Local Recurrence in the Neck and Survival After Thyroidectomy for Metastatic Renal Cell Carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-12-04

AUTHORS

Igors Iesalnieks, Andreas Machens, Claudia Bures, Detlef Krenz, Hauke Winter, Christian Vorländer, Evelyne Bareck, Pier F. Alesina, Thomas Musholt, Thomas Steinmüller, Matthias Anthuber, Peter Goretzki, Arnold Trupka, Max Mayr, Theresia Weber, Hans J. Schlitt, Henning Dralle, Michael Hermann, Ayman Agha

ABSTRACT

BackgroundMost investigations of thyroidectomy for metastatic renal cell carcinoma (RCC) are case studies or small series. This study was conducted to determine the contribution of clinical and histopathologic variables to local recurrence in the neck and overall survival after thyroidectomy for RCC metastases.MethodsThe medical records of 140 patients with thyroidectomy for metastatic RCC performed between 1979 and 2012 at 25 institutions in Germany and Austria were analyzed.Results The median interval between nephrectomy and thyroidectomy was 120 months. Concurrence of thyroid and pancreatic metastases was present in 23 % of the patients and concurrence of thyroid and adrenal metastases in 13 % of the patients. Clinical outcome data were available for 130 patients with a median follow-up period of 34 months. The 5-year overall survival rate was 46 %, and 28 % of patients developed a local neck recurrence at a median of 12 months after thyroidectomy. Multivariate analysis showed that invasion of adjacent cervical structures (hazard ratio [HR] 3.2; p = 0.001), patient age exceeding 70 years (HR 2.5; p = 0.004), and current or past evidence of metastases to nonendocrine organs (HR 2.4; p = 0.003) were independent determinants of inferior overall survival. Conversely, invasion of adjacent cervical structures (HR 12.1; p < 0.0001) and year of thyroidectomy (HR 5.7 before 2000; p < 0.0001) were shown to be independently associated with local recurrence in the neck by multivariate analysis.Conclusions Although significant improvement of local disease control in patients with thyroid metastases of RCC has been achieved during the last decade, overall outcome continues to be poor for patients with locally invasive thyroid metastases. More... »

PAGES

1798-1805

References to SciGraph publications

Journal

TITLE

Annals of Surgical Oncology

ISSUE

6

VOLUME

22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-014-4266-5

DOI

http://dx.doi.org/10.1245/s10434-014-4266-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020387057

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25472649


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Renal Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neck", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroidectomy", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Klinikum Bogenhausen Munich, Englschalkinger Strasse 77, 81925, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.414523.5", 
          "name": [
            "Department of Surgery, University of Regensburg, Regensburg, Germany", 
            "Department of Surgery, Klinikum Bogenhausen Munich, Englschalkinger Strasse 77, 81925, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iesalnieks", 
        "givenName": "Igors", 
        "id": "sg:person.01370145063.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370145063.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, University of Halle (Saale), Halle, Germany", 
          "id": "http://www.grid.ac/institutes/grid.9018.0", 
          "name": [
            "Department of Surgery, University of Halle (Saale), Halle, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Machens", 
        "givenName": "Andreas", 
        "id": "sg:person.0707663341.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707663341.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Krankenanstalt Rudolfstiftung, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.413303.6", 
          "name": [
            "Department of Surgery, Krankenanstalt Rudolfstiftung, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bures", 
        "givenName": "Claudia", 
        "id": "sg:person.01340065504.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340065504.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Klinikum Dritter Orden, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Surgery, Klinikum Dritter Orden, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krenz", 
        "givenName": "Detlef", 
        "id": "sg:person.0647316225.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647316225.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Klinikum Grosshadern, LMU, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411095.8", 
          "name": [
            "Department of Surgery, Klinikum Grosshadern, LMU, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winter", 
        "givenName": "Hauke", 
        "id": "sg:person.0767175335.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767175335.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrine Surgery, B\u00fcrgerhospital Frankfurt/Main, Frankfurt, Germany", 
          "id": "http://www.grid.ac/institutes/grid.500078.a", 
          "name": [
            "Department of Endocrine Surgery, B\u00fcrgerhospital Frankfurt/Main, Frankfurt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vorl\u00e4nder", 
        "givenName": "Christian", 
        "id": "sg:person.0631552647.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631552647.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Landesklinikum Wiener Neustadt, Neustadt, Austria", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Surgery, Landesklinikum Wiener Neustadt, Neustadt, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bareck", 
        "givenName": "Evelyne", 
        "id": "sg:person.01145414055.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145414055.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinik f\u00fcr Chirurgie und Zentrum f\u00fcr Minimal Invasive Chirurgie, Kliniken Essen-Mitte, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.461714.1", 
          "name": [
            "Klinik f\u00fcr Chirurgie und Zentrum f\u00fcr Minimal Invasive Chirurgie, Kliniken Essen-Mitte, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alesina", 
        "givenName": "Pier F.", 
        "id": "sg:person.01053047413.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053047413.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, University of Mainz, Mainz, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5802.f", 
          "name": [
            "Department of Surgery, University of Mainz, Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Musholt", 
        "givenName": "Thomas", 
        "id": "sg:person.01235603113.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235603113.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, DRK Kliniken Berlin Westend, Berlin, Germany", 
          "id": "http://www.grid.ac/institutes/grid.433743.4", 
          "name": [
            "Department of Surgery, DRK Kliniken Berlin Westend, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steinm\u00fcller", 
        "givenName": "Thomas", 
        "id": "sg:person.013705117434.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013705117434.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General, Visceral and Transplantation Surgery, Zentralklinikum Augsburg, Augsburg, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of General, Visceral and Transplantation Surgery, Zentralklinikum Augsburg, Augsburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anthuber", 
        "givenName": "Matthias", 
        "id": "sg:person.01243757517.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243757517.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery I, Lukaskrankenhaus Neuss, Neuss, Germany", 
          "id": "http://www.grid.ac/institutes/grid.416164.0", 
          "name": [
            "Department of Surgery I, Lukaskrankenhaus Neuss, Neuss, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goretzki", 
        "givenName": "Peter", 
        "id": "sg:person.01076650120.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076650120.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Klinikum Starnberg, Starnberg, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Surgery, Klinikum Starnberg, Starnberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trupka", 
        "givenName": "Arnold", 
        "id": "sg:person.0735564416.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735564416.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Krankenhaus der Barmherzigen Br\u00fcder, Regensburg, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Surgery, Krankenhaus der Barmherzigen Br\u00fcder, Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayr", 
        "givenName": "Max", 
        "id": "sg:person.01265503555.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265503555.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrine Surgery, Katholisches Klinikum Mainz, Mainz, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Endocrine Surgery, Katholisches Klinikum Mainz, Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weber", 
        "givenName": "Theresia", 
        "id": "sg:person.0763175511.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763175511.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, University of Regensburg, Regensburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7727.5", 
          "name": [
            "Department of Surgery, University of Regensburg, Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlitt", 
        "givenName": "Hans J.", 
        "id": "sg:person.010361144542.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010361144542.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Klinikum Bogenhausen Munich, Englschalkinger Strasse 77, 81925, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.414523.5", 
          "name": [
            "Department of Surgery, Klinikum Bogenhausen Munich, Englschalkinger Strasse 77, 81925, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dralle", 
        "givenName": "Henning", 
        "id": "sg:person.0761262105.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761262105.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, University of Halle (Saale), Halle, Germany", 
          "id": "http://www.grid.ac/institutes/grid.9018.0", 
          "name": [
            "Department of Surgery, University of Halle (Saale), Halle, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hermann", 
        "givenName": "Michael", 
        "id": "sg:person.01362143765.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362143765.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Klinikum Bogenhausen Munich, Englschalkinger Strasse 77, 81925, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.414523.5", 
          "name": [
            "Department of Surgery, University of Regensburg, Regensburg, Germany", 
            "Department of Surgery, Klinikum Bogenhausen Munich, Englschalkinger Strasse 77, 81925, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agha", 
        "givenName": "Ayman", 
        "id": "sg:person.0641357463.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641357463.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11605-013-2278-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014301896", 
          "https://doi.org/10.1007/s11605-013-2278-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12-04", 
    "datePublishedReg": "2014-12-04", 
    "description": "BackgroundMost investigations of thyroidectomy for metastatic renal cell carcinoma (RCC) are case studies or small series. This study was conducted to determine the contribution of clinical and histopathologic variables to local recurrence in the neck and overall survival after thyroidectomy for RCC metastases.MethodsThe medical records of 140 patients with thyroidectomy for metastatic RCC performed between 1979 and 2012 at 25 institutions in Germany and Austria were analyzed.Results The median interval between nephrectomy and thyroidectomy was 120\u00a0months. Concurrence of thyroid and pancreatic metastases was present in 23\u00a0% of the patients and concurrence of thyroid and adrenal metastases in 13\u00a0% of the patients. Clinical outcome data were available for 130 patients with a median follow-up period of 34\u00a0months. The 5-year overall survival rate was 46\u00a0%, and 28\u00a0% of patients developed a local neck recurrence at a median of 12\u00a0months after thyroidectomy. Multivariate analysis showed that invasion of adjacent cervical structures (hazard ratio [HR] 3.2; p\u00a0=\u00a00.001), patient age exceeding 70\u00a0years (HR 2.5; p\u00a0=\u00a00.004), and current or past evidence of metastases to nonendocrine organs (HR 2.4; p\u00a0=\u00a00.003) were independent determinants of inferior overall survival. Conversely, invasion of adjacent cervical structures (HR 12.1; p\u00a0<\u00a00.0001) and year of thyroidectomy (HR 5.7 before 2000; p\u00a0<\u00a00.0001) were shown to be independently associated with local recurrence in the neck by multivariate analysis.Conclusions\nAlthough significant improvement of local disease control in patients with thyroid metastases of RCC has been achieved during the last decade, overall outcome continues to be poor for patients with locally invasive thyroid metastases.", 
    "genre": "article", 
    "id": "sg:pub.10.1245/s10434-014-4266-5", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "keywords": [
      "metastatic renal cell carcinoma", 
      "renal cell carcinoma", 
      "local recurrence", 
      "thyroid metastasis", 
      "overall survival", 
      "cell carcinoma", 
      "cervical structures", 
      "multivariate analysis", 
      "MethodsThe medical records", 
      "local neck recurrence", 
      "year of thyroidectomy", 
      "local disease control", 
      "overall survival rate", 
      "inferior overall survival", 
      "clinical outcome data", 
      "median follow", 
      "neck recurrence", 
      "adrenal metastasis", 
      "median interval", 
      "pancreatic metastasis", 
      "patient age", 
      "independent determinants", 
      "RCC metastasis", 
      "medical records", 
      "histopathologic variables", 
      "thyroidectomy", 
      "outcome data", 
      "patients", 
      "small series", 
      "metastasis", 
      "survival rate", 
      "recurrence", 
      "overall outcome", 
      "Disease Control", 
      "neck", 
      "months", 
      "carcinoma", 
      "survival", 
      "thyroid", 
      "significant improvement", 
      "invasion", 
      "nephrectomy", 
      "follow", 
      "years", 
      "median", 
      "outcomes", 
      "age", 
      "past evidence", 
      "organs", 
      "study", 
      "conclusion", 
      "concurrence", 
      "last decade", 
      "intervals", 
      "evidence", 
      "determinants", 
      "period", 
      "control", 
      "records", 
      "rate", 
      "analysis", 
      "improvement", 
      "institutions", 
      "data", 
      "variables", 
      "investigation", 
      "decades", 
      "series", 
      "results", 
      "Austria", 
      "Germany", 
      "contribution", 
      "structure", 
      "case study", 
      "BackgroundMost investigations", 
      "Concurrence of thyroid", 
      "adjacent cervical structures", 
      "invasive thyroid metastases"
    ], 
    "name": "Local Recurrence in the Neck and Survival After Thyroidectomy for Metastatic Renal Cell Carcinoma", 
    "pagination": "1798-1805", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020387057"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-014-4266-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25472649"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-014-4266-5", 
      "https://app.dimensions.ai/details/publication/pub.1020387057"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_642.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1245/s10434-014-4266-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4266-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4266-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4266-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4266-5'


 

This table displays all metadata directly associated to this object as RDF triples.

379 TRIPLES      22 PREDICATES      122 URIs      113 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-014-4266-5 schema:about N05b44595e6c3484b8072b0853c78d5ad
2 N084c7fcab501443baeb033105ad1ee61
3 N1f722275bd684c0585d651ecb1a023f9
4 N2bcd61c6fccb4f0198e95d237566c273
5 N356bd361fdfb4cddbeebece43d379c09
6 N433005aa668148528568657259616190
7 N4880962d9f354a909805af37adee015d
8 N515d4c357f2d44dca95da33a70b59deb
9 N625141ade38d4ff2b95fa0c5df404590
10 N62fb3f76efd548459f5828fb891f7c82
11 Na559807d447b408888fe3f21fe64c6da
12 Na635b1c23e29496c954fe3012d9898ca
13 Na6658690d3344d249534ac1f0159ad6b
14 Nd021f13fef354d2f8be140115a714832
15 Nd6dc7b40729a4910adac82a59c9d6350
16 Ne5e923be2a6f48ba85a49b5a97ed081f
17 Nfdc37363d4494bebada5c6180104e31d
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author N34d0405997914023b8fc557b1eae24cc
21 schema:citation sg:pub.10.1007/s11605-013-2278-2
22 schema:datePublished 2014-12-04
23 schema:datePublishedReg 2014-12-04
24 schema:description BackgroundMost investigations of thyroidectomy for metastatic renal cell carcinoma (RCC) are case studies or small series. This study was conducted to determine the contribution of clinical and histopathologic variables to local recurrence in the neck and overall survival after thyroidectomy for RCC metastases.MethodsThe medical records of 140 patients with thyroidectomy for metastatic RCC performed between 1979 and 2012 at 25 institutions in Germany and Austria were analyzed.Results The median interval between nephrectomy and thyroidectomy was 120 months. Concurrence of thyroid and pancreatic metastases was present in 23 % of the patients and concurrence of thyroid and adrenal metastases in 13 % of the patients. Clinical outcome data were available for 130 patients with a median follow-up period of 34 months. The 5-year overall survival rate was 46 %, and 28 % of patients developed a local neck recurrence at a median of 12 months after thyroidectomy. Multivariate analysis showed that invasion of adjacent cervical structures (hazard ratio [HR] 3.2; p = 0.001), patient age exceeding 70 years (HR 2.5; p = 0.004), and current or past evidence of metastases to nonendocrine organs (HR 2.4; p = 0.003) were independent determinants of inferior overall survival. Conversely, invasion of adjacent cervical structures (HR 12.1; p < 0.0001) and year of thyroidectomy (HR 5.7 before 2000; p < 0.0001) were shown to be independently associated with local recurrence in the neck by multivariate analysis.Conclusions Although significant improvement of local disease control in patients with thyroid metastases of RCC has been achieved during the last decade, overall outcome continues to be poor for patients with locally invasive thyroid metastases.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree false
28 schema:isPartOf N1815627416964354a3d9569a3974d669
29 N5763309bd3844db982f036a7f3bc58cb
30 sg:journal.1105545
31 schema:keywords Austria
32 BackgroundMost investigations
33 Concurrence of thyroid
34 Disease Control
35 Germany
36 MethodsThe medical records
37 RCC metastasis
38 adjacent cervical structures
39 adrenal metastasis
40 age
41 analysis
42 carcinoma
43 case study
44 cell carcinoma
45 cervical structures
46 clinical outcome data
47 conclusion
48 concurrence
49 contribution
50 control
51 data
52 decades
53 determinants
54 evidence
55 follow
56 histopathologic variables
57 improvement
58 independent determinants
59 inferior overall survival
60 institutions
61 intervals
62 invasion
63 invasive thyroid metastases
64 investigation
65 last decade
66 local disease control
67 local neck recurrence
68 local recurrence
69 median
70 median follow
71 median interval
72 medical records
73 metastasis
74 metastatic renal cell carcinoma
75 months
76 multivariate analysis
77 neck
78 neck recurrence
79 nephrectomy
80 organs
81 outcome data
82 outcomes
83 overall outcome
84 overall survival
85 overall survival rate
86 pancreatic metastasis
87 past evidence
88 patient age
89 patients
90 period
91 rate
92 records
93 recurrence
94 renal cell carcinoma
95 results
96 series
97 significant improvement
98 small series
99 structure
100 study
101 survival
102 survival rate
103 thyroid
104 thyroid metastasis
105 thyroidectomy
106 variables
107 year of thyroidectomy
108 years
109 schema:name Local Recurrence in the Neck and Survival After Thyroidectomy for Metastatic Renal Cell Carcinoma
110 schema:pagination 1798-1805
111 schema:productId N4332b29c141740bd922002c7957d1532
112 N581713295f5b4faf8d71e98d14ae47ae
113 N75986cbb11ca4897bb98b11019626f29
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020387057
115 https://doi.org/10.1245/s10434-014-4266-5
116 schema:sdDatePublished 2022-01-01T18:34
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher Nd66f7ad92f3a46b695af2837c0f8dc7a
119 schema:url https://doi.org/10.1245/s10434-014-4266-5
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N028116942e8448e4b6b7cbfb300a7283 rdf:first sg:person.0735564416.70
124 rdf:rest Nbe3623d5a6424397a03064acd106498c
125 N05b44595e6c3484b8072b0853c78d5ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N084c7fcab501443baeb033105ad1ee61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Aged, 80 and over
130 rdf:type schema:DefinedTerm
131 N0d306af8fa2445b29875283297c374e5 rdf:first sg:person.0631552647.71
132 rdf:rest N4d18abca1b2f455eb2ac2e73d442db56
133 N0e54bded725347db8dc2c2c5778e5116 rdf:first sg:person.01053047413.74
134 rdf:rest Nef20b12c0866454fa2df849f3aff6547
135 N1815627416964354a3d9569a3974d669 schema:issueNumber 6
136 rdf:type schema:PublicationIssue
137 N1adc6d873ac448939eca65ab42855cac rdf:first sg:person.0647316225.40
138 rdf:rest N7fcf7ac8398a4a8b8a5daedecb1f54f9
139 N1f722275bd684c0585d651ecb1a023f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Neoplasm Recurrence, Local
141 rdf:type schema:DefinedTerm
142 N20271a61f3694e50b306a3205989c867 rdf:first sg:person.010361144542.53
143 rdf:rest N98636f1aa6dd44b9b99482c99e8880e1
144 N2ad622ebd91643359556f77b86ade267 rdf:first sg:person.013705117434.77
145 rdf:rest Nb0b73f2bcb1f4ffd9a987c094f4d677f
146 N2bcd61c6fccb4f0198e95d237566c273 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Middle Aged
148 rdf:type schema:DefinedTerm
149 N34d0405997914023b8fc557b1eae24cc rdf:first sg:person.01370145063.07
150 rdf:rest N8098bdfed012435bb96c04cc08d7c854
151 N356bd361fdfb4cddbeebece43d379c09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Follow-Up Studies
153 rdf:type schema:DefinedTerm
154 N433005aa668148528568657259616190 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Kidney Neoplasms
156 rdf:type schema:DefinedTerm
157 N4332b29c141740bd922002c7957d1532 schema:name pubmed_id
158 schema:value 25472649
159 rdf:type schema:PropertyValue
160 N4880962d9f354a909805af37adee015d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Neck
162 rdf:type schema:DefinedTerm
163 N4d18abca1b2f455eb2ac2e73d442db56 rdf:first sg:person.01145414055.94
164 rdf:rest N0e54bded725347db8dc2c2c5778e5116
165 N505e29cd5a1142c6b2527574d52aa4f8 rdf:first sg:person.01076650120.88
166 rdf:rest N028116942e8448e4b6b7cbfb300a7283
167 N515d4c357f2d44dca95da33a70b59deb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Female
169 rdf:type schema:DefinedTerm
170 N5763309bd3844db982f036a7f3bc58cb schema:volumeNumber 22
171 rdf:type schema:PublicationVolume
172 N581713295f5b4faf8d71e98d14ae47ae schema:name dimensions_id
173 schema:value pub.1020387057
174 rdf:type schema:PropertyValue
175 N60864b1e18074c4bb5f5f6da0a16f226 rdf:first sg:person.01362143765.03
176 rdf:rest Nd43c025b3cc3434a9343013a8b2e0d9d
177 N625141ade38d4ff2b95fa0c5df404590 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Survival Rate
179 rdf:type schema:DefinedTerm
180 N62fb3f76efd548459f5828fb891f7c82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Thyroidectomy
182 rdf:type schema:DefinedTerm
183 N75986cbb11ca4897bb98b11019626f29 schema:name doi
184 schema:value 10.1245/s10434-014-4266-5
185 rdf:type schema:PropertyValue
186 N759d380e318d46549fcba194cf4eda02 rdf:first sg:person.01340065504.12
187 rdf:rest N1adc6d873ac448939eca65ab42855cac
188 N7fcf7ac8398a4a8b8a5daedecb1f54f9 rdf:first sg:person.0767175335.25
189 rdf:rest N0d306af8fa2445b29875283297c374e5
190 N8098bdfed012435bb96c04cc08d7c854 rdf:first sg:person.0707663341.94
191 rdf:rest N759d380e318d46549fcba194cf4eda02
192 N98636f1aa6dd44b9b99482c99e8880e1 rdf:first sg:person.0761262105.04
193 rdf:rest N60864b1e18074c4bb5f5f6da0a16f226
194 Na559807d447b408888fe3f21fe64c6da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Prognosis
196 rdf:type schema:DefinedTerm
197 Na635b1c23e29496c954fe3012d9898ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Male
199 rdf:type schema:DefinedTerm
200 Na6658690d3344d249534ac1f0159ad6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Lymphatic Metastasis
202 rdf:type schema:DefinedTerm
203 Nb0b73f2bcb1f4ffd9a987c094f4d677f rdf:first sg:person.01243757517.26
204 rdf:rest N505e29cd5a1142c6b2527574d52aa4f8
205 Nbe3623d5a6424397a03064acd106498c rdf:first sg:person.01265503555.38
206 rdf:rest Ne539ee80c7c14bd6938b12dcd1e8f8f4
207 Nd021f13fef354d2f8be140115a714832 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Carcinoma, Renal Cell
209 rdf:type schema:DefinedTerm
210 Nd43c025b3cc3434a9343013a8b2e0d9d rdf:first sg:person.0641357463.07
211 rdf:rest rdf:nil
212 Nd66f7ad92f3a46b695af2837c0f8dc7a schema:name Springer Nature - SN SciGraph project
213 rdf:type schema:Organization
214 Nd6dc7b40729a4910adac82a59c9d6350 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Neoplasm Staging
216 rdf:type schema:DefinedTerm
217 Ne539ee80c7c14bd6938b12dcd1e8f8f4 rdf:first sg:person.0763175511.29
218 rdf:rest N20271a61f3694e50b306a3205989c867
219 Ne5e923be2a6f48ba85a49b5a97ed081f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Thyroid Neoplasms
221 rdf:type schema:DefinedTerm
222 Nef20b12c0866454fa2df849f3aff6547 rdf:first sg:person.01235603113.45
223 rdf:rest N2ad622ebd91643359556f77b86ade267
224 Nfdc37363d4494bebada5c6180104e31d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Aged
226 rdf:type schema:DefinedTerm
227 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
228 schema:name Medical and Health Sciences
229 rdf:type schema:DefinedTerm
230 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
231 schema:name Oncology and Carcinogenesis
232 rdf:type schema:DefinedTerm
233 sg:journal.1105545 schema:issn 1068-9265
234 1534-4681
235 schema:name Annals of Surgical Oncology
236 schema:publisher Springer Nature
237 rdf:type schema:Periodical
238 sg:person.010361144542.53 schema:affiliation grid-institutes:grid.7727.5
239 schema:familyName Schlitt
240 schema:givenName Hans J.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010361144542.53
242 rdf:type schema:Person
243 sg:person.01053047413.74 schema:affiliation grid-institutes:grid.461714.1
244 schema:familyName Alesina
245 schema:givenName Pier F.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053047413.74
247 rdf:type schema:Person
248 sg:person.01076650120.88 schema:affiliation grid-institutes:grid.416164.0
249 schema:familyName Goretzki
250 schema:givenName Peter
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076650120.88
252 rdf:type schema:Person
253 sg:person.01145414055.94 schema:affiliation grid-institutes:None
254 schema:familyName Bareck
255 schema:givenName Evelyne
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145414055.94
257 rdf:type schema:Person
258 sg:person.01235603113.45 schema:affiliation grid-institutes:grid.5802.f
259 schema:familyName Musholt
260 schema:givenName Thomas
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235603113.45
262 rdf:type schema:Person
263 sg:person.01243757517.26 schema:affiliation grid-institutes:None
264 schema:familyName Anthuber
265 schema:givenName Matthias
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243757517.26
267 rdf:type schema:Person
268 sg:person.01265503555.38 schema:affiliation grid-institutes:None
269 schema:familyName Mayr
270 schema:givenName Max
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265503555.38
272 rdf:type schema:Person
273 sg:person.01340065504.12 schema:affiliation grid-institutes:grid.413303.6
274 schema:familyName Bures
275 schema:givenName Claudia
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340065504.12
277 rdf:type schema:Person
278 sg:person.01362143765.03 schema:affiliation grid-institutes:grid.9018.0
279 schema:familyName Hermann
280 schema:givenName Michael
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362143765.03
282 rdf:type schema:Person
283 sg:person.01370145063.07 schema:affiliation grid-institutes:grid.414523.5
284 schema:familyName Iesalnieks
285 schema:givenName Igors
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370145063.07
287 rdf:type schema:Person
288 sg:person.013705117434.77 schema:affiliation grid-institutes:grid.433743.4
289 schema:familyName Steinmüller
290 schema:givenName Thomas
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013705117434.77
292 rdf:type schema:Person
293 sg:person.0631552647.71 schema:affiliation grid-institutes:grid.500078.a
294 schema:familyName Vorländer
295 schema:givenName Christian
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631552647.71
297 rdf:type schema:Person
298 sg:person.0641357463.07 schema:affiliation grid-institutes:grid.414523.5
299 schema:familyName Agha
300 schema:givenName Ayman
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641357463.07
302 rdf:type schema:Person
303 sg:person.0647316225.40 schema:affiliation grid-institutes:None
304 schema:familyName Krenz
305 schema:givenName Detlef
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647316225.40
307 rdf:type schema:Person
308 sg:person.0707663341.94 schema:affiliation grid-institutes:grid.9018.0
309 schema:familyName Machens
310 schema:givenName Andreas
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707663341.94
312 rdf:type schema:Person
313 sg:person.0735564416.70 schema:affiliation grid-institutes:None
314 schema:familyName Trupka
315 schema:givenName Arnold
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735564416.70
317 rdf:type schema:Person
318 sg:person.0761262105.04 schema:affiliation grid-institutes:grid.414523.5
319 schema:familyName Dralle
320 schema:givenName Henning
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761262105.04
322 rdf:type schema:Person
323 sg:person.0763175511.29 schema:affiliation grid-institutes:None
324 schema:familyName Weber
325 schema:givenName Theresia
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763175511.29
327 rdf:type schema:Person
328 sg:person.0767175335.25 schema:affiliation grid-institutes:grid.411095.8
329 schema:familyName Winter
330 schema:givenName Hauke
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767175335.25
332 rdf:type schema:Person
333 sg:pub.10.1007/s11605-013-2278-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014301896
334 https://doi.org/10.1007/s11605-013-2278-2
335 rdf:type schema:CreativeWork
336 grid-institutes:None schema:alternateName Department of Endocrine Surgery, Katholisches Klinikum Mainz, Mainz, Germany
337 Department of General, Visceral and Transplantation Surgery, Zentralklinikum Augsburg, Augsburg, Germany
338 Department of Surgery, Klinikum Dritter Orden, Munich, Germany
339 Department of Surgery, Klinikum Starnberg, Starnberg, Germany
340 Department of Surgery, Krankenhaus der Barmherzigen Brüder, Regensburg, Germany
341 Department of Surgery, Landesklinikum Wiener Neustadt, Neustadt, Austria
342 schema:name Department of Endocrine Surgery, Katholisches Klinikum Mainz, Mainz, Germany
343 Department of General, Visceral and Transplantation Surgery, Zentralklinikum Augsburg, Augsburg, Germany
344 Department of Surgery, Klinikum Dritter Orden, Munich, Germany
345 Department of Surgery, Klinikum Starnberg, Starnberg, Germany
346 Department of Surgery, Krankenhaus der Barmherzigen Brüder, Regensburg, Germany
347 Department of Surgery, Landesklinikum Wiener Neustadt, Neustadt, Austria
348 rdf:type schema:Organization
349 grid-institutes:grid.411095.8 schema:alternateName Department of Surgery, Klinikum Grosshadern, LMU, Munich, Germany
350 schema:name Department of Surgery, Klinikum Grosshadern, LMU, Munich, Germany
351 rdf:type schema:Organization
352 grid-institutes:grid.413303.6 schema:alternateName Department of Surgery, Krankenanstalt Rudolfstiftung, Vienna, Austria
353 schema:name Department of Surgery, Krankenanstalt Rudolfstiftung, Vienna, Austria
354 rdf:type schema:Organization
355 grid-institutes:grid.414523.5 schema:alternateName Department of Surgery, Klinikum Bogenhausen Munich, Englschalkinger Strasse 77, 81925, Munich, Germany
356 schema:name Department of Surgery, Klinikum Bogenhausen Munich, Englschalkinger Strasse 77, 81925, Munich, Germany
357 Department of Surgery, University of Regensburg, Regensburg, Germany
358 rdf:type schema:Organization
359 grid-institutes:grid.416164.0 schema:alternateName Department of Surgery I, Lukaskrankenhaus Neuss, Neuss, Germany
360 schema:name Department of Surgery I, Lukaskrankenhaus Neuss, Neuss, Germany
361 rdf:type schema:Organization
362 grid-institutes:grid.433743.4 schema:alternateName Department of Surgery, DRK Kliniken Berlin Westend, Berlin, Germany
363 schema:name Department of Surgery, DRK Kliniken Berlin Westend, Berlin, Germany
364 rdf:type schema:Organization
365 grid-institutes:grid.461714.1 schema:alternateName Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Kliniken Essen-Mitte, Essen, Germany
366 schema:name Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Kliniken Essen-Mitte, Essen, Germany
367 rdf:type schema:Organization
368 grid-institutes:grid.500078.a schema:alternateName Department of Endocrine Surgery, Bürgerhospital Frankfurt/Main, Frankfurt, Germany
369 schema:name Department of Endocrine Surgery, Bürgerhospital Frankfurt/Main, Frankfurt, Germany
370 rdf:type schema:Organization
371 grid-institutes:grid.5802.f schema:alternateName Department of Surgery, University of Mainz, Mainz, Germany
372 schema:name Department of Surgery, University of Mainz, Mainz, Germany
373 rdf:type schema:Organization
374 grid-institutes:grid.7727.5 schema:alternateName Department of Surgery, University of Regensburg, Regensburg, Germany
375 schema:name Department of Surgery, University of Regensburg, Regensburg, Germany
376 rdf:type schema:Organization
377 grid-institutes:grid.9018.0 schema:alternateName Department of Surgery, University of Halle (Saale), Halle, Germany
378 schema:name Department of Surgery, University of Halle (Saale), Halle, Germany
379 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...