Predictors that Influence Contralateral Prophylactic Mastectomy Election Among Women with Ductal Carcinoma In Situ Who Were Evaluated for BRCA Genetic ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10

AUTHORS

Nisreen Elsayegh, Henry M. Kuerer, Heather Lin, Angelica M. Gutierrez Barrera, Michelle Jackson, Kimberly I. Muse, Jennifer K. Litton, Constance Albarracin, Aimaz Afrough, Gabriel N. Hortobagyi, Banu K. Arun

ABSTRACT

BACKGROUND: Patients with ductal carcinoma in situ (DCIS) are at increased risk for developing contralateral breast cancer (CBC). Consequently, more women with DCIS are electing to undergo contralateral prophylactic mastectomy (CPM). We evaluated factors associated with CPM in patients with DCIS who underwent genetic counseling for BRCA testing. METHODS: This retrospective study involved 165 women with DCIS referred for genetic counseling between 2003 and 2011. Patient characteristics were age, marital and educational status, tumor markers, nuclear grade, family history of breast cancer (BC) and ovarian cancer (OC), race, Ashkenazi Jewish ancestry, and BRCA results. Univariate and multivariate logistic regression analyses were used to determine predictive factors associated with CPM election. RESULTS: Of 165 patients, 44 (27 %) underwent CPM. Patients <45 years of age were more likely to elect CPM (p = 0.0098). A BRCA+ mutation was found in 17 patients (10.3 %), and BRCA+ women were more likely to elect CPM than BRCA or untested women (p = 0.0001). Patients who had a family history of OC (57.7 %) were more likely to choose CPM than those with no family history (p = 0.0004). Younger age, BRCA+, and an OC family history remained significant in the multivariate model (p < 0.008). CONCLUSION: The CPM rate among patients with DCIS who undergo genetic counseling is high. Factors associated with increased likelihood of CPM among this group were age, BRCA+, and a family history of OC. Further studies are needed to evaluate patients' perceptions of CBC risk and their role in the likelihood of CPM choice. More... »

PAGES

3466-3472

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-014-3747-x

DOI

http://dx.doi.org/10.1245/s10434-014-3747-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017806679

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24796968


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "BRCA1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "BRCA2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Ductal, Breast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Intraductal, Noninfiltrating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Testing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mastectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elsayegh", 
        "givenName": "Nisreen", 
        "id": "sg:person.0625512053.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625512053.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuerer", 
        "givenName": "Henry M.", 
        "id": "sg:person.0735722260.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735722260.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Heather", 
        "id": "sg:person.07516466074.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07516466074.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gutierrez Barrera", 
        "givenName": "Angelica M.", 
        "id": "sg:person.01215721203.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215721203.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Clinical Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jackson", 
        "givenName": "Michelle", 
        "id": "sg:person.01005417060.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005417060.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Clinical Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muse", 
        "givenName": "Kimberly I.", 
        "id": "sg:person.01023575060.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023575060.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Litton", 
        "givenName": "Jennifer K.", 
        "id": "sg:person.01066346453.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066346453.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Albarracin", 
        "givenName": "Constance", 
        "id": "sg:person.0635671453.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635671453.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Afrough", 
        "givenName": "Aimaz", 
        "id": "sg:person.0750744070.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750744070.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hortobagyi", 
        "givenName": "Gabriel N.", 
        "id": "sg:person.01365732165.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365732165.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
            "Department of Clinical Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arun", 
        "givenName": "Banu K.", 
        "id": "sg:person.0763665266.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763665266.91"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1245/s10434-012-2413-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004272330", 
          "https://doi.org/10.1245/s10434-012-2413-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.04.188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004923574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012331329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012331329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-012-2299-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015015285", 
          "https://doi.org/10.1245/s10434-012-2299-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200107193450301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016947831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1940-6207.capr-09-0130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017331677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.0345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027266692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjsurg.2011.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029825282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2009.01329.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029925199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2009.01329.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029925199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.18.3103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031005539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033613328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/90.15.1138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035190509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038373421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.6772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039322271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000276573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040750964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.20.1681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045270246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/93.21.1633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045594547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10434-999-0542-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052817805", 
          "https://doi.org/10.1007/s10434-999-0542-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-007-9449-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052936329", 
          "https://doi.org/10.1245/s10434-007-9449-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/301749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058609356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.6.1480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076979930", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1109491887", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1109491887", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-10", 
    "datePublishedReg": "2014-10-01", 
    "description": "BACKGROUND: Patients with ductal carcinoma in situ (DCIS) are at increased risk for developing contralateral breast cancer (CBC). Consequently, more women with DCIS are electing to undergo contralateral prophylactic mastectomy (CPM). We evaluated factors associated with CPM in patients with DCIS who underwent genetic counseling for BRCA testing.\nMETHODS: This retrospective study involved 165 women with DCIS referred for genetic counseling between 2003 and 2011. Patient characteristics\u00a0were age, marital and educational status, tumor markers, nuclear grade, family history of breast cancer (BC) and ovarian cancer (OC), race, Ashkenazi Jewish ancestry, and BRCA results. Univariate and multivariate logistic regression analyses were used to determine predictive factors associated with CPM election.\nRESULTS: Of 165 patients, 44 (27\u00a0%) underwent CPM. Patients <45\u00a0years of age were more likely to elect CPM (p\u00a0=\u00a00.0098). A BRCA+ mutation was found in 17 patients (10.3\u00a0%), and BRCA+ women were more likely to elect CPM than BRCA or untested women (p\u00a0=\u00a00.0001). Patients who had a family history of OC (57.7\u00a0%) were more likely to choose CPM than those with no family history (p\u00a0=\u00a00.0004). Younger age, BRCA+, and an OC family history remained significant in the multivariate model (p\u00a0<\u00a00.008).\nCONCLUSION: The CPM rate among patients with DCIS who undergo genetic counseling is high. Factors associated with increased likelihood of CPM among this group were age, BRCA+, and a family history of OC. Further studies are needed to evaluate patients' perceptions of CBC risk and their role in the likelihood of CPM choice.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-014-3747-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Predictors that Influence Contralateral Prophylactic Mastectomy Election Among Women with Ductal Carcinoma In Situ Who Were Evaluated for BRCA Genetic Testing", 
    "pagination": "3466-3472", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "54d7be631baf08fccb01965adf191b4b0a64696fdfb3d8c8c5d7fbc35d67b8a7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24796968"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-014-3747-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017806679"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-014-3747-x", 
      "https://app.dimensions.ai/details/publication/pub.1017806679"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000584.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1245/s10434-014-3747-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-3747-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-3747-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-3747-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-014-3747-x'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      70 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-014-3747-x schema:about N0ff91f02af9f42bf864db5b3ddf79874
2 N159a2001af9c4fbb939e0df2344e87f7
3 N1ad7043d0d8244889149ddff5c361749
4 N2179ddd1b149475399dcbda30b8cb069
5 N3365eb7f138f4c4ab5d9b4b558189460
6 N468df82900f1402d84c76f33df1369f1
7 N6440f17a6303490f928412054c783d70
8 N6fc6043099fa46398b53467362cd00e8
9 N790c45a41bf5442390089b774a2bee03
10 N7c708728f86d4841ab23ad6caa8a294f
11 N7ed139566d8b4bbfbbfbc54070495e89
12 N9b8b6ade67ab49818900034834831236
13 Naf6ab1735d8c4411bb221a9484096c0c
14 Nb2844f83e50b4daeb7edcd3de5b61e79
15 Nde93fb4e99f44b0ca49e6e3750433a08
16 Ne57dbb3835af450f966d8392d0d5ed37
17 Nec836814c158447f99ca3f4235ecaee9
18 Nfb9ecdabb73c4d9e8db0374cdd86e977
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author Nde2187c66daa4fb2995f31ee26ce68a2
22 schema:citation sg:pub.10.1007/s10434-999-0542-1
23 sg:pub.10.1245/s10434-007-9449-x
24 sg:pub.10.1245/s10434-012-2299-1
25 sg:pub.10.1245/s10434-012-2413-4
26 https://app.dimensions.ai/details/publication/pub.1076979930
27 https://app.dimensions.ai/details/publication/pub.1109491887
28 https://doi.org/10.1002/cncr.20617
29 https://doi.org/10.1002/cncr.24199
30 https://doi.org/10.1002/cncr.26428
31 https://doi.org/10.1016/j.amjsurg.2011.04.001
32 https://doi.org/10.1056/nejm200107193450301
33 https://doi.org/10.1086/301749
34 https://doi.org/10.1093/jnci/90.15.1138
35 https://doi.org/10.1093/jnci/93.21.1633
36 https://doi.org/10.1111/j.1399-0004.2009.01329.x
37 https://doi.org/10.1158/1940-6207.capr-09-0130
38 https://doi.org/10.1159/000276573
39 https://doi.org/10.1200/jco.20.6.1480
40 https://doi.org/10.1200/jco.2004.04.188
41 https://doi.org/10.1200/jco.2005.03.6772
42 https://doi.org/10.1200/jco.2005.04.0345
43 https://doi.org/10.1200/jco.2008.18.3103
44 https://doi.org/10.1200/jco.2008.20.1681
45 schema:datePublished 2014-10
46 schema:datePublishedReg 2014-10-01
47 schema:description BACKGROUND: Patients with ductal carcinoma in situ (DCIS) are at increased risk for developing contralateral breast cancer (CBC). Consequently, more women with DCIS are electing to undergo contralateral prophylactic mastectomy (CPM). We evaluated factors associated with CPM in patients with DCIS who underwent genetic counseling for BRCA testing. METHODS: This retrospective study involved 165 women with DCIS referred for genetic counseling between 2003 and 2011. Patient characteristics were age, marital and educational status, tumor markers, nuclear grade, family history of breast cancer (BC) and ovarian cancer (OC), race, Ashkenazi Jewish ancestry, and BRCA results. Univariate and multivariate logistic regression analyses were used to determine predictive factors associated with CPM election. RESULTS: Of 165 patients, 44 (27 %) underwent CPM. Patients <45 years of age were more likely to elect CPM (p = 0.0098). A BRCA+ mutation was found in 17 patients (10.3 %), and BRCA+ women were more likely to elect CPM than BRCA or untested women (p = 0.0001). Patients who had a family history of OC (57.7 %) were more likely to choose CPM than those with no family history (p = 0.0004). Younger age, BRCA+, and an OC family history remained significant in the multivariate model (p < 0.008). CONCLUSION: The CPM rate among patients with DCIS who undergo genetic counseling is high. Factors associated with increased likelihood of CPM among this group were age, BRCA+, and a family history of OC. Further studies are needed to evaluate patients' perceptions of CBC risk and their role in the likelihood of CPM choice.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf Nab9dfad8c2b444d595f6fcc627f853d7
52 Nb0b8cd2bf6c4446aa4dd1b36c074152d
53 sg:journal.1105545
54 schema:name Predictors that Influence Contralateral Prophylactic Mastectomy Election Among Women with Ductal Carcinoma In Situ Who Were Evaluated for BRCA Genetic Testing
55 schema:pagination 3466-3472
56 schema:productId N14e58b34270245a3a9d355b294b0d3c4
57 N433b242603704f4b87ad18200c02f443
58 N4bf588864ef24350b87dda7dd07994a9
59 N999416cd075542c7900420c394a7f48f
60 Nf1596e82f8104b169dd1324c3b471aef
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017806679
62 https://doi.org/10.1245/s10434-014-3747-x
63 schema:sdDatePublished 2019-04-10T18:30
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N372b2f34e8e84d77b77868f7ee0acb61
66 schema:url http://link.springer.com/10.1245/s10434-014-3747-x
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N0ff91f02af9f42bf864db5b3ddf79874 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Humans
72 rdf:type schema:DefinedTerm
73 N14e58b34270245a3a9d355b294b0d3c4 schema:name nlm_unique_id
74 schema:value 9420840
75 rdf:type schema:PropertyValue
76 N159a2001af9c4fbb939e0df2344e87f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Retrospective Studies
78 rdf:type schema:DefinedTerm
79 N17eefa4840904c5781e8cd68ff2e547c rdf:first sg:person.01005417060.91
80 rdf:rest N791f7b46b686472c805bbf6722abaf4f
81 N1ad7043d0d8244889149ddff5c361749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Ovarian Neoplasms
83 rdf:type schema:DefinedTerm
84 N2179ddd1b149475399dcbda30b8cb069 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Carcinoma, Intraductal, Noninfiltrating
86 rdf:type schema:DefinedTerm
87 N3365eb7f138f4c4ab5d9b4b558189460 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name BRCA1 Protein
89 rdf:type schema:DefinedTerm
90 N372b2f34e8e84d77b77868f7ee0acb61 schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N39ec843f716d44bb88f96b2f829e44ac rdf:first sg:person.01066346453.04
93 rdf:rest N751754324c4e47598022750d041ede91
94 N433b242603704f4b87ad18200c02f443 schema:name dimensions_id
95 schema:value pub.1017806679
96 rdf:type schema:PropertyValue
97 N468df82900f1402d84c76f33df1369f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Female
99 rdf:type schema:DefinedTerm
100 N4bf588864ef24350b87dda7dd07994a9 schema:name readcube_id
101 schema:value 54d7be631baf08fccb01965adf191b4b0a64696fdfb3d8c8c5d7fbc35d67b8a7
102 rdf:type schema:PropertyValue
103 N6440f17a6303490f928412054c783d70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Mastectomy
105 rdf:type schema:DefinedTerm
106 N6fc6043099fa46398b53467362cd00e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Neoplasm Staging
108 rdf:type schema:DefinedTerm
109 N751754324c4e47598022750d041ede91 rdf:first sg:person.0635671453.50
110 rdf:rest Na49a18da410b49b3acde1fc029e31534
111 N790c45a41bf5442390089b774a2bee03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Age Factors
113 rdf:type schema:DefinedTerm
114 N791f7b46b686472c805bbf6722abaf4f rdf:first sg:person.01023575060.08
115 rdf:rest N39ec843f716d44bb88f96b2f829e44ac
116 N7c708728f86d4841ab23ad6caa8a294f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Middle Aged
118 rdf:type schema:DefinedTerm
119 N7ed139566d8b4bbfbbfbc54070495e89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Carcinoma, Ductal, Breast
121 rdf:type schema:DefinedTerm
122 N999416cd075542c7900420c394a7f48f schema:name doi
123 schema:value 10.1245/s10434-014-3747-x
124 rdf:type schema:PropertyValue
125 N9b8b6ade67ab49818900034834831236 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Follow-Up Studies
127 rdf:type schema:DefinedTerm
128 N9ffce9eb89a44852abc1fe08fac7e685 rdf:first sg:person.07516466074.95
129 rdf:rest Nb5d158544b0b4c1da4e1c4e197681cd7
130 Na49a18da410b49b3acde1fc029e31534 rdf:first sg:person.0750744070.11
131 rdf:rest Nde452ec919db4712894f1df1ebe5ebea
132 Nab9dfad8c2b444d595f6fcc627f853d7 schema:volumeNumber 21
133 rdf:type schema:PublicationVolume
134 Naf6ab1735d8c4411bb221a9484096c0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Mutation
136 rdf:type schema:DefinedTerm
137 Nb0b8cd2bf6c4446aa4dd1b36c074152d schema:issueNumber 11
138 rdf:type schema:PublicationIssue
139 Nb19718d0c2d24445853ec9044fe267e5 rdf:first sg:person.0735722260.03
140 rdf:rest N9ffce9eb89a44852abc1fe08fac7e685
141 Nb2844f83e50b4daeb7edcd3de5b61e79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name BRCA2 Protein
143 rdf:type schema:DefinedTerm
144 Nb5d158544b0b4c1da4e1c4e197681cd7 rdf:first sg:person.01215721203.23
145 rdf:rest N17eefa4840904c5781e8cd68ff2e547c
146 Ndad39944b51f45e0908e56e67c01a28f rdf:first sg:person.0763665266.91
147 rdf:rest rdf:nil
148 Nde2187c66daa4fb2995f31ee26ce68a2 rdf:first sg:person.0625512053.90
149 rdf:rest Nb19718d0c2d24445853ec9044fe267e5
150 Nde452ec919db4712894f1df1ebe5ebea rdf:first sg:person.01365732165.24
151 rdf:rest Ndad39944b51f45e0908e56e67c01a28f
152 Nde93fb4e99f44b0ca49e6e3750433a08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Prognosis
154 rdf:type schema:DefinedTerm
155 Ne57dbb3835af450f966d8392d0d5ed37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Genetic Testing
157 rdf:type schema:DefinedTerm
158 Nec836814c158447f99ca3f4235ecaee9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Breast Neoplasms
160 rdf:type schema:DefinedTerm
161 Nf1596e82f8104b169dd1324c3b471aef schema:name pubmed_id
162 schema:value 24796968
163 rdf:type schema:PropertyValue
164 Nfb9ecdabb73c4d9e8db0374cdd86e977 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Neoplasm Grading
166 rdf:type schema:DefinedTerm
167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
168 schema:name Medical and Health Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
171 schema:name Oncology and Carcinogenesis
172 rdf:type schema:DefinedTerm
173 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1245/s10434-014-3747-x
174 rdf:type schema:MonetaryGrant
175 sg:journal.1105545 schema:issn 1068-9265
176 1534-4681
177 schema:name Annals of Surgical Oncology
178 rdf:type schema:Periodical
179 sg:person.01005417060.91 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
180 schema:familyName Jackson
181 schema:givenName Michelle
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005417060.91
183 rdf:type schema:Person
184 sg:person.01023575060.08 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
185 schema:familyName Muse
186 schema:givenName Kimberly I.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023575060.08
188 rdf:type schema:Person
189 sg:person.01066346453.04 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
190 schema:familyName Litton
191 schema:givenName Jennifer K.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066346453.04
193 rdf:type schema:Person
194 sg:person.01215721203.23 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
195 schema:familyName Gutierrez Barrera
196 schema:givenName Angelica M.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215721203.23
198 rdf:type schema:Person
199 sg:person.01365732165.24 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
200 schema:familyName Hortobagyi
201 schema:givenName Gabriel N.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365732165.24
203 rdf:type schema:Person
204 sg:person.0625512053.90 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
205 schema:familyName Elsayegh
206 schema:givenName Nisreen
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625512053.90
208 rdf:type schema:Person
209 sg:person.0635671453.50 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
210 schema:familyName Albarracin
211 schema:givenName Constance
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635671453.50
213 rdf:type schema:Person
214 sg:person.0735722260.03 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
215 schema:familyName Kuerer
216 schema:givenName Henry M.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735722260.03
218 rdf:type schema:Person
219 sg:person.0750744070.11 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
220 schema:familyName Afrough
221 schema:givenName Aimaz
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750744070.11
223 rdf:type schema:Person
224 sg:person.07516466074.95 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
225 schema:familyName Lin
226 schema:givenName Heather
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07516466074.95
228 rdf:type schema:Person
229 sg:person.0763665266.91 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
230 schema:familyName Arun
231 schema:givenName Banu K.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763665266.91
233 rdf:type schema:Person
234 sg:pub.10.1007/s10434-999-0542-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052817805
235 https://doi.org/10.1007/s10434-999-0542-1
236 rdf:type schema:CreativeWork
237 sg:pub.10.1245/s10434-007-9449-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052936329
238 https://doi.org/10.1245/s10434-007-9449-x
239 rdf:type schema:CreativeWork
240 sg:pub.10.1245/s10434-012-2299-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015015285
241 https://doi.org/10.1245/s10434-012-2299-1
242 rdf:type schema:CreativeWork
243 sg:pub.10.1245/s10434-012-2413-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004272330
244 https://doi.org/10.1245/s10434-012-2413-4
245 rdf:type schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1076979930 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1109491887 schema:CreativeWork
248 https://doi.org/10.1002/cncr.20617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038373421
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1002/cncr.24199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012331329
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/cncr.26428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033613328
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.amjsurg.2011.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029825282
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1056/nejm200107193450301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016947831
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1086/301749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058609356
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1093/jnci/90.15.1138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035190509
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1093/jnci/93.21.1633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045594547
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/j.1399-0004.2009.01329.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029925199
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1158/1940-6207.capr-09-0130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017331677
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1159/000276573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040750964
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1200/jco.20.6.1480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202871
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1200/jco.2004.04.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004923574
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1200/jco.2005.03.6772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039322271
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1200/jco.2005.04.0345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027266692
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1200/jco.2008.18.3103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031005539
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1200/jco.2008.20.1681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045270246
281 rdf:type schema:CreativeWork
282 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
283 schema:name Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
284 Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
285 Department of Clinical Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
286 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...