RAS Mutations Predict Radiologic and Pathologic Response in Patients Treated with Chemotherapy Before Resection of Colorectal Liver Metastases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-09-17

AUTHORS

Yoshihiro Mise, Giuseppe Zimmitti, Junichi Shindoh, Scott Kopetz, Evelyne M. Loyer, Andreas Andreou, Amanda B. Cooper, Harmeet Kaur, Thomas A. Aloia, Dipen M. Maru, Jean-Nicolas Vauthey

ABSTRACT

BackgroundRAS mutations have been reported to be a potential prognostic factor in patients with colorectal liver metastases (CLM). However, the impact of RAS mutations on response to chemotherapy remains unclear. The purpose of this study was to investigate the correlation between RAS mutations and response to preoperative chemotherapy and their impact on survival in patients undergoing curative resection of CLM.MethodsRAS mutational status was assessed and its relation to morphologic response and pathologic response was investigated in 184 patients meeting inclusion criteria. Predictors of survival were assessed. The prognostic impact of RAS mutational status was then analyzed using two different multivariate models, including either radiologic morphologic response (model 1) or pathologic response (model 2).ResultsOptimal morphologic response and major pathologic response were more common in patients with wild-type RAS (32.9 and 58.9 %, respectively) than in patients with RAS mutations (10.5 and 36.8 %; P = 0.006 and 0.015, respectively). Multivariate analysis confirmed that wild-type RAS was a strong predictor of optimal morphologic response [odds ratio (OR), 4.38; 95 % CI 1.45–13.15] and major pathologic response (OR, 2.61; 95 % CI 1.17–5.80). RAS mutations were independently correlated with both overall survival and recurrence free-survival (hazard ratios, 3.57 and 2.30, respectively, in model 1, and 3.19 and 2.09, respectively, in model 2). Subanalysis revealed that RAS mutational status clearly stratified survival in patients with inadequate response to preoperative chemotherapy.ConclusionsRAS mutational status can be used to complement the current prognostic indicators for patients undergoing curative resection of CLM after preoperative modern chemotherapy. More... »

PAGES

834-842

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-014-4042-6

DOI

http://dx.doi.org/10.1245/s10434-014-4042-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028729249

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25227306


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GTP Phosphohydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins p21(ras)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ras Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mise", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.0626665021.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626665021.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zimmitti", 
        "givenName": "Giuseppe", 
        "id": "sg:person.012176654227.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012176654227.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shindoh", 
        "givenName": "Junichi", 
        "id": "sg:person.01366151362.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366151362.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kopetz", 
        "givenName": "Scott", 
        "id": "sg:person.01320500077.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320500077.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loyer", 
        "givenName": "Evelyne M.", 
        "id": "sg:person.012431413407.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012431413407.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andreou", 
        "givenName": "Andreas", 
        "id": "sg:person.01066733202.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066733202.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cooper", 
        "givenName": "Amanda B.", 
        "id": "sg:person.01346406461.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346406461.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaur", 
        "givenName": "Harmeet", 
        "id": "sg:person.01342526774.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342526774.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aloia", 
        "givenName": "Thomas A.", 
        "id": "sg:person.0762234740.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762234740.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maru", 
        "givenName": "Dipen M.", 
        "id": "sg:person.01232724076.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232724076.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vauthey", 
        "givenName": "Jean-Nicolas", 
        "id": "sg:person.07742537757.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07742537757.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1245/s10434-014-3590-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021315449", 
          "https://doi.org/10.1245/s10434-014-3590-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0605-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048935334", 
          "https://doi.org/10.1245/s10434-009-0605-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/327293a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035638144", 
          "https://doi.org/10.1038/327293a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-011-1821-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052586865", 
          "https://doi.org/10.1245/s10434-011-1821-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0864-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029653695", 
          "https://doi.org/10.1245/s10434-009-0864-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021860958", 
          "https://doi.org/10.1038/ng1975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2011.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049880373", 
          "https://doi.org/10.1038/bjc.2011.26"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-012-2335-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052082386", 
          "https://doi.org/10.1245/s10434-012-2335-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-09-17", 
    "datePublishedReg": "2014-09-17", 
    "description": "BackgroundRAS mutations have been reported to be a potential prognostic factor in patients with colorectal liver metastases (CLM). However, the impact of RAS mutations on response to chemotherapy remains unclear. The purpose of this study was to investigate the correlation between RAS mutations and response to preoperative chemotherapy and their impact on survival in patients undergoing curative resection of CLM.MethodsRAS mutational status was assessed and its relation to morphologic response and pathologic response was investigated in 184 patients meeting inclusion criteria. Predictors of survival were assessed. The prognostic impact of RAS mutational status was then analyzed using two different multivariate models, including either radiologic morphologic response (model 1) or pathologic response (model 2).ResultsOptimal morphologic response and major pathologic response were more common in patients with wild-type RAS (32.9 and 58.9\u00a0%, respectively) than in patients with RAS mutations (10.5 and 36.8\u00a0%; P\u00a0=\u00a00.006 and 0.015, respectively). Multivariate analysis confirmed that wild-type RAS was a strong predictor of optimal morphologic response [odds ratio (OR), 4.38; 95\u00a0% CI 1.45\u201313.15] and major pathologic response (OR, 2.61; 95\u00a0% CI 1.17\u20135.80). RAS mutations were independently correlated with both overall survival and recurrence free-survival (hazard ratios, 3.57 and 2.30, respectively, in model 1, and 3.19 and 2.09, respectively, in model 2). Subanalysis revealed that RAS mutational status clearly stratified survival in patients with inadequate response to preoperative chemotherapy.ConclusionsRAS mutational status can be used to complement the current prognostic indicators for patients undergoing curative resection of CLM after preoperative modern chemotherapy.", 
    "genre": "article", 
    "id": "sg:pub.10.1245/s10434-014-4042-6", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "keywords": [
      "colorectal liver metastases", 
      "major pathologic response", 
      "pathologic response", 
      "RAS mutational status", 
      "RAS mutations", 
      "mutational status", 
      "wild-type RAS", 
      "curative resection", 
      "preoperative chemotherapy", 
      "liver metastases", 
      "morphologic response", 
      "patients meeting inclusion criteria", 
      "optimal morphologic response", 
      "predictors of survival", 
      "potential prognostic factors", 
      "current prognostic indicators", 
      "meeting inclusion criteria", 
      "overall survival", 
      "prognostic factors", 
      "prognostic impact", 
      "prognostic indicator", 
      "inadequate response", 
      "modern chemotherapy", 
      "inclusion criteria", 
      "patients", 
      "chemotherapy", 
      "multivariate analysis", 
      "resection", 
      "multivariate model", 
      "different multivariate models", 
      "survival", 
      "strongest predictor", 
      "metastasis", 
      "status", 
      "predictors", 
      "mutations", 
      "response", 
      "subanalysis", 
      "radiologic", 
      "recurrence", 
      "RAS", 
      "factors", 
      "impact", 
      "criteria", 
      "study", 
      "correlation", 
      "indicators", 
      "purpose", 
      "analysis", 
      "relation", 
      "model"
    ], 
    "name": "RAS Mutations Predict Radiologic and Pathologic Response in Patients Treated with Chemotherapy Before Resection of Colorectal Liver Metastases", 
    "pagination": "834-842", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028729249"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-014-4042-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25227306"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-014-4042-6", 
      "https://app.dimensions.ai/details/publication/pub.1028729249"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_618.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1245/s10434-014-4042-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4042-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4042-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4042-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-4042-6'


 

This table displays all metadata directly associated to this object as RDF triples.

322 TRIPLES      21 PREDICATES      109 URIs      93 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-014-4042-6 schema:about N112f3d8410c644fa8558d42d6fc8f930
2 N218df68087b343f5af87a77f0b5bdf13
3 N2258fc68a5c44bf8bc66bf57eeba90ae
4 N2462c12ecbbf4c41ad02a0b157173298
5 N2d55a4c5bf374dd1aa53031c043e08d5
6 N30c3e22e7efc49f1a4a4d83cfc6d4a18
7 N39850534bbda4174b248b542ac95525c
8 N3e06565738204f85ba53331b928de5dc
9 N4953d24f37264acc81fd4dfb2b0ee7bd
10 N570859747bf341559eb559b48e61bed1
11 N5daccc07a0f74eddad5a011f62ef5713
12 N74711e3ffc4d4b6bbbc4912c0c555f31
13 N762619021d694658a45a4f056f06318c
14 N87ba078ac2594a0aa4edfb9b29207ed4
15 N8aae77d2d9fd4ab99f98ea38bd00af88
16 Nab9adb287e6f43439f2444a0af2f78a0
17 Naef8c8ae51564a9585509b22f8a24920
18 Nb4e2529c104c42d58d8cf17ef44a5522
19 Nbf08509f4f224820b6f96e6aa74ef05b
20 Nc734e5960a7d4150bd406599993b7266
21 Nca3c793d50814519895984c3b6bee1d0
22 Ncdebf56a4ad8450b9f5fb347a3efe35d
23 Nd40375333dd24877a1c7a46c0dc4c017
24 Nd5a60e55f3014b04b7e8daf7ad5e6e64
25 Nf5b2539cf4ec4845aab44ce047bb4df1
26 anzsrc-for:11
27 anzsrc-for:1112
28 schema:author N13d7cbc56ba3430980d10ad7197f5d1a
29 schema:citation sg:pub.10.1038/327293a0
30 sg:pub.10.1038/bjc.2011.26
31 sg:pub.10.1038/ng1975
32 sg:pub.10.1245/s10434-009-0605-3
33 sg:pub.10.1245/s10434-009-0864-z
34 sg:pub.10.1245/s10434-011-1821-1
35 sg:pub.10.1245/s10434-012-2335-1
36 sg:pub.10.1245/s10434-014-3590-0
37 schema:datePublished 2014-09-17
38 schema:datePublishedReg 2014-09-17
39 schema:description BackgroundRAS mutations have been reported to be a potential prognostic factor in patients with colorectal liver metastases (CLM). However, the impact of RAS mutations on response to chemotherapy remains unclear. The purpose of this study was to investigate the correlation between RAS mutations and response to preoperative chemotherapy and their impact on survival in patients undergoing curative resection of CLM.MethodsRAS mutational status was assessed and its relation to morphologic response and pathologic response was investigated in 184 patients meeting inclusion criteria. Predictors of survival were assessed. The prognostic impact of RAS mutational status was then analyzed using two different multivariate models, including either radiologic morphologic response (model 1) or pathologic response (model 2).ResultsOptimal morphologic response and major pathologic response were more common in patients with wild-type RAS (32.9 and 58.9 %, respectively) than in patients with RAS mutations (10.5 and 36.8 %; P = 0.006 and 0.015, respectively). Multivariate analysis confirmed that wild-type RAS was a strong predictor of optimal morphologic response [odds ratio (OR), 4.38; 95 % CI 1.45–13.15] and major pathologic response (OR, 2.61; 95 % CI 1.17–5.80). RAS mutations were independently correlated with both overall survival and recurrence free-survival (hazard ratios, 3.57 and 2.30, respectively, in model 1, and 3.19 and 2.09, respectively, in model 2). Subanalysis revealed that RAS mutational status clearly stratified survival in patients with inadequate response to preoperative chemotherapy.ConclusionsRAS mutational status can be used to complement the current prognostic indicators for patients undergoing curative resection of CLM after preoperative modern chemotherapy.
40 schema:genre article
41 schema:isAccessibleForFree true
42 schema:isPartOf N50bbd5f004934b948e0ae763df91fc58
43 N8d78898abcca444db20e796418f53120
44 sg:journal.1105545
45 schema:keywords RAS
46 RAS mutational status
47 RAS mutations
48 analysis
49 chemotherapy
50 colorectal liver metastases
51 correlation
52 criteria
53 curative resection
54 current prognostic indicators
55 different multivariate models
56 factors
57 impact
58 inadequate response
59 inclusion criteria
60 indicators
61 liver metastases
62 major pathologic response
63 meeting inclusion criteria
64 metastasis
65 model
66 modern chemotherapy
67 morphologic response
68 multivariate analysis
69 multivariate model
70 mutational status
71 mutations
72 optimal morphologic response
73 overall survival
74 pathologic response
75 patients
76 patients meeting inclusion criteria
77 potential prognostic factors
78 predictors
79 predictors of survival
80 preoperative chemotherapy
81 prognostic factors
82 prognostic impact
83 prognostic indicator
84 purpose
85 radiologic
86 recurrence
87 relation
88 resection
89 response
90 status
91 strongest predictor
92 study
93 subanalysis
94 survival
95 wild-type RAS
96 schema:name RAS Mutations Predict Radiologic and Pathologic Response in Patients Treated with Chemotherapy Before Resection of Colorectal Liver Metastases
97 schema:pagination 834-842
98 schema:productId N5096e613471c46bf9c0b4ef47f9a5816
99 N6d6e39406a7641209b0b2c9448e63ecf
100 Nb176cc9f0308490581743cd2cafacc7c
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028729249
102 https://doi.org/10.1245/s10434-014-4042-6
103 schema:sdDatePublished 2022-08-04T17:01
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N956b081cdfeb442da2cda4816a326ba7
106 schema:url https://doi.org/10.1245/s10434-014-4042-6
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N0960c7f921a44c8ab091e01318c88ea9 rdf:first sg:person.07742537757.29
111 rdf:rest rdf:nil
112 N112f3d8410c644fa8558d42d6fc8f930 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Combined Modality Therapy
114 rdf:type schema:DefinedTerm
115 N13d7cbc56ba3430980d10ad7197f5d1a rdf:first sg:person.0626665021.66
116 rdf:rest Nd6bb2f222f7041cb84b956a5f920abef
117 N218df68087b343f5af87a77f0b5bdf13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Aged, 80 and over
119 rdf:type schema:DefinedTerm
120 N2258fc68a5c44bf8bc66bf57eeba90ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Neoplasm Recurrence, Local
122 rdf:type schema:DefinedTerm
123 N2462c12ecbbf4c41ad02a0b157173298 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name GTP Phosphohydrolases
125 rdf:type schema:DefinedTerm
126 N2a57472e6ce74d36bd3047fbe05c8d12 rdf:first sg:person.012431413407.71
127 rdf:rest N38943cdda2ff4c95be0981473e21f5fa
128 N2d55a4c5bf374dd1aa53031c043e08d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Humans
130 rdf:type schema:DefinedTerm
131 N30c3e22e7efc49f1a4a4d83cfc6d4a18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Proto-Oncogene Proteins p21(ras)
133 rdf:type schema:DefinedTerm
134 N317fdeb764a849b59926d8cd45c267e6 rdf:first sg:person.01366151362.29
135 rdf:rest N4c32313d97b64ebca573709cda850a70
136 N33d49b8cf7f045f49a029c2fc1081707 rdf:first sg:person.01342526774.54
137 rdf:rest N412037b7cc644b4a9ceb1232608f8007
138 N38943cdda2ff4c95be0981473e21f5fa rdf:first sg:person.01066733202.34
139 rdf:rest N85d8cae776fa42109a3efafe2d4b5845
140 N39850534bbda4174b248b542ac95525c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Prognosis
142 rdf:type schema:DefinedTerm
143 N3e06565738204f85ba53331b928de5dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Membrane Proteins
145 rdf:type schema:DefinedTerm
146 N412037b7cc644b4a9ceb1232608f8007 rdf:first sg:person.0762234740.61
147 rdf:rest Ndfefb3b22bc54071ae957eb028c5fb83
148 N4953d24f37264acc81fd4dfb2b0ee7bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Colorectal Neoplasms
150 rdf:type schema:DefinedTerm
151 N4c32313d97b64ebca573709cda850a70 rdf:first sg:person.01320500077.48
152 rdf:rest N2a57472e6ce74d36bd3047fbe05c8d12
153 N5096e613471c46bf9c0b4ef47f9a5816 schema:name dimensions_id
154 schema:value pub.1028729249
155 rdf:type schema:PropertyValue
156 N50bbd5f004934b948e0ae763df91fc58 schema:issueNumber 3
157 rdf:type schema:PublicationIssue
158 N570859747bf341559eb559b48e61bed1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Follow-Up Studies
160 rdf:type schema:DefinedTerm
161 N5daccc07a0f74eddad5a011f62ef5713 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Liver Neoplasms
163 rdf:type schema:DefinedTerm
164 N6d6e39406a7641209b0b2c9448e63ecf schema:name pubmed_id
165 schema:value 25227306
166 rdf:type schema:PropertyValue
167 N74711e3ffc4d4b6bbbc4912c0c555f31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Mutation
169 rdf:type schema:DefinedTerm
170 N762619021d694658a45a4f056f06318c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Male
172 rdf:type schema:DefinedTerm
173 N85d8cae776fa42109a3efafe2d4b5845 rdf:first sg:person.01346406461.35
174 rdf:rest N33d49b8cf7f045f49a029c2fc1081707
175 N87ba078ac2594a0aa4edfb9b29207ed4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Adult
177 rdf:type schema:DefinedTerm
178 N8aae77d2d9fd4ab99f98ea38bd00af88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Prospective Studies
180 rdf:type schema:DefinedTerm
181 N8d78898abcca444db20e796418f53120 schema:volumeNumber 22
182 rdf:type schema:PublicationVolume
183 N956b081cdfeb442da2cda4816a326ba7 schema:name Springer Nature - SN SciGraph project
184 rdf:type schema:Organization
185 Nab9adb287e6f43439f2444a0af2f78a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Antineoplastic Combined Chemotherapy Protocols
187 rdf:type schema:DefinedTerm
188 Naef8c8ae51564a9585509b22f8a24920 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name ras Proteins
190 rdf:type schema:DefinedTerm
191 Nb176cc9f0308490581743cd2cafacc7c schema:name doi
192 schema:value 10.1245/s10434-014-4042-6
193 rdf:type schema:PropertyValue
194 Nb4e2529c104c42d58d8cf17ef44a5522 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Survival Rate
196 rdf:type schema:DefinedTerm
197 Nbf08509f4f224820b6f96e6aa74ef05b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Hepatectomy
199 rdf:type schema:DefinedTerm
200 Nc734e5960a7d4150bd406599993b7266 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Aged
202 rdf:type schema:DefinedTerm
203 Nca3c793d50814519895984c3b6bee1d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Female
205 rdf:type schema:DefinedTerm
206 Ncdebf56a4ad8450b9f5fb347a3efe35d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Neoplasm Staging
208 rdf:type schema:DefinedTerm
209 Nd40375333dd24877a1c7a46c0dc4c017 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Proto-Oncogene Proteins
211 rdf:type schema:DefinedTerm
212 Nd5a60e55f3014b04b7e8daf7ad5e6e64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Chemotherapy, Adjuvant
214 rdf:type schema:DefinedTerm
215 Nd6bb2f222f7041cb84b956a5f920abef rdf:first sg:person.012176654227.25
216 rdf:rest N317fdeb764a849b59926d8cd45c267e6
217 Ndfefb3b22bc54071ae957eb028c5fb83 rdf:first sg:person.01232724076.44
218 rdf:rest N0960c7f921a44c8ab091e01318c88ea9
219 Nf5b2539cf4ec4845aab44ce047bb4df1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Middle Aged
221 rdf:type schema:DefinedTerm
222 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
223 schema:name Medical and Health Sciences
224 rdf:type schema:DefinedTerm
225 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
226 schema:name Oncology and Carcinogenesis
227 rdf:type schema:DefinedTerm
228 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1245/s10434-014-4042-6
229 rdf:type schema:MonetaryGrant
230 sg:journal.1105545 schema:issn 1068-9265
231 1534-4681
232 schema:name Annals of Surgical Oncology
233 schema:publisher Springer Nature
234 rdf:type schema:Periodical
235 sg:person.01066733202.34 schema:affiliation grid-institutes:grid.240145.6
236 schema:familyName Andreou
237 schema:givenName Andreas
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066733202.34
239 rdf:type schema:Person
240 sg:person.012176654227.25 schema:affiliation grid-institutes:grid.240145.6
241 schema:familyName Zimmitti
242 schema:givenName Giuseppe
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012176654227.25
244 rdf:type schema:Person
245 sg:person.01232724076.44 schema:affiliation grid-institutes:grid.240145.6
246 schema:familyName Maru
247 schema:givenName Dipen M.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232724076.44
249 rdf:type schema:Person
250 sg:person.012431413407.71 schema:affiliation grid-institutes:grid.240145.6
251 schema:familyName Loyer
252 schema:givenName Evelyne M.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012431413407.71
254 rdf:type schema:Person
255 sg:person.01320500077.48 schema:affiliation grid-institutes:grid.240145.6
256 schema:familyName Kopetz
257 schema:givenName Scott
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320500077.48
259 rdf:type schema:Person
260 sg:person.01342526774.54 schema:affiliation grid-institutes:grid.240145.6
261 schema:familyName Kaur
262 schema:givenName Harmeet
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342526774.54
264 rdf:type schema:Person
265 sg:person.01346406461.35 schema:affiliation grid-institutes:grid.240145.6
266 schema:familyName Cooper
267 schema:givenName Amanda B.
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346406461.35
269 rdf:type schema:Person
270 sg:person.01366151362.29 schema:affiliation grid-institutes:grid.240145.6
271 schema:familyName Shindoh
272 schema:givenName Junichi
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366151362.29
274 rdf:type schema:Person
275 sg:person.0626665021.66 schema:affiliation grid-institutes:grid.240145.6
276 schema:familyName Mise
277 schema:givenName Yoshihiro
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626665021.66
279 rdf:type schema:Person
280 sg:person.0762234740.61 schema:affiliation grid-institutes:grid.240145.6
281 schema:familyName Aloia
282 schema:givenName Thomas A.
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762234740.61
284 rdf:type schema:Person
285 sg:person.07742537757.29 schema:affiliation grid-institutes:grid.240145.6
286 schema:familyName Vauthey
287 schema:givenName Jean-Nicolas
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07742537757.29
289 rdf:type schema:Person
290 sg:pub.10.1038/327293a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035638144
291 https://doi.org/10.1038/327293a0
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/bjc.2011.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049880373
294 https://doi.org/10.1038/bjc.2011.26
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/ng1975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021860958
297 https://doi.org/10.1038/ng1975
298 rdf:type schema:CreativeWork
299 sg:pub.10.1245/s10434-009-0605-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048935334
300 https://doi.org/10.1245/s10434-009-0605-3
301 rdf:type schema:CreativeWork
302 sg:pub.10.1245/s10434-009-0864-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1029653695
303 https://doi.org/10.1245/s10434-009-0864-z
304 rdf:type schema:CreativeWork
305 sg:pub.10.1245/s10434-011-1821-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052586865
306 https://doi.org/10.1245/s10434-011-1821-1
307 rdf:type schema:CreativeWork
308 sg:pub.10.1245/s10434-012-2335-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052082386
309 https://doi.org/10.1245/s10434-012-2335-1
310 rdf:type schema:CreativeWork
311 sg:pub.10.1245/s10434-014-3590-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021315449
312 https://doi.org/10.1245/s10434-014-3590-0
313 rdf:type schema:CreativeWork
314 grid-institutes:grid.240145.6 schema:alternateName Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
315 Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
316 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
317 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
318 schema:name Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
319 Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
320 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
321 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
322 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...