Progression while Receiving Preoperative Chemotherapy Should Not Be an Absolute Contraindication to Liver Resection for Colorectal Metastases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-05-24

AUTHORS

Luca Viganò, Lorenzo Capussotti, Eduardo Barroso, Gennaro Nuzzo, Christophe Laurent, Jan N. M. Ijzermans, Jean-François Gigot, Joan Figueras, Thomas Gruenberger, Darius F. Mirza, Dominique Elias, Graeme Poston, Christian Letoublon, Helena Isoniemi, Javier Herrera, Francisco Castro Sousa, Fernando Pardo, Valerio Lucidi, Irinel Popescu, René Adam

ABSTRACT

PurposeTumor progression while receiving neoadjuvant chemotherapy (PD) has been associated with poor outcome and is commonly considered a contraindication to liver resection (LR). This study aims to clarify in a large multicenter setting whether PD is always a contraindication to LR.MethodsData from the LiverMetSurvey international registry were analyzed. Patients undergoing LR for colorectal metastases without extrahepatic disease after neoadjuvant chemotherapy between 1990 and 2009 were reviewed.ResultsAmong 2143 patients, PD occurred in 176 (8.2 %). Risk of progression was increased after 5-FU or irinotecan (22.7 % vs. 6.8 % after other regimens, p < 0.0001; 14.9 % vs. 7.2 %, p < 0.0001), while it was reduced after oxaliplatin (5.6 % vs. 12.0 %, p < 0.0001) and still diminished among patients receiving targeted therapies (2.6 %). PD was an independent prognostic factor of survival at multivariate analysis (35 % vs. 49 %, p = 0.0006). In the PD group, 3 independent prognostic factors were identified: carcinoembryonic antigen (CEA) ≥200 ng/mL (p = 0.003), >3 metastases (p = 0.028), and tumor diameter ≥50 mm (p = 0.002). A survival predictive model showed that patients without any risk factors had 5-year survival rates of 53.3 %; good survival results were still observed if metastases were >3 or ≥50 mm (29.9 and 19.1 %, respectively). On the contrary, survival was less than 10 % at 3 years in the presence of >1 prognostic factor or CEA of ≥200 ng/mL.ConclusionsPD is a negative prognostic factor, but it is not an absolute contraindication to LR. Patients with PD could be scheduled for LR except for those with >3 metastases and ≥50 mm, or CEA ≥200 ng/mL in whom further chemotherapy is recommended. More... »

PAGES

2786-2796

Journal

TITLE

Annals of Surgical Oncology

ISSUE

9

VOLUME

19

Author Affiliations

  • Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy
  • Department of HPB Surgery and Transplantation, Curry Cabral Hospital, Lisbon, Portugal
  • Hepatobiliary Unit, Department of Surgery, Catholic University of the Sacred Heart School of Medicine, Rome, Italy
  • Department of Surgery, Hôpital Saint André, Bordeaux, France
  • Department of Transplantation and Hepato-biliary Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
  • Unit of HPB Surgery, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCL), Brussels, Belgium
  • Department of Surgery, “Josep Trueta” Hospital, Girona, Spain
  • Department of Surgery, Medical University of Vienna, Vienna, Austria
  • Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
  • Department of Surgery, Institute Gustave Roussy, Villejuif, France
  • Department of Surgery, University Hospital Aintree, Liverpool, UK
  • Department of Digestive and Emergency Surgery, University Hospital, University Joseph Fourier, Grenoble, France
  • Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland
  • Department of Surgery, Navarra Hospital, Pamplona, Spain
  • Department of Surgery, Surgery 3, Coimbra University Hospital, Coimbra, Portugal
  • Department of General Surgery, Clínica Universidad de Navarra, Pamplona, Spain
  • Liver Transplantation Unit, Department of Surgery, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
  • Department of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania
  • AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire, Université Paris-Sud, Villejuif, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1245/s10434-012-2382-7

    DOI

    http://dx.doi.org/10.1245/s10434-012-2382-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031829239

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22622469


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies, Monoclonal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies, Monoclonal, Humanized", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bevacizumab", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Camptothecin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoembryonic Antigen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cetuximab", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Contraindications", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease-Free Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorouracil", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hepatectomy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Irinotecan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kaplan-Meier Estimate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multivariate Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoadjuvant Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organoplatinum Compounds", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxaliplatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proportional Hazards Models", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Burden", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/grid.414700.6", 
              "name": [
                "Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vigan\u00f2", 
            "givenName": "Luca", 
            "id": "sg:person.01110043213.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110043213.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/grid.414700.6", 
              "name": [
                "Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Capussotti", 
            "givenName": "Lorenzo", 
            "id": "sg:person.0605432266.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605432266.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of HPB Surgery and Transplantation, Curry Cabral Hospital, Lisbon, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.413362.1", 
              "name": [
                "Department of HPB Surgery and Transplantation, Curry Cabral Hospital, Lisbon, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barroso", 
            "givenName": "Eduardo", 
            "id": "sg:person.01042754411.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042754411.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hepatobiliary Unit, Department of Surgery, Catholic University of the Sacred Heart School of Medicine, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8142.f", 
              "name": [
                "Hepatobiliary Unit, Department of Surgery, Catholic University of the Sacred Heart School of Medicine, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nuzzo", 
            "givenName": "Gennaro", 
            "id": "sg:person.01133764026.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133764026.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, H\u00f4pital Saint Andr\u00e9, Bordeaux, France", 
              "id": "http://www.grid.ac/institutes/grid.414339.8", 
              "name": [
                "Department of Surgery, H\u00f4pital Saint Andr\u00e9, Bordeaux, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Laurent", 
            "givenName": "Christophe", 
            "id": "sg:person.01275745276.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275745276.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Transplantation and Hepato-biliary Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Department of Transplantation and Hepato-biliary Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ijzermans", 
            "givenName": "Jan N. M.", 
            "id": "sg:person.014376165757.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014376165757.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Unit of HPB Surgery, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain (UCL), Brussels, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.48769.34", 
              "name": [
                "Unit of HPB Surgery, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain (UCL), Brussels, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gigot", 
            "givenName": "Jean-Fran\u00e7ois", 
            "id": "sg:person.01371206063.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371206063.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, \u201cJosep Trueta\u201d Hospital, Girona, Spain", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Surgery, \u201cJosep Trueta\u201d Hospital, Girona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Figueras", 
            "givenName": "Joan", 
            "id": "sg:person.011172561042.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011172561042.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Medical University of Vienna, Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.22937.3d", 
              "name": [
                "Department of Surgery, Medical University of Vienna, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gruenberger", 
            "givenName": "Thomas", 
            "id": "sg:person.01156246422.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156246422.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Liver Unit, Queen Elizabeth Hospital, Birmingham, UK", 
              "id": "http://www.grid.ac/institutes/grid.415490.d", 
              "name": [
                "Liver Unit, Queen Elizabeth Hospital, Birmingham, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mirza", 
            "givenName": "Darius F.", 
            "id": "sg:person.01064605320.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064605320.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Institute Gustave Roussy, Villejuif, France", 
              "id": "http://www.grid.ac/institutes/grid.14925.3b", 
              "name": [
                "Department of Surgery, Institute Gustave Roussy, Villejuif, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Elias", 
            "givenName": "Dominique", 
            "id": "sg:person.01260460625.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260460625.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, University Hospital Aintree, Liverpool, UK", 
              "id": "http://www.grid.ac/institutes/grid.411255.6", 
              "name": [
                "Department of Surgery, University Hospital Aintree, Liverpool, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Poston", 
            "givenName": "Graeme", 
            "id": "sg:person.0607370647.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607370647.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Digestive and Emergency Surgery, University Hospital, University Joseph Fourier, Grenoble, France", 
              "id": "http://www.grid.ac/institutes/grid.410529.b", 
              "name": [
                "Department of Digestive and Emergency Surgery, University Hospital, University Joseph Fourier, Grenoble, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Letoublon", 
            "givenName": "Christian", 
            "id": "sg:person.01153410535.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153410535.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Isoniemi", 
            "givenName": "Helena", 
            "id": "sg:person.0746463325.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746463325.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Navarra Hospital, Pamplona, Spain", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Surgery, Navarra Hospital, Pamplona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herrera", 
            "givenName": "Javier", 
            "id": "sg:person.01016066143.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016066143.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Surgery 3, Coimbra University Hospital, Coimbra, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.28911.33", 
              "name": [
                "Department of Surgery, Surgery 3, Coimbra University Hospital, Coimbra, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Castro Sousa", 
            "givenName": "Francisco", 
            "id": "sg:person.013457604412.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013457604412.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Surgery, Cl\u00ednica Universidad de Navarra, Pamplona, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411730.0", 
              "name": [
                "Department of General Surgery, Cl\u00ednica Universidad de Navarra, Pamplona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pardo", 
            "givenName": "Fernando", 
            "id": "sg:person.0734706372.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734706372.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Liver Transplantation Unit, Department of Surgery, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.4989.c", 
              "name": [
                "Liver Transplantation Unit, Department of Surgery, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lucidi", 
            "givenName": "Valerio", 
            "id": "sg:person.0726062650.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726062650.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania", 
              "id": "http://www.grid.ac/institutes/grid.415180.9", 
              "name": [
                "Department of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Popescu", 
            "givenName": "Irinel", 
            "id": "sg:person.0660433203.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660433203.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AP-HP H\u00f4pital Paul Brousse, Centre H\u00e9pato-Biliaire, Universit\u00e9 Paris-Sud, Villejuif, France", 
              "id": "http://www.grid.ac/institutes/grid.413133.7", 
              "name": [
                "AP-HP H\u00f4pital Paul Brousse, Centre H\u00e9pato-Biliaire, Universit\u00e9 Paris-Sud, Villejuif, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adam", 
            "givenName": "Ren\u00e9", 
            "id": "sg:person.01153120500.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153120500.12"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1245/s10434-006-9284-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041426567", 
              "https://doi.org/10.1245/s10434-006-9284-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-006-9068-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034768212", 
              "https://doi.org/10.1245/s10434-006-9068-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-009-0348-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028630724", 
              "https://doi.org/10.1245/s10434-009-0348-1"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-05-24", 
        "datePublishedReg": "2012-05-24", 
        "description": "PurposeTumor progression while receiving neoadjuvant chemotherapy (PD) has been associated with poor outcome and is commonly considered a contraindication to liver resection (LR). This study aims to clarify in a large multicenter setting whether PD is always a contraindication to LR.MethodsData from the LiverMetSurvey international registry were analyzed. Patients undergoing LR for colorectal metastases without extrahepatic disease after neoadjuvant chemotherapy between 1990 and 2009 were reviewed.ResultsAmong 2143 patients, PD occurred in 176 (8.2\u00a0%). Risk of progression was increased after 5-FU or irinotecan (22.7\u00a0% vs. 6.8\u00a0% after other regimens, p\u00a0<\u00a00.0001; 14.9\u00a0% vs. 7.2\u00a0%, p\u00a0<\u00a00.0001), while it was reduced after oxaliplatin (5.6\u00a0% vs. 12.0\u00a0%, p\u00a0<\u00a00.0001) and still diminished among patients receiving targeted therapies (2.6\u00a0%). PD was an independent prognostic factor of survival at multivariate analysis (35\u00a0% vs. 49\u00a0%, p\u00a0=\u00a00.0006). In the PD group, 3 independent prognostic factors were identified: carcinoembryonic antigen (CEA) \u2265200\u00a0ng/mL (p\u00a0=\u00a00.003), >3 metastases (p\u00a0=\u00a00.028), and tumor diameter \u226550\u00a0mm (p\u00a0=\u00a00.002). A survival predictive model showed that patients without any risk factors had 5-year survival rates of 53.3\u00a0%; good survival results were still observed if metastases were >3 or \u226550\u00a0mm (29.9 and 19.1\u00a0%, respectively). On the contrary, survival was less than 10\u00a0% at 3\u00a0years in the presence of >1 prognostic factor or CEA of \u2265200\u00a0ng/mL.ConclusionsPD is a negative prognostic factor, but it is not an absolute contraindication to LR. Patients with PD could be scheduled for LR except for those with >3 metastases and \u226550\u00a0mm, or CEA \u2265200\u00a0ng/mL in whom further chemotherapy is recommended.", 
        "genre": "article", 
        "id": "sg:pub.10.1245/s10434-012-2382-7", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1105545", 
            "issn": [
              "1068-9265", 
              "1534-4681"
            ], 
            "name": "Annals of Surgical Oncology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "keywords": [
          "independent prognostic factor", 
          "prognostic factors", 
          "carcinoembryonic antigen", 
          "neoadjuvant chemotherapy", 
          "colorectal metastases", 
          "absolute contraindication", 
          "risk of progression", 
          "negative prognostic factor", 
          "better survival results", 
          "survival predictive model", 
          "extrahepatic disease", 
          "further chemotherapy", 
          "preoperative chemotherapy", 
          "liver resection", 
          "large multicenter", 
          "tumor diameter", 
          "poor outcome", 
          "international registry", 
          "risk factors", 
          "survival results", 
          "PD group", 
          "patients", 
          "contraindications", 
          "chemotherapy", 
          "survival rate", 
          "metastasis", 
          "multivariate analysis", 
          "progression", 
          "resection", 
          "survival", 
          "multicenter", 
          "factors", 
          "ConclusionsPD", 
          "registry", 
          "oxaliplatin", 
          "MethodsData", 
          "therapy", 
          "antigen", 
          "disease", 
          "outcomes", 
          "LR", 
          "risk", 
          "group", 
          "years", 
          "predictive model", 
          "Pd", 
          "study", 
          "rate", 
          "presence", 
          "analysis", 
          "diameter", 
          "results", 
          "contrary", 
          "model"
        ], 
        "name": "Progression while Receiving Preoperative Chemotherapy Should Not Be an Absolute Contraindication to Liver Resection for Colorectal Metastases", 
        "pagination": "2786-2796", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1031829239"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1245/s10434-012-2382-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22622469"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1245/s10434-012-2382-7", 
          "https://app.dimensions.ai/details/publication/pub.1031829239"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_571.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1245/s10434-012-2382-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2382-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2382-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2382-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2382-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    429 TRIPLES      21 PREDICATES      111 URIs      100 LITERALS      36 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1245/s10434-012-2382-7 schema:about N0c7bf094915b4637ad92fbd5e9050e3f
    2 N10b1845eebed416e8caa828ca3b48732
    3 N1827c0a3424c4037b059594232ef3bfc
    4 N1b100dd11f8e4898af7ef04d5b552497
    5 N1df4aa1745794ecf980c563ec1a2a25b
    6 N1e179157bab544cb9f405c6483ad6105
    7 N2021e68c87dc4c4bb1130a234726147b
    8 N20cf428f8b084e7695acccc960320895
    9 N2853fa84863d43f5bcc68f7fb3617dd9
    10 N2eec63d29ec04a409e1f29d8ea337283
    11 N3e20fbef099148c7844873bdc250e7de
    12 N53153c75b66d403c93a2d2f608898a49
    13 N5f4833a05ec641b0b939bf47e09f8bd2
    14 N617375eb59ee42bebc0ca610c89f91d5
    15 N7ad3cc7bd8b54e3683f55b3c6169e059
    16 N85816683040042ae9f9bc3ddd0cd701e
    17 N8a1732c58caa4c76ba1a3fcc3cbca145
    18 N971ab49617ab4ea784d588fac820631c
    19 N99944700b1634f83a2c56c5121a8f0ed
    20 Na1fffa7fbcd14b7691599b7588351be2
    21 Na2051aa442c74244879744538178da42
    22 Nab396264165c4552b5b41c41a5baa86f
    23 Nbc9bec8f05d644579b9aa19a2916f2f7
    24 Ncd294b958e1d425889a3302986eeaf3f
    25 Nd73171483c284011a0862e36cd8b1735
    26 Ndaadc27394ff406f9427a86d08ed5eb9
    27 Ne86098bde50547ec8e2ab837424d72eb
    28 Nf2b6fa50dd0a46e6b2e66f5a07753aaf
    29 Nf8e9b3bea3b84c43a25b3da837361490
    30 anzsrc-for:11
    31 anzsrc-for:1112
    32 schema:author N3a32adeb65f1421ea364a1a7bd1f76f4
    33 schema:citation sg:pub.10.1245/s10434-006-9068-y
    34 sg:pub.10.1245/s10434-006-9284-5
    35 sg:pub.10.1245/s10434-009-0348-1
    36 schema:datePublished 2012-05-24
    37 schema:datePublishedReg 2012-05-24
    38 schema:description PurposeTumor progression while receiving neoadjuvant chemotherapy (PD) has been associated with poor outcome and is commonly considered a contraindication to liver resection (LR). This study aims to clarify in a large multicenter setting whether PD is always a contraindication to LR.MethodsData from the LiverMetSurvey international registry were analyzed. Patients undergoing LR for colorectal metastases without extrahepatic disease after neoadjuvant chemotherapy between 1990 and 2009 were reviewed.ResultsAmong 2143 patients, PD occurred in 176 (8.2 %). Risk of progression was increased after 5-FU or irinotecan (22.7 % vs. 6.8 % after other regimens, p < 0.0001; 14.9 % vs. 7.2 %, p < 0.0001), while it was reduced after oxaliplatin (5.6 % vs. 12.0 %, p < 0.0001) and still diminished among patients receiving targeted therapies (2.6 %). PD was an independent prognostic factor of survival at multivariate analysis (35 % vs. 49 %, p = 0.0006). In the PD group, 3 independent prognostic factors were identified: carcinoembryonic antigen (CEA) ≥200 ng/mL (p = 0.003), >3 metastases (p = 0.028), and tumor diameter ≥50 mm (p = 0.002). A survival predictive model showed that patients without any risk factors had 5-year survival rates of 53.3 %; good survival results were still observed if metastases were >3 or ≥50 mm (29.9 and 19.1 %, respectively). On the contrary, survival was less than 10 % at 3 years in the presence of >1 prognostic factor or CEA of ≥200 ng/mL.ConclusionsPD is a negative prognostic factor, but it is not an absolute contraindication to LR. Patients with PD could be scheduled for LR except for those with >3 metastases and ≥50 mm, or CEA ≥200 ng/mL in whom further chemotherapy is recommended.
    39 schema:genre article
    40 schema:isAccessibleForFree false
    41 schema:isPartOf N0acc329d312a49ebad7e044a03dc0358
    42 N532419c141c2476195d310b189ea685b
    43 sg:journal.1105545
    44 schema:keywords ConclusionsPD
    45 LR
    46 MethodsData
    47 PD group
    48 Pd
    49 absolute contraindication
    50 analysis
    51 antigen
    52 better survival results
    53 carcinoembryonic antigen
    54 chemotherapy
    55 colorectal metastases
    56 contraindications
    57 contrary
    58 diameter
    59 disease
    60 extrahepatic disease
    61 factors
    62 further chemotherapy
    63 group
    64 independent prognostic factor
    65 international registry
    66 large multicenter
    67 liver resection
    68 metastasis
    69 model
    70 multicenter
    71 multivariate analysis
    72 negative prognostic factor
    73 neoadjuvant chemotherapy
    74 outcomes
    75 oxaliplatin
    76 patients
    77 poor outcome
    78 predictive model
    79 preoperative chemotherapy
    80 presence
    81 prognostic factors
    82 progression
    83 rate
    84 registry
    85 resection
    86 results
    87 risk
    88 risk factors
    89 risk of progression
    90 study
    91 survival
    92 survival predictive model
    93 survival rate
    94 survival results
    95 therapy
    96 tumor diameter
    97 years
    98 schema:name Progression while Receiving Preoperative Chemotherapy Should Not Be an Absolute Contraindication to Liver Resection for Colorectal Metastases
    99 schema:pagination 2786-2796
    100 schema:productId N697fd87185ed447f9e59ed02aa5f2f44
    101 N8d741b4831c643aab83883e9f7e88ca2
    102 Nf32d8c8ef6054477967ae18415c42e95
    103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031829239
    104 https://doi.org/10.1245/s10434-012-2382-7
    105 schema:sdDatePublished 2022-10-01T06:38
    106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    107 schema:sdPublisher Na34f0cb0030a435fb077d0a087cf634b
    108 schema:url https://doi.org/10.1245/s10434-012-2382-7
    109 sgo:license sg:explorer/license/
    110 sgo:sdDataset articles
    111 rdf:type schema:ScholarlyArticle
    112 N0acc329d312a49ebad7e044a03dc0358 schema:issueNumber 9
    113 rdf:type schema:PublicationIssue
    114 N0c7bf094915b4637ad92fbd5e9050e3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Oxaliplatin
    116 rdf:type schema:DefinedTerm
    117 N0c8338b6824e4ed19be637a5477b081d rdf:first sg:person.01042754411.09
    118 rdf:rest N74bca28276354ffea91e521889e8d5e1
    119 N10b1845eebed416e8caa828ca3b48732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Tumor Burden
    121 rdf:type schema:DefinedTerm
    122 N1827c0a3424c4037b059594232ef3bfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Disease Progression
    124 rdf:type schema:DefinedTerm
    125 N1b100dd11f8e4898af7ef04d5b552497 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Carcinoembryonic Antigen
    127 rdf:type schema:DefinedTerm
    128 N1df4aa1745794ecf980c563ec1a2a25b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Colorectal Neoplasms
    130 rdf:type schema:DefinedTerm
    131 N1e179157bab544cb9f405c6483ad6105 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Male
    133 rdf:type schema:DefinedTerm
    134 N2021e68c87dc4c4bb1130a234726147b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Antibodies, Monoclonal
    136 rdf:type schema:DefinedTerm
    137 N20cf428f8b084e7695acccc960320895 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Survival Rate
    139 rdf:type schema:DefinedTerm
    140 N2853fa84863d43f5bcc68f7fb3617dd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Risk Factors
    142 rdf:type schema:DefinedTerm
    143 N2eec63d29ec04a409e1f29d8ea337283 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Fluorouracil
    145 rdf:type schema:DefinedTerm
    146 N34a67d023a334218b60b127853a29d8c rdf:first sg:person.0734706372.03
    147 rdf:rest N5bf0f376a4874b279f60d32e15220cd8
    148 N3a32adeb65f1421ea364a1a7bd1f76f4 rdf:first sg:person.01110043213.64
    149 rdf:rest Nc13d1cd6bb114c1ca28087b69dbc57d3
    150 N3e20fbef099148c7844873bdc250e7de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Aged
    152 rdf:type schema:DefinedTerm
    153 N529f2acaf1b245e2b8c97e8cb5c2fb0a rdf:first sg:person.011172561042.20
    154 rdf:rest N787d7190dc8f41c69f644fb6fb27117e
    155 N53153c75b66d403c93a2d2f608898a49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Disease-Free Survival
    157 rdf:type schema:DefinedTerm
    158 N532419c141c2476195d310b189ea685b schema:volumeNumber 19
    159 rdf:type schema:PublicationVolume
    160 N5bf0f376a4874b279f60d32e15220cd8 rdf:first sg:person.0726062650.45
    161 rdf:rest Nc35927272db04e9e9fd8b68731bb3fc2
    162 N5f4833a05ec641b0b939bf47e09f8bd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Camptothecin
    164 rdf:type schema:DefinedTerm
    165 N617375eb59ee42bebc0ca610c89f91d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Antineoplastic Combined Chemotherapy Protocols
    167 rdf:type schema:DefinedTerm
    168 N697fd87185ed447f9e59ed02aa5f2f44 schema:name pubmed_id
    169 schema:value 22622469
    170 rdf:type schema:PropertyValue
    171 N74bca28276354ffea91e521889e8d5e1 rdf:first sg:person.01133764026.15
    172 rdf:rest Nef14e02d83f84935baca5612d4017c89
    173 N75bc4dedc26b43cf955f88699aef287e rdf:first sg:person.013457604412.63
    174 rdf:rest N34a67d023a334218b60b127853a29d8c
    175 N787d7190dc8f41c69f644fb6fb27117e rdf:first sg:person.01156246422.84
    176 rdf:rest N8e3d0686c10146bcaf1a0a831bda3788
    177 N7ad3cc7bd8b54e3683f55b3c6169e059 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Liver Neoplasms
    179 rdf:type schema:DefinedTerm
    180 N7c2728afc6d24efbadd48f3fc82e984c rdf:first sg:person.01260460625.42
    181 rdf:rest N8210421d875b4762bf1259c3faf00a87
    182 N8210421d875b4762bf1259c3faf00a87 rdf:first sg:person.0607370647.42
    183 rdf:rest Nce5e4890baaa48afa272402fca85ceb3
    184 N85816683040042ae9f9bc3ddd0cd701e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Irinotecan
    186 rdf:type schema:DefinedTerm
    187 N8a1732c58caa4c76ba1a3fcc3cbca145 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Female
    189 rdf:type schema:DefinedTerm
    190 N8d741b4831c643aab83883e9f7e88ca2 schema:name dimensions_id
    191 schema:value pub.1031829239
    192 rdf:type schema:PropertyValue
    193 N8e3d0686c10146bcaf1a0a831bda3788 rdf:first sg:person.01064605320.06
    194 rdf:rest N7c2728afc6d24efbadd48f3fc82e984c
    195 N971ab49617ab4ea784d588fac820631c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Bevacizumab
    197 rdf:type schema:DefinedTerm
    198 N99944700b1634f83a2c56c5121a8f0ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Proportional Hazards Models
    200 rdf:type schema:DefinedTerm
    201 Na1fffa7fbcd14b7691599b7588351be2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Hepatectomy
    203 rdf:type schema:DefinedTerm
    204 Na2051aa442c74244879744538178da42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Neoadjuvant Therapy
    206 rdf:type schema:DefinedTerm
    207 Na34f0cb0030a435fb077d0a087cf634b schema:name Springer Nature - SN SciGraph project
    208 rdf:type schema:Organization
    209 Nab396264165c4552b5b41c41a5baa86f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Antibodies, Monoclonal, Humanized
    211 rdf:type schema:DefinedTerm
    212 Nafec2d0d34b7493388efc50f3f9dd05b rdf:first sg:person.01371206063.43
    213 rdf:rest N529f2acaf1b245e2b8c97e8cb5c2fb0a
    214 Nb09bfbecef174d3a803a575c84a11f35 rdf:first sg:person.0746463325.19
    215 rdf:rest Nbbc5721a5d1941af9e7435d493d6191e
    216 Nb94d1e129c6a4ea0a25e1dc95ed43bf8 rdf:first sg:person.01153120500.12
    217 rdf:rest rdf:nil
    218 Nbbc5721a5d1941af9e7435d493d6191e rdf:first sg:person.01016066143.92
    219 rdf:rest N75bc4dedc26b43cf955f88699aef287e
    220 Nbc9bec8f05d644579b9aa19a2916f2f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Kaplan-Meier Estimate
    222 rdf:type schema:DefinedTerm
    223 Nc13d1cd6bb114c1ca28087b69dbc57d3 rdf:first sg:person.0605432266.18
    224 rdf:rest N0c8338b6824e4ed19be637a5477b081d
    225 Nc35927272db04e9e9fd8b68731bb3fc2 rdf:first sg:person.0660433203.71
    226 rdf:rest Nb94d1e129c6a4ea0a25e1dc95ed43bf8
    227 Ncd294b958e1d425889a3302986eeaf3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    228 schema:name Organoplatinum Compounds
    229 rdf:type schema:DefinedTerm
    230 Nce5e4890baaa48afa272402fca85ceb3 rdf:first sg:person.01153410535.93
    231 rdf:rest Nb09bfbecef174d3a803a575c84a11f35
    232 Nd73171483c284011a0862e36cd8b1735 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    233 schema:name Humans
    234 rdf:type schema:DefinedTerm
    235 Ndaadc27394ff406f9427a86d08ed5eb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Cetuximab
    237 rdf:type schema:DefinedTerm
    238 Ne86098bde50547ec8e2ab837424d72eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Contraindications
    240 rdf:type schema:DefinedTerm
    241 Nef14e02d83f84935baca5612d4017c89 rdf:first sg:person.01275745276.40
    242 rdf:rest Nfae940be776047b8b556ec519869b132
    243 Nf2b6fa50dd0a46e6b2e66f5a07753aaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    244 schema:name Multivariate Analysis
    245 rdf:type schema:DefinedTerm
    246 Nf32d8c8ef6054477967ae18415c42e95 schema:name doi
    247 schema:value 10.1245/s10434-012-2382-7
    248 rdf:type schema:PropertyValue
    249 Nf8e9b3bea3b84c43a25b3da837361490 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    250 schema:name Retrospective Studies
    251 rdf:type schema:DefinedTerm
    252 Nfae940be776047b8b556ec519869b132 rdf:first sg:person.014376165757.48
    253 rdf:rest Nafec2d0d34b7493388efc50f3f9dd05b
    254 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    255 schema:name Medical and Health Sciences
    256 rdf:type schema:DefinedTerm
    257 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    258 schema:name Oncology and Carcinogenesis
    259 rdf:type schema:DefinedTerm
    260 sg:journal.1105545 schema:issn 1068-9265
    261 1534-4681
    262 schema:name Annals of Surgical Oncology
    263 schema:publisher Springer Nature
    264 rdf:type schema:Periodical
    265 sg:person.01016066143.92 schema:affiliation grid-institutes:None
    266 schema:familyName Herrera
    267 schema:givenName Javier
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016066143.92
    269 rdf:type schema:Person
    270 sg:person.01042754411.09 schema:affiliation grid-institutes:grid.413362.1
    271 schema:familyName Barroso
    272 schema:givenName Eduardo
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042754411.09
    274 rdf:type schema:Person
    275 sg:person.01064605320.06 schema:affiliation grid-institutes:grid.415490.d
    276 schema:familyName Mirza
    277 schema:givenName Darius F.
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064605320.06
    279 rdf:type schema:Person
    280 sg:person.01110043213.64 schema:affiliation grid-institutes:grid.414700.6
    281 schema:familyName Viganò
    282 schema:givenName Luca
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110043213.64
    284 rdf:type schema:Person
    285 sg:person.011172561042.20 schema:affiliation grid-institutes:None
    286 schema:familyName Figueras
    287 schema:givenName Joan
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011172561042.20
    289 rdf:type schema:Person
    290 sg:person.01133764026.15 schema:affiliation grid-institutes:grid.8142.f
    291 schema:familyName Nuzzo
    292 schema:givenName Gennaro
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133764026.15
    294 rdf:type schema:Person
    295 sg:person.01153120500.12 schema:affiliation grid-institutes:grid.413133.7
    296 schema:familyName Adam
    297 schema:givenName René
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153120500.12
    299 rdf:type schema:Person
    300 sg:person.01153410535.93 schema:affiliation grid-institutes:grid.410529.b
    301 schema:familyName Letoublon
    302 schema:givenName Christian
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153410535.93
    304 rdf:type schema:Person
    305 sg:person.01156246422.84 schema:affiliation grid-institutes:grid.22937.3d
    306 schema:familyName Gruenberger
    307 schema:givenName Thomas
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156246422.84
    309 rdf:type schema:Person
    310 sg:person.01260460625.42 schema:affiliation grid-institutes:grid.14925.3b
    311 schema:familyName Elias
    312 schema:givenName Dominique
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260460625.42
    314 rdf:type schema:Person
    315 sg:person.01275745276.40 schema:affiliation grid-institutes:grid.414339.8
    316 schema:familyName Laurent
    317 schema:givenName Christophe
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275745276.40
    319 rdf:type schema:Person
    320 sg:person.013457604412.63 schema:affiliation grid-institutes:grid.28911.33
    321 schema:familyName Castro Sousa
    322 schema:givenName Francisco
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013457604412.63
    324 rdf:type schema:Person
    325 sg:person.01371206063.43 schema:affiliation grid-institutes:grid.48769.34
    326 schema:familyName Gigot
    327 schema:givenName Jean-François
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371206063.43
    329 rdf:type schema:Person
    330 sg:person.014376165757.48 schema:affiliation grid-institutes:grid.5645.2
    331 schema:familyName Ijzermans
    332 schema:givenName Jan N. M.
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014376165757.48
    334 rdf:type schema:Person
    335 sg:person.0605432266.18 schema:affiliation grid-institutes:grid.414700.6
    336 schema:familyName Capussotti
    337 schema:givenName Lorenzo
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605432266.18
    339 rdf:type schema:Person
    340 sg:person.0607370647.42 schema:affiliation grid-institutes:grid.411255.6
    341 schema:familyName Poston
    342 schema:givenName Graeme
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607370647.42
    344 rdf:type schema:Person
    345 sg:person.0660433203.71 schema:affiliation grid-institutes:grid.415180.9
    346 schema:familyName Popescu
    347 schema:givenName Irinel
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660433203.71
    349 rdf:type schema:Person
    350 sg:person.0726062650.45 schema:affiliation grid-institutes:grid.4989.c
    351 schema:familyName Lucidi
    352 schema:givenName Valerio
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726062650.45
    354 rdf:type schema:Person
    355 sg:person.0734706372.03 schema:affiliation grid-institutes:grid.411730.0
    356 schema:familyName Pardo
    357 schema:givenName Fernando
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734706372.03
    359 rdf:type schema:Person
    360 sg:person.0746463325.19 schema:affiliation grid-institutes:grid.15485.3d
    361 schema:familyName Isoniemi
    362 schema:givenName Helena
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746463325.19
    364 rdf:type schema:Person
    365 sg:pub.10.1245/s10434-006-9068-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1034768212
    366 https://doi.org/10.1245/s10434-006-9068-y
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1245/s10434-006-9284-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041426567
    369 https://doi.org/10.1245/s10434-006-9284-5
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1245/s10434-009-0348-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028630724
    372 https://doi.org/10.1245/s10434-009-0348-1
    373 rdf:type schema:CreativeWork
    374 grid-institutes:None schema:alternateName Department of Surgery, Navarra Hospital, Pamplona, Spain
    375 Department of Surgery, “Josep Trueta” Hospital, Girona, Spain
    376 schema:name Department of Surgery, Navarra Hospital, Pamplona, Spain
    377 Department of Surgery, “Josep Trueta” Hospital, Girona, Spain
    378 rdf:type schema:Organization
    379 grid-institutes:grid.14925.3b schema:alternateName Department of Surgery, Institute Gustave Roussy, Villejuif, France
    380 schema:name Department of Surgery, Institute Gustave Roussy, Villejuif, France
    381 rdf:type schema:Organization
    382 grid-institutes:grid.15485.3d schema:alternateName Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland
    383 schema:name Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland
    384 rdf:type schema:Organization
    385 grid-institutes:grid.22937.3d schema:alternateName Department of Surgery, Medical University of Vienna, Vienna, Austria
    386 schema:name Department of Surgery, Medical University of Vienna, Vienna, Austria
    387 rdf:type schema:Organization
    388 grid-institutes:grid.28911.33 schema:alternateName Department of Surgery, Surgery 3, Coimbra University Hospital, Coimbra, Portugal
    389 schema:name Department of Surgery, Surgery 3, Coimbra University Hospital, Coimbra, Portugal
    390 rdf:type schema:Organization
    391 grid-institutes:grid.410529.b schema:alternateName Department of Digestive and Emergency Surgery, University Hospital, University Joseph Fourier, Grenoble, France
    392 schema:name Department of Digestive and Emergency Surgery, University Hospital, University Joseph Fourier, Grenoble, France
    393 rdf:type schema:Organization
    394 grid-institutes:grid.411255.6 schema:alternateName Department of Surgery, University Hospital Aintree, Liverpool, UK
    395 schema:name Department of Surgery, University Hospital Aintree, Liverpool, UK
    396 rdf:type schema:Organization
    397 grid-institutes:grid.411730.0 schema:alternateName Department of General Surgery, Clínica Universidad de Navarra, Pamplona, Spain
    398 schema:name Department of General Surgery, Clínica Universidad de Navarra, Pamplona, Spain
    399 rdf:type schema:Organization
    400 grid-institutes:grid.413133.7 schema:alternateName AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire, Université Paris-Sud, Villejuif, France
    401 schema:name AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire, Université Paris-Sud, Villejuif, France
    402 rdf:type schema:Organization
    403 grid-institutes:grid.413362.1 schema:alternateName Department of HPB Surgery and Transplantation, Curry Cabral Hospital, Lisbon, Portugal
    404 schema:name Department of HPB Surgery and Transplantation, Curry Cabral Hospital, Lisbon, Portugal
    405 rdf:type schema:Organization
    406 grid-institutes:grid.414339.8 schema:alternateName Department of Surgery, Hôpital Saint André, Bordeaux, France
    407 schema:name Department of Surgery, Hôpital Saint André, Bordeaux, France
    408 rdf:type schema:Organization
    409 grid-institutes:grid.414700.6 schema:alternateName Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy
    410 schema:name Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy
    411 rdf:type schema:Organization
    412 grid-institutes:grid.415180.9 schema:alternateName Department of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania
    413 schema:name Department of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania
    414 rdf:type schema:Organization
    415 grid-institutes:grid.415490.d schema:alternateName Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
    416 schema:name Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
    417 rdf:type schema:Organization
    418 grid-institutes:grid.48769.34 schema:alternateName Unit of HPB Surgery, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCL), Brussels, Belgium
    419 schema:name Unit of HPB Surgery, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCL), Brussels, Belgium
    420 rdf:type schema:Organization
    421 grid-institutes:grid.4989.c schema:alternateName Liver Transplantation Unit, Department of Surgery, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
    422 schema:name Liver Transplantation Unit, Department of Surgery, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
    423 rdf:type schema:Organization
    424 grid-institutes:grid.5645.2 schema:alternateName Department of Transplantation and Hepato-biliary Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    425 schema:name Department of Transplantation and Hepato-biliary Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    426 rdf:type schema:Organization
    427 grid-institutes:grid.8142.f schema:alternateName Hepatobiliary Unit, Department of Surgery, Catholic University of the Sacred Heart School of Medicine, Rome, Italy
    428 schema:name Hepatobiliary Unit, Department of Surgery, Catholic University of the Sacred Heart School of Medicine, Rome, Italy
    429 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...