Treatment Efficacy with Accelerated Partial Breast Irradiation (APBI): Final Analysis of the American Society of Breast Surgeons MammoSite® Breast Brachytherapy ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-10

AUTHORS

Chirag Shah, Shahed Badiyan, J. Ben Wilkinson, Frank Vicini, Peter Beitsch, Martin Keisch, Douglas Arthur, Maureen Lyden

ABSTRACT

BACKGROUND: The purpose of this study was to examine data on treatment efficacy, cosmesis and toxicities for the final analysis of the American Society of Breast Surgeons MammoSite(®) breast brachytherapy registry trial. METHODS: A total of 1,449 cases of early-stage breast cancer underwent breast conserving therapy. The single-lumen MammoSite(®) device was used to deliver accelerated partial breast irradiation (APBI) (34 Gy in 3.4 Gy fractions). Of these, 1,255 cases (87 %) had invasive breast cancer (IBC) and 194 cases had DCIS. Median follow-up was 63.1 months with 45 % of all patients having follow-up of 6 years or longer. RESULTS: There were 41 cases (2.8 %) that developed an ipsilateral breast tumor recurrence (IBTR) for a 5-year actuarial rate of 3.8 % (3.7 % for IBC and 4.1 % for DCIS). Tumor size (odds ratio [OR] = 1.1, p = 0.03) and estrogen receptor negativity (OR = 3.0, p = 0.0009) were associated with IBTR, while a trend was noted for positive margins (OR = 2.0, p = 0.06) and cautionary/unsuitable status compared with suitable status (OR = 1.8, p = 0.07). The percentage of patients with excellent/good cosmetic results at 60, 72, and 84 months was 91.3, 90.5, and 90.6 %, respectively. The overall rates of fat necrosis and infections remained low at 2.5 and 9.6 % with few late toxicity events beyond 2 years. The overall symptomatic seroma rate was 13.4 and 0.6 % beyond 2 years. CONCLUSIONS: The final analysis of treatment efficacy, cosmesis, and toxicity from the American Society of Breast Surgeons MammoSite(®) breast brachytherapy registry trial confirms previously noted excellent results and compares favorably with other forms of APBI with similar follow-up and to outcomes seen in selected patients treated with whole breast irradiation. More... »

PAGES

3279-3285

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-013-3158-4

DOI

http://dx.doi.org/10.1245/s10434-013-3158-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015952877

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23975302


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brachytherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Ductal, Breast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Intraductal, Noninfiltrating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mastectomy, Segmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Registries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Summa Health System", 
          "id": "https://www.grid.ac/institutes/grid.416711.4", 
          "name": [
            "Department of Radiation Oncology, Summa Health System, Akron, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shah", 
        "givenName": "Chirag", 
        "id": "sg:person.0747662642.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747662642.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Summa Health System", 
          "id": "https://www.grid.ac/institutes/grid.416711.4", 
          "name": [
            "Department of Radiation Oncology, Summa Health System, Akron, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Badiyan", 
        "givenName": "Shahed", 
        "id": "sg:person.0717466406.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717466406.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oakland University", 
          "id": "https://www.grid.ac/institutes/grid.261277.7", 
          "name": [
            "Department of Radiation Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ben Wilkinson", 
        "givenName": "J.", 
        "id": "sg:person.0651353206.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651353206.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Michigan Healthcare Professionals/21st Century Oncology, Farmington Hills, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vicini", 
        "givenName": "Frank", 
        "id": "sg:person.01115035023.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115035023.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dallas Surgical Group", 
          "id": "https://www.grid.ac/institutes/grid.477059.8", 
          "name": [
            "Dallas Surgical Group, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beitsch", 
        "givenName": "Peter", 
        "id": "sg:person.01150535406.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150535406.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Miami Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413057.4", 
          "name": [
            "Cancer HealthCare Associates, University of Miami Hospital, Miami, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keisch", 
        "givenName": "Martin", 
        "id": "sg:person.01317534703.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317534703.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virginia Commonwealth University", 
          "id": "https://www.grid.ac/institutes/grid.224260.0", 
          "name": [
            "Department of Radiation Oncology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arthur", 
        "givenName": "Douglas", 
        "id": "sg:person.011601172377.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011601172377.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Biostat International, Inc, Tampa, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lyden", 
        "givenName": "Maureen", 
        "id": "sg:person.01050463645.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050463645.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa040587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003108241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.25383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011726834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.25383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011726834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.43.5297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013620494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.41.1090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016159672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-8140(12)71978-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016912115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2009.02.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019658859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2012.3481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020587349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(85)90241-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022827897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4741.2010.01041.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024892102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djr495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025084838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2006.12.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026260569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brachy.2008.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026950314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.14.1143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027184958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa022152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036865265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.04.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037649850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2011.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041210311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjsurg.2007.06.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045467556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1989.01410020023002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046097822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)04277-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049402890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)04277-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049402890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.sabcs12-s4-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063222251"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-10", 
    "datePublishedReg": "2013-10-01", 
    "description": "BACKGROUND: The purpose of this study was to examine data on treatment efficacy, cosmesis and toxicities for the final analysis of the American Society of Breast Surgeons MammoSite(\u00ae) breast brachytherapy registry trial.\nMETHODS: A total of 1,449 cases of early-stage breast cancer underwent breast conserving therapy. The single-lumen MammoSite(\u00ae) device was used to deliver accelerated partial breast irradiation (APBI) (34 Gy in 3.4 Gy fractions). Of these, 1,255 cases (87 %) had invasive breast cancer (IBC) and 194 cases had DCIS. Median follow-up was 63.1 months with 45 % of all patients having follow-up of 6 years or longer.\nRESULTS: There were 41 cases (2.8 %) that developed an ipsilateral breast tumor recurrence (IBTR) for a 5-year actuarial rate of 3.8 % (3.7 % for IBC and 4.1 % for DCIS). Tumor size (odds ratio [OR] = 1.1, p = 0.03) and estrogen receptor negativity (OR = 3.0, p = 0.0009) were associated with IBTR, while a trend was noted for positive margins (OR = 2.0, p = 0.06) and cautionary/unsuitable status compared with suitable status (OR = 1.8, p = 0.07). The percentage of patients with excellent/good cosmetic results at 60, 72, and 84 months was 91.3, 90.5, and 90.6 %, respectively. The overall rates of fat necrosis and infections remained low at 2.5 and 9.6 % with few late toxicity events beyond 2 years. The overall symptomatic seroma rate was 13.4 and 0.6 % beyond 2 years.\nCONCLUSIONS: The final analysis of treatment efficacy, cosmesis, and toxicity from the American Society of Breast Surgeons MammoSite(\u00ae) breast brachytherapy registry trial confirms previously noted excellent results and compares favorably with other forms of APBI with similar follow-up and to outcomes seen in selected patients treated with whole breast irradiation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-013-3158-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "Treatment Efficacy with Accelerated Partial Breast Irradiation (APBI): Final Analysis of the American Society of Breast Surgeons MammoSite\u00ae Breast Brachytherapy Registry Trial", 
    "pagination": "3279-3285", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4c034e730a7836486622d6cea8aa6b67999c29a33c0f6092cd2f7e73b4e3e6ea"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23975302"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-013-3158-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015952877"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-013-3158-4", 
      "https://app.dimensions.ai/details/publication/pub.1015952877"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000499.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1245/s10434-013-3158-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3158-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3158-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3158-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-3158-4'


 

This table displays all metadata directly associated to this object as RDF triples.

274 TRIPLES      21 PREDICATES      69 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-013-3158-4 schema:about N0190022d177d45009e7cbf7ee60a21c8
2 N066e946fe6f24327be3867d5c65e6e4b
3 N0bedee7198d441918456a9eb1b741650
4 N1b85056b5c0945a8be69b0b261fff019
5 N264fa79772e740c7a09b88ef66050c7b
6 N3d601af13d01416897eb93c06e461a66
7 N4fd40c885048498aace03e5fedcffa79
8 N5044ac6a916943e494be3eeb92ad1bdc
9 N62544bd2a0bc4d91aa5de41e06a8a794
10 N63d118a11ac249f689b99769b5aeecd0
11 N63efab3c3e2740708ce61a1b7f804359
12 N7f14fe61ce834c1f984d4f7086253970
13 N85930c07dd194a859545e03bc439ab55
14 N86f411c5cb204efcad03cf417ecd8003
15 Na08357c4329840e78e129fdb5b820bda
16 Nb69a4add4d134f918fb686da0c78dd94
17 Nbade5c42a13847d9b7d5b4752f25e4ea
18 Nc7c7fc7dcff141999f9bce95fec85b9f
19 Nd8fad20e3aa64dab993d956c7aee0a46
20 Nddfbfbf7172a4d97aa0be47eebc624ae
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author Naaa613d7830f4be7bd12094a81789ce4
24 schema:citation https://doi.org/10.1001/archsurg.1989.01410020023002
25 https://doi.org/10.1001/jama.2012.3481
26 https://doi.org/10.1002/cncr.25383
27 https://doi.org/10.1016/0360-3016(85)90241-x
28 https://doi.org/10.1016/j.amjsurg.2007.06.010
29 https://doi.org/10.1016/j.brachy.2008.11.007
30 https://doi.org/10.1016/j.ijrobp.2007.04.022
31 https://doi.org/10.1016/j.ijrobp.2009.02.031
32 https://doi.org/10.1016/j.radonc.2011.03.011
33 https://doi.org/10.1016/j.surg.2006.12.011
34 https://doi.org/10.1016/s0167-8140(12)71978-3
35 https://doi.org/10.1016/s0360-3016(02)04277-3
36 https://doi.org/10.1056/nejmoa022152
37 https://doi.org/10.1056/nejmoa040587
38 https://doi.org/10.1093/jnci/92.14.1143
39 https://doi.org/10.1093/jnci/djr495
40 https://doi.org/10.1111/j.1524-4741.2010.01041.x
41 https://doi.org/10.1158/0008-5472.sabcs12-s4-2
42 https://doi.org/10.1200/jco.2011.41.1090
43 https://doi.org/10.1200/jco.2012.43.5297
44 schema:datePublished 2013-10
45 schema:datePublishedReg 2013-10-01
46 schema:description BACKGROUND: The purpose of this study was to examine data on treatment efficacy, cosmesis and toxicities for the final analysis of the American Society of Breast Surgeons MammoSite(®) breast brachytherapy registry trial. METHODS: A total of 1,449 cases of early-stage breast cancer underwent breast conserving therapy. The single-lumen MammoSite(®) device was used to deliver accelerated partial breast irradiation (APBI) (34 Gy in 3.4 Gy fractions). Of these, 1,255 cases (87 %) had invasive breast cancer (IBC) and 194 cases had DCIS. Median follow-up was 63.1 months with 45 % of all patients having follow-up of 6 years or longer. RESULTS: There were 41 cases (2.8 %) that developed an ipsilateral breast tumor recurrence (IBTR) for a 5-year actuarial rate of 3.8 % (3.7 % for IBC and 4.1 % for DCIS). Tumor size (odds ratio [OR] = 1.1, p = 0.03) and estrogen receptor negativity (OR = 3.0, p = 0.0009) were associated with IBTR, while a trend was noted for positive margins (OR = 2.0, p = 0.06) and cautionary/unsuitable status compared with suitable status (OR = 1.8, p = 0.07). The percentage of patients with excellent/good cosmetic results at 60, 72, and 84 months was 91.3, 90.5, and 90.6 %, respectively. The overall rates of fat necrosis and infections remained low at 2.5 and 9.6 % with few late toxicity events beyond 2 years. The overall symptomatic seroma rate was 13.4 and 0.6 % beyond 2 years. CONCLUSIONS: The final analysis of treatment efficacy, cosmesis, and toxicity from the American Society of Breast Surgeons MammoSite(®) breast brachytherapy registry trial confirms previously noted excellent results and compares favorably with other forms of APBI with similar follow-up and to outcomes seen in selected patients treated with whole breast irradiation.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf N7ebfad09796340c7a40b2805210e1d7b
51 Nc1a1120a798a46ec8be3ee540b3b4922
52 sg:journal.1105545
53 schema:name Treatment Efficacy with Accelerated Partial Breast Irradiation (APBI): Final Analysis of the American Society of Breast Surgeons MammoSite® Breast Brachytherapy Registry Trial
54 schema:pagination 3279-3285
55 schema:productId N23b274ddb7364b27a3406b187e96fda6
56 N4ad7038af94d496b9e4bd95a4bd90728
57 N9648975223934c34ad6177f2e2b0916d
58 Nc14b8af2702e4893a9744e75f9af738a
59 Ncc52d34990d6409099690c6f3daf02de
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015952877
61 https://doi.org/10.1245/s10434-013-3158-4
62 schema:sdDatePublished 2019-04-10T18:17
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N5f26b00cce5a46df9312306d5cd6a476
65 schema:url http://link.springer.com/10.1245/s10434-013-3158-4
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N0190022d177d45009e7cbf7ee60a21c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Neoplasm Invasiveness
71 rdf:type schema:DefinedTerm
72 N066e946fe6f24327be3867d5c65e6e4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Combined Modality Therapy
74 rdf:type schema:DefinedTerm
75 N0bedee7198d441918456a9eb1b741650 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Aged
77 rdf:type schema:DefinedTerm
78 N124249a02eac4a29988525bfa4d9024e rdf:first sg:person.011601172377.98
79 rdf:rest Nf71710a0b87247f7a7919b934dc97da3
80 N153efd38751a4c1990efbbbb263314c4 rdf:first sg:person.0717466406.86
81 rdf:rest N1fa7f07cd3214af7887d2eb6e15839a0
82 N1b85056b5c0945a8be69b0b261fff019 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Survival Rate
84 rdf:type schema:DefinedTerm
85 N1fa7f07cd3214af7887d2eb6e15839a0 rdf:first sg:person.0651353206.75
86 rdf:rest N606b623915ad47ab8d5daaed2821b392
87 N23b274ddb7364b27a3406b187e96fda6 schema:name nlm_unique_id
88 schema:value 9420840
89 rdf:type schema:PropertyValue
90 N264fa79772e740c7a09b88ef66050c7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Breast Neoplasms
92 rdf:type schema:DefinedTerm
93 N317ef77521ff424aacc7bf2bca0dba57 rdf:first sg:person.01317534703.08
94 rdf:rest N124249a02eac4a29988525bfa4d9024e
95 N3238ab06d49049379607b6bf1a462327 schema:name Biostat International, Inc, Tampa, FL, USA
96 rdf:type schema:Organization
97 N3d601af13d01416897eb93c06e461a66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Neoplasm Recurrence, Local
99 rdf:type schema:DefinedTerm
100 N4ad7038af94d496b9e4bd95a4bd90728 schema:name doi
101 schema:value 10.1245/s10434-013-3158-4
102 rdf:type schema:PropertyValue
103 N4fd40c885048498aace03e5fedcffa79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Prognosis
105 rdf:type schema:DefinedTerm
106 N5044ac6a916943e494be3eeb92ad1bdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Registries
108 rdf:type schema:DefinedTerm
109 N5f26b00cce5a46df9312306d5cd6a476 schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 N606b623915ad47ab8d5daaed2821b392 rdf:first sg:person.01115035023.34
112 rdf:rest N748447e241bd4f1ea527eca749f0df3f
113 N62544bd2a0bc4d91aa5de41e06a8a794 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Brachytherapy
115 rdf:type schema:DefinedTerm
116 N63d118a11ac249f689b99769b5aeecd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Cohort Studies
118 rdf:type schema:DefinedTerm
119 N63efab3c3e2740708ce61a1b7f804359 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Carcinoma, Intraductal, Noninfiltrating
121 rdf:type schema:DefinedTerm
122 N748447e241bd4f1ea527eca749f0df3f rdf:first sg:person.01150535406.46
123 rdf:rest N317ef77521ff424aacc7bf2bca0dba57
124 N7ebfad09796340c7a40b2805210e1d7b schema:volumeNumber 20
125 rdf:type schema:PublicationVolume
126 N7f14fe61ce834c1f984d4f7086253970 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Follow-Up Studies
128 rdf:type schema:DefinedTerm
129 N85930c07dd194a859545e03bc439ab55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Carcinoma, Ductal, Breast
131 rdf:type schema:DefinedTerm
132 N86f411c5cb204efcad03cf417ecd8003 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Humans
134 rdf:type schema:DefinedTerm
135 N9648975223934c34ad6177f2e2b0916d schema:name pubmed_id
136 schema:value 23975302
137 rdf:type schema:PropertyValue
138 Na08357c4329840e78e129fdb5b820bda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Aged, 80 and over
140 rdf:type schema:DefinedTerm
141 Naaa613d7830f4be7bd12094a81789ce4 rdf:first sg:person.0747662642.56
142 rdf:rest N153efd38751a4c1990efbbbb263314c4
143 Nb69a4add4d134f918fb686da0c78dd94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Mastectomy, Segmental
145 rdf:type schema:DefinedTerm
146 Nbade5c42a13847d9b7d5b4752f25e4ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Female
148 rdf:type schema:DefinedTerm
149 Nc14b8af2702e4893a9744e75f9af738a schema:name readcube_id
150 schema:value 4c034e730a7836486622d6cea8aa6b67999c29a33c0f6092cd2f7e73b4e3e6ea
151 rdf:type schema:PropertyValue
152 Nc1a1120a798a46ec8be3ee540b3b4922 schema:issueNumber 10
153 rdf:type schema:PublicationIssue
154 Nc377b9f7a94341b5b14574401cd7a6e4 schema:name Michigan Healthcare Professionals/21st Century Oncology, Farmington Hills, MI, USA
155 rdf:type schema:Organization
156 Nc7c7fc7dcff141999f9bce95fec85b9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Neoplasm Staging
158 rdf:type schema:DefinedTerm
159 Ncc52d34990d6409099690c6f3daf02de schema:name dimensions_id
160 schema:value pub.1015952877
161 rdf:type schema:PropertyValue
162 Nd8fad20e3aa64dab993d956c7aee0a46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Middle Aged
164 rdf:type schema:DefinedTerm
165 Nddfbfbf7172a4d97aa0be47eebc624ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Adult
167 rdf:type schema:DefinedTerm
168 Nf71710a0b87247f7a7919b934dc97da3 rdf:first sg:person.01050463645.04
169 rdf:rest rdf:nil
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
174 schema:name Oncology and Carcinogenesis
175 rdf:type schema:DefinedTerm
176 sg:journal.1105545 schema:issn 1068-9265
177 1534-4681
178 schema:name Annals of Surgical Oncology
179 rdf:type schema:Periodical
180 sg:person.01050463645.04 schema:affiliation N3238ab06d49049379607b6bf1a462327
181 schema:familyName Lyden
182 schema:givenName Maureen
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050463645.04
184 rdf:type schema:Person
185 sg:person.01115035023.34 schema:affiliation Nc377b9f7a94341b5b14574401cd7a6e4
186 schema:familyName Vicini
187 schema:givenName Frank
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115035023.34
189 rdf:type schema:Person
190 sg:person.01150535406.46 schema:affiliation https://www.grid.ac/institutes/grid.477059.8
191 schema:familyName Beitsch
192 schema:givenName Peter
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150535406.46
194 rdf:type schema:Person
195 sg:person.011601172377.98 schema:affiliation https://www.grid.ac/institutes/grid.224260.0
196 schema:familyName Arthur
197 schema:givenName Douglas
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011601172377.98
199 rdf:type schema:Person
200 sg:person.01317534703.08 schema:affiliation https://www.grid.ac/institutes/grid.413057.4
201 schema:familyName Keisch
202 schema:givenName Martin
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317534703.08
204 rdf:type schema:Person
205 sg:person.0651353206.75 schema:affiliation https://www.grid.ac/institutes/grid.261277.7
206 schema:familyName Ben Wilkinson
207 schema:givenName J.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651353206.75
209 rdf:type schema:Person
210 sg:person.0717466406.86 schema:affiliation https://www.grid.ac/institutes/grid.416711.4
211 schema:familyName Badiyan
212 schema:givenName Shahed
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717466406.86
214 rdf:type schema:Person
215 sg:person.0747662642.56 schema:affiliation https://www.grid.ac/institutes/grid.416711.4
216 schema:familyName Shah
217 schema:givenName Chirag
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747662642.56
219 rdf:type schema:Person
220 https://doi.org/10.1001/archsurg.1989.01410020023002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046097822
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1001/jama.2012.3481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020587349
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/cncr.25383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011726834
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/0360-3016(85)90241-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022827897
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.amjsurg.2007.06.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045467556
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.brachy.2008.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026950314
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.ijrobp.2007.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037649850
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.ijrobp.2009.02.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019658859
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.radonc.2011.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041210311
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.surg.2006.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026260569
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0167-8140(12)71978-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016912115
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0360-3016(02)04277-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049402890
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1056/nejmoa022152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036865265
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejmoa040587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003108241
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1093/jnci/92.14.1143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027184958
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1093/jnci/djr495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025084838
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1111/j.1524-4741.2010.01041.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024892102
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1158/0008-5472.sabcs12-s4-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063222251
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1200/jco.2011.41.1090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016159672
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1200/jco.2012.43.5297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013620494
259 rdf:type schema:CreativeWork
260 https://www.grid.ac/institutes/grid.224260.0 schema:alternateName Virginia Commonwealth University
261 schema:name Department of Radiation Oncology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.261277.7 schema:alternateName Oakland University
264 schema:name Department of Radiation Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA
265 rdf:type schema:Organization
266 https://www.grid.ac/institutes/grid.413057.4 schema:alternateName University of Miami Hospital
267 schema:name Cancer HealthCare Associates, University of Miami Hospital, Miami, FL, USA
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.416711.4 schema:alternateName Summa Health System
270 schema:name Department of Radiation Oncology, Summa Health System, Akron, OH, USA
271 rdf:type schema:Organization
272 https://www.grid.ac/institutes/grid.477059.8 schema:alternateName Dallas Surgical Group
273 schema:name Dallas Surgical Group, Dallas, TX, USA
274 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...