Effects of Preoperative Chemoradiotherapy on the Likelihood of Sphincter Preservation Surgery in Locally Advanced Distal Rectal Cancer: A Longitudinal Study ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-12-12

AUTHORS

Myong Hoon Ihn, Young Hoon Kim, Duck-Woo Kim, Heung-Kwon Oh, Soo Young Lee, Jin Taek Park, Il Tae Son, Ji Hoon Park, Yoon Jin Lee, Jin Won Kim, Keun-Wook Lee, Jee Hyun Kim, Eun Shin, Hye Seung Lee, Soyeon Ahn, Sung-Bum Kang

ABSTRACT

Background It is unclear whether preoperative chemoradiotherapy (pCRT) increases the rate of sphincter-preserving surgery (SPS), avoiding abdominoperineal resection (APR), for the treatment of distal rectal cancer. We examined whether pCRT increases the likelihood of SPS based on changes in tumor height using pelvic magnetic resonance imaging (MRI).MethodsBetween January 2009 and December 2013, 105 patients underwent long-course pCRT for locally advanced distal rectal cancer (≤5 cm from the anal verge) and were included in this study. The surgical procedures were analyzed in terms of radiologic findings, including the distance from the inferior margin of tumor to the superior margin of the anorectal ring (tumor height) measured by pelvic MRI before and after pCRT.ResultsEighty-six (81.9 %) patients underwent SPS. Overall clinical downstaging occurred in 48 (45.7 %) patients. Tumor height increased significantly after pCRT (from 15.0 ± 15.3 to 18.1 ± 16.9 mm, change 3.1 ± 9.7 mm, p = 0.01). The mean change in tumor height was not significantly different between patients who underwent SPS or APR (mean change 3.3 ± 9.6 vs. 2.3 ± 10.5 mm, p = 0.68). The mean change was significantly greater in the double-stapled anastomosis group than in the handsewn anastomosis group (mean change 5.6 ± 9.9 vs. −0.6 ± 8.6 mm, p = 0.02).ConclusionsThis was the first MRI-based longitudinal study to show that pCRT does not appear to increase the likelihood of SPS in locally advanced distal rectal cancer, although it could improve the potential of double-stapled anastomoses. More... »

PAGES

2159-2167

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-014-4286-1

DOI

http://dx.doi.org/10.1245/s10434-014-4286-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038574078

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25503346


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anal Canal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoradiotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Digestive System Surgical Procedures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Longitudinal Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoadjuvant Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Sparing Treatments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Preoperative Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ihn", 
        "givenName": "Myong Hoon", 
        "id": "sg:person.01371165614.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371165614.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Young Hoon", 
        "id": "sg:person.015510376344.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015510376344.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Duck-Woo", 
        "id": "sg:person.01355515405.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355515405.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Heung-Kwon", 
        "id": "sg:person.0632111305.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632111305.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Soo Young", 
        "id": "sg:person.01072536072.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072536072.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Jin Taek", 
        "id": "sg:person.01143561007.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143561007.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Son", 
        "givenName": "Il Tae", 
        "id": "sg:person.01211674207.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211674207.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Ji Hoon", 
        "id": "sg:person.01300550161.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300550161.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Yoon Jin", 
        "id": "sg:person.01104720560.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104720560.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jin Won", 
        "id": "sg:person.014140742307.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014140742307.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Keun-Wook", 
        "id": "sg:person.01222627344.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222627344.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jee Hyun", 
        "id": "sg:person.012332532224.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012332532224.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shin", 
        "givenName": "Eun", 
        "id": "sg:person.01111377733.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111377733.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hye Seung", 
        "id": "sg:person.014357233714.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357233714.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Division of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "Soyeon", 
        "id": "sg:person.0612662613.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612662613.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Sung-Bum", 
        "id": "sg:person.0747637353.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747637353.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00330-013-2864-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034026206", 
          "https://doi.org/10.1007/s00330-013-2864-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003840050072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028995544", 
          "https://doi.org/10.1007/s003840050072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10434-001-0163-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026383263", 
          "https://doi.org/10.1007/s10434-001-0163-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-36374-5_30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005327654", 
          "https://doi.org/10.1007/978-0-387-36374-5_30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-011-2210-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052997255", 
          "https://doi.org/10.1245/s10434-011-2210-5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12-12", 
    "datePublishedReg": "2014-12-12", 
    "description": "Background\nIt is unclear whether preoperative chemoradiotherapy (pCRT) increases the rate of sphincter-preserving surgery (SPS), avoiding abdominoperineal resection (APR), for the treatment of distal rectal cancer. We examined whether pCRT increases the likelihood of SPS based on changes in tumor height using pelvic magnetic resonance imaging (MRI).MethodsBetween January 2009 and December 2013, 105 patients underwent long-course pCRT for locally advanced distal rectal cancer (\u22645\u00a0cm from the anal verge) and were included in this study. The surgical procedures were analyzed in terms of radiologic findings, including the distance from the inferior margin of tumor to the superior margin of the anorectal ring (tumor height) measured by pelvic MRI before and after pCRT.ResultsEighty-six (81.9\u00a0%) patients underwent SPS. Overall clinical downstaging occurred in 48 (45.7\u00a0%) patients. Tumor height increased significantly after pCRT (from 15.0\u00a0\u00b1\u00a015.3 to 18.1\u00a0\u00b1\u00a016.9\u00a0mm, change 3.1\u00a0\u00b1\u00a09.7\u00a0mm, p\u00a0=\u00a00.01). The mean change in tumor height was not significantly different between patients who underwent SPS or APR (mean change 3.3\u00a0\u00b1\u00a09.6 vs. 2.3\u00a0\u00b1\u00a010.5\u00a0mm, p\u00a0=\u00a00.68). The mean change was significantly greater in the double-stapled anastomosis group than in the handsewn anastomosis group (mean change 5.6\u00a0\u00b1\u00a09.9 vs. \u22120.6\u00a0\u00b1\u00a08.6\u00a0mm, p\u00a0=\u00a00.02).ConclusionsThis was the first MRI-based longitudinal study to show that pCRT does not appear to increase the likelihood of SPS in locally advanced distal rectal cancer, although it could improve the potential of double-stapled anastomoses.", 
    "genre": "article", 
    "id": "sg:pub.10.1245/s10434-014-4286-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "keywords": [
      "sphincter-preserving surgery", 
      "advanced distal rectal cancer", 
      "pelvic magnetic resonance imaging", 
      "distal rectal cancer", 
      "magnetic resonance imaging", 
      "preoperative chemoradiotherapy", 
      "rectal cancer", 
      "tumor height", 
      "abdominoperineal resection", 
      "mean change", 
      "long-course preoperative chemoradiotherapy", 
      "double-stapled anastomosis", 
      "resonance imaging", 
      "first magnetic resonance imaging", 
      "sphincter preservation surgery", 
      "longitudinal study", 
      "clinical downstaging", 
      "radiologic findings", 
      "preservation surgery", 
      "anorectal ring", 
      "surgical procedures", 
      "patients", 
      "inferior margin", 
      "superior margin", 
      "cancer", 
      "anastomosis group", 
      "chemoradiotherapy", 
      "surgery", 
      "imaging", 
      "downstaging", 
      "resection", 
      "group", 
      "anastomosis", 
      "ResultsEighty", 
      "tumors", 
      "study", 
      "likelihood", 
      "treatment", 
      "ConclusionsThis", 
      "changes", 
      "findings", 
      "margin", 
      "background", 
      "rate", 
      "effect", 
      "procedure", 
      "height", 
      "potential", 
      "terms", 
      "ring", 
      "distance", 
      "likelihood of SPS", 
      "Overall clinical downstaging", 
      "double-stapled anastomosis group", 
      "Locally Advanced Distal Rectal Cancer"
    ], 
    "name": "Effects of Preoperative Chemoradiotherapy on the Likelihood of Sphincter Preservation Surgery in Locally Advanced Distal Rectal Cancer: A Longitudinal Study Based on Pelvic Magnetic Resonance Imaging", 
    "pagination": "2159-2167", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038574078"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-014-4286-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25503346"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-014-4286-1", 
      "https://app.dimensions.ai/details/publication/pub.1038574078"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_646.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1245/s10434-014-4286-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4286-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4286-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4286-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4286-1'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      22 PREDICATES      108 URIs      94 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-014-4286-1 schema:about N1586836442ea4fed8d473dd810f905cc
2 N3dcfc2974b97472c9d8bd3cc5a472362
3 N4df6631fbaa6439f97fe5db45025653f
4 N57abb83aa83744b79d719999ecb81ca8
5 N5ece3458d609409e907f0533c9c2f172
6 N6a37d57565c24906bf71e4f3cce069a7
7 N6c0619d294574ba2abcf1a416d1c34ec
8 N8de9e0db826b42f6b743723526c86b6d
9 N8f782db3048042bd937cedee608c71bb
10 N9af8afd015244703b77d19513f2972ed
11 Na3cb84a70bcd49888668dcd039c6d2d6
12 Na5b815d548b7438b9e8f8848e001bcd2
13 Na6becd87b5034af9a58bc66b8e0b2397
14 Na96df2a709404d35a296b9a5169dd874
15 Nafc8808b858b4611ae56d0a79a45542d
16 Nb233d84c81fd4347bda85dd576476949
17 Ne669235e4bc14e189c745fa4cc7b3bbe
18 Neab1d11060e842ffb1bb630cb0549d3d
19 Nfc6d739bbd5945e1a75da4f4861cd245
20 Nfd507f9728dc4b988bc788fd57bfbd4e
21 Nfe10a2ce38044d48b77d46549d5731e9
22 anzsrc-for:11
23 anzsrc-for:1103
24 anzsrc-for:1112
25 schema:author N17e4220f9d1e42df8b3ba1b731367c1f
26 schema:citation sg:pub.10.1007/978-0-387-36374-5_30
27 sg:pub.10.1007/s00330-013-2864-4
28 sg:pub.10.1007/s003840050072
29 sg:pub.10.1007/s10434-001-0163-9
30 sg:pub.10.1245/s10434-011-2210-5
31 schema:datePublished 2014-12-12
32 schema:datePublishedReg 2014-12-12
33 schema:description Background It is unclear whether preoperative chemoradiotherapy (pCRT) increases the rate of sphincter-preserving surgery (SPS), avoiding abdominoperineal resection (APR), for the treatment of distal rectal cancer. We examined whether pCRT increases the likelihood of SPS based on changes in tumor height using pelvic magnetic resonance imaging (MRI).MethodsBetween January 2009 and December 2013, 105 patients underwent long-course pCRT for locally advanced distal rectal cancer (≤5 cm from the anal verge) and were included in this study. The surgical procedures were analyzed in terms of radiologic findings, including the distance from the inferior margin of tumor to the superior margin of the anorectal ring (tumor height) measured by pelvic MRI before and after pCRT.ResultsEighty-six (81.9 %) patients underwent SPS. Overall clinical downstaging occurred in 48 (45.7 %) patients. Tumor height increased significantly after pCRT (from 15.0 ± 15.3 to 18.1 ± 16.9 mm, change 3.1 ± 9.7 mm, p = 0.01). The mean change in tumor height was not significantly different between patients who underwent SPS or APR (mean change 3.3 ± 9.6 vs. 2.3 ± 10.5 mm, p = 0.68). The mean change was significantly greater in the double-stapled anastomosis group than in the handsewn anastomosis group (mean change 5.6 ± 9.9 vs. −0.6 ± 8.6 mm, p = 0.02).ConclusionsThis was the first MRI-based longitudinal study to show that pCRT does not appear to increase the likelihood of SPS in locally advanced distal rectal cancer, although it could improve the potential of double-stapled anastomoses.
34 schema:genre article
35 schema:inLanguage en
36 schema:isAccessibleForFree false
37 schema:isPartOf Nb6b4ec0ebe794203a0eaa9da9cb602d6
38 Nd90409dfc12e475e81fae678db425eae
39 sg:journal.1105545
40 schema:keywords ConclusionsThis
41 Locally Advanced Distal Rectal Cancer
42 Overall clinical downstaging
43 ResultsEighty
44 abdominoperineal resection
45 advanced distal rectal cancer
46 anastomosis
47 anastomosis group
48 anorectal ring
49 background
50 cancer
51 changes
52 chemoradiotherapy
53 clinical downstaging
54 distal rectal cancer
55 distance
56 double-stapled anastomosis
57 double-stapled anastomosis group
58 downstaging
59 effect
60 findings
61 first magnetic resonance imaging
62 group
63 height
64 imaging
65 inferior margin
66 likelihood
67 likelihood of SPS
68 long-course preoperative chemoradiotherapy
69 longitudinal study
70 magnetic resonance imaging
71 margin
72 mean change
73 patients
74 pelvic magnetic resonance imaging
75 potential
76 preoperative chemoradiotherapy
77 preservation surgery
78 procedure
79 radiologic findings
80 rate
81 rectal cancer
82 resection
83 resonance imaging
84 ring
85 sphincter preservation surgery
86 sphincter-preserving surgery
87 study
88 superior margin
89 surgery
90 surgical procedures
91 terms
92 treatment
93 tumor height
94 tumors
95 schema:name Effects of Preoperative Chemoradiotherapy on the Likelihood of Sphincter Preservation Surgery in Locally Advanced Distal Rectal Cancer: A Longitudinal Study Based on Pelvic Magnetic Resonance Imaging
96 schema:pagination 2159-2167
97 schema:productId N54acb5dc8a57416494bbdcca3428d16d
98 N5af69a0323494936a38bd1a2508c2bb1
99 N6daab141b9e14c4ab1425d4950094a99
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038574078
101 https://doi.org/10.1245/s10434-014-4286-1
102 schema:sdDatePublished 2021-12-01T19:32
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher Nc3ef53f57a6b4ee3b98501b0b004d1cc
105 schema:url https://doi.org/10.1245/s10434-014-4286-1
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N062d4d6adc364a23933e00b87bc3d6e2 rdf:first sg:person.012332532224.22
110 rdf:rest Ne14b795fa8d54e508b0ee6ce065a84f4
111 N1586836442ea4fed8d473dd810f905cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Antineoplastic Combined Chemotherapy Protocols
113 rdf:type schema:DefinedTerm
114 N17e4220f9d1e42df8b3ba1b731367c1f rdf:first sg:person.01371165614.22
115 rdf:rest N336ba39e20ba4047ac421005d44814f5
116 N22971e69262346ed9ef9ab7956782c45 rdf:first sg:person.01222627344.39
117 rdf:rest N062d4d6adc364a23933e00b87bc3d6e2
118 N25057d6b02864ecf979a0a22adc38ab5 rdf:first sg:person.01072536072.36
119 rdf:rest N7265912a79da482ba09a5ab7a9b51bdc
120 N2a8ace62099a447cb1f2d0a9246edc9d rdf:first sg:person.014140742307.30
121 rdf:rest N22971e69262346ed9ef9ab7956782c45
122 N336ba39e20ba4047ac421005d44814f5 rdf:first sg:person.015510376344.15
123 rdf:rest N8ab558c5d63a4e1084f7853dadd7a467
124 N3dcfc2974b97472c9d8bd3cc5a472362 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Male
126 rdf:type schema:DefinedTerm
127 N4df6631fbaa6439f97fe5db45025653f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Prospective Studies
129 rdf:type schema:DefinedTerm
130 N54acb5dc8a57416494bbdcca3428d16d schema:name dimensions_id
131 schema:value pub.1038574078
132 rdf:type schema:PropertyValue
133 N57abb83aa83744b79d719999ecb81ca8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Neoadjuvant Therapy
135 rdf:type schema:DefinedTerm
136 N591527a66d07438bb5a2dd5621e63fa9 rdf:first sg:person.01211674207.31
137 rdf:rest N777bb5e16b044b3daadc6bca726d4d61
138 N5af69a0323494936a38bd1a2508c2bb1 schema:name doi
139 schema:value 10.1245/s10434-014-4286-1
140 rdf:type schema:PropertyValue
141 N5ece3458d609409e907f0533c9c2f172 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Prognosis
143 rdf:type schema:DefinedTerm
144 N5f77c544b6df49b8b47886cb59763933 rdf:first sg:person.0612662613.04
145 rdf:rest Ne5221fb4e8d04e67b3ee6f3c21761f8a
146 N6a37d57565c24906bf71e4f3cce069a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Preoperative Care
148 rdf:type schema:DefinedTerm
149 N6c0619d294574ba2abcf1a416d1c34ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Chemoradiotherapy
151 rdf:type schema:DefinedTerm
152 N6daab141b9e14c4ab1425d4950094a99 schema:name pubmed_id
153 schema:value 25503346
154 rdf:type schema:PropertyValue
155 N7265912a79da482ba09a5ab7a9b51bdc rdf:first sg:person.01143561007.81
156 rdf:rest N591527a66d07438bb5a2dd5621e63fa9
157 N777bb5e16b044b3daadc6bca726d4d61 rdf:first sg:person.01300550161.94
158 rdf:rest N77c90a5198924f42bba6177f9e741a68
159 N77c90a5198924f42bba6177f9e741a68 rdf:first sg:person.01104720560.84
160 rdf:rest N2a8ace62099a447cb1f2d0a9246edc9d
161 N8ab558c5d63a4e1084f7853dadd7a467 rdf:first sg:person.01355515405.70
162 rdf:rest Na6d81639cd1c40899084dff04dff53b6
163 N8de9e0db826b42f6b743723526c86b6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Anal Canal
165 rdf:type schema:DefinedTerm
166 N8f782db3048042bd937cedee608c71bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Follow-Up Studies
168 rdf:type schema:DefinedTerm
169 N9af8afd015244703b77d19513f2972ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Aged
171 rdf:type schema:DefinedTerm
172 Na3cb84a70bcd49888668dcd039c6d2d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Organ Sparing Treatments
174 rdf:type schema:DefinedTerm
175 Na5b815d548b7438b9e8f8848e001bcd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Retrospective Studies
177 rdf:type schema:DefinedTerm
178 Na6becd87b5034af9a58bc66b8e0b2397 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Neoplasm Staging
180 rdf:type schema:DefinedTerm
181 Na6d81639cd1c40899084dff04dff53b6 rdf:first sg:person.0632111305.12
182 rdf:rest N25057d6b02864ecf979a0a22adc38ab5
183 Na96df2a709404d35a296b9a5169dd874 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Humans
185 rdf:type schema:DefinedTerm
186 Nafc8808b858b4611ae56d0a79a45542d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Rectal Neoplasms
188 rdf:type schema:DefinedTerm
189 Nb233d84c81fd4347bda85dd576476949 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Female
191 rdf:type schema:DefinedTerm
192 Nb6b4ec0ebe794203a0eaa9da9cb602d6 schema:issueNumber 7
193 rdf:type schema:PublicationIssue
194 Nc3c9e537fb2a46f886a4f8ce7a20ff77 rdf:first sg:person.014357233714.08
195 rdf:rest N5f77c544b6df49b8b47886cb59763933
196 Nc3ef53f57a6b4ee3b98501b0b004d1cc schema:name Springer Nature - SN SciGraph project
197 rdf:type schema:Organization
198 Nd90409dfc12e475e81fae678db425eae schema:volumeNumber 22
199 rdf:type schema:PublicationVolume
200 Ne14b795fa8d54e508b0ee6ce065a84f4 rdf:first sg:person.01111377733.12
201 rdf:rest Nc3c9e537fb2a46f886a4f8ce7a20ff77
202 Ne5221fb4e8d04e67b3ee6f3c21761f8a rdf:first sg:person.0747637353.34
203 rdf:rest rdf:nil
204 Ne669235e4bc14e189c745fa4cc7b3bbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Middle Aged
206 rdf:type schema:DefinedTerm
207 Neab1d11060e842ffb1bb630cb0549d3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Digestive System Surgical Procedures
209 rdf:type schema:DefinedTerm
210 Nfc6d739bbd5945e1a75da4f4861cd245 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Adenocarcinoma
212 rdf:type schema:DefinedTerm
213 Nfd507f9728dc4b988bc788fd57bfbd4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Longitudinal Studies
215 rdf:type schema:DefinedTerm
216 Nfe10a2ce38044d48b77d46549d5731e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Combined Modality Therapy
218 rdf:type schema:DefinedTerm
219 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
220 schema:name Medical and Health Sciences
221 rdf:type schema:DefinedTerm
222 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
223 schema:name Clinical Sciences
224 rdf:type schema:DefinedTerm
225 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
226 schema:name Oncology and Carcinogenesis
227 rdf:type schema:DefinedTerm
228 sg:journal.1105545 schema:issn 1068-9265
229 1534-4681
230 schema:name Annals of Surgical Oncology
231 schema:publisher Springer Nature
232 rdf:type schema:Periodical
233 sg:person.01072536072.36 schema:affiliation grid-institutes:grid.412480.b
234 schema:familyName Lee
235 schema:givenName Soo Young
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072536072.36
237 rdf:type schema:Person
238 sg:person.01104720560.84 schema:affiliation grid-institutes:grid.412480.b
239 schema:familyName Lee
240 schema:givenName Yoon Jin
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104720560.84
242 rdf:type schema:Person
243 sg:person.01111377733.12 schema:affiliation grid-institutes:grid.412480.b
244 schema:familyName Shin
245 schema:givenName Eun
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111377733.12
247 rdf:type schema:Person
248 sg:person.01143561007.81 schema:affiliation grid-institutes:grid.412480.b
249 schema:familyName Park
250 schema:givenName Jin Taek
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143561007.81
252 rdf:type schema:Person
253 sg:person.01211674207.31 schema:affiliation grid-institutes:grid.412480.b
254 schema:familyName Son
255 schema:givenName Il Tae
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211674207.31
257 rdf:type schema:Person
258 sg:person.01222627344.39 schema:affiliation grid-institutes:grid.412480.b
259 schema:familyName Lee
260 schema:givenName Keun-Wook
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222627344.39
262 rdf:type schema:Person
263 sg:person.012332532224.22 schema:affiliation grid-institutes:grid.412480.b
264 schema:familyName Kim
265 schema:givenName Jee Hyun
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012332532224.22
267 rdf:type schema:Person
268 sg:person.01300550161.94 schema:affiliation grid-institutes:grid.412480.b
269 schema:familyName Park
270 schema:givenName Ji Hoon
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300550161.94
272 rdf:type schema:Person
273 sg:person.01355515405.70 schema:affiliation grid-institutes:grid.412480.b
274 schema:familyName Kim
275 schema:givenName Duck-Woo
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355515405.70
277 rdf:type schema:Person
278 sg:person.01371165614.22 schema:affiliation grid-institutes:grid.412480.b
279 schema:familyName Ihn
280 schema:givenName Myong Hoon
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371165614.22
282 rdf:type schema:Person
283 sg:person.014140742307.30 schema:affiliation grid-institutes:grid.412480.b
284 schema:familyName Kim
285 schema:givenName Jin Won
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014140742307.30
287 rdf:type schema:Person
288 sg:person.014357233714.08 schema:affiliation grid-institutes:grid.412480.b
289 schema:familyName Lee
290 schema:givenName Hye Seung
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357233714.08
292 rdf:type schema:Person
293 sg:person.015510376344.15 schema:affiliation grid-institutes:grid.412480.b
294 schema:familyName Kim
295 schema:givenName Young Hoon
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015510376344.15
297 rdf:type schema:Person
298 sg:person.0612662613.04 schema:affiliation grid-institutes:grid.412480.b
299 schema:familyName Ahn
300 schema:givenName Soyeon
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612662613.04
302 rdf:type schema:Person
303 sg:person.0632111305.12 schema:affiliation grid-institutes:grid.412480.b
304 schema:familyName Oh
305 schema:givenName Heung-Kwon
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632111305.12
307 rdf:type schema:Person
308 sg:person.0747637353.34 schema:affiliation grid-institutes:grid.412480.b
309 schema:familyName Kang
310 schema:givenName Sung-Bum
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747637353.34
312 rdf:type schema:Person
313 sg:pub.10.1007/978-0-387-36374-5_30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005327654
314 https://doi.org/10.1007/978-0-387-36374-5_30
315 rdf:type schema:CreativeWork
316 sg:pub.10.1007/s00330-013-2864-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034026206
317 https://doi.org/10.1007/s00330-013-2864-4
318 rdf:type schema:CreativeWork
319 sg:pub.10.1007/s003840050072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028995544
320 https://doi.org/10.1007/s003840050072
321 rdf:type schema:CreativeWork
322 sg:pub.10.1007/s10434-001-0163-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026383263
323 https://doi.org/10.1007/s10434-001-0163-9
324 rdf:type schema:CreativeWork
325 sg:pub.10.1245/s10434-011-2210-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052997255
326 https://doi.org/10.1245/s10434-011-2210-5
327 rdf:type schema:CreativeWork
328 grid-institutes:grid.412480.b schema:alternateName Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
329 Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
330 Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
331 Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea
332 Division of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Korea
333 schema:name Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
334 Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
335 Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
336 Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea
337 Division of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Korea
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...