Peritoneal Carcinomatosis in T4 Colorectal Cancer: Occurrence and Risk Factors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-05

AUTHORS

H. C. van Santvoort, H. J. Braam, K. R. Spekreijse, N. R. Koning, P. C. de Bruin, T. S. de Vries Reilingh, D. Boerma, A. B. Smits, M. J. Wiezer, B. van Ramshorst

ABSTRACT

BACKGROUND: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy improves outcome of patients with peritoneal carcinomatosis (PC) of colorectal carcinoma. Data on the occurrence of PC in T4 colorectal carcinoma are scarce. We investigated the occurrence and risk factors for PC in these patients. METHODS: This was a retrospective cohort study of patients undergoing a first resection of a T4 colorectal carcinoma in a tertiary hospital between January 2000 and December 2007. Primary outcome was the occurrence of synchronous or metachronous PC. The association with PC and several patient and tumor characteristics was evaluated using logistic regression. RESULTS: A total of 200 patients underwent resection of a T4 colorectal carcinoma. Median follow-up censored for death was 66 months (18-89 months). Synchronous PC was found in 46 of 200 patients (23 %) and metachronous PC in 33 of 154 patients (21 %). In univariable analysis, factors associated with PC were: age (OR 0.97; 95 % CI 0.94-0.99; P = 0.03), radical resection (OR 0.32; 95 % CI 0.11-0.91; P = 0.03), and N stage (OR 1.63; 95 % CI 1.36-2.34; P = 0.008). In multivariable analysis, only N stage was associated with PC (OR 1.62; 95 % CI 1.12-2.34; P = 0.01). This association was not significant for the 154 patients at risk for metachronous PC. CONCLUSIONS: Around 1 in 5 patients undergoing resection of a T4 colorectal carcinoma either have PC during primary resection or develop PC during follow-up. N stage was associated with PC in the entire study population. However, none of the clinical or pathological variables were associated with the risk of metachronous PC and therefore cannot be used to develop targeted surveillance strategies. More... »

PAGES

1686-1691

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-013-3461-0

DOI

http://dx.doi.org/10.1245/s10434-013-3461-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053623103

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24398543


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