Breast Cancer Subtype and Distant Recurrence after Ipsilateral Breast Tumor Recurrence View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-01-06

AUTHORS

Makoto Ishitobi, Yasuhiro Okumura, Nobuyuki Arima, Atsushi Yoshida, Katsuhiko Nakatsukasa, Takuji Iwase, Tadahiko Shien, Norikazu Masuda, Satoru Tanaka, Masahiko Tanabe, Takehiro Tanaka, Yoshifumi Komoike, Tetsuya Taguchi, Reiki Nishimura, Hideo Inaji

ABSTRACT

BackgroundThere is little information about the impact of breast cancer subtype on prognosis after ipsilateral breast tumor recurrence (IBTR).MethodsOne hundred eighty-five patients were classified according to breast cancer subtype, as approximated by estrogen receptor, human epidermal growth factor receptor 2 (HER2), and Ki-67, of IBTR, and we evaluated whether breast cancer subtype was associated with distant recurrence after IBTR.ResultsThere was a significant difference in distant disease-free survival (DDFS) after IBTR according to breast cancer subtype defined by a cutoff of the Ki-67 index of 20 % (p = 0.0074, log-rank test). The 5-year DDFS rates for patients with luminal A, luminal B, triple-negative, and HER2 types were 86.3, 57.1, 56.6, and 65.9 %, respectively. In addition, breast cancer subtype was significantly associated with distant recurrence after IBTR on adjustment for various clinicopathologic factors (p = 0.0027, Cox proportional hazards model).ConclusionsOur study suggests that breast cancer subtype based on immunohistochemical staining predicts the outcomes of patients with IBTR. Further analyses are needed (UMIN-CTR number UMIN000008136). More... »

PAGES

1886-1892

Journal

TITLE

Annals of Surgical Oncology

ISSUE

6

VOLUME

20

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-012-2825-1

DOI

http://dx.doi.org/10.1245/s10434-012-2825-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050799015

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23292516


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34 schema:description BackgroundThere is little information about the impact of breast cancer subtype on prognosis after ipsilateral breast tumor recurrence (IBTR).MethodsOne hundred eighty-five patients were classified according to breast cancer subtype, as approximated by estrogen receptor, human epidermal growth factor receptor 2 (HER2), and Ki-67, of IBTR, and we evaluated whether breast cancer subtype was associated with distant recurrence after IBTR.ResultsThere was a significant difference in distant disease-free survival (DDFS) after IBTR according to breast cancer subtype defined by a cutoff of the Ki-67 index of 20 % (p = 0.0074, log-rank test). The 5-year DDFS rates for patients with luminal A, luminal B, triple-negative, and HER2 types were 86.3, 57.1, 56.6, and 65.9 %, respectively. In addition, breast cancer subtype was significantly associated with distant recurrence after IBTR on adjustment for various clinicopathologic factors (p = 0.0027, Cox proportional hazards model).ConclusionsOur study suggests that breast cancer subtype based on immunohistochemical staining predicts the outcomes of patients with IBTR. Further analyses are needed (UMIN-CTR number UMIN000008136).
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42 ConclusionsOur study
43 Further analysis
44 HER2 type
45 Ki-67
46 Ki-67 index
47 MethodsOne hundred eighty
48 ResultsThere
49 addition
50 adjustment
51 analysis
52 breast cancer subtypes
53 breast tumor recurrence
54 cancer subtypes
55 clinicopathologic factors
56 cutoff
57 differences
58 disease-free survival
59 distant disease-free survival
60 distant recurrence
61 eighties
62 epidermal growth factor receptor 2
63 estrogen receptor
64 factor receptor 2
65 factors
66 growth factor receptor 2
67 human epidermal growth factor receptor 2
68 immunohistochemical staining
69 impact
70 index
71 information
72 ipsilateral breast tumor recurrence
73 little information
74 outcome of patients
75 outcomes
76 patients
77 prognosis
78 rate
79 receptor 2
80 receptors
81 recurrence
82 significant differences
83 staining
84 study
85 subtypes
86 survival
87 tumor recurrence
88 types
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