the nonelderly group (6 %) (P = 0.003). Complications with a Clavien-Dindo classification of grade 3a or higher were more frequently observed in the elderly group (41 %) than in the nonelderly group (17 %) (P = 0.006). Multivariate logistic regression showed ECOG performance status 1 as the only independent predictor of complications classified as Clavien-Dindo grade 3a or higher. The in-hospital mortality rates were similar between the two groups (P = 0.20). During a median follow-up period of 47 months, the unadjusted 5-year recurrence-free survival rates were similar in the elderly (25 %) and nonelderly (33 %) groups (P = 0.80). Multiple tumors and high alpha-fetoprotein levels emerged as independent negative indicators of recurrence-free survival using multivariate Cox analyses. The adjusted risk for recurrence was not elevated in the elderly group (hazard ratio [HR], 0.92; 95 % confidence interval [CI] 0.50-1.68; P = 0.78). CONCLUSIONS: Despite the more frequent occurrence of complications with a Clavien-Dindo grade of 3a or higher among the elderly patients undergoing hepatectomy for HCC, their mortality and recurrence rates were comparable with those of the nonelderly patients. Therefore, age alone is not a determinant of surgical candidacy for HCC. More... »

PAGES

3094-3101

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-014-4350-x

DOI

http://dx.doi.org/10.1245/s10434-014-4350-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001109541

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25582743


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feasibility Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospital Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postoperative Complications", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kishida", 
        "givenName": "Norihiro", 
        "id": "sg:person.01230022640.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230022640.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hibi", 
        "givenName": "Taizo", 
        "id": "sg:person.01320563025.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320563025.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Itano", 
        "givenName": "Osamu", 
        "id": "sg:person.01214612211.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214612211.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okabayashi", 
        "givenName": "Koji", 
        "id": "sg:person.01133541461.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133541461.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shinoda", 
        "givenName": "Masahiro", 
        "id": "sg:person.01177072567.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177072567.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitago", 
        "givenName": "Minoru", 
        "id": "sg:person.01331040611.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331040611.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abe", 
        "givenName": "Yuta", 
        "id": "sg:person.0701304263.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701304263.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yagi", 
        "givenName": "Hiroshi", 
        "id": "sg:person.0771375402.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771375402.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitagawa", 
        "givenName": "Yuko", 
        "id": "sg:person.01015255273.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015255273.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jamda.2013.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004378393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1872-034x.2011.00952.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004957340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2009.10.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007894825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2010.12.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013579164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2006.07.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013696560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ageing/afq034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022003795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ageing/afq034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022003795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00464-013-2795-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022653286", 
          "https://doi.org/10.1007/s00464-013-2795-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.21932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022660975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1001683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023862882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2013.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024766876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ssu.2980090404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025546871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.1840200104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029401994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2010.01.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030832769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.23335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035023750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyr154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038587488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31827b947a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038762706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31827b947a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038762706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-012-1621-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039005051", 
          "https://doi.org/10.1007/s00268-012-1621-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70259-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039105216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000346224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040874334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-014-2659-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043225090", 
          "https://doi.org/10.1007/s00268-014-2659-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2012.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045260007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181b13ca2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046194794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181b13ca2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046194794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181b13ca2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046194794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2010.03.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049711317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-009-0933-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051135426", 
          "https://doi.org/10.1007/s11605-009-0933-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-009-0933-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051135426", 
          "https://doi.org/10.1007/s11605-009-0933-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0000000000000226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051837213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0000000000000226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051837213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181b45598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077952930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5754/hge09485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078575346"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-09", 
    "datePublishedReg": "2015-09-01", 
    "description": "BACKGROUND: The safety and feasibility of hepatectomy for hepatocellular carcinoma (HCC) in the elderly population have not been defined to date.\nMETHODS: A single-center, retrospective cohort study was conducted with 104 patients who underwent hepatectomy for HCC from 2005 to 2010. The patients were divided into two groups, the elderly group (age, \u226575 years; n = 22) and the nonelderly group (age, <75 years; n = 82), for comparison of short- and long-term outcomes.\nRESULTS: More patients were categorized as preoperative Eastern Cooperative Oncology Group (ECOG) performance status 1 in the elderly group (32 %) than in the nonelderly group (6 %) (P = 0.003). Complications with a Clavien-Dindo classification of grade 3a or higher were more frequently observed in the elderly group (41 %) than in the nonelderly group (17 %) (P = 0.006). Multivariate logistic regression showed ECOG performance status 1 as the only independent predictor of complications classified as Clavien-Dindo grade 3a or higher. The in-hospital mortality rates were similar between the two groups (P = 0.20). During a median follow-up period of 47 months, the unadjusted 5-year recurrence-free survival rates were similar in the elderly (25 %) and nonelderly (33 %) groups (P = 0.80). Multiple tumors and high alpha-fetoprotein levels emerged as independent negative indicators of recurrence-free survival using multivariate Cox analyses. The adjusted risk for recurrence was not elevated in the elderly group (hazard ratio [HR], 0.92; 95 % confidence interval [CI] 0.50-1.68; P = 0.78).\nCONCLUSIONS: Despite the more frequent occurrence of complications with a Clavien-Dindo grade of 3a or higher among the elderly patients undergoing hepatectomy for HCC, their mortality and recurrence rates were comparable with those of the nonelderly patients. Therefore, age alone is not a determinant of surgical candidacy for HCC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-014-4350-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "Validation of Hepatectomy for Elderly Patients with Hepatocellular Carcinoma", 
    "pagination": "3094-3101", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "05493e10fd9ef67c0ff145e66045e800c39b42288f315bb1ea6d426b6848bd03"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25582743"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-014-4350-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001109541"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-014-4350-x", 
      "https://app.dimensions.ai/details/publication/pub.1001109541"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000498.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1245/s10434-014-4350-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4350-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4350-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4350-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4350-x'


 

This table displays all metadata directly associated to this object as RDF triples.

278 TRIPLES      21 PREDICATES      73 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-014-4350-x schema:about N02e8eddd019c40e58a7dba79e42727e0
2 N0580340744774588a625fe6c0c00f9d4
3 N0fc075335f6f4fc29e08925953485098
4 N108c8acde9bc40e99f4f2b2089dc3ba2
5 N1d1d82e77a674399b6fc1df6a35a94ad
6 N34ca98d27b264d63acc1d1cc6a81206a
7 N3a11ceebbc634d17b829e45d4ec1b505
8 N3a2fb14c95484722bfcdb20c490b5fd5
9 N477a8dc24910443c813881982bbb862d
10 N4d3242d515e14f11be428969cd46facf
11 N5501045c1999405ba2285323072652c6
12 N6439ad194e4d4a8caf6de8114b7373f2
13 N8dffd917dbd24cf1827d0db74b594004
14 Nc028ae37fdc84d59b19ae7f92d47b188
15 Ne66fd9fbacb1449d986b490cbe5b1d6e
16 Ne7c25afb91014966a0ea46575e58d4ca
17 Nf622da5aec554edfb96ad9be1a51f581
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author Na6923b08b76e4c9ca0a207a6e31800e4
21 schema:citation sg:pub.10.1007/s00268-012-1621-1
22 sg:pub.10.1007/s00268-014-2659-z
23 sg:pub.10.1007/s00464-013-2795-9
24 sg:pub.10.1007/s11605-009-0933-4
25 https://doi.org/10.1002/hep.1840200104
26 https://doi.org/10.1002/jso.21932
27 https://doi.org/10.1002/jso.23335
28 https://doi.org/10.1002/ssu.2980090404
29 https://doi.org/10.1016/j.jamcollsurg.2006.07.025
30 https://doi.org/10.1016/j.jamcollsurg.2010.01.028
31 https://doi.org/10.1016/j.jamcollsurg.2010.03.012
32 https://doi.org/10.1016/j.jamcollsurg.2010.12.048
33 https://doi.org/10.1016/j.jamcollsurg.2012.06.017
34 https://doi.org/10.1016/j.jamcollsurg.2013.06.012
35 https://doi.org/10.1016/j.jamda.2013.03.010
36 https://doi.org/10.1016/j.surg.2009.10.054
37 https://doi.org/10.1016/s1470-2045(12)70259-0
38 https://doi.org/10.1056/nejmra1001683
39 https://doi.org/10.1093/ageing/afq034
40 https://doi.org/10.1093/jjco/hyr154
41 https://doi.org/10.1097/sla.0000000000000226
42 https://doi.org/10.1097/sla.0b013e3181b13ca2
43 https://doi.org/10.1097/sla.0b013e3181b45598
44 https://doi.org/10.1097/sla.0b013e31827b947a
45 https://doi.org/10.1111/j.1872-034x.2011.00952.x
46 https://doi.org/10.1159/000346224
47 https://doi.org/10.5754/hge09485
48 schema:datePublished 2015-09
49 schema:datePublishedReg 2015-09-01
50 schema:description BACKGROUND: The safety and feasibility of hepatectomy for hepatocellular carcinoma (HCC) in the elderly population have not been defined to date. METHODS: A single-center, retrospective cohort study was conducted with 104 patients who underwent hepatectomy for HCC from 2005 to 2010. The patients were divided into two groups, the elderly group (age, ≥75 years; n = 22) and the nonelderly group (age, <75 years; n = 82), for comparison of short- and long-term outcomes. RESULTS: More patients were categorized as preoperative Eastern Cooperative Oncology Group (ECOG) performance status 1 in the elderly group (32 %) than in the nonelderly group (6 %) (P = 0.003). Complications with a Clavien-Dindo classification of grade 3a or higher were more frequently observed in the elderly group (41 %) than in the nonelderly group (17 %) (P = 0.006). Multivariate logistic regression showed ECOG performance status 1 as the only independent predictor of complications classified as Clavien-Dindo grade 3a or higher. The in-hospital mortality rates were similar between the two groups (P = 0.20). During a median follow-up period of 47 months, the unadjusted 5-year recurrence-free survival rates were similar in the elderly (25 %) and nonelderly (33 %) groups (P = 0.80). Multiple tumors and high alpha-fetoprotein levels emerged as independent negative indicators of recurrence-free survival using multivariate Cox analyses. The adjusted risk for recurrence was not elevated in the elderly group (hazard ratio [HR], 0.92; 95 % confidence interval [CI] 0.50-1.68; P = 0.78). CONCLUSIONS: Despite the more frequent occurrence of complications with a Clavien-Dindo grade of 3a or higher among the elderly patients undergoing hepatectomy for HCC, their mortality and recurrence rates were comparable with those of the nonelderly patients. Therefore, age alone is not a determinant of surgical candidacy for HCC.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree false
54 schema:isPartOf N4c48c573991d40988d5e4ac58d0f2fbf
55 Nadaf5128d9a644d59cd129486715f65d
56 sg:journal.1105545
57 schema:name Validation of Hepatectomy for Elderly Patients with Hepatocellular Carcinoma
58 schema:pagination 3094-3101
59 schema:productId N0373fb49b4484e869a341cbb5ec5972e
60 N1978f1065848487d9437d2f5939f9b94
61 N98ae7bcae52742f39f062d4e4575d549
62 Na434a39c26b54f41b9cea687f82ad398
63 Nb0f2a5ac2e904b35bc945b2c29c4e62e
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001109541
65 https://doi.org/10.1245/s10434-014-4350-x
66 schema:sdDatePublished 2019-04-10T14:06
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N13594648eddb4743a3c9b65bda19a8e2
69 schema:url http://link.springer.com/10.1245/s10434-014-4350-x
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N02e8eddd019c40e58a7dba79e42727e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Male
75 rdf:type schema:DefinedTerm
76 N0373fb49b4484e869a341cbb5ec5972e schema:name readcube_id
77 schema:value 05493e10fd9ef67c0ff145e66045e800c39b42288f315bb1ea6d426b6848bd03
78 rdf:type schema:PropertyValue
79 N0580340744774588a625fe6c0c00f9d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Neoplasm Recurrence, Local
81 rdf:type schema:DefinedTerm
82 N0fc075335f6f4fc29e08925953485098 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Retrospective Studies
84 rdf:type schema:DefinedTerm
85 N108c8acde9bc40e99f4f2b2089dc3ba2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Neoplasm Staging
87 rdf:type schema:DefinedTerm
88 N13594648eddb4743a3c9b65bda19a8e2 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N1978f1065848487d9437d2f5939f9b94 schema:name pubmed_id
91 schema:value 25582743
92 rdf:type schema:PropertyValue
93 N1d1d82e77a674399b6fc1df6a35a94ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Hepatectomy
95 rdf:type schema:DefinedTerm
96 N2d86306a922b4911a339e04a89d7c804 rdf:first sg:person.0701304263.44
97 rdf:rest N94cabed8742843db8bebe0208fd4aea8
98 N34ca98d27b264d63acc1d1cc6a81206a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Feasibility Studies
100 rdf:type schema:DefinedTerm
101 N3a11ceebbc634d17b829e45d4ec1b505 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Female
103 rdf:type schema:DefinedTerm
104 N3a2fb14c95484722bfcdb20c490b5fd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Postoperative Complications
106 rdf:type schema:DefinedTerm
107 N413bd2a2581a4955b146fe98fdec61e5 rdf:first sg:person.01015255273.74
108 rdf:rest rdf:nil
109 N477a8dc24910443c813881982bbb862d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Survival Rate
111 rdf:type schema:DefinedTerm
112 N4c48c573991d40988d5e4ac58d0f2fbf schema:volumeNumber 22
113 rdf:type schema:PublicationVolume
114 N4d3242d515e14f11be428969cd46facf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Middle Aged
116 rdf:type schema:DefinedTerm
117 N5501045c1999405ba2285323072652c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Aged
119 rdf:type schema:DefinedTerm
120 N6439ad194e4d4a8caf6de8114b7373f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Follow-Up Studies
122 rdf:type schema:DefinedTerm
123 N699284d9bfc94cd78c4e2df655c04c0a rdf:first sg:person.01331040611.15
124 rdf:rest N2d86306a922b4911a339e04a89d7c804
125 N8dffd917dbd24cf1827d0db74b594004 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Carcinoma, Hepatocellular
127 rdf:type schema:DefinedTerm
128 N94cabed8742843db8bebe0208fd4aea8 rdf:first sg:person.0771375402.07
129 rdf:rest N413bd2a2581a4955b146fe98fdec61e5
130 N98ae7bcae52742f39f062d4e4575d549 schema:name doi
131 schema:value 10.1245/s10434-014-4350-x
132 rdf:type schema:PropertyValue
133 N9f6c680865c447a29d46a030a6f650a8 rdf:first sg:person.01177072567.83
134 rdf:rest N699284d9bfc94cd78c4e2df655c04c0a
135 Na095c6b818c847cdb2ceb21c95d852d2 rdf:first sg:person.01320563025.46
136 rdf:rest Na0cd152bc1fa4836b761d4f56b4abbff
137 Na0cd152bc1fa4836b761d4f56b4abbff rdf:first sg:person.01214612211.03
138 rdf:rest Ne1beb20363ee474c850ac3811a6be2cd
139 Na434a39c26b54f41b9cea687f82ad398 schema:name dimensions_id
140 schema:value pub.1001109541
141 rdf:type schema:PropertyValue
142 Na6923b08b76e4c9ca0a207a6e31800e4 rdf:first sg:person.01230022640.55
143 rdf:rest Na095c6b818c847cdb2ceb21c95d852d2
144 Nadaf5128d9a644d59cd129486715f65d schema:issueNumber 9
145 rdf:type schema:PublicationIssue
146 Nb0f2a5ac2e904b35bc945b2c29c4e62e schema:name nlm_unique_id
147 schema:value 9420840
148 rdf:type schema:PropertyValue
149 Nc028ae37fdc84d59b19ae7f92d47b188 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Liver Neoplasms
151 rdf:type schema:DefinedTerm
152 Ne1beb20363ee474c850ac3811a6be2cd rdf:first sg:person.01133541461.19
153 rdf:rest N9f6c680865c447a29d46a030a6f650a8
154 Ne66fd9fbacb1449d986b490cbe5b1d6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Prognosis
156 rdf:type schema:DefinedTerm
157 Ne7c25afb91014966a0ea46575e58d4ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Hospital Mortality
159 rdf:type schema:DefinedTerm
160 Nf622da5aec554edfb96ad9be1a51f581 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Humans
162 rdf:type schema:DefinedTerm
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
167 schema:name Clinical Sciences
168 rdf:type schema:DefinedTerm
169 sg:journal.1105545 schema:issn 1068-9265
170 1534-4681
171 schema:name Annals of Surgical Oncology
172 rdf:type schema:Periodical
173 sg:person.01015255273.74 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
174 schema:familyName Kitagawa
175 schema:givenName Yuko
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015255273.74
177 rdf:type schema:Person
178 sg:person.01133541461.19 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
179 schema:familyName Okabayashi
180 schema:givenName Koji
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133541461.19
182 rdf:type schema:Person
183 sg:person.01177072567.83 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
184 schema:familyName Shinoda
185 schema:givenName Masahiro
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177072567.83
187 rdf:type schema:Person
188 sg:person.01214612211.03 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
189 schema:familyName Itano
190 schema:givenName Osamu
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214612211.03
192 rdf:type schema:Person
193 sg:person.01230022640.55 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
194 schema:familyName Kishida
195 schema:givenName Norihiro
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230022640.55
197 rdf:type schema:Person
198 sg:person.01320563025.46 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
199 schema:familyName Hibi
200 schema:givenName Taizo
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320563025.46
202 rdf:type schema:Person
203 sg:person.01331040611.15 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
204 schema:familyName Kitago
205 schema:givenName Minoru
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331040611.15
207 rdf:type schema:Person
208 sg:person.0701304263.44 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
209 schema:familyName Abe
210 schema:givenName Yuta
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701304263.44
212 rdf:type schema:Person
213 sg:person.0771375402.07 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
214 schema:familyName Yagi
215 schema:givenName Hiroshi
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771375402.07
217 rdf:type schema:Person
218 sg:pub.10.1007/s00268-012-1621-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039005051
219 https://doi.org/10.1007/s00268-012-1621-1
220 rdf:type schema:CreativeWork
221 sg:pub.10.1007/s00268-014-2659-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1043225090
222 https://doi.org/10.1007/s00268-014-2659-z
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s00464-013-2795-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022653286
225 https://doi.org/10.1007/s00464-013-2795-9
226 rdf:type schema:CreativeWork
227 sg:pub.10.1007/s11605-009-0933-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051135426
228 https://doi.org/10.1007/s11605-009-0933-4
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/hep.1840200104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029401994
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/jso.21932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022660975
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1002/jso.23335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035023750
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1002/ssu.2980090404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025546871
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.jamcollsurg.2006.07.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013696560
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.jamcollsurg.2010.01.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030832769
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.jamcollsurg.2010.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049711317
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.jamcollsurg.2010.12.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013579164
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.jamcollsurg.2012.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045260007
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.jamcollsurg.2013.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024766876
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.jamda.2013.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004378393
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.surg.2009.10.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007894825
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/s1470-2045(12)70259-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039105216
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1056/nejmra1001683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023862882
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1093/ageing/afq034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022003795
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1093/jjco/hyr154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038587488
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1097/sla.0000000000000226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051837213
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1097/sla.0b013e3181b13ca2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046194794
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1097/sla.0b013e3181b45598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077952930
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1097/sla.0b013e31827b947a schema:sameAs https://app.dimensions.ai/details/publication/pub.1038762706
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1111/j.1872-034x.2011.00952.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004957340
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1159/000346224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040874334
273 rdf:type schema:CreativeWork
274 https://doi.org/10.5754/hge09485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078575346
275 rdf:type schema:CreativeWork
276 https://www.grid.ac/institutes/grid.26091.3c schema:alternateName Keio University
277 schema:name Department of Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan
278 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...