Ontology type: schema:ScholarlyArticle
2014-02
AUTHORSIgor Langer, Ulrich Guller, Mathias Worni, Gilles Berclaz, Gad Singer, Gabriel Schaer, Mathias K. Fehr, Thomas Hess, Carsten Viehl, Lucio Bronz, Beate Schnarwyler, Edward Wight, Eduard Infanger, Daniel Burger, Ossi R. Koechli, Markus Zuber, for the Swiss Multicenter Sentinel Lymph Node Study Group in Breast Cancer
ABSTRACTBACKGROUND: The presence of lymph node metastases is the most important prognostic factor in early stage breast cancer. Whether bone marrow micrometastases (BMM) impact the prognosis in sentinel lymph node (SLN)-negative breast cancer patients remains a matter of debate. Therefore, the objective of this study was to assess the impact of BMM on 5-year disease-free and overall survival among those patients. METHODS: We analyzed 410 patients with early stage breast cancer (pT1 and pT2 ≤ 3 cm, cN0) who were prospectively enrolled into the Swiss Multicenter Sentinel Lymph Node Study in Breast Cancer between January 2000 and December 2003. All patients underwent bone marrow aspiration followed by SLN biopsy. All SLN were stained with hematoxylin and eosin and immunohistochemistry (Lu-5, CK-22). Cancer cells in the bone marrow were identified after staining with monoclonal antibodies A45-B/B3 against CK-8, -18, and -19. RESULTS: Negative SLN were found in 67.6% (277 of 410) of the enrolled patients. Of those, BMM status was negative in 75.8% (210 of 277) and positive in 24.2% (67 of 277) patients. Median follow-up was 61 (range 11-96) months. Five-year disease-free survival was 93.6% (95% confidence interval [CI] 89.1-96.0) in BMM-negative and 92.2% (95% CI 82.5-96.2) in BMM-positive patients (p = 0.50). Five-year overall survival was 92.7% (95% CI 87.9-95.8) for the BMM-negative and 92.5% (95% CI 83.4-96.2) for the BMM-positive group (p = 0.85). CONCLUSIONS: This is one of the first prospective studies to examine 5-year disease-free and overall survivals in SLN-negative patients in correlation to their BMM status. Although BMM are identified in one of four SLN-negative patients, they do not impact disease-free and overall survival. More... »
PAGES401-407
http://scigraph.springernature.com/pub.10.1245/s10434-013-3315-9
DOIhttp://dx.doi.org/10.1245/s10434-013-3315-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1048565232
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24145993
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Marrow Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma, Ductal, Breast",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma, Lobular",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follow-Up Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Micrometastasis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Staging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sentinel Lymph Node Biopsy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Lindenhofspital",
"id": "https://www.grid.ac/institutes/grid.415941.c",
"name": [
"Department of Surgery, Lindenhof Hospital, Berne, Switzerland"
],
"type": "Organization"
},
"familyName": "Langer",
"givenName": "Igor",
"id": "sg:person.0726745065.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726745065.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital of Bern",
"id": "https://www.grid.ac/institutes/grid.411656.1",
"name": [
"Division of Medical Oncology and Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland",
"Department of Surgery, University Hospital Berne, Berne, Switzerland"
],
"type": "Organization"
},
"familyName": "Guller",
"givenName": "Ulrich",
"id": "sg:person.0612516465.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612516465.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital of Bern",
"id": "https://www.grid.ac/institutes/grid.411656.1",
"name": [
"Department of Surgery, University Hospital Berne, Berne, Switzerland"
],
"type": "Organization"
},
"familyName": "Worni",
"givenName": "Mathias",
"id": "sg:person.0611605504.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611605504.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Engeriedspital",
"id": "https://www.grid.ac/institutes/grid.483322.c",
"name": [
"Division of Gynecology, Engeriedspital, Berne, Switzerland"
],
"type": "Organization"
},
"familyName": "Berclaz",
"givenName": "Gilles",
"id": "sg:person.01051441340.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051441340.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kantonsspital Baden",
"id": "https://www.grid.ac/institutes/grid.482962.3",
"name": [
"Institute of Pathology, Kantonsspital Baden, Baden, Switzerland"
],
"type": "Organization"
},
"familyName": "Singer",
"givenName": "Gad",
"id": "sg:person.0643670133.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643670133.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kantonsspital Aarau",
"id": "https://www.grid.ac/institutes/grid.413357.7",
"name": [
"Department of Obstetrics and Gynecology, Kantonsspital Aarau, Aarau, Switzerland"
],
"type": "Organization"
},
"familyName": "Schaer",
"givenName": "Gabriel",
"id": "sg:person.0640657127.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640657127.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kantonsspital Frauenfeld",
"id": "https://www.grid.ac/institutes/grid.459679.0",
"name": [
"Division of Gynecology, Kantonsspital Frauenfeld, Frauenfeld, Switzerland"
],
"type": "Organization"
},
"familyName": "Fehr",
"givenName": "Mathias K.",
"id": "sg:person.01305127055.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305127055.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kantonsspital Winterthur",
"id": "https://www.grid.ac/institutes/grid.452288.1",
"name": [
"Division of Gynecology, Kantonsspital Winterthur, Winterthur, Switzerland"
],
"type": "Organization"
},
"familyName": "Hess",
"givenName": "Thomas",
"id": "sg:person.0763127365.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763127365.92"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital of Basel",
"id": "https://www.grid.ac/institutes/grid.410567.1",
"name": [
"Department of Surgery, University Hospital Basel, Basel, Switzerland"
],
"type": "Organization"
},
"familyName": "Viehl",
"givenName": "Carsten",
"id": "sg:person.01256263601.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256263601.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ospedale San Giovanni Bellinzona",
"id": "https://www.grid.ac/institutes/grid.415065.3",
"name": [
"Department of Obstetrics and Gynecology, Ospedale San Giovanni, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Bronz",
"givenName": "Lucio",
"id": "sg:person.0636673513.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636673513.43"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Private Practice, Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Schnarwyler",
"givenName": "Beate",
"id": "sg:person.01161446244.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161446244.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital of Basel",
"id": "https://www.grid.ac/institutes/grid.410567.1",
"name": [
"Division of Gynecology, University Hospital Basel, Basel, Switzerland"
],
"type": "Organization"
},
"familyName": "Wight",
"givenName": "Edward",
"id": "sg:person.01325514011.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325514011.64"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Obstetrics and Gynecology, Kantonales Spital Sursee-Wolhusen, Sursee, Switzerland"
],
"type": "Organization"
},
"familyName": "Infanger",
"givenName": "Eduard",
"id": "sg:person.0650223111.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650223111.52"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Obstetrics and Gynecology, Hospital Lachen, Lachen, Switzerland"
],
"type": "Organization"
},
"familyName": "Burger",
"givenName": "Daniel",
"id": "sg:person.0716336311.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716336311.35"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Bethanien Clinic, Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Koechli",
"givenName": "Ossi R.",
"id": "sg:person.0751341176.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751341176.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Solothurner Spit\u00e4ler",
"id": "https://www.grid.ac/institutes/grid.477516.6",
"name": [
"Department of Surgery, Kantonsspital Olten, Olten, Switzerland"
],
"type": "Organization"
},
"familyName": "Zuber",
"givenName": "Markus",
"id": "sg:person.01361436034.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361436034.91"
],
"type": "Person"
},
{
"familyName": "for the Swiss Multicenter Sentinel Lymph Node Study Group in Breast Cancer",
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/1471-2407-11-252",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001616837",
"https://doi.org/10.1186/1471-2407-11-252"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djq008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004418833"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/88.22.1652",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010213025"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-008-0244-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011966762",
"https://doi.org/10.1245/s10434-008-0244-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-009-0619-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015903453",
"https://doi.org/10.1245/s10434-009-0619-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-009-0619-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015903453",
"https://doi.org/10.1245/s10434-009-0619-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19910215)67:4<1033::aid-cncr2820670428>3.0.co;2-h",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027250690"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-006-9193-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029580922",
"https://doi.org/10.1245/s10434-006-9193-7"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm200002243420801",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030050346"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.21576",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033160899"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.21576",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033160899"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000245472.47748.ec",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036165407"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000245472.47748.ec",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036165407"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-06-0169",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036703046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(98)10175-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042224217"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1981.152",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043699279",
"https://doi.org/10.1038/bjc.1981.152"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1981.152",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043699279",
"https://doi.org/10.1038/bjc.1981.152"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.2011.1034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043934297"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1008108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047423753"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa050434",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048972336"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa050434",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048972336"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jamcollsurg.2004.12.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050329238"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/ctrv.1999.0150",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050520697"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2001.19.5.1468",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074777256"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078059869",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1017/cbo9780511974175",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1098699158"
],
"type": "CreativeWork"
}
],
"datePublished": "2014-02",
"datePublishedReg": "2014-02-01",
"description": "BACKGROUND: The presence of lymph node metastases is the most important prognostic factor in early stage breast cancer. Whether bone marrow micrometastases (BMM) impact the prognosis in sentinel lymph node (SLN)-negative breast cancer patients remains a matter of debate. Therefore, the objective of this study was to assess the impact of BMM on 5-year disease-free and overall survival among those patients.\nMETHODS: We analyzed 410 patients with early stage breast cancer (pT1 and pT2 \u2264 3 cm, cN0) who were prospectively enrolled into the Swiss Multicenter Sentinel Lymph Node Study in Breast Cancer between January 2000 and December 2003. All patients underwent bone marrow aspiration followed by SLN biopsy. All SLN were stained with hematoxylin and eosin and immunohistochemistry (Lu-5, CK-22). Cancer cells in the bone marrow were identified after staining with monoclonal antibodies A45-B/B3 against CK-8, -18, and -19.\nRESULTS: Negative SLN were found in 67.6% (277 of 410) of the enrolled patients. Of those, BMM status was negative in 75.8% (210 of 277) and positive in 24.2% (67 of 277) patients. Median follow-up was 61 (range 11-96) months. Five-year disease-free survival was 93.6% (95% confidence interval [CI] 89.1-96.0) in BMM-negative and 92.2% (95% CI 82.5-96.2) in BMM-positive patients (p = 0.50). Five-year overall survival was 92.7% (95% CI 87.9-95.8) for the BMM-negative and 92.5% (95% CI 83.4-96.2) for the BMM-positive group (p = 0.85).\nCONCLUSIONS: This is one of the first prospective studies to examine 5-year disease-free and overall survivals in SLN-negative patients in correlation to their BMM status. Although BMM are identified in one of four SLN-negative patients, they do not impact disease-free and overall survival.",
"genre": "research_article",
"id": "sg:pub.10.1245/s10434-013-3315-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1105545",
"issn": [
"1068-9265",
"1534-4681"
],
"name": "Annals of Surgical Oncology",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "21"
}
],
"name": "Bone Marrow Micrometastases Do Not Impact Disease-Free and Overall Survival in Early Stage Sentinel Lymph Node\u2013Negative Breast Cancer Patients",
"pagination": "401-407",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"e75b6a50eeef523858d9ce4fcbaeebe3151e1b877769acc75b92d93eab4e5f3d"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"24145993"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9420840"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1245/s10434-013-3315-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1048565232"
]
}
],
"sameAs": [
"https://doi.org/10.1245/s10434-013-3315-9",
"https://app.dimensions.ai/details/publication/pub.1048565232"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T01:57",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000501.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1245/s10434-013-3315-9"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3315-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3315-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3315-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3315-9'
This table displays all metadata directly associated to this object as RDF triples.
350 TRIPLES
21 PREDICATES
67 URIs
38 LITERALS
26 BLANK NODES