Prognostic Value of Mucinous Histology Depends on Microsatellite Instability Status in Patients with Stage III Colon Cancer Treated with Adjuvant ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08-14

AUTHORS

Se Hyun Kim, Sang Joon Shin, Kang Young Lee, Hyunki Kim, Tae Il Kim, Dae Ryong Kang, Hyuk Hur, Byung So Min, Nam Kyu Kim, Hyun Chul Chung, Jae Kyung Roh, Joong Bae Ahn

ABSTRACT

BackgroundThe close association between mucinous histology and microsatellite instability (MSI) may have hindered the evaluation of prognostic significance of mucinous histology. The aim of this retrospective study was to investigate whether mucinous histology was associated with a worse prognosis, independent of MSI status, compared to nonmucinous histology in patients with stage III colon cancer.MethodsThis study enrolled 394 consecutive patients with stage III colorectal cancer treated with adjuvant FOLFOX after curative resection (R0). Clinicopathological information was retrospectively reviewed. Tumors were analyzed for MSI by polymerase chain reaction to determine MSI status. Kaplan–Meier method, log-rank test, and Cox proportional hazard regression models were used.ResultsThe estimated rate of 3-year disease-free survival (DFS) in patients with nonmucinous adenocarcinoma (NMA 79.2 %) was significantly greater than that in patients with mucinous adenocarcinoma (MA) and adenocarcinoma with mucinous component (MC) (56.9 %; log-rank, P = 0.002). In univariate analysis, histology (NMA vs. MA/MC), American Joint Committee on Cancer stage (IIIA, IIIB, and IIIC), and lymphovascular invasion (present vs. absent) were significantly associated with DFS. In multivariate analysis, mucinous histology (MA/MC) was associated with decreased DFS in all patients (hazard ratio 1.82, 95 % confidence interval 1.03–3.23, P = 0.0403). In patients with MA/MC, no difference in DFS was observed between MSI and microsatellite stability (log-rank, P = 0.732).ConclusionsMucinous histology is an independent poor prognostic factor for DFS in patients with stage III colon cancer after adjuvant FOLFOX chemotherapy. More... »

PAGES

3407-3413

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-013-3169-1

DOI

http://dx.doi.org/10.1245/s10434-013-3169-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031795663

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23943026


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma, Mucinous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leucovorin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microsatellite Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organoplatinum Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Se Hyun", 
        "id": "sg:person.01331736400.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331736400.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shin", 
        "givenName": "Sang Joon", 
        "id": "sg:person.011321544242.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011321544242.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kang Young", 
        "id": "sg:person.0620015762.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620015762.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Pathology, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyunki", 
        "id": "sg:person.01061166771.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061166771.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Tae Il", 
        "id": "sg:person.015302742440.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015302742440.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Dae Ryong", 
        "id": "sg:person.01161204647.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161204647.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hur", 
        "givenName": "Hyuk", 
        "id": "sg:person.01064426114.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064426114.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Min", 
        "givenName": "Byung So", 
        "id": "sg:person.01313235143.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313235143.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Nam Kyu", 
        "id": "sg:person.01034544570.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034544570.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Hyun Chul", 
        "id": "sg:person.01334631160.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334631160.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roh", 
        "givenName": "Jae Kyung", 
        "id": "sg:person.0767622633.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767622633.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "Joong Bae", 
        "id": "sg:person.010673374672.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010673374672.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s002689900666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016926339", 
          "https://doi.org/10.1007/s002689900666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-012-2321-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005591362", 
          "https://doi.org/10.1245/s10434-012-2321-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044629730", 
          "https://doi.org/10.1038/modpathol.3800482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-009-0634-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010327659", 
          "https://doi.org/10.1007/s00384-009-0634-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-007-9757-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030869188", 
          "https://doi.org/10.1245/s10434-007-9757-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-009-0701-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001000120", 
          "https://doi.org/10.1007/s00384-009-0701-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008988272", 
          "https://doi.org/10.1038/sj.bjc.6604955"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-08-14", 
    "datePublishedReg": "2013-08-14", 
    "description": "BackgroundThe close association between mucinous histology and microsatellite instability (MSI) may have hindered the evaluation of prognostic significance of mucinous histology. The aim of this retrospective study was to investigate whether mucinous histology was associated with a worse prognosis, independent of MSI status, compared to nonmucinous histology in patients with stage III colon cancer.MethodsThis study enrolled 394 consecutive patients with stage III colorectal cancer treated with adjuvant FOLFOX after curative resection (R0). Clinicopathological information was retrospectively reviewed. Tumors were analyzed for MSI by polymerase chain reaction to determine MSI status. Kaplan\u2013Meier method, log-rank test, and Cox proportional hazard regression models were used.ResultsThe estimated rate of 3-year disease-free survival (DFS) in patients with nonmucinous adenocarcinoma (NMA 79.2\u00a0%) was significantly greater than that in patients with mucinous adenocarcinoma (MA) and adenocarcinoma with mucinous component (MC) (56.9\u00a0%; log-rank, P\u00a0=\u00a00.002). In univariate analysis, histology (NMA vs. MA/MC), American Joint Committee on Cancer stage (IIIA, IIIB, and IIIC), and lymphovascular invasion (present vs. absent) were significantly associated with DFS. In multivariate analysis, mucinous histology (MA/MC) was associated with decreased DFS in all patients (hazard ratio 1.82, 95\u00a0% confidence interval 1.03\u20133.23, P\u00a0=\u00a00.0403). In patients with MA/MC, no difference in DFS was observed between MSI and microsatellite stability (log-rank, P\u00a0=\u00a00.732).ConclusionsMucinous histology is an independent poor prognostic factor for DFS in patients with stage III colon cancer after adjuvant FOLFOX chemotherapy.", 
    "genre": "article", 
    "id": "sg:pub.10.1245/s10434-013-3169-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "keywords": [
      "disease-free survival", 
      "stage III colon cancer", 
      "adjuvant FOLFOX chemotherapy", 
      "mucinous histology", 
      "mucinous component", 
      "microsatellite instability", 
      "colon cancer", 
      "FOLFOX chemotherapy", 
      "mucinous adenocarcinoma", 
      "MSI status", 
      "Cox proportional hazards regression model", 
      "stage III colorectal cancer", 
      "Kaplan-Meier method", 
      "independent poor prognostic factor", 
      "proportional hazards regression models", 
      "log-rank test", 
      "retrospective cohort study", 
      "poor prognostic factor", 
      "American Joint Committee", 
      "hazards regression models", 
      "microsatellite instability status", 
      "nonmucinous histology", 
      "adjuvant FOLFOX", 
      "curative resection", 
      "consecutive patients", 
      "lymphovascular invasion", 
      "cohort study", 
      "nonmucinous adenocarcinoma", 
      "prognostic factors", 
      "retrospective study", 
      "worse prognosis", 
      "prognostic value", 
      "prognostic significance", 
      "colorectal cancer", 
      "clinicopathological information", 
      "univariate analysis", 
      "cancer stage", 
      "polymerase chain reaction", 
      "MethodsThis study", 
      "patients", 
      "instability status", 
      "Joint Committee", 
      "multivariate analysis", 
      "histology", 
      "cancer", 
      "adenocarcinoma", 
      "microsatellite stability", 
      "chain reaction", 
      "chemotherapy", 
      "regression models", 
      "status", 
      "close association", 
      "FOLFOX", 
      "resection", 
      "prognosis", 
      "tumors", 
      "study", 
      "survival", 
      "ResultsThe", 
      "invasion", 
      "association", 
      "aim", 
      "factors", 
      "significance", 
      "differences", 
      "evaluation", 
      "Committee", 
      "rate", 
      "test", 
      "analysis", 
      "stage", 
      "information", 
      "values", 
      "reaction", 
      "components", 
      "instability", 
      "method", 
      "model", 
      "stability", 
      "III colon cancer", 
      "III colorectal cancer", 
      "MA/MC", 
      "ConclusionsMucinous histology"
    ], 
    "name": "Prognostic Value of Mucinous Histology Depends on Microsatellite Instability Status in Patients with Stage III Colon Cancer Treated with Adjuvant FOLFOX Chemotherapy: A Retrospective Cohort Study", 
    "pagination": "3407-3413", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031795663"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-013-3169-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23943026"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-013-3169-1", 
      "https://app.dimensions.ai/details/publication/pub.1031795663"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_600.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1245/s10434-013-3169-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3169-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3169-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3169-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3169-1'


 

This table displays all metadata directly associated to this object as RDF triples.

346 TRIPLES      22 PREDICATES      138 URIs      123 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-013-3169-1 schema:about N0b9c10833dc440688a88675a85512898
2 N11cd8c0baa724605972e7f67d4766875
3 N1371261a176d4ac19cfeacf0a01d962f
4 N176fb0e2dbdb4f51bb80be8b130803dc
5 N1a9b0bc5ffbe4101aa9dded8b1f5d00c
6 N1f6f845f123d42c1b37a846e2922dca4
7 N345885ee2ac042ea8567515be6735bc9
8 N389841b1edde4cc886d79c8e555a6303
9 N42ee041949b14236904a2c55b2e73eb7
10 N4cb123664eb5487a9a511275c5bbd962
11 N5cab94118eac40dd9dca54d51ec43749
12 N5e08d45f28b94a989b83398dd4f3a910
13 N643e2ee9a4a34463848f01dfbd530944
14 N7ca06ed093514a77ad2fb24e79ddd2aa
15 N8ca6d1e4fed54521a274529a9d9af6bb
16 N8ea1e3b59f764094ad7a3a18d460d3f3
17 N9df826f9ea974f24b63953236fc67f3d
18 Na2a8d95e36fe4563a4648e9f1a7d3bc7
19 Ne96590158b7b45e4a6c82071a807a94c
20 Ned8efb3b8295480dbeb070824c2c60ad
21 Nf19b218141024157aefde3a319975eb3
22 Nfda8f8575873426c8135e08ad3a2af26
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author N220e65f42aa34b95a138e9c7a8b86c3a
26 schema:citation sg:pub.10.1007/s002689900666
27 sg:pub.10.1007/s00384-009-0634-1
28 sg:pub.10.1007/s00384-009-0701-7
29 sg:pub.10.1038/modpathol.3800482
30 sg:pub.10.1038/sj.bjc.6604955
31 sg:pub.10.1245/s10434-007-9757-1
32 sg:pub.10.1245/s10434-012-2321-7
33 schema:datePublished 2013-08-14
34 schema:datePublishedReg 2013-08-14
35 schema:description BackgroundThe close association between mucinous histology and microsatellite instability (MSI) may have hindered the evaluation of prognostic significance of mucinous histology. The aim of this retrospective study was to investigate whether mucinous histology was associated with a worse prognosis, independent of MSI status, compared to nonmucinous histology in patients with stage III colon cancer.MethodsThis study enrolled 394 consecutive patients with stage III colorectal cancer treated with adjuvant FOLFOX after curative resection (R0). Clinicopathological information was retrospectively reviewed. Tumors were analyzed for MSI by polymerase chain reaction to determine MSI status. Kaplan–Meier method, log-rank test, and Cox proportional hazard regression models were used.ResultsThe estimated rate of 3-year disease-free survival (DFS) in patients with nonmucinous adenocarcinoma (NMA 79.2 %) was significantly greater than that in patients with mucinous adenocarcinoma (MA) and adenocarcinoma with mucinous component (MC) (56.9 %; log-rank, P = 0.002). In univariate analysis, histology (NMA vs. MA/MC), American Joint Committee on Cancer stage (IIIA, IIIB, and IIIC), and lymphovascular invasion (present vs. absent) were significantly associated with DFS. In multivariate analysis, mucinous histology (MA/MC) was associated with decreased DFS in all patients (hazard ratio 1.82, 95 % confidence interval 1.03–3.23, P = 0.0403). In patients with MA/MC, no difference in DFS was observed between MSI and microsatellite stability (log-rank, P = 0.732).ConclusionsMucinous histology is an independent poor prognostic factor for DFS in patients with stage III colon cancer after adjuvant FOLFOX chemotherapy.
36 schema:genre article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N47cc8d31151c418fa680b1dbbdb59a1b
40 N545d83c5db4744df8f69e277d84f1bc1
41 sg:journal.1105545
42 schema:keywords American Joint Committee
43 Committee
44 ConclusionsMucinous histology
45 Cox proportional hazards regression model
46 FOLFOX
47 FOLFOX chemotherapy
48 III colon cancer
49 III colorectal cancer
50 Joint Committee
51 Kaplan-Meier method
52 MA/MC
53 MSI status
54 MethodsThis study
55 ResultsThe
56 adenocarcinoma
57 adjuvant FOLFOX
58 adjuvant FOLFOX chemotherapy
59 aim
60 analysis
61 association
62 cancer
63 cancer stage
64 chain reaction
65 chemotherapy
66 clinicopathological information
67 close association
68 cohort study
69 colon cancer
70 colorectal cancer
71 components
72 consecutive patients
73 curative resection
74 differences
75 disease-free survival
76 evaluation
77 factors
78 hazards regression models
79 histology
80 independent poor prognostic factor
81 information
82 instability
83 instability status
84 invasion
85 log-rank test
86 lymphovascular invasion
87 method
88 microsatellite instability
89 microsatellite instability status
90 microsatellite stability
91 model
92 mucinous adenocarcinoma
93 mucinous component
94 mucinous histology
95 multivariate analysis
96 nonmucinous adenocarcinoma
97 nonmucinous histology
98 patients
99 polymerase chain reaction
100 poor prognostic factor
101 prognosis
102 prognostic factors
103 prognostic significance
104 prognostic value
105 proportional hazards regression models
106 rate
107 reaction
108 regression models
109 resection
110 retrospective cohort study
111 retrospective study
112 significance
113 stability
114 stage
115 stage III colon cancer
116 stage III colorectal cancer
117 status
118 study
119 survival
120 test
121 tumors
122 univariate analysis
123 values
124 worse prognosis
125 schema:name Prognostic Value of Mucinous Histology Depends on Microsatellite Instability Status in Patients with Stage III Colon Cancer Treated with Adjuvant FOLFOX Chemotherapy: A Retrospective Cohort Study
126 schema:pagination 3407-3413
127 schema:productId N24af481a10a6449ebe842ba21e3da325
128 N3906a30daa38465583a05888c692e823
129 N494805f3d5904a4080d36826253cca34
130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031795663
131 https://doi.org/10.1245/s10434-013-3169-1
132 schema:sdDatePublished 2021-11-01T18:20
133 schema:sdLicense https://scigraph.springernature.com/explorer/license/
134 schema:sdPublisher N2378db2cdb084a70a480e4bfeb64d2ce
135 schema:url https://doi.org/10.1245/s10434-013-3169-1
136 sgo:license sg:explorer/license/
137 sgo:sdDataset articles
138 rdf:type schema:ScholarlyArticle
139 N00631e46c0774d9b86816ae622212d88 rdf:first sg:person.01334631160.87
140 rdf:rest Nc065b0a93a39409da3940a2d11a09ca8
141 N0b9c10833dc440688a88675a85512898 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Neoplasm Staging
143 rdf:type schema:DefinedTerm
144 N0d474bf99b9644c19029f7258ae23a3e rdf:first sg:person.01161204647.90
145 rdf:rest N956c5b7df1fc4f62a4e4578c32e7c48d
146 N0f32f5870c84479386fc0f547883bfc4 rdf:first sg:person.015302742440.35
147 rdf:rest N0d474bf99b9644c19029f7258ae23a3e
148 N11cd8c0baa724605972e7f67d4766875 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Prognosis
150 rdf:type schema:DefinedTerm
151 N1371261a176d4ac19cfeacf0a01d962f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Aged
153 rdf:type schema:DefinedTerm
154 N138e87d4e03d46dd9d16d8b5ab407d72 rdf:first sg:person.01034544570.10
155 rdf:rest N00631e46c0774d9b86816ae622212d88
156 N176fb0e2dbdb4f51bb80be8b130803dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Organoplatinum Compounds
158 rdf:type schema:DefinedTerm
159 N1a9b0bc5ffbe4101aa9dded8b1f5d00c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Survival Rate
161 rdf:type schema:DefinedTerm
162 N1f6f845f123d42c1b37a846e2922dca4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Microsatellite Instability
164 rdf:type schema:DefinedTerm
165 N220e65f42aa34b95a138e9c7a8b86c3a rdf:first sg:person.01331736400.09
166 rdf:rest Nf0c62927200141e6968110e96e843a89
167 N2378db2cdb084a70a480e4bfeb64d2ce schema:name Springer Nature - SN SciGraph project
168 rdf:type schema:Organization
169 N24af481a10a6449ebe842ba21e3da325 schema:name doi
170 schema:value 10.1245/s10434-013-3169-1
171 rdf:type schema:PropertyValue
172 N345885ee2ac042ea8567515be6735bc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Neoplasm Recurrence, Local
174 rdf:type schema:DefinedTerm
175 N389841b1edde4cc886d79c8e555a6303 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Retrospective Studies
177 rdf:type schema:DefinedTerm
178 N3906a30daa38465583a05888c692e823 schema:name dimensions_id
179 schema:value pub.1031795663
180 rdf:type schema:PropertyValue
181 N42ee041949b14236904a2c55b2e73eb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Middle Aged
183 rdf:type schema:DefinedTerm
184 N47cc8d31151c418fa680b1dbbdb59a1b schema:issueNumber 11
185 rdf:type schema:PublicationIssue
186 N494805f3d5904a4080d36826253cca34 schema:name pubmed_id
187 schema:value 23943026
188 rdf:type schema:PropertyValue
189 N4cb123664eb5487a9a511275c5bbd962 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Humans
191 rdf:type schema:DefinedTerm
192 N4f68aceb863a403f9b60f9c46d6eb773 rdf:first sg:person.01313235143.44
193 rdf:rest N138e87d4e03d46dd9d16d8b5ab407d72
194 N545d83c5db4744df8f69e277d84f1bc1 schema:volumeNumber 20
195 rdf:type schema:PublicationVolume
196 N5cab94118eac40dd9dca54d51ec43749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Adult
198 rdf:type schema:DefinedTerm
199 N5e08d45f28b94a989b83398dd4f3a910 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Female
201 rdf:type schema:DefinedTerm
202 N643e2ee9a4a34463848f01dfbd530944 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Male
204 rdf:type schema:DefinedTerm
205 N7ca06ed093514a77ad2fb24e79ddd2aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Antineoplastic Combined Chemotherapy Protocols
207 rdf:type schema:DefinedTerm
208 N7efe1567e52e41b7ae83cd4bb3d4a65a rdf:first sg:person.010673374672.49
209 rdf:rest rdf:nil
210 N8c5784031614415d9a79548e00dda5fd rdf:first sg:person.01061166771.52
211 rdf:rest N0f32f5870c84479386fc0f547883bfc4
212 N8ca6d1e4fed54521a274529a9d9af6bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Adenocarcinoma, Mucinous
214 rdf:type schema:DefinedTerm
215 N8ea1e3b59f764094ad7a3a18d460d3f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Follow-Up Studies
217 rdf:type schema:DefinedTerm
218 N956c5b7df1fc4f62a4e4578c32e7c48d rdf:first sg:person.01064426114.19
219 rdf:rest N4f68aceb863a403f9b60f9c46d6eb773
220 N9df826f9ea974f24b63953236fc67f3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Colonic Neoplasms
222 rdf:type schema:DefinedTerm
223 Na2a8d95e36fe4563a4648e9f1a7d3bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Young Adult
225 rdf:type schema:DefinedTerm
226 Nc065b0a93a39409da3940a2d11a09ca8 rdf:first sg:person.0767622633.82
227 rdf:rest N7efe1567e52e41b7ae83cd4bb3d4a65a
228 Nd7730251ca154039b77b51e719d8ce51 rdf:first sg:person.0620015762.60
229 rdf:rest N8c5784031614415d9a79548e00dda5fd
230 Ne96590158b7b45e4a6c82071a807a94c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Fluorouracil
232 rdf:type schema:DefinedTerm
233 Ned8efb3b8295480dbeb070824c2c60ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
234 schema:name Adolescent
235 rdf:type schema:DefinedTerm
236 Nf0c62927200141e6968110e96e843a89 rdf:first sg:person.011321544242.27
237 rdf:rest Nd7730251ca154039b77b51e719d8ce51
238 Nf19b218141024157aefde3a319975eb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
239 schema:name Leucovorin
240 rdf:type schema:DefinedTerm
241 Nfda8f8575873426c8135e08ad3a2af26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
242 schema:name Aged, 80 and over
243 rdf:type schema:DefinedTerm
244 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
245 schema:name Medical and Health Sciences
246 rdf:type schema:DefinedTerm
247 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
248 schema:name Oncology and Carcinogenesis
249 rdf:type schema:DefinedTerm
250 sg:journal.1105545 schema:issn 1068-9265
251 1534-4681
252 schema:name Annals of Surgical Oncology
253 schema:publisher Springer Nature
254 rdf:type schema:Periodical
255 sg:person.01034544570.10 schema:affiliation grid-institutes:grid.15444.30
256 schema:familyName Kim
257 schema:givenName Nam Kyu
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034544570.10
259 rdf:type schema:Person
260 sg:person.01061166771.52 schema:affiliation grid-institutes:grid.15444.30
261 schema:familyName Kim
262 schema:givenName Hyunki
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061166771.52
264 rdf:type schema:Person
265 sg:person.01064426114.19 schema:affiliation grid-institutes:grid.15444.30
266 schema:familyName Hur
267 schema:givenName Hyuk
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064426114.19
269 rdf:type schema:Person
270 sg:person.010673374672.49 schema:affiliation grid-institutes:grid.15444.30
271 schema:familyName Ahn
272 schema:givenName Joong Bae
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010673374672.49
274 rdf:type schema:Person
275 sg:person.011321544242.27 schema:affiliation grid-institutes:grid.15444.30
276 schema:familyName Shin
277 schema:givenName Sang Joon
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011321544242.27
279 rdf:type schema:Person
280 sg:person.01161204647.90 schema:affiliation grid-institutes:grid.15444.30
281 schema:familyName Kang
282 schema:givenName Dae Ryong
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161204647.90
284 rdf:type schema:Person
285 sg:person.01313235143.44 schema:affiliation grid-institutes:grid.15444.30
286 schema:familyName Min
287 schema:givenName Byung So
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313235143.44
289 rdf:type schema:Person
290 sg:person.01331736400.09 schema:affiliation grid-institutes:grid.15444.30
291 schema:familyName Kim
292 schema:givenName Se Hyun
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331736400.09
294 rdf:type schema:Person
295 sg:person.01334631160.87 schema:affiliation grid-institutes:grid.15444.30
296 schema:familyName Chung
297 schema:givenName Hyun Chul
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334631160.87
299 rdf:type schema:Person
300 sg:person.015302742440.35 schema:affiliation grid-institutes:grid.15444.30
301 schema:familyName Kim
302 schema:givenName Tae Il
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015302742440.35
304 rdf:type schema:Person
305 sg:person.0620015762.60 schema:affiliation grid-institutes:grid.15444.30
306 schema:familyName Lee
307 schema:givenName Kang Young
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620015762.60
309 rdf:type schema:Person
310 sg:person.0767622633.82 schema:affiliation grid-institutes:grid.15444.30
311 schema:familyName Roh
312 schema:givenName Jae Kyung
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767622633.82
314 rdf:type schema:Person
315 sg:pub.10.1007/s002689900666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016926339
316 https://doi.org/10.1007/s002689900666
317 rdf:type schema:CreativeWork
318 sg:pub.10.1007/s00384-009-0634-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010327659
319 https://doi.org/10.1007/s00384-009-0634-1
320 rdf:type schema:CreativeWork
321 sg:pub.10.1007/s00384-009-0701-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001000120
322 https://doi.org/10.1007/s00384-009-0701-7
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/modpathol.3800482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044629730
325 https://doi.org/10.1038/modpathol.3800482
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/sj.bjc.6604955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008988272
328 https://doi.org/10.1038/sj.bjc.6604955
329 rdf:type schema:CreativeWork
330 sg:pub.10.1245/s10434-007-9757-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030869188
331 https://doi.org/10.1245/s10434-007-9757-1
332 rdf:type schema:CreativeWork
333 sg:pub.10.1245/s10434-012-2321-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005591362
334 https://doi.org/10.1245/s10434-012-2321-7
335 rdf:type schema:CreativeWork
336 grid-institutes:grid.15444.30 schema:alternateName Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea
337 Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
338 Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
339 Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
340 Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Korea
341 schema:name Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea
342 Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
343 Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
344 Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
345 Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Korea
346 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...