Peritoneal Carcinomatosis in T4 Colorectal Cancer: Occurrence and Risk Factors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-05

AUTHORS

H. C. van Santvoort, H. J. Braam, K. R. Spekreijse, N. R. Koning, P. C. de Bruin, T. S. de Vries Reilingh, D. Boerma, A. B. Smits, M. J. Wiezer, B. van Ramshorst

ABSTRACT

BACKGROUND: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy improves outcome of patients with peritoneal carcinomatosis (PC) of colorectal carcinoma. Data on the occurrence of PC in T4 colorectal carcinoma are scarce. We investigated the occurrence and risk factors for PC in these patients. METHODS: This was a retrospective cohort study of patients undergoing a first resection of a T4 colorectal carcinoma in a tertiary hospital between January 2000 and December 2007. Primary outcome was the occurrence of synchronous or metachronous PC. The association with PC and several patient and tumor characteristics was evaluated using logistic regression. RESULTS: A total of 200 patients underwent resection of a T4 colorectal carcinoma. Median follow-up censored for death was 66 months (18-89 months). Synchronous PC was found in 46 of 200 patients (23 %) and metachronous PC in 33 of 154 patients (21 %). In univariable analysis, factors associated with PC were: age (OR 0.97; 95 % CI 0.94-0.99; P = 0.03), radical resection (OR 0.32; 95 % CI 0.11-0.91; P = 0.03), and N stage (OR 1.63; 95 % CI 1.36-2.34; P = 0.008). In multivariable analysis, only N stage was associated with PC (OR 1.62; 95 % CI 1.12-2.34; P = 0.01). This association was not significant for the 154 patients at risk for metachronous PC. CONCLUSIONS: Around 1 in 5 patients undergoing resection of a T4 colorectal carcinoma either have PC during primary resection or develop PC during follow-up. N stage was associated with PC in the entire study population. However, none of the clinical or pathological variables were associated with the risk of metachronous PC and therefore cannot be used to develop targeted surveillance strategies. More... »

PAGES

1686-1691

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-013-3461-0

DOI

http://dx.doi.org/10.1245/s10434-013-3461-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053623103

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24398543


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peritoneal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postoperative Complications", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Santvoort", 
        "givenName": "H. C.", 
        "id": "sg:person.01004354234.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004354234.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braam", 
        "givenName": "H. J.", 
        "id": "sg:person.01001031234.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001031234.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spekreijse", 
        "givenName": "K. R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koning", 
        "givenName": "N. R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Pathology, St. Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Bruin", 
        "givenName": "P. C.", 
        "id": "sg:person.01227107510.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227107510.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Vries Reilingh", 
        "givenName": "T. S.", 
        "id": "sg:person.0673036360.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673036360.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boerma", 
        "givenName": "D.", 
        "id": "sg:person.01177737131.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177737131.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smits", 
        "givenName": "A. B.", 
        "id": "sg:person.01032543451.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032543451.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wiezer", 
        "givenName": "M. J.", 
        "id": "sg:person.01314165531.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314165531.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Ramshorst", 
        "givenName": "B.", 
        "id": "sg:person.0756446730.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756446730.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/cncr.25250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001280325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.25250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001280325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02656730701455318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003470891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31815f0113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007455066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31815f0113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007455066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31815f0113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007455066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009055747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.294.21.2703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010628322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181a45d86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019299634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181a45d86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019299634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181a45d86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019299634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000197702.46394.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019731745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000197702.46394.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019731745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000197702.46394.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019731745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19980815)83:4<666::aid-cncr6>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025416621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.8679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028483593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2168.2002.02274.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028716593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181d9765d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030051577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181d9765d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030051577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181d9765d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030051577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-008-9966-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030091417", 
          "https://doi.org/10.1245/s10434-008-9966-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2008.10.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031190495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.6622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033642170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.6622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033642170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034294500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61602-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036200026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-012-2473-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038298896", 
          "https://doi.org/10.1245/s10434-012-2473-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2012.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039663666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/aso.2004.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040637674", 
          "https://doi.org/10.1245/aso.2004.08.014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/aso.2004.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040637674", 
          "https://doi.org/10.1245/aso.2004.08.014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-2456(96)00075-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047730164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.04.187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203564"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-05", 
    "datePublishedReg": "2014-05-01", 
    "description": "BACKGROUND: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy improves outcome of patients with peritoneal carcinomatosis (PC) of colorectal carcinoma. Data on the occurrence of PC in T4 colorectal carcinoma are scarce. We investigated the occurrence and risk factors for PC in these patients.\nMETHODS: This was a retrospective cohort study of patients undergoing a first resection of a T4 colorectal carcinoma in a tertiary hospital between January 2000 and December 2007. Primary outcome was the occurrence of synchronous or metachronous PC. The association with PC and several patient and tumor characteristics was evaluated using logistic regression.\nRESULTS: A total of 200 patients underwent resection of a T4 colorectal carcinoma. Median follow-up censored for death was 66 months (18-89 months). Synchronous PC was found in 46 of 200 patients (23 %) and metachronous PC in 33 of 154 patients (21 %). In univariable analysis, factors associated with PC were: age (OR 0.97; 95 % CI 0.94-0.99; P = 0.03), radical resection (OR 0.32; 95 % CI 0.11-0.91; P = 0.03), and N stage (OR 1.63; 95 % CI 1.36-2.34; P = 0.008). In multivariable analysis, only N stage was associated with PC (OR 1.62; 95 % CI 1.12-2.34; P = 0.01). This association was not significant for the 154 patients at risk for metachronous PC.\nCONCLUSIONS: Around 1 in 5 patients undergoing resection of a T4 colorectal carcinoma either have PC during primary resection or develop PC during follow-up. N stage was associated with PC in the entire study population. However, none of the clinical or pathological variables were associated with the risk of metachronous PC and therefore cannot be used to develop targeted surveillance strategies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-013-3461-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Peritoneal Carcinomatosis in T4 Colorectal Cancer: Occurrence and Risk Factors", 
    "pagination": "1686-1691", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ff69bd66cc127055dd709b8274f302d6afa61275834d4dfe662c972b30d3de88"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24398543"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-013-3461-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053623103"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-013-3461-0", 
      "https://app.dimensions.ai/details/publication/pub.1053623103"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000501.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1245/s10434-013-3461-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3461-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3461-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3461-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3461-0'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      65 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-013-3461-0 schema:about N043bd763d347448d9cc33fefadd715ae
2 N2018eca09f8a42a29ca08faf7d51faf0
3 N5f013c642d2e4edf92a27226ce43f9c7
4 N5f34929bf0ac402097af4a75f40831c4
5 N77818133eca0480097568acf8e5c755a
6 N77cbf6a8e10248dca0a5a653fabb573d
7 N78a138b63aaf4e2d9d465fff5edeb934
8 N7977c12f31604b8590cee30f9c6b557e
9 N7a6edad7b1d14bc589984addab876362
10 Na1b2c02f04d04a41abd86c8eb7280522
11 Nae7820d2c7c34064af38c968209e0c9c
12 Ncea00d9901fc46bf8ac0c1cf5d4a5cbc
13 Nd6ee0c2007f741e79cceb5c0777a2459
14 Ne8e35cc2156c4335b7b12e59f738e686
15 Nff0edcbf2f0f46d6b2df9e943693a753
16 anzsrc-for:11
17 anzsrc-for:1117
18 schema:author N1bad9a818bbd4d58a8375cf57f88d2d3
19 schema:citation sg:pub.10.1245/aso.2004.08.014
20 sg:pub.10.1245/s10434-008-9966-2
21 sg:pub.10.1245/s10434-012-2473-5
22 https://doi.org/10.1001/jama.294.21.2703
23 https://doi.org/10.1002/(sici)1097-0142(19980815)83:4<666::aid-cncr6>3.0.co;2-i
24 https://doi.org/10.1002/bjs.6622
25 https://doi.org/10.1002/bjs.8679
26 https://doi.org/10.1002/cncr.25250
27 https://doi.org/10.1016/0197-2456(96)00075-x
28 https://doi.org/10.1016/j.ctrv.2012.11.003
29 https://doi.org/10.1016/j.ejso.2008.10.006
30 https://doi.org/10.1016/s0140-6736(07)61602-x
31 https://doi.org/10.1046/j.1365-2168.2002.02274.x
32 https://doi.org/10.1080/02656730701455318
33 https://doi.org/10.1093/annonc/mds236
34 https://doi.org/10.1097/01.sla.0000197702.46394.16
35 https://doi.org/10.1097/sla.0b013e31815f0113
36 https://doi.org/10.1097/sla.0b013e3181a45d86
37 https://doi.org/10.1097/sla.0b013e3181d9765d
38 https://doi.org/10.1200/jco.2003.04.187
39 https://doi.org/10.3322/caac.20107
40 schema:datePublished 2014-05
41 schema:datePublishedReg 2014-05-01
42 schema:description BACKGROUND: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy improves outcome of patients with peritoneal carcinomatosis (PC) of colorectal carcinoma. Data on the occurrence of PC in T4 colorectal carcinoma are scarce. We investigated the occurrence and risk factors for PC in these patients. METHODS: This was a retrospective cohort study of patients undergoing a first resection of a T4 colorectal carcinoma in a tertiary hospital between January 2000 and December 2007. Primary outcome was the occurrence of synchronous or metachronous PC. The association with PC and several patient and tumor characteristics was evaluated using logistic regression. RESULTS: A total of 200 patients underwent resection of a T4 colorectal carcinoma. Median follow-up censored for death was 66 months (18-89 months). Synchronous PC was found in 46 of 200 patients (23 %) and metachronous PC in 33 of 154 patients (21 %). In univariable analysis, factors associated with PC were: age (OR 0.97; 95 % CI 0.94-0.99; P = 0.03), radical resection (OR 0.32; 95 % CI 0.11-0.91; P = 0.03), and N stage (OR 1.63; 95 % CI 1.36-2.34; P = 0.008). In multivariable analysis, only N stage was associated with PC (OR 1.62; 95 % CI 1.12-2.34; P = 0.01). This association was not significant for the 154 patients at risk for metachronous PC. CONCLUSIONS: Around 1 in 5 patients undergoing resection of a T4 colorectal carcinoma either have PC during primary resection or develop PC during follow-up. N stage was associated with PC in the entire study population. However, none of the clinical or pathological variables were associated with the risk of metachronous PC and therefore cannot be used to develop targeted surveillance strategies.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree false
46 schema:isPartOf Ncf7ce90887c444f8a02a0649d865e7a3
47 Ndaf532d667894df18ca91eace7ea4ae2
48 sg:journal.1105545
49 schema:name Peritoneal Carcinomatosis in T4 Colorectal Cancer: Occurrence and Risk Factors
50 schema:pagination 1686-1691
51 schema:productId N39cd291656324f5d9eb1b54e74340371
52 N5ee3857f61684cfa9769819f80ac6aeb
53 N7be7a01ef8c543a887783794e035799b
54 N85dfdb67bfeb42378ff871064b1048d5
55 Nbc44f33dcab14b1a8281a9e351af9dea
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053623103
57 https://doi.org/10.1245/s10434-013-3461-0
58 schema:sdDatePublished 2019-04-10T22:29
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N3578cdf84a5545599110f6aee53c7dff
61 schema:url http://link.springer.com/10.1245/s10434-013-3461-0
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N043bd763d347448d9cc33fefadd715ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Postoperative Complications
67 rdf:type schema:DefinedTerm
68 N10d98933e1964bf6be6f6ed9e4eb6071 rdf:first N44a4ba598f0845a88cc7e2c82652b13e
69 rdf:rest N348f5e8655524284b9486df9cc490834
70 N1bad9a818bbd4d58a8375cf57f88d2d3 rdf:first sg:person.01004354234.80
71 rdf:rest N1fe10816d5b6444bacf2bb90c9820460
72 N1fe10816d5b6444bacf2bb90c9820460 rdf:first sg:person.01001031234.10
73 rdf:rest N710ad83817a54629a20f96ac13858097
74 N2018eca09f8a42a29ca08faf7d51faf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Retrospective Studies
76 rdf:type schema:DefinedTerm
77 N348f5e8655524284b9486df9cc490834 rdf:first sg:person.01227107510.45
78 rdf:rest N811f8ae982b14103afae2a4e11ecd472
79 N3578cdf84a5545599110f6aee53c7dff schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N39cd291656324f5d9eb1b54e74340371 schema:name doi
82 schema:value 10.1245/s10434-013-3461-0
83 rdf:type schema:PropertyValue
84 N44a4ba598f0845a88cc7e2c82652b13e schema:affiliation https://www.grid.ac/institutes/grid.415960.f
85 schema:familyName Koning
86 schema:givenName N. R.
87 rdf:type schema:Person
88 N4a29cfa1d7c34f38b46cd23c7c11c24e rdf:first sg:person.0756446730.73
89 rdf:rest rdf:nil
90 N5ee3857f61684cfa9769819f80ac6aeb schema:name dimensions_id
91 schema:value pub.1053623103
92 rdf:type schema:PropertyValue
93 N5f013c642d2e4edf92a27226ce43f9c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Survival Rate
95 rdf:type schema:DefinedTerm
96 N5f34929bf0ac402097af4a75f40831c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Neoplasm Staging
98 rdf:type schema:DefinedTerm
99 N710ad83817a54629a20f96ac13858097 rdf:first Nbc941960400c46d9bec8f508c1d04840
100 rdf:rest N10d98933e1964bf6be6f6ed9e4eb6071
101 N77818133eca0480097568acf8e5c755a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 N77cbf6a8e10248dca0a5a653fabb573d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Follow-Up Studies
106 rdf:type schema:DefinedTerm
107 N78a138b63aaf4e2d9d465fff5edeb934 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Prognosis
109 rdf:type schema:DefinedTerm
110 N7977c12f31604b8590cee30f9c6b557e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Colorectal Neoplasms
112 rdf:type schema:DefinedTerm
113 N7a6edad7b1d14bc589984addab876362 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Aged
115 rdf:type schema:DefinedTerm
116 N7be7a01ef8c543a887783794e035799b schema:name readcube_id
117 schema:value ff69bd66cc127055dd709b8274f302d6afa61275834d4dfe662c972b30d3de88
118 rdf:type schema:PropertyValue
119 N811f8ae982b14103afae2a4e11ecd472 rdf:first sg:person.0673036360.89
120 rdf:rest Nb2ff62a700114eb882b43f6e3e038a7d
121 N85dfdb67bfeb42378ff871064b1048d5 schema:name nlm_unique_id
122 schema:value 9420840
123 rdf:type schema:PropertyValue
124 Na1b2c02f04d04a41abd86c8eb7280522 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Incidence
126 rdf:type schema:DefinedTerm
127 Nae7820d2c7c34064af38c968209e0c9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Male
129 rdf:type schema:DefinedTerm
130 Nb2ff62a700114eb882b43f6e3e038a7d rdf:first sg:person.01177737131.63
131 rdf:rest Nf5fc3bf4f7d740d2a6d354075ecad2f1
132 Nbc44f33dcab14b1a8281a9e351af9dea schema:name pubmed_id
133 schema:value 24398543
134 rdf:type schema:PropertyValue
135 Nbc941960400c46d9bec8f508c1d04840 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
136 schema:familyName Spekreijse
137 schema:givenName K. R.
138 rdf:type schema:Person
139 Ncea00d9901fc46bf8ac0c1cf5d4a5cbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Peritoneal Neoplasms
141 rdf:type schema:DefinedTerm
142 Ncf7ce90887c444f8a02a0649d865e7a3 schema:issueNumber 5
143 rdf:type schema:PublicationIssue
144 Nd6ee0c2007f741e79cceb5c0777a2459 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Risk Factors
146 rdf:type schema:DefinedTerm
147 Ndaf532d667894df18ca91eace7ea4ae2 schema:volumeNumber 21
148 rdf:type schema:PublicationVolume
149 Ne791f40058c64c229ac81c82243039d7 rdf:first sg:person.01314165531.02
150 rdf:rest N4a29cfa1d7c34f38b46cd23c7c11c24e
151 Ne8e35cc2156c4335b7b12e59f738e686 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Aged, 80 and over
153 rdf:type schema:DefinedTerm
154 Nf5fc3bf4f7d740d2a6d354075ecad2f1 rdf:first sg:person.01032543451.61
155 rdf:rest Ne791f40058c64c229ac81c82243039d7
156 Nff0edcbf2f0f46d6b2df9e943693a753 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Female
158 rdf:type schema:DefinedTerm
159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical and Health Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
163 schema:name Public Health and Health Services
164 rdf:type schema:DefinedTerm
165 sg:journal.1105545 schema:issn 1068-9265
166 1534-4681
167 schema:name Annals of Surgical Oncology
168 rdf:type schema:Periodical
169 sg:person.01001031234.10 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
170 schema:familyName Braam
171 schema:givenName H. J.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001031234.10
173 rdf:type schema:Person
174 sg:person.01004354234.80 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
175 schema:familyName van Santvoort
176 schema:givenName H. C.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004354234.80
178 rdf:type schema:Person
179 sg:person.01032543451.61 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
180 schema:familyName Smits
181 schema:givenName A. B.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032543451.61
183 rdf:type schema:Person
184 sg:person.01177737131.63 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
185 schema:familyName Boerma
186 schema:givenName D.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177737131.63
188 rdf:type schema:Person
189 sg:person.01227107510.45 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
190 schema:familyName de Bruin
191 schema:givenName P. C.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227107510.45
193 rdf:type schema:Person
194 sg:person.01314165531.02 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
195 schema:familyName Wiezer
196 schema:givenName M. J.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314165531.02
198 rdf:type schema:Person
199 sg:person.0673036360.89 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
200 schema:familyName de Vries Reilingh
201 schema:givenName T. S.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673036360.89
203 rdf:type schema:Person
204 sg:person.0756446730.73 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
205 schema:familyName van Ramshorst
206 schema:givenName B.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756446730.73
208 rdf:type schema:Person
209 sg:pub.10.1245/aso.2004.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040637674
210 https://doi.org/10.1245/aso.2004.08.014
211 rdf:type schema:CreativeWork
212 sg:pub.10.1245/s10434-008-9966-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030091417
213 https://doi.org/10.1245/s10434-008-9966-2
214 rdf:type schema:CreativeWork
215 sg:pub.10.1245/s10434-012-2473-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038298896
216 https://doi.org/10.1245/s10434-012-2473-5
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1001/jama.294.21.2703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010628322
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/(sici)1097-0142(19980815)83:4<666::aid-cncr6>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1025416621
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/bjs.6622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033642170
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/bjs.8679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028483593
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/cncr.25250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001280325
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/0197-2456(96)00075-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047730164
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.ctrv.2012.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039663666
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.ejso.2008.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031190495
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0140-6736(07)61602-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036200026
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1046/j.1365-2168.2002.02274.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028716593
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1080/02656730701455318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003470891
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/annonc/mds236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034294500
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/01.sla.0000197702.46394.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019731745
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1097/sla.0b013e31815f0113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007455066
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1097/sla.0b013e3181a45d86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019299634
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1097/sla.0b013e3181d9765d schema:sameAs https://app.dimensions.ai/details/publication/pub.1030051577
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1200/jco.2003.04.187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203564
251 rdf:type schema:CreativeWork
252 https://doi.org/10.3322/caac.20107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055747
253 rdf:type schema:CreativeWork
254 https://www.grid.ac/institutes/grid.415960.f schema:alternateName St. Antonius Ziekenhuis
255 schema:name Department of Pathology, St. Antonius Hospital, Nieuwegein, The Netherlands
256 Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...