Paratesticular Liposarcoma: Unusual Patterns of Recurrence and Importance of Margins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-07

AUTHORS

Melin J. Khandekar, Chandrajit P. Raut, Jason L. Hornick, Qian Wang, Brian M. Alexander, Elizabeth H. Baldini

ABSTRACT

BACKGROUND: Paratesticular liposarcoma (LPS) is a rare entity for which optimal treatment has not been defined. We sought to determine recurrence patterns and prognostic factors. METHODS: A total of 25 patients with localized paratesticular LPS between 1987 and 2009 were reviewed. Actuarial local-recurrence-free survival (LRFS), disease-free-survival (DFS), and overall survival (OS) were determined using the Kaplan-Meier method. RESULTS: LPS histology was well differentiated for 10 patients (40 %), de-differentiated for 14 (56 %), and pleomorphic for 1 (4 %). Final margins were positive in 8 patients (32 %). Radiation therapy (RT) was given to 10 patients; fields included inguinal canal ± scrotum and low pelvis. LRFS rates at 3 and 5 years were 76 and 67 %. The 3-year LRFS rates were lower in patients with positive margins compared with those with negative margins (29 vs 100 %, p = .0005) and in patients with recurrent versus primary disease (38 vs 83 %, p = .04). Among patients who received surgery and RT, margins remained a significant predictor of local recurrence (p = .009). Interestingly, recurrences in 4 patients tracked along gonadal vessels, and only 1 patient had a distant recurrence. OS at 5 years was 100 %. CONCLUSIONS: For patients with localized paratesticular LPS, positive margins and presentation with recurrent disease are adverse prognostic factors for LRFS. LR for patients with positive margins is still high despite RT; thus aggressive surgery to attain negative margins should be attempted in all cases. The finding of regional recurrences along gonadal vessels should be validated, and imaging studies should be tailored to reflect potential patterns of disease at presentation and subsequent recurrence. More... »

PAGES

2148-2155

References to SciGraph publications

  • 2003-07. Adult Spermatic Cord Sarcomas: Management and Results in ANNALS OF SURGICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1245/s10434-013-2963-0

    DOI

    http://dx.doi.org/10.1245/s10434-013-2963-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036463927

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23591942


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease-Free Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genital Neoplasms, Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kaplan-Meier Estimate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liposarcoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Recurrence, Local", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm, Residual", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Radiotherapy, Adjuvant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Brigham and Women's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "Harvard Radiation Oncology Program, Brigham and Women\u2019s Hospital, Boston, MA, USA", 
                "Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Khandekar", 
            "givenName": "Melin J.", 
            "id": "sg:person.01015346502.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015346502.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Division of Surgical Oncology, Brigham and Women\u2019s Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA", 
                "Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raut", 
            "givenName": "Chandrajit P.", 
            "id": "sg:person.0724431476.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724431476.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA", 
                "Department of Pathology, Brigham and Women\u2019s Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hornick", 
            "givenName": "Jason L.", 
            "id": "sg:person.01054675477.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054675477.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Senior Biometrician II, Beijing Novartis Pharma Co. Ltd, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Qian", 
            "id": "sg:person.01142204213.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142204213.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Radiation Oncology, Brigham and Women\u2019s Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alexander", 
            "givenName": "Brian M.", 
            "id": "sg:person.0647031722.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647031722.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA", 
                "Department of Radiation Oncology, Brigham and Women\u2019s Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baldini", 
            "givenName": "Elizabeth H.", 
            "id": "sg:person.01244366402.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244366402.68"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/cncr.11365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000222610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(05)68823-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002301730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.1800820247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003281162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/coc.0b013e318248dc51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017854169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/coc.0b013e318248dc51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017854169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(05)65758-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018271888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2012.07.158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018580334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.04.160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021803956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-200005000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023993327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-200005000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023993327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-200005000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023993327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000478-200301000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024086436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000478-200301000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024086436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000478-200301000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024086436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/aso.2003.11.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025875659", 
              "https://doi.org/10.1245/aso.2003.11.014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2006.08.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027446116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jso.20975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028001060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1873::aid-cncr17>3.0.co;2-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030211320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005392-199501000-00055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035053924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005392-199501000-00055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035053924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005392-199501000-00055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035053924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1464-410x.2002.02992.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035489823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.11367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037306781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2007.02.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041307298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2004.09.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042955746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9098(199907)71:3<155::aid-jso4>3.0.co;2-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043368711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2006.07.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053024876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/01621459.1958.10501452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058299418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000478-199703000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060122273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000478-199703000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060122273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000478-199703000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060122273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075282698", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076569290", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(17)37787-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077821118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(17)62016-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081083474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081436209", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(17)54650-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082270727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1996.14.5.1679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082882844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1302/0301-620x.78b4.0780658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082907207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1998.16.1.197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083201636"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-07", 
        "datePublishedReg": "2013-07-01", 
        "description": "BACKGROUND: Paratesticular liposarcoma (LPS) is a rare entity for which optimal treatment has not been defined. We sought to determine recurrence patterns and prognostic factors.\nMETHODS: A total of 25 patients with localized paratesticular LPS between 1987 and 2009 were reviewed. Actuarial local-recurrence-free survival (LRFS), disease-free-survival (DFS), and overall survival (OS) were determined using the Kaplan-Meier method.\nRESULTS: LPS histology was well differentiated for 10 patients (40 %), de-differentiated for 14 (56 %), and pleomorphic for 1 (4 %). Final margins were positive in 8 patients (32 %). Radiation therapy (RT) was given to 10 patients; fields included inguinal canal \u00b1 scrotum and low pelvis. LRFS rates at 3 and 5 years were 76 and 67 %. The 3-year LRFS rates were lower in patients with positive margins compared with those with negative margins (29 vs 100 %, p = .0005) and in patients with recurrent versus primary disease (38 vs 83 %, p = .04). Among patients who received surgery and RT, margins remained a significant predictor of local recurrence (p = .009). Interestingly, recurrences in 4 patients tracked along gonadal vessels, and only 1 patient had a distant recurrence. OS at 5 years was 100 %.\nCONCLUSIONS: For patients with localized paratesticular LPS, positive margins and presentation with recurrent disease are adverse prognostic factors for LRFS. LR for patients with positive margins is still high despite RT; thus aggressive surgery to attain negative margins should be attempted in all cases. The finding of regional recurrences along gonadal vessels should be validated, and imaging studies should be tailored to reflect potential patterns of disease at presentation and subsequent recurrence.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1245/s10434-013-2963-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1105545", 
            "issn": [
              "1068-9265", 
              "1534-4681"
            ], 
            "name": "Annals of Surgical Oncology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "name": "Paratesticular Liposarcoma: Unusual Patterns of Recurrence and Importance of Margins", 
        "pagination": "2148-2155", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "adb32946308bb0dcaf8f2b1aeb1dc6357b948d9134ceadaae1c25c898a9ca56d"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23591942"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9420840"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1245/s10434-013-2963-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1036463927"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1245/s10434-013-2963-0", 
          "https://app.dimensions.ai/details/publication/pub.1036463927"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000500.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1245/s10434-013-2963-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-2963-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-2963-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-2963-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-013-2963-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    263 TRIPLES      21 PREDICATES      74 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1245/s10434-013-2963-0 schema:about N1a9a0e8eebc24d4fb94dab834b2e5cda
    2 N1cc76285b9464dbe8ce108da2110b21d
    3 N26127526e44c4214b263a793383434da
    4 N2cef59f515754717a35ce873141a3678
    5 N3dbb587a62cf4c23815f0d4728207ab8
    6 N438cec664f1340be99d94a2030afc65b
    7 N4a7f478fe7df4eb98f55f669418c569f
    8 N55dd2e157c924523944fa29cf9c49191
    9 N5d0638ab5f6f424d96e25f84b81d140d
    10 N5ef9eb761585436d98fb1acf00101872
    11 N9a38684cd1214012a3bfec4a7f52ba80
    12 Nc57dabd91afb4d49a602c8c8de08dd11
    13 Nd089ec295fda40f48d74f4ed57caa674
    14 Nf4aae28e684c413aa0a913357845d0c3
    15 anzsrc-for:11
    16 anzsrc-for:1112
    17 schema:author N564e58170eba42c4b221a6af8020b6e3
    18 schema:citation sg:pub.10.1245/aso.2003.11.014
    19 https://app.dimensions.ai/details/publication/pub.1075282698
    20 https://app.dimensions.ai/details/publication/pub.1076569290
    21 https://app.dimensions.ai/details/publication/pub.1081436209
    22 https://doi.org/10.1002/(sici)1096-9098(199907)71:3<155::aid-jso4>3.0.co;2-7
    23 https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1873::aid-cncr17>3.0.co;2-x
    24 https://doi.org/10.1002/bjs.1800820247
    25 https://doi.org/10.1002/cncr.11365
    26 https://doi.org/10.1002/cncr.11367
    27 https://doi.org/10.1002/jso.20975
    28 https://doi.org/10.1016/j.eururo.2004.09.013
    29 https://doi.org/10.1016/j.ijrobp.2006.08.025
    30 https://doi.org/10.1016/j.ijrobp.2007.02.041
    31 https://doi.org/10.1016/j.ijrobp.2012.07.158
    32 https://doi.org/10.1016/j.juro.2006.07.021
    33 https://doi.org/10.1016/s0022-5347(05)65758-8
    34 https://doi.org/10.1016/s0022-5347(05)68823-4
    35 https://doi.org/10.1016/s0022-5347(17)37787-x
    36 https://doi.org/10.1016/s0022-5347(17)54650-9
    37 https://doi.org/10.1016/s0022-5347(17)62016-0
    38 https://doi.org/10.1046/j.1464-410x.2002.02992.x
    39 https://doi.org/10.1080/01621459.1958.10501452
    40 https://doi.org/10.1097/00000478-199703000-00002
    41 https://doi.org/10.1097/00000478-200301000-00005
    42 https://doi.org/10.1097/00000658-200005000-00005
    43 https://doi.org/10.1097/00005392-199501000-00055
    44 https://doi.org/10.1097/coc.0b013e318248dc51
    45 https://doi.org/10.1200/jco.1996.14.5.1679
    46 https://doi.org/10.1200/jco.1998.16.1.197
    47 https://doi.org/10.1200/jco.2005.04.160
    48 https://doi.org/10.1302/0301-620x.78b4.0780658
    49 schema:datePublished 2013-07
    50 schema:datePublishedReg 2013-07-01
    51 schema:description BACKGROUND: Paratesticular liposarcoma (LPS) is a rare entity for which optimal treatment has not been defined. We sought to determine recurrence patterns and prognostic factors. METHODS: A total of 25 patients with localized paratesticular LPS between 1987 and 2009 were reviewed. Actuarial local-recurrence-free survival (LRFS), disease-free-survival (DFS), and overall survival (OS) were determined using the Kaplan-Meier method. RESULTS: LPS histology was well differentiated for 10 patients (40 %), de-differentiated for 14 (56 %), and pleomorphic for 1 (4 %). Final margins were positive in 8 patients (32 %). Radiation therapy (RT) was given to 10 patients; fields included inguinal canal ± scrotum and low pelvis. LRFS rates at 3 and 5 years were 76 and 67 %. The 3-year LRFS rates were lower in patients with positive margins compared with those with negative margins (29 vs 100 %, p = .0005) and in patients with recurrent versus primary disease (38 vs 83 %, p = .04). Among patients who received surgery and RT, margins remained a significant predictor of local recurrence (p = .009). Interestingly, recurrences in 4 patients tracked along gonadal vessels, and only 1 patient had a distant recurrence. OS at 5 years was 100 %. CONCLUSIONS: For patients with localized paratesticular LPS, positive margins and presentation with recurrent disease are adverse prognostic factors for LRFS. LR for patients with positive margins is still high despite RT; thus aggressive surgery to attain negative margins should be attempted in all cases. The finding of regional recurrences along gonadal vessels should be validated, and imaging studies should be tailored to reflect potential patterns of disease at presentation and subsequent recurrence.
    52 schema:genre research_article
    53 schema:inLanguage en
    54 schema:isAccessibleForFree false
    55 schema:isPartOf N690d526fa28345f699a6f8d48c8b5b95
    56 Ne11032ce95a24c31aeebe67af8503e46
    57 sg:journal.1105545
    58 schema:name Paratesticular Liposarcoma: Unusual Patterns of Recurrence and Importance of Margins
    59 schema:pagination 2148-2155
    60 schema:productId N4724366fe42049b9a10ea113b93d44d2
    61 N748c726ae08147c99bf06c28ba52d6d1
    62 Nb699d55e258b4e53a78e1f4b89c98392
    63 Nd13ba7ca39ef418d9cdd6abf2600cc43
    64 Ned57bab2144044b184bc731b430137f0
    65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036463927
    66 https://doi.org/10.1245/s10434-013-2963-0
    67 schema:sdDatePublished 2019-04-11T01:04
    68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    69 schema:sdPublisher N1326989133214f2992c4e437da57b7a1
    70 schema:url http://link.springer.com/10.1245/s10434-013-2963-0
    71 sgo:license sg:explorer/license/
    72 sgo:sdDataset articles
    73 rdf:type schema:ScholarlyArticle
    74 N1326989133214f2992c4e437da57b7a1 schema:name Springer Nature - SN SciGraph project
    75 rdf:type schema:Organization
    76 N1a9a0e8eebc24d4fb94dab834b2e5cda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    77 schema:name Aged, 80 and over
    78 rdf:type schema:DefinedTerm
    79 N1cc76285b9464dbe8ce108da2110b21d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Kaplan-Meier Estimate
    81 rdf:type schema:DefinedTerm
    82 N26127526e44c4214b263a793383434da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Middle Aged
    84 rdf:type schema:DefinedTerm
    85 N26b4aad70f9b4c83ac1e9ea0cb52c39c rdf:first sg:person.01244366402.68
    86 rdf:rest rdf:nil
    87 N2cef59f515754717a35ce873141a3678 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    88 schema:name Genital Neoplasms, Male
    89 rdf:type schema:DefinedTerm
    90 N3dbb587a62cf4c23815f0d4728207ab8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name Neoplasm Recurrence, Local
    92 rdf:type schema:DefinedTerm
    93 N438cec664f1340be99d94a2030afc65b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Retrospective Studies
    95 rdf:type schema:DefinedTerm
    96 N4724366fe42049b9a10ea113b93d44d2 schema:name readcube_id
    97 schema:value adb32946308bb0dcaf8f2b1aeb1dc6357b948d9134ceadaae1c25c898a9ca56d
    98 rdf:type schema:PropertyValue
    99 N4a7f478fe7df4eb98f55f669418c569f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Neoplasm, Residual
    101 rdf:type schema:DefinedTerm
    102 N55dd2e157c924523944fa29cf9c49191 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Male
    104 rdf:type schema:DefinedTerm
    105 N564e58170eba42c4b221a6af8020b6e3 rdf:first sg:person.01015346502.42
    106 rdf:rest Nacf86f62dccf46d3867b5dd404484ea4
    107 N5d0638ab5f6f424d96e25f84b81d140d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Humans
    109 rdf:type schema:DefinedTerm
    110 N5ef98bb075a94dfcbccbe5e038219a75 rdf:first sg:person.01142204213.25
    111 rdf:rest Nb032812cd52a4fc2b65107171949966e
    112 N5ef9eb761585436d98fb1acf00101872 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Radiotherapy, Adjuvant
    114 rdf:type schema:DefinedTerm
    115 N690d526fa28345f699a6f8d48c8b5b95 schema:issueNumber 7
    116 rdf:type schema:PublicationIssue
    117 N748c726ae08147c99bf06c28ba52d6d1 schema:name nlm_unique_id
    118 schema:value 9420840
    119 rdf:type schema:PropertyValue
    120 N757488d2aff44a959f592b371ff58834 rdf:first sg:person.01054675477.69
    121 rdf:rest N5ef98bb075a94dfcbccbe5e038219a75
    122 N8b008c7ae8474cd4b5abf1a9ac54ee81 schema:name Senior Biometrician II, Beijing Novartis Pharma Co. Ltd, Beijing, China
    123 rdf:type schema:Organization
    124 N9a38684cd1214012a3bfec4a7f52ba80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Liposarcoma
    126 rdf:type schema:DefinedTerm
    127 Nacf86f62dccf46d3867b5dd404484ea4 rdf:first sg:person.0724431476.35
    128 rdf:rest N757488d2aff44a959f592b371ff58834
    129 Nb032812cd52a4fc2b65107171949966e rdf:first sg:person.0647031722.42
    130 rdf:rest N26b4aad70f9b4c83ac1e9ea0cb52c39c
    131 Nb699d55e258b4e53a78e1f4b89c98392 schema:name doi
    132 schema:value 10.1245/s10434-013-2963-0
    133 rdf:type schema:PropertyValue
    134 Nc57dabd91afb4d49a602c8c8de08dd11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Aged
    136 rdf:type schema:DefinedTerm
    137 Nd089ec295fda40f48d74f4ed57caa674 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Disease-Free Survival
    139 rdf:type schema:DefinedTerm
    140 Nd13ba7ca39ef418d9cdd6abf2600cc43 schema:name dimensions_id
    141 schema:value pub.1036463927
    142 rdf:type schema:PropertyValue
    143 Ne11032ce95a24c31aeebe67af8503e46 schema:volumeNumber 20
    144 rdf:type schema:PublicationVolume
    145 Ned57bab2144044b184bc731b430137f0 schema:name pubmed_id
    146 schema:value 23591942
    147 rdf:type schema:PropertyValue
    148 Nf4aae28e684c413aa0a913357845d0c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Adult
    150 rdf:type schema:DefinedTerm
    151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    152 schema:name Medical and Health Sciences
    153 rdf:type schema:DefinedTerm
    154 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Oncology and Carcinogenesis
    156 rdf:type schema:DefinedTerm
    157 sg:journal.1105545 schema:issn 1068-9265
    158 1534-4681
    159 schema:name Annals of Surgical Oncology
    160 rdf:type schema:Periodical
    161 sg:person.01015346502.42 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
    162 schema:familyName Khandekar
    163 schema:givenName Melin J.
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015346502.42
    165 rdf:type schema:Person
    166 sg:person.01054675477.69 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    167 schema:familyName Hornick
    168 schema:givenName Jason L.
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054675477.69
    170 rdf:type schema:Person
    171 sg:person.01142204213.25 schema:affiliation N8b008c7ae8474cd4b5abf1a9ac54ee81
    172 schema:familyName Wang
    173 schema:givenName Qian
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142204213.25
    175 rdf:type schema:Person
    176 sg:person.01244366402.68 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    177 schema:familyName Baldini
    178 schema:givenName Elizabeth H.
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244366402.68
    180 rdf:type schema:Person
    181 sg:person.0647031722.42 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    182 schema:familyName Alexander
    183 schema:givenName Brian M.
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647031722.42
    185 rdf:type schema:Person
    186 sg:person.0724431476.35 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    187 schema:familyName Raut
    188 schema:givenName Chandrajit P.
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724431476.35
    190 rdf:type schema:Person
    191 sg:pub.10.1245/aso.2003.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025875659
    192 https://doi.org/10.1245/aso.2003.11.014
    193 rdf:type schema:CreativeWork
    194 https://app.dimensions.ai/details/publication/pub.1075282698 schema:CreativeWork
    195 https://app.dimensions.ai/details/publication/pub.1076569290 schema:CreativeWork
    196 https://app.dimensions.ai/details/publication/pub.1081436209 schema:CreativeWork
    197 https://doi.org/10.1002/(sici)1096-9098(199907)71:3<155::aid-jso4>3.0.co;2-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043368711
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1873::aid-cncr17>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030211320
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1002/bjs.1800820247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003281162
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1002/cncr.11365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000222610
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1002/cncr.11367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037306781
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1002/jso.20975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028001060
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/j.eururo.2004.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042955746
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/j.ijrobp.2006.08.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027446116
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/j.ijrobp.2007.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041307298
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1016/j.ijrobp.2012.07.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018580334
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1016/j.juro.2006.07.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053024876
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1016/s0022-5347(05)65758-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018271888
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1016/s0022-5347(05)68823-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002301730
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1016/s0022-5347(17)37787-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077821118
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1016/s0022-5347(17)54650-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082270727
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1016/s0022-5347(17)62016-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081083474
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1046/j.1464-410x.2002.02992.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035489823
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1080/01621459.1958.10501452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058299418
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1097/00000478-199703000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060122273
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1097/00000478-200301000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024086436
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1097/00000658-200005000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023993327
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1097/00005392-199501000-00055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035053924
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1097/coc.0b013e318248dc51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017854169
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1200/jco.1996.14.5.1679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082882844
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1200/jco.1998.16.1.197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083201636
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1200/jco.2005.04.160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021803956
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1302/0301-620x.78b4.0780658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082907207
    250 rdf:type schema:CreativeWork
    251 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    252 schema:name Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
    253 Department of Pathology, Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    254 Department of Radiation Oncology, Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    255 rdf:type schema:Organization
    256 https://www.grid.ac/institutes/grid.62560.37 schema:alternateName Brigham and Women's Hospital
    257 schema:name Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    258 Harvard Radiation Oncology Program, Brigham and Women’s Hospital, Boston, MA, USA
    259 rdf:type schema:Organization
    260 https://www.grid.ac/institutes/grid.65499.37 schema:alternateName Dana–Farber Cancer Institute
    261 schema:name Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
    262 Division of Surgical Oncology, Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    263 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...