FOLFIRINOX for Locally Advanced Pancreatic Adenocarcinoma: Results of an AGEO Multicenter Prospective Observational Cohort View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01

AUTHORS

L. Marthey, A. Sa-Cunha, J. F. Blanc, M. Gauthier, A. Cueff, E. Francois, I. Trouilloud, D. Malka, J. B. Bachet, R. Coriat, E. Terrebonne, C. De La Fouchardière, S. Manfredi, D. Solub, C. Lécaille, A. Thirot Bidault, F. Carbonnel, J. Taieb

ABSTRACT

BACKGROUND: First-line treatment with FOLFIRINOX significantly increases overall survival (OS) in patients with metastatic pancreatic adenocarcinoma (PA) compared with gemcitabine. The aim of this observational cohort was to evaluate the tolerability and efficacy of this regimen in unresectable locally advanced PA (LAPA). PATIENTS AND METHODS: From February 2010 to February 2012, all consecutive patients from 11 French centers treated by FOLFIRINOX for a histologically proven LAPA were prospectively enrolled. Unresectability was defined independently by each center's multidisciplinary staff at diagnosis. Absence of metastatic disease was confirmed by chest-abdomen-pelvis computed tomography scan. FOLFIRINOX was delivered every 2 weeks as previously reported until progressive disease, major toxicity, or consolidation treatment by radiotherapy and/or surgery. RESULTS: Seventy-seven patients were enrolled. They received a median number of five cycles (1-30). Grade 3-4 toxicities were neutropenia (11 %), nausea (9 %), diarrhea (6 %), fatigue (6 %), and anemia (1 %). Grade 2-3 sensory neuropathy occurred in 25 % of patients. No toxic death was reported and only 6 % of patients had to stop treatment because of toxicity. Disease control rate was 84 with 28 % of objective response (Response Evaluation Criteria in Solid Tumors). Seventy-five percent of patients received a consolidation therapy: 70 % had radiotherapy and 36 % underwent a surgical resection, with a curative intent. Within the whole cohort, 1-year OS rate was 77 % (95 % CI 65-86) and 1-year progression-free survival rate was 59 % (95 % CI 46-70). CONCLUSION: First-line FOLFIRINOX for LAPA seems to be effective and have a manageable toxicity profile. These promising results will have to be confirmed in a phase III randomized trial. More... »

PAGES

295-301

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-014-3898-9

DOI

http://dx.doi.org/10.1245/s10434-014-3898-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030376143

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25037971


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Camptothecin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxycytidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leucovorin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Maximum Tolerated Dose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology, Kremlin Bic\u00eatre Hospital, Assistance publique-H\u00f4pitaux de Paris (AP-HP), Paris Sud University, Le Kremlin Bic\u00eatre, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marthey", 
        "givenName": "L.", 
        "id": "sg:person.01335760213.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335760213.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque", 
          "id": "https://www.grid.ac/institutes/grid.469409.6", 
          "name": [
            "Department of Digestive Surgery, Haut-L\u00e9v\u00eaque Hospital, Pessac, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sa-Cunha", 
        "givenName": "A.", 
        "id": "sg:person.01161065723.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161065723.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Andr\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.414339.8", 
          "name": [
            "Department of Gastroenterology, Saint-Andr\u00e9 Hospital, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blanc", 
        "givenName": "J. F.", 
        "id": "sg:person.01344060476.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344060476.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Biostatistics, Anticancer Center G.F. Leclerc, Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gauthier", 
        "givenName": "M.", 
        "id": "sg:person.01257672243.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257672243.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Biostatistics, Anticancer Center G.F. Leclerc, Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cueff", 
        "givenName": "A.", 
        "id": "sg:person.0717271020.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717271020.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Anticancer Center A. Lacassagne, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Francois", 
        "givenName": "E.", 
        "id": "sg:person.01211341242.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211341242.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology and Digestive Oncology, HEGP Hospital, Assistance publique-H\u00f4pitaux de Paris (AP-HP), Paris Descartes University, Cancer Research Personalized Medicine (CARPEM), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trouilloud", 
        "givenName": "I.", 
        "id": "sg:person.01061023113.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061023113.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Oncology, Institut Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malka", 
        "givenName": "D.", 
        "id": "sg:person.01030003625.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030003625.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Department of Gastroenterology, La Piti\u00e9-Salp\u00e9tri\u00e8re Hospital, Assistance publique-H\u00f4pitaux de Paris (AP-HP), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bachet", 
        "givenName": "J. B.", 
        "id": "sg:person.0765746641.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765746641.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Department of Gastroenterology, Cochin Hospital, Assistance publique-H\u00f4pitaux de Paris (AP-HP), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coriat", 
        "givenName": "R.", 
        "id": "sg:person.01274370774.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274370774.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque", 
          "id": "https://www.grid.ac/institutes/grid.469409.6", 
          "name": [
            "Department of Gastroenterology, Haut-L\u00e9v\u00eaque Hospital, Pessac, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terrebonne", 
        "givenName": "E.", 
        "id": "sg:person.01273613126.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273613126.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Anticancer Center L. B\u00e9rard, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De La Fouchardi\u00e8re", 
        "givenName": "C.", 
        "id": "sg:person.01304763136.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304763136.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "l'H\u00f4pital Pontchaillou", 
          "id": "https://www.grid.ac/institutes/grid.414271.5", 
          "name": [
            "Department of Gastroenterology, Pontchaillou Hospital, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manfredi", 
        "givenName": "S.", 
        "id": "sg:person.0747131643.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747131643.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, L. Pasteur Hospital, Chartres, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Solub", 
        "givenName": "D.", 
        "id": "sg:person.01325517414.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325517414.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Polyclinic Bordeaux North Aquitaine", 
          "id": "https://www.grid.ac/institutes/grid.492937.2", 
          "name": [
            "Department of Gastroenterology, Polyclinique Bordeaux Nord Aquitaine, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00e9caille", 
        "givenName": "C.", 
        "id": "sg:person.01177602206.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177602206.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology, Kremlin Bic\u00eatre Hospital, Assistance publique-H\u00f4pitaux de Paris (AP-HP), Paris Sud University, Le Kremlin Bic\u00eatre, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thirot Bidault", 
        "givenName": "A.", 
        "id": "sg:person.01013547071.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013547071.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology, Kremlin Bic\u00eatre Hospital, Assistance publique-H\u00f4pitaux de Paris (AP-HP), Paris Sud University, Le Kremlin Bic\u00eatre, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carbonnel", 
        "givenName": "F.", 
        "id": "sg:person.01102050226.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102050226.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology and Digestive Oncology, HEGP Hospital, Assistance publique-H\u00f4pitaux de Paris (AP-HP), Paris Descartes University, Cancer Research Personalized Medicine (CARPEM), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taieb", 
        "givenName": "J.", 
        "id": "sg:person.01203564254.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203564254.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1245/s10434-008-0295-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005006861", 
          "https://doi.org/10.1245/s10434-008-0295-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.07.9525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005176755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(01)02740-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008452911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.19.7921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010404921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.297.3.267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010434617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.2009.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011824921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2012-0435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011973810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1285-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012685239", 
          "https://doi.org/10.1245/s10434-010-1285-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1285-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012685239", 
          "https://doi.org/10.1245/s10434-010-1285-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2005.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015633345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2005.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015633345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2008.11.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018937917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdn281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019387985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020626779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1011923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022967950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.07.5663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028501594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.3.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032301848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181ad657b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033637948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181ad657b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033637948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181ad657b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033637948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12032-012-0361-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041672338", 
          "https://doi.org/10.1007/s12032-012-0361-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s1091-255x(03)00113-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042903832", 
          "https://doi.org/10.1016/s1091-255x(03)00113-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s1091-255x(03)00113-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042903832", 
          "https://doi.org/10.1016/s1091-255x(03)00113-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.06.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044349219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1000267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045271156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-12-199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046942754", 
          "https://doi.org/10.1186/1471-2407-12-199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048680038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.34.8904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049252722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.6.2403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083106816"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-01", 
    "datePublishedReg": "2015-01-01", 
    "description": "BACKGROUND: First-line treatment with FOLFIRINOX significantly increases overall survival (OS) in patients with metastatic pancreatic adenocarcinoma (PA) compared with gemcitabine. The aim of this observational cohort was to evaluate the tolerability and efficacy of this regimen in unresectable locally advanced PA (LAPA).\nPATIENTS AND METHODS: From February 2010 to February 2012, all consecutive patients from 11 French centers treated by FOLFIRINOX for a histologically proven LAPA were prospectively enrolled. Unresectability was defined independently by each center's multidisciplinary staff at diagnosis. Absence of metastatic disease was confirmed by chest-abdomen-pelvis computed tomography scan. FOLFIRINOX was delivered every 2 weeks as previously reported until progressive disease, major toxicity, or consolidation treatment by radiotherapy and/or surgery.\nRESULTS: Seventy-seven patients were enrolled. They received a median number of five cycles (1-30). Grade 3-4 toxicities were neutropenia (11 %), nausea (9 %), diarrhea (6 %), fatigue (6 %), and anemia (1 %). Grade 2-3 sensory neuropathy occurred in 25 % of patients. No toxic death was reported and only 6 % of patients had to stop treatment because of toxicity. Disease control rate was 84 with 28 % of objective response (Response Evaluation Criteria in Solid Tumors). Seventy-five percent of patients received a consolidation therapy: 70 % had radiotherapy and 36 % underwent a surgical resection, with a curative intent. Within the whole cohort, 1-year OS rate was 77 % (95 % CI 65-86) and 1-year progression-free survival rate was 59 % (95 % CI 46-70).\nCONCLUSION: First-line FOLFIRINOX for LAPA seems to be effective and have a manageable toxicity profile. These promising results will have to be confirmed in a phase III randomized trial.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-014-3898-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "FOLFIRINOX for Locally Advanced Pancreatic Adenocarcinoma: Results of an AGEO Multicenter Prospective Observational Cohort", 
    "pagination": "295-301", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "90b4f2ac28f73221b77ec519d1099b2e1f1c0d2872c0aac21caaedf56c230424"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25037971"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-014-3898-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030376143"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-014-3898-9", 
      "https://app.dimensions.ai/details/publication/pub.1030376143"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000500.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1245/s10434-014-3898-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-3898-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-3898-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-3898-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-3898-9'


 

This table displays all metadata directly associated to this object as RDF triples.

392 TRIPLES      21 PREDICATES      75 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-014-3898-9 schema:about N2aa88ad362084082a1d7ce04ce55e462
2 N2c41295f29e248c3a0e08f4d5de3788a
3 N4b367fc946954cbeb6e3325b9bcdd7f4
4 N56c5c46d5044458e9b530cea435329c7
5 N650b7250efe441d88c93921aacae2a67
6 N6960a527c3884d42a59dd36c8a2f0b1b
7 N69e87dd7d9c64424a53cfe196d1ac5e0
8 N700a9fb41d604e799f1b67ee37a5c5cd
9 N71199cd6849347c5ad65a0c7e48eebfa
10 N7e509d5d261d4a029433cb06794e8bb3
11 N7e9492f4ad564a8bb0052f707111b2d6
12 N82b1f0da14514eca8964b5878170ce24
13 N83d05cc3ac5e42be85bfdb7c4b71bcd7
14 N964d447adf744b058b8f8b5044c6e11f
15 Nad0aefb4bd634205a523e8b374dfc3e7
16 Nb854c13b30f14cf194c086f51ac48da3
17 Nc02945576c8d4fbba345951f8feee26a
18 Ncc70b349d5954e838c0d1ce523a065dd
19 Ndebb63c4302d448692726a3419ba8010
20 Ne49a735cede846f6936bddc958f0253b
21 Nef229a9ef5ba4b9088787ef810ff6ba0
22 Nfd73012c225a4e1e85224db7a76d5977
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author N927e890c85f5418583da07efec7dbca2
26 schema:citation sg:pub.10.1007/s12032-012-0361-2
27 sg:pub.10.1016/s1091-255x(03)00113-6
28 sg:pub.10.1186/1471-2407-12-199
29 sg:pub.10.1245/s10434-008-0295-2
30 sg:pub.10.1245/s10434-010-1285-8
31 https://doi.org/10.1001/archsurg.2009.67
32 https://doi.org/10.1001/jama.297.3.267
33 https://doi.org/10.1016/j.ejca.2008.11.018
34 https://doi.org/10.1016/j.jamcollsurg.2005.04.008
35 https://doi.org/10.1016/s0360-3016(01)02740-7
36 https://doi.org/10.1056/nejmoa032295
37 https://doi.org/10.1056/nejmoa1011923
38 https://doi.org/10.1093/annonc/mdn281
39 https://doi.org/10.1093/jnci/92.3.205
40 https://doi.org/10.1097/sla.0b013e3181ad657b
41 https://doi.org/10.1200/jco.1997.15.6.2403
42 https://doi.org/10.1200/jco.2005.06.050
43 https://doi.org/10.1200/jco.2006.07.5663
44 https://doi.org/10.1200/jco.2006.07.9525
45 https://doi.org/10.1200/jco.2008.19.7921
46 https://doi.org/10.1200/jco.2011.34.8904
47 https://doi.org/10.1371/journal.pmed.1000267
48 https://doi.org/10.1634/theoncologist.2012-0435
49 https://doi.org/10.3322/caac.20138
50 schema:datePublished 2015-01
51 schema:datePublishedReg 2015-01-01
52 schema:description BACKGROUND: First-line treatment with FOLFIRINOX significantly increases overall survival (OS) in patients with metastatic pancreatic adenocarcinoma (PA) compared with gemcitabine. The aim of this observational cohort was to evaluate the tolerability and efficacy of this regimen in unresectable locally advanced PA (LAPA). PATIENTS AND METHODS: From February 2010 to February 2012, all consecutive patients from 11 French centers treated by FOLFIRINOX for a histologically proven LAPA were prospectively enrolled. Unresectability was defined independently by each center's multidisciplinary staff at diagnosis. Absence of metastatic disease was confirmed by chest-abdomen-pelvis computed tomography scan. FOLFIRINOX was delivered every 2 weeks as previously reported until progressive disease, major toxicity, or consolidation treatment by radiotherapy and/or surgery. RESULTS: Seventy-seven patients were enrolled. They received a median number of five cycles (1-30). Grade 3-4 toxicities were neutropenia (11 %), nausea (9 %), diarrhea (6 %), fatigue (6 %), and anemia (1 %). Grade 2-3 sensory neuropathy occurred in 25 % of patients. No toxic death was reported and only 6 % of patients had to stop treatment because of toxicity. Disease control rate was 84 with 28 % of objective response (Response Evaluation Criteria in Solid Tumors). Seventy-five percent of patients received a consolidation therapy: 70 % had radiotherapy and 36 % underwent a surgical resection, with a curative intent. Within the whole cohort, 1-year OS rate was 77 % (95 % CI 65-86) and 1-year progression-free survival rate was 59 % (95 % CI 46-70). CONCLUSION: First-line FOLFIRINOX for LAPA seems to be effective and have a manageable toxicity profile. These promising results will have to be confirmed in a phase III randomized trial.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree false
56 schema:isPartOf N39b3c81165b04c35b2c6b4a99d100311
57 N8c63fc99c0cf43a6985c7609dda32ff5
58 sg:journal.1105545
59 schema:name FOLFIRINOX for Locally Advanced Pancreatic Adenocarcinoma: Results of an AGEO Multicenter Prospective Observational Cohort
60 schema:pagination 295-301
61 schema:productId N1526052773534813a515bbc94c9705c4
62 N635183dfc4c94a2d8d12811aabea1e52
63 N9f1130ca7a634016b53a6f42ae16567e
64 Na159cdedef0245e5ae477a7a4b9c6089
65 Nad43771f8f244fc493bd6d90b0f08454
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030376143
67 https://doi.org/10.1245/s10434-014-3898-9
68 schema:sdDatePublished 2019-04-10T19:54
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N25027fb969f44d7cbf6dc95cdf711b22
71 schema:url http://link.springer.com/10.1245/s10434-014-3898-9
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N08d6ca7891984a85bd781eda31147a3f schema:name Department of Biostatistics, Anticancer Center G.F. Leclerc, Dijon, France
76 rdf:type schema:Organization
77 N0a7430578fcc4610b617d51bc2e6b198 rdf:first sg:person.01102050226.24
78 rdf:rest Nbe789b0664994c7ca5feb3c1f5775fda
79 N146de5a928ee4e9d8a5d4a8976bf000f schema:name Department of Oncology, Anticancer Center A. Lacassagne, Nice, France
80 rdf:type schema:Organization
81 N1526052773534813a515bbc94c9705c4 schema:name dimensions_id
82 schema:value pub.1030376143
83 rdf:type schema:PropertyValue
84 N20e4c52d832f4d9f9be2665e04232158 rdf:first sg:person.01304763136.25
85 rdf:rest N7addd405434b4bc49342c51b505c4728
86 N23eb604b237a4b62b036290953d0f689 rdf:first sg:person.01325517414.48
87 rdf:rest N2b7b2ed76ed846868daf63fc0bb5af8b
88 N25027fb969f44d7cbf6dc95cdf711b22 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N2aa88ad362084082a1d7ce04ce55e462 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Follow-Up Studies
92 rdf:type schema:DefinedTerm
93 N2b7b2ed76ed846868daf63fc0bb5af8b rdf:first sg:person.01177602206.40
94 rdf:rest N7cfa06f6d3a545de9191828f0ccbde28
95 N2c41295f29e248c3a0e08f4d5de3788a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Neoplasm Invasiveness
97 rdf:type schema:DefinedTerm
98 N2f9a21d38c344c01a6b5212d2b291c30 rdf:first sg:person.01274370774.96
99 rdf:rest N9c1ed883298b4a2cadac067996b11a6e
100 N32860e0cb9b04b9cb39b9cdfc8374883 rdf:first sg:person.01344060476.84
101 rdf:rest Nf3777f43f8ee4e739a0c0b9afa716ced
102 N371b63916ce64a1fa33387b7611bb270 rdf:first sg:person.0717271020.72
103 rdf:rest Nc0b81434af234f289022514c892c3d64
104 N39b3c81165b04c35b2c6b4a99d100311 schema:issueNumber 1
105 rdf:type schema:PublicationIssue
106 N493d239030bf4ad39fff1c4ddc9fe6ec schema:name Department of Gastroenterology, Kremlin Bicêtre Hospital, Assistance publique-Hôpitaux de Paris (AP-HP), Paris Sud University, Le Kremlin Bicêtre, France
107 rdf:type schema:Organization
108 N4b367fc946954cbeb6e3325b9bcdd7f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Middle Aged
110 rdf:type schema:DefinedTerm
111 N56c5c46d5044458e9b530cea435329c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Female
113 rdf:type schema:DefinedTerm
114 N5aaf037613bd40b3be930ad8eac43dc1 schema:name Department of Biostatistics, Anticancer Center G.F. Leclerc, Dijon, France
115 rdf:type schema:Organization
116 N6015041c626a4f368eea53f99806d371 rdf:first sg:person.01161065723.52
117 rdf:rest N32860e0cb9b04b9cb39b9cdfc8374883
118 N635183dfc4c94a2d8d12811aabea1e52 schema:name pubmed_id
119 schema:value 25037971
120 rdf:type schema:PropertyValue
121 N650b7250efe441d88c93921aacae2a67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Pancreatic Neoplasms
123 rdf:type schema:DefinedTerm
124 N6960a527c3884d42a59dd36c8a2f0b1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Deoxycytidine
126 rdf:type schema:DefinedTerm
127 N69e87dd7d9c64424a53cfe196d1ac5e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Adenocarcinoma
129 rdf:type schema:DefinedTerm
130 N700a9fb41d604e799f1b67ee37a5c5cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Cisplatin
132 rdf:type schema:DefinedTerm
133 N71199cd6849347c5ad65a0c7e48eebfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Camptothecin
135 rdf:type schema:DefinedTerm
136 N7addd405434b4bc49342c51b505c4728 rdf:first sg:person.0747131643.21
137 rdf:rest N23eb604b237a4b62b036290953d0f689
138 N7cfa06f6d3a545de9191828f0ccbde28 rdf:first sg:person.01013547071.99
139 rdf:rest N0a7430578fcc4610b617d51bc2e6b198
140 N7e509d5d261d4a029433cb06794e8bb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adult
142 rdf:type schema:DefinedTerm
143 N7e9492f4ad564a8bb0052f707111b2d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Prospective Studies
145 rdf:type schema:DefinedTerm
146 N820d6582da0a4ef4984d2bdbd5880cb4 schema:name Department of Gastroenterology, Kremlin Bicêtre Hospital, Assistance publique-Hôpitaux de Paris (AP-HP), Paris Sud University, Le Kremlin Bicêtre, France
147 rdf:type schema:Organization
148 N8248c6540241418da4099ab856d7109c rdf:first sg:person.01030003625.43
149 rdf:rest Nfe0a2e82467b450e9fac2a848d668d5e
150 N82b1f0da14514eca8964b5878170ce24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Male
152 rdf:type schema:DefinedTerm
153 N83d05cc3ac5e42be85bfdb7c4b71bcd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Humans
155 rdf:type schema:DefinedTerm
156 N8c63fc99c0cf43a6985c7609dda32ff5 schema:volumeNumber 22
157 rdf:type schema:PublicationVolume
158 N927e890c85f5418583da07efec7dbca2 rdf:first sg:person.01335760213.46
159 rdf:rest N6015041c626a4f368eea53f99806d371
160 N964d447adf744b058b8f8b5044c6e11f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Antineoplastic Combined Chemotherapy Protocols
162 rdf:type schema:DefinedTerm
163 N9c1ed883298b4a2cadac067996b11a6e rdf:first sg:person.01273613126.15
164 rdf:rest N20e4c52d832f4d9f9be2665e04232158
165 N9ec5e8f7e25a4d08b7742de874f84300 schema:name Department of Oncology, L. Pasteur Hospital, Chartres, France
166 rdf:type schema:Organization
167 N9f1130ca7a634016b53a6f42ae16567e schema:name readcube_id
168 schema:value 90b4f2ac28f73221b77ec519d1099b2e1f1c0d2872c0aac21caaedf56c230424
169 rdf:type schema:PropertyValue
170 Na159cdedef0245e5ae477a7a4b9c6089 schema:name doi
171 schema:value 10.1245/s10434-014-3898-9
172 rdf:type schema:PropertyValue
173 Naa639910b47745958696f937f2f47f4a schema:name Department of Gastroenterology and Digestive Oncology, HEGP Hospital, Assistance publique-Hôpitaux de Paris (AP-HP), Paris Descartes University, Cancer Research Personalized Medicine (CARPEM), Paris, France
174 rdf:type schema:Organization
175 Nad0aefb4bd634205a523e8b374dfc3e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Neoplasm Staging
177 rdf:type schema:DefinedTerm
178 Nad43771f8f244fc493bd6d90b0f08454 schema:name nlm_unique_id
179 schema:value 9420840
180 rdf:type schema:PropertyValue
181 Nb854c13b30f14cf194c086f51ac48da3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Aged
183 rdf:type schema:DefinedTerm
184 Nbe789b0664994c7ca5feb3c1f5775fda rdf:first sg:person.01203564254.60
185 rdf:rest rdf:nil
186 Nc02945576c8d4fbba345951f8feee26a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Survival Rate
188 rdf:type schema:DefinedTerm
189 Nc0b81434af234f289022514c892c3d64 rdf:first sg:person.01211341242.65
190 rdf:rest Nfa674c191a7f440a909558aab4a3dc0e
191 Nca938983f58846a28420ee26350c3b76 schema:name Department of Gastroenterology, Kremlin Bicêtre Hospital, Assistance publique-Hôpitaux de Paris (AP-HP), Paris Sud University, Le Kremlin Bicêtre, France
192 rdf:type schema:Organization
193 Ncc70b349d5954e838c0d1ce523a065dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Prognosis
195 rdf:type schema:DefinedTerm
196 Nd57e487e7f2f4e4a92bf0b8943bb3ecc schema:name Department of Gastroenterology and Digestive Oncology, HEGP Hospital, Assistance publique-Hôpitaux de Paris (AP-HP), Paris Descartes University, Cancer Research Personalized Medicine (CARPEM), Paris, France
197 rdf:type schema:Organization
198 Ndebb63c4302d448692726a3419ba8010 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Fluorouracil
200 rdf:type schema:DefinedTerm
201 Ne49a735cede846f6936bddc958f0253b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Neoplasm Recurrence, Local
203 rdf:type schema:DefinedTerm
204 Nef229a9ef5ba4b9088787ef810ff6ba0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Maximum Tolerated Dose
206 rdf:type schema:DefinedTerm
207 Nf3777f43f8ee4e739a0c0b9afa716ced rdf:first sg:person.01257672243.78
208 rdf:rest N371b63916ce64a1fa33387b7611bb270
209 Nf3c598e24bc74d75913c2c7d32dade1e schema:name Department of Oncology, Anticancer Center L. Bérard, Lyon, France
210 rdf:type schema:Organization
211 Nfa674c191a7f440a909558aab4a3dc0e rdf:first sg:person.01061023113.42
212 rdf:rest N8248c6540241418da4099ab856d7109c
213 Nfd73012c225a4e1e85224db7a76d5977 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Leucovorin
215 rdf:type schema:DefinedTerm
216 Nfe0a2e82467b450e9fac2a848d668d5e rdf:first sg:person.0765746641.37
217 rdf:rest N2f9a21d38c344c01a6b5212d2b291c30
218 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
219 schema:name Medical and Health Sciences
220 rdf:type schema:DefinedTerm
221 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
222 schema:name Clinical Sciences
223 rdf:type schema:DefinedTerm
224 sg:journal.1105545 schema:issn 1068-9265
225 1534-4681
226 schema:name Annals of Surgical Oncology
227 rdf:type schema:Periodical
228 sg:person.01013547071.99 schema:affiliation N493d239030bf4ad39fff1c4ddc9fe6ec
229 schema:familyName Thirot Bidault
230 schema:givenName A.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013547071.99
232 rdf:type schema:Person
233 sg:person.01030003625.43 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
234 schema:familyName Malka
235 schema:givenName D.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030003625.43
237 rdf:type schema:Person
238 sg:person.01061023113.42 schema:affiliation Naa639910b47745958696f937f2f47f4a
239 schema:familyName Trouilloud
240 schema:givenName I.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061023113.42
242 rdf:type schema:Person
243 sg:person.01102050226.24 schema:affiliation N820d6582da0a4ef4984d2bdbd5880cb4
244 schema:familyName Carbonnel
245 schema:givenName F.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102050226.24
247 rdf:type schema:Person
248 sg:person.01161065723.52 schema:affiliation https://www.grid.ac/institutes/grid.469409.6
249 schema:familyName Sa-Cunha
250 schema:givenName A.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161065723.52
252 rdf:type schema:Person
253 sg:person.01177602206.40 schema:affiliation https://www.grid.ac/institutes/grid.492937.2
254 schema:familyName Lécaille
255 schema:givenName C.
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177602206.40
257 rdf:type schema:Person
258 sg:person.01203564254.60 schema:affiliation Nd57e487e7f2f4e4a92bf0b8943bb3ecc
259 schema:familyName Taieb
260 schema:givenName J.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203564254.60
262 rdf:type schema:Person
263 sg:person.01211341242.65 schema:affiliation N146de5a928ee4e9d8a5d4a8976bf000f
264 schema:familyName Francois
265 schema:givenName E.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211341242.65
267 rdf:type schema:Person
268 sg:person.01257672243.78 schema:affiliation N5aaf037613bd40b3be930ad8eac43dc1
269 schema:familyName Gauthier
270 schema:givenName M.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257672243.78
272 rdf:type schema:Person
273 sg:person.01273613126.15 schema:affiliation https://www.grid.ac/institutes/grid.469409.6
274 schema:familyName Terrebonne
275 schema:givenName E.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273613126.15
277 rdf:type schema:Person
278 sg:person.01274370774.96 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
279 schema:familyName Coriat
280 schema:givenName R.
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274370774.96
282 rdf:type schema:Person
283 sg:person.01304763136.25 schema:affiliation Nf3c598e24bc74d75913c2c7d32dade1e
284 schema:familyName De La Fouchardière
285 schema:givenName C.
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304763136.25
287 rdf:type schema:Person
288 sg:person.01325517414.48 schema:affiliation N9ec5e8f7e25a4d08b7742de874f84300
289 schema:familyName Solub
290 schema:givenName D.
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325517414.48
292 rdf:type schema:Person
293 sg:person.01335760213.46 schema:affiliation Nca938983f58846a28420ee26350c3b76
294 schema:familyName Marthey
295 schema:givenName L.
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335760213.46
297 rdf:type schema:Person
298 sg:person.01344060476.84 schema:affiliation https://www.grid.ac/institutes/grid.414339.8
299 schema:familyName Blanc
300 schema:givenName J. F.
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344060476.84
302 rdf:type schema:Person
303 sg:person.0717271020.72 schema:affiliation N08d6ca7891984a85bd781eda31147a3f
304 schema:familyName Cueff
305 schema:givenName A.
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717271020.72
307 rdf:type schema:Person
308 sg:person.0747131643.21 schema:affiliation https://www.grid.ac/institutes/grid.414271.5
309 schema:familyName Manfredi
310 schema:givenName S.
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747131643.21
312 rdf:type schema:Person
313 sg:person.0765746641.37 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
314 schema:familyName Bachet
315 schema:givenName J. B.
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765746641.37
317 rdf:type schema:Person
318 sg:pub.10.1007/s12032-012-0361-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041672338
319 https://doi.org/10.1007/s12032-012-0361-2
320 rdf:type schema:CreativeWork
321 sg:pub.10.1016/s1091-255x(03)00113-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042903832
322 https://doi.org/10.1016/s1091-255x(03)00113-6
323 rdf:type schema:CreativeWork
324 sg:pub.10.1186/1471-2407-12-199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046942754
325 https://doi.org/10.1186/1471-2407-12-199
326 rdf:type schema:CreativeWork
327 sg:pub.10.1245/s10434-008-0295-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005006861
328 https://doi.org/10.1245/s10434-008-0295-2
329 rdf:type schema:CreativeWork
330 sg:pub.10.1245/s10434-010-1285-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012685239
331 https://doi.org/10.1245/s10434-010-1285-8
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1001/archsurg.2009.67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011824921
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1001/jama.297.3.267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010434617
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.ejca.2008.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018937917
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.jamcollsurg.2005.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015633345
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/s0360-3016(01)02740-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008452911
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1056/nejmoa032295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048680038
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1056/nejmoa1011923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022967950
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1093/annonc/mdn281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019387985
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1093/jnci/92.3.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032301848
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1097/sla.0b013e3181ad657b schema:sameAs https://app.dimensions.ai/details/publication/pub.1033637948
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1200/jco.1997.15.6.2403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083106816
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1200/jco.2005.06.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044349219
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1200/jco.2006.07.5663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028501594
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1200/jco.2006.07.9525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005176755
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1200/jco.2008.19.7921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010404921
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1200/jco.2011.34.8904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049252722
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1371/journal.pmed.1000267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045271156
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1634/theoncologist.2012-0435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011973810
368 rdf:type schema:CreativeWork
369 https://doi.org/10.3322/caac.20138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020626779
370 rdf:type schema:CreativeWork
371 https://www.grid.ac/institutes/grid.14925.3b schema:alternateName Institut Gustave Roussy
372 schema:name Department of Oncology, Institut Gustave Roussy, Villejuif, France
373 rdf:type schema:Organization
374 https://www.grid.ac/institutes/grid.411439.a schema:alternateName Pitié-Salpêtrière Hospital
375 schema:name Department of Gastroenterology, La Pitié-Salpétrière Hospital, Assistance publique-Hôpitaux de Paris (AP-HP), Paris, France
376 rdf:type schema:Organization
377 https://www.grid.ac/institutes/grid.411784.f schema:alternateName Hôpital Cochin
378 schema:name Department of Gastroenterology, Cochin Hospital, Assistance publique-Hôpitaux de Paris (AP-HP), Paris, France
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.414271.5 schema:alternateName l'Hôpital Pontchaillou
381 schema:name Department of Gastroenterology, Pontchaillou Hospital, Rennes, France
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.414339.8 schema:alternateName Hôpital Saint-André
384 schema:name Department of Gastroenterology, Saint-André Hospital, Bordeaux, France
385 rdf:type schema:Organization
386 https://www.grid.ac/institutes/grid.469409.6 schema:alternateName Hôpital Cardiologique du Haut-Lévêque
387 schema:name Department of Digestive Surgery, Haut-Lévêque Hospital, Pessac, France
388 Department of Gastroenterology, Haut-Lévêque Hospital, Pessac, France
389 rdf:type schema:Organization
390 https://www.grid.ac/institutes/grid.492937.2 schema:alternateName Polyclinic Bordeaux North Aquitaine
391 schema:name Department of Gastroenterology, Polyclinique Bordeaux Nord Aquitaine, Bordeaux, France
392 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...