Progression while Receiving Preoperative Chemotherapy Should Not Be an Absolute Contraindication to Liver Resection for Colorectal Metastases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-09

AUTHORS

Luca Viganò, Lorenzo Capussotti, Eduardo Barroso, Gennaro Nuzzo, Christophe Laurent, Jan N. M. Ijzermans, Jean-François Gigot, Joan Figueras, Thomas Gruenberger, Darius F. Mirza, Dominique Elias, Graeme Poston, Christian Letoublon, Helena Isoniemi, Javier Herrera, Francisco Castro Sousa, Fernando Pardo, Valerio Lucidi, Irinel Popescu, René Adam

ABSTRACT

PURPOSE: Tumor progression while receiving neoadjuvant chemotherapy (PD) has been associated with poor outcome and is commonly considered a contraindication to liver resection (LR). This study aims to clarify in a large multicenter setting whether PD is always a contraindication to LR. METHODS: Data from the LiverMetSurvey international registry were analyzed. Patients undergoing LR for colorectal metastases without extrahepatic disease after neoadjuvant chemotherapy between 1990 and 2009 were reviewed. RESULTS: Among 2143 patients, PD occurred in 176 (8.2 %). Risk of progression was increased after 5-FU or irinotecan (22.7 % vs. 6.8 % after other regimens, p < 0.0001; 14.9 % vs. 7.2 %, p < 0.0001), while it was reduced after oxaliplatin (5.6 % vs. 12.0 %, p < 0.0001) and still diminished among patients receiving targeted therapies (2.6 %). PD was an independent prognostic factor of survival at multivariate analysis (35 % vs. 49 %, p = 0.0006). In the PD group, 3 independent prognostic factors were identified: carcinoembryonic antigen (CEA) ≥ 200 ng/mL (p = 0.003), >3 metastases (p = 0.028), and tumor diameter ≥ 5 0 mm (p = 0.002). A survival predictive model showed that patients without any risk factors had 5-year survival rates of 53.3 %; good survival results were still observed if metastases were >3 or ≥ 50 mm (29.9 and 19.1 %, respectively). On the contrary, survival was less than 10 % at 3 years in the presence of >1 prognostic factor or CEA of ≥ 200 ng/mL. CONCLUSIONS: PD is a negative prognostic factor, but it is not an absolute contraindication to LR. Patients with PD could be scheduled for LR except for those with >3 metastases and ≥ 50 mm, or CEA ≥ 200 ng/mL in whom further chemotherapy is recommended. More... »

PAGES

2786-2796

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-012-2382-7

DOI

http://dx.doi.org/10.1245/s10434-012-2382-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031829239

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22622469


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Humanized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bevacizumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Camptothecin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoembryonic Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cetuximab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Contraindications", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multivariate Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoadjuvant Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organoplatinum Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proportional Hazards Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Burden", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "A. O. Ordine Mauriziano di Torino", 
          "id": "https://www.grid.ac/institutes/grid.414700.6", 
          "name": [
            "Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vigan\u00f2", 
        "givenName": "Luca", 
        "id": "sg:person.01110043213.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110043213.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "A. O. Ordine Mauriziano di Torino", 
          "id": "https://www.grid.ac/institutes/grid.414700.6", 
          "name": [
            "Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Capussotti", 
        "givenName": "Lorenzo", 
        "id": "sg:person.0605432266.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605432266.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Curry Cabral", 
          "id": "https://www.grid.ac/institutes/grid.413362.1", 
          "name": [
            "Department of HPB Surgery and Transplantation, Curry Cabral Hospital, Lisbon, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barroso", 
        "givenName": "Eduardo", 
        "id": "sg:person.01042754411.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042754411.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catholic University of the Sacred Heart", 
          "id": "https://www.grid.ac/institutes/grid.8142.f", 
          "name": [
            "Hepatobiliary Unit, Department of Surgery, Catholic University of the Sacred Heart School of Medicine, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nuzzo", 
        "givenName": "Gennaro", 
        "id": "sg:person.01133764026.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133764026.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Andr\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.414339.8", 
          "name": [
            "Department of Surgery, H\u00f4pital Saint Andr\u00e9, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laurent", 
        "givenName": "Christophe", 
        "id": "sg:person.01275745276.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275745276.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Erasmus University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5645.2", 
          "name": [
            "Department of Transplantation and Hepato-biliary Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ijzermans", 
        "givenName": "Jan N. M.", 
        "id": "sg:person.014376165757.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014376165757.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cliniques Universitaires Saint-Luc", 
          "id": "https://www.grid.ac/institutes/grid.48769.34", 
          "name": [
            "Unit of HPB Surgery, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain (UCL), Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gigot", 
        "givenName": "Jean-Fran\u00e7ois", 
        "id": "sg:person.01371206063.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371206063.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, \u201cJosep Trueta\u201d Hospital, Girona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Figueras", 
        "givenName": "Joan", 
        "id": "sg:person.011172561042.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011172561042.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Surgery, Medical University of Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gruenberger", 
        "givenName": "Thomas", 
        "id": "sg:person.01156246422.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156246422.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen Elizabeth Hospital Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.415490.d", 
          "name": [
            "Liver Unit, Queen Elizabeth Hospital, Birmingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mirza", 
        "givenName": "Darius F.", 
        "id": "sg:person.01064605320.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064605320.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Surgery, Institute Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elias", 
        "givenName": "Dominique", 
        "id": "sg:person.01260460625.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260460625.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aintree University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411255.6", 
          "name": [
            "Department of Surgery, University Hospital Aintree, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poston", 
        "givenName": "Graeme", 
        "id": "sg:person.0607370647.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607370647.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Digestive and Emergency Surgery, University Hospital, University Joseph Fourier, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Letoublon", 
        "givenName": "Christian", 
        "id": "sg:person.01153410535.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153410535.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Isoniemi", 
        "givenName": "Helena", 
        "id": "sg:person.0746463325.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746463325.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Navarra Hospital, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herrera", 
        "givenName": "Javier", 
        "id": "sg:person.01016066143.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016066143.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospitais da Universidade de Coimbra", 
          "id": "https://www.grid.ac/institutes/grid.28911.33", 
          "name": [
            "Department of Surgery, Surgery 3, Coimbra University Hospital, Coimbra, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castro Sousa", 
        "givenName": "Francisco", 
        "id": "sg:person.01127700373.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127700373.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinica Universidad de Navarra", 
          "id": "https://www.grid.ac/institutes/grid.411730.0", 
          "name": [
            "Department of General Surgery, Cl\u00ednica Universidad de Navarra, Pamplona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pardo", 
        "givenName": "Fernando", 
        "id": "sg:person.0734706372.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734706372.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Liver Transplantation Unit, Department of Surgery, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lucidi", 
        "givenName": "Valerio", 
        "id": "sg:person.0726062650.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726062650.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institutul Clinic Fundeni", 
          "id": "https://www.grid.ac/institutes/grid.415180.9", 
          "name": [
            "Department of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Popescu", 
        "givenName": "Irinel", 
        "id": "sg:person.0660433203.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660433203.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Paul Brousse", 
          "id": "https://www.grid.ac/institutes/grid.413133.7", 
          "name": [
            "AP-HP H\u00f4pital Paul Brousse, Centre H\u00e9pato-Biliaire, Universit\u00e9 Paris-Sud, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adam", 
        "givenName": "Ren\u00e9", 
        "id": "sg:person.01153120500.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153120500.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1016/s1091-255x(02)00121-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009452701", 
          "https://doi.org/10.1016/s1091-255x(02)00121-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s1091-255x(02)00121-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009452701", 
          "https://doi.org/10.1016/s1091-255x(02)00121-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.05.8727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010256912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.13.7471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011463806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181fcf3e3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018330460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181fcf3e3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018330460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181fcf3e3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018330460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000145964.08365.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022055193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000145964.08365.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022055193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.5386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027975622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0348-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028630724", 
          "https://doi.org/10.1245/s10434-009-0348-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.3.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032301848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-006-9068-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034768212", 
          "https://doi.org/10.1245/s10434-006-9068-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdl386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036275458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)60455-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038419533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.13.7679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041363961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-006-9284-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041426567", 
          "https://doi.org/10.1245/s10434-006-9284-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.05.3074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043576224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.4160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045165820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2009.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046409701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199610000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/2529620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069975249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181b4539b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077952929"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-09", 
    "datePublishedReg": "2012-09-01", 
    "description": "PURPOSE: Tumor progression while receiving neoadjuvant chemotherapy (PD) has been associated with poor outcome and is commonly considered a contraindication to liver resection (LR). This study aims to clarify in a large multicenter setting whether PD is always a contraindication to LR.\nMETHODS: Data from the LiverMetSurvey international registry were analyzed. Patients undergoing LR for colorectal metastases without extrahepatic disease after neoadjuvant chemotherapy between 1990 and 2009 were reviewed.\nRESULTS: Among 2143 patients, PD occurred in 176 (8.2 %). Risk of progression was increased after 5-FU or irinotecan (22.7 % vs. 6.8 % after other regimens, p < 0.0001; 14.9 % vs. 7.2 %, p < 0.0001), while it was reduced after oxaliplatin (5.6 % vs. 12.0 %, p < 0.0001) and still diminished among patients receiving targeted therapies (2.6 %). PD was an independent prognostic factor of survival at multivariate analysis (35 % vs. 49 %, p = 0.0006). In the PD group, 3 independent prognostic factors were identified: carcinoembryonic antigen (CEA) \u2265 200 ng/mL (p = 0.003), >3 metastases (p = 0.028), and tumor diameter \u2265 5 0 mm (p = 0.002). A survival predictive model showed that patients without any risk factors had 5-year survival rates of 53.3 %; good survival results were still observed if metastases were >3 or \u2265 50 mm (29.9 and 19.1 %, respectively). On the contrary, survival was less than 10 % at 3 years in the presence of >1 prognostic factor or CEA of \u2265 200 ng/mL.\nCONCLUSIONS: PD is a negative prognostic factor, but it is not an absolute contraindication to LR. Patients with PD could be scheduled for LR except for those with >3 metastases and \u2265 50 mm, or CEA \u2265 200 ng/mL in whom further chemotherapy is recommended.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-012-2382-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Progression while Receiving Preoperative Chemotherapy Should Not Be an Absolute Contraindication to Liver Resection for Colorectal Metastases", 
    "pagination": "2786-2796", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "97a080a8a08a8a2d7c4ae7ad758b56ca4f55f31676ee36a9d740afdfe059d89b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22622469"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-012-2382-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031829239"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-012-2382-7", 
      "https://app.dimensions.ai/details/publication/pub.1031829239"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000500.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1245/s10434-012-2382-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2382-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2382-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2382-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2382-7'


 

This table displays all metadata directly associated to this object as RDF triples.

421 TRIPLES      21 PREDICATES      75 URIs      48 LITERALS      36 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-012-2382-7 schema:about N0388ca39a39d49e4a5a388eb4aaebb33
2 N0c1762369a0543b49f3d957abe9d4dd3
3 N0eb4677174654b2983dd05fe97ed110b
4 N1a33f9750ae64e9ea200fa7e114b5618
5 N231a16fd7172498489e0ff0e637fa272
6 N28e730dc279e4b12a96109d369f8e8bf
7 N2df721e4711544e88c892bb46f50494d
8 N34496d25077b48a6b8c6294d2a29b0cd
9 N34dda28137474718953a9e77ec5b20f9
10 N3fdde32623f148f6b2231cb3f8f265e2
11 N4bff1e1e7e3f44478c33dcca63359ec9
12 N5f3cefb0786b4d8d8ac02617706acf26
13 N664a12d2ff6b459d8185822b10306661
14 N713f23da6f9d4b8db0da70bcb26f3295
15 N819a735a44a04353ab2e72c1b9b18c21
16 N8370f33b43864d2cb9a2fcfcc363bc1e
17 N8af41b76d837464bb624ba86a189a683
18 N8ed26a145faa45288a029a53eeb14864
19 N9c01d40853cd4a0ab079a3320fc2c1c4
20 Nb418650b42b044c8b9cd9f3fcf0b30fd
21 Nc3a7cd5e079f430ca867d23c0c2c89e7
22 Nd013388f29c94a4baa8ff6d40846f2ec
23 Ndb416b28a5b3427c8e3b2f1ae04ef18e
24 Ndb7743e1378b4d4d9e973c4d965c560d
25 Ndc3e8be977924ecfabd9954c770d31eb
26 Ndd958a6ba40f4ebd965a35ebeeb370ec
27 Nf245203fa38c4908ab744d12453e01c1
28 anzsrc-for:11
29 anzsrc-for:1112
30 schema:author Nb2b4187c94ff42af8cf21da4a3215431
31 schema:citation sg:pub.10.1016/s1091-255x(02)00121-x
32 sg:pub.10.1245/s10434-006-9068-y
33 sg:pub.10.1245/s10434-006-9284-5
34 sg:pub.10.1245/s10434-009-0348-1
35 https://doi.org/10.1002/bjs.4160
36 https://doi.org/10.1002/bjs.5386
37 https://doi.org/10.1016/j.surg.2009.02.004
38 https://doi.org/10.1016/s0140-6736(08)60455-9
39 https://doi.org/10.1093/annonc/mdl386
40 https://doi.org/10.1093/jnci/92.3.205
41 https://doi.org/10.1097/00000658-199610000-00009
42 https://doi.org/10.1097/01.sla.0000145964.08365.01
43 https://doi.org/10.1097/sla.0b013e3181b4539b
44 https://doi.org/10.1097/sla.0b013e3181fcf3e3
45 https://doi.org/10.1200/jco.2005.05.3074
46 https://doi.org/10.1200/jco.2006.05.8727
47 https://doi.org/10.1200/jco.2007.13.7471
48 https://doi.org/10.1200/jco.2007.13.7679
49 https://doi.org/10.2307/2529620
50 schema:datePublished 2012-09
51 schema:datePublishedReg 2012-09-01
52 schema:description PURPOSE: Tumor progression while receiving neoadjuvant chemotherapy (PD) has been associated with poor outcome and is commonly considered a contraindication to liver resection (LR). This study aims to clarify in a large multicenter setting whether PD is always a contraindication to LR. METHODS: Data from the LiverMetSurvey international registry were analyzed. Patients undergoing LR for colorectal metastases without extrahepatic disease after neoadjuvant chemotherapy between 1990 and 2009 were reviewed. RESULTS: Among 2143 patients, PD occurred in 176 (8.2 %). Risk of progression was increased after 5-FU or irinotecan (22.7 % vs. 6.8 % after other regimens, p < 0.0001; 14.9 % vs. 7.2 %, p < 0.0001), while it was reduced after oxaliplatin (5.6 % vs. 12.0 %, p < 0.0001) and still diminished among patients receiving targeted therapies (2.6 %). PD was an independent prognostic factor of survival at multivariate analysis (35 % vs. 49 %, p = 0.0006). In the PD group, 3 independent prognostic factors were identified: carcinoembryonic antigen (CEA) ≥ 200 ng/mL (p = 0.003), >3 metastases (p = 0.028), and tumor diameter ≥ 5 0 mm (p = 0.002). A survival predictive model showed that patients without any risk factors had 5-year survival rates of 53.3 %; good survival results were still observed if metastases were >3 or ≥ 50 mm (29.9 and 19.1 %, respectively). On the contrary, survival was less than 10 % at 3 years in the presence of >1 prognostic factor or CEA of ≥ 200 ng/mL. CONCLUSIONS: PD is a negative prognostic factor, but it is not an absolute contraindication to LR. Patients with PD could be scheduled for LR except for those with >3 metastases and ≥ 50 mm, or CEA ≥ 200 ng/mL in whom further chemotherapy is recommended.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree false
56 schema:isPartOf N1190f4d29406487ea85f927339198bf7
57 N3f74d01d1f744cb5b379f3fd72fac427
58 sg:journal.1105545
59 schema:name Progression while Receiving Preoperative Chemotherapy Should Not Be an Absolute Contraindication to Liver Resection for Colorectal Metastases
60 schema:pagination 2786-2796
61 schema:productId N06cc29f0cfd74449aaa9aae715fdd410
62 N0accae806b104d439df85c9f034a1d56
63 N900d4b1b59254a9e9fcbcc2aa3c60860
64 Nb77a521385f7433f94566f6d3a36fd7e
65 Nbb0569f9f6cf41f6b417c9d88e75d01c
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031829239
67 https://doi.org/10.1245/s10434-012-2382-7
68 schema:sdDatePublished 2019-04-10T14:06
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N74924ea724f946f38eaa5529ce26df31
71 schema:url http://link.springer.com/10.1245/s10434-012-2382-7
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0388ca39a39d49e4a5a388eb4aaebb33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Disease-Free Survival
77 rdf:type schema:DefinedTerm
78 N06cc29f0cfd74449aaa9aae715fdd410 schema:name pubmed_id
79 schema:value 22622469
80 rdf:type schema:PropertyValue
81 N07a12325f47a4759a6e8ff97a6e87ab4 rdf:first sg:person.01153120500.12
82 rdf:rest rdf:nil
83 N0accae806b104d439df85c9f034a1d56 schema:name nlm_unique_id
84 schema:value 9420840
85 rdf:type schema:PropertyValue
86 N0b262bc5a5034a4d811dd05be8cc2ca4 rdf:first sg:person.01153410535.93
87 rdf:rest Naf936e37456d473e956c7aea851ddefc
88 N0c1762369a0543b49f3d957abe9d4dd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Kaplan-Meier Estimate
90 rdf:type schema:DefinedTerm
91 N0eb4677174654b2983dd05fe97ed110b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Proportional Hazards Models
93 rdf:type schema:DefinedTerm
94 N1190f4d29406487ea85f927339198bf7 schema:issueNumber 9
95 rdf:type schema:PublicationIssue
96 N1a33f9750ae64e9ea200fa7e114b5618 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Fluorouracil
98 rdf:type schema:DefinedTerm
99 N231a16fd7172498489e0ff0e637fa272 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Disease Progression
101 rdf:type schema:DefinedTerm
102 N283e0268e92f456181f6991f6c1d2488 rdf:first sg:person.01260460625.42
103 rdf:rest N2c88e9a5046c45d5abadd3aa8d19d834
104 N28e730dc279e4b12a96109d369f8e8bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Antibodies, Monoclonal, Humanized
106 rdf:type schema:DefinedTerm
107 N2922a619444248d299800109521845f8 rdf:first sg:person.01127700373.79
108 rdf:rest N5e75cb05d3cb466c97801f025f9bd959
109 N2c88e9a5046c45d5abadd3aa8d19d834 rdf:first sg:person.0607370647.42
110 rdf:rest N0b262bc5a5034a4d811dd05be8cc2ca4
111 N2cac90fc244b4aedba8fe0f15a48635a rdf:first sg:person.01156246422.84
112 rdf:rest N3575f4bcbdfe4db7b9d24af8d8796198
113 N2df721e4711544e88c892bb46f50494d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Humans
115 rdf:type schema:DefinedTerm
116 N34496d25077b48a6b8c6294d2a29b0cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Tumor Burden
118 rdf:type schema:DefinedTerm
119 N34dda28137474718953a9e77ec5b20f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Aged
121 rdf:type schema:DefinedTerm
122 N3575f4bcbdfe4db7b9d24af8d8796198 rdf:first sg:person.01064605320.06
123 rdf:rest N283e0268e92f456181f6991f6c1d2488
124 N3f74d01d1f744cb5b379f3fd72fac427 schema:volumeNumber 19
125 rdf:type schema:PublicationVolume
126 N3fb0085913544ce395593dfdad32f823 rdf:first sg:person.0605432266.18
127 rdf:rest N835340ff68544f4f9c1cb21ca14243ce
128 N3fdde32623f148f6b2231cb3f8f265e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Bevacizumab
130 rdf:type schema:DefinedTerm
131 N42d6374a31084a84ae731eba66372334 rdf:first sg:person.014376165757.48
132 rdf:rest Nf1d4c3e754c9414b9bce7981d15ad76a
133 N4bff1e1e7e3f44478c33dcca63359ec9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Colorectal Neoplasms
135 rdf:type schema:DefinedTerm
136 N5e75cb05d3cb466c97801f025f9bd959 rdf:first sg:person.0734706372.03
137 rdf:rest N727ccfbf125c4da7bc986264d58997c2
138 N5f3cefb0786b4d8d8ac02617706acf26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Antibodies, Monoclonal
140 rdf:type schema:DefinedTerm
141 N5f7368c090074c90a918b184dd914bf3 rdf:first sg:person.01275745276.40
142 rdf:rest N42d6374a31084a84ae731eba66372334
143 N60415bc11adc4a668183f97a89c98273 schema:name Department of Surgery, Navarra Hospital, Pamplona, Spain
144 rdf:type schema:Organization
145 N664a12d2ff6b459d8185822b10306661 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Liver Neoplasms
147 rdf:type schema:DefinedTerm
148 N6c232753cf9746d699a634636feb70c7 rdf:first sg:person.0660433203.71
149 rdf:rest N07a12325f47a4759a6e8ff97a6e87ab4
150 N713f23da6f9d4b8db0da70bcb26f3295 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Antineoplastic Combined Chemotherapy Protocols
152 rdf:type schema:DefinedTerm
153 N727ccfbf125c4da7bc986264d58997c2 rdf:first sg:person.0726062650.45
154 rdf:rest N6c232753cf9746d699a634636feb70c7
155 N74924ea724f946f38eaa5529ce26df31 schema:name Springer Nature - SN SciGraph project
156 rdf:type schema:Organization
157 N7d013a0274f84c7da23cf497796093dc rdf:first sg:person.01133764026.15
158 rdf:rest N5f7368c090074c90a918b184dd914bf3
159 N819a735a44a04353ab2e72c1b9b18c21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Organoplatinum Compounds
161 rdf:type schema:DefinedTerm
162 N835340ff68544f4f9c1cb21ca14243ce rdf:first sg:person.01042754411.09
163 rdf:rest N7d013a0274f84c7da23cf497796093dc
164 N8370f33b43864d2cb9a2fcfcc363bc1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Neoadjuvant Therapy
166 rdf:type schema:DefinedTerm
167 N8983094050bb4b6d9dc081e85098bf4b rdf:first sg:person.01016066143.92
168 rdf:rest N2922a619444248d299800109521845f8
169 N8af41b76d837464bb624ba86a189a683 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Carcinoembryonic Antigen
171 rdf:type schema:DefinedTerm
172 N8ed26a145faa45288a029a53eeb14864 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Camptothecin
174 rdf:type schema:DefinedTerm
175 N900d4b1b59254a9e9fcbcc2aa3c60860 schema:name doi
176 schema:value 10.1245/s10434-012-2382-7
177 rdf:type schema:PropertyValue
178 N9c01d40853cd4a0ab079a3320fc2c1c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Survival Rate
180 rdf:type schema:DefinedTerm
181 Na3558a49472f42a89b78bb3d2d005c33 schema:name Liver Transplantation Unit, Department of Surgery, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
182 rdf:type schema:Organization
183 Naf936e37456d473e956c7aea851ddefc rdf:first sg:person.0746463325.19
184 rdf:rest N8983094050bb4b6d9dc081e85098bf4b
185 Nb2b4187c94ff42af8cf21da4a3215431 rdf:first sg:person.01110043213.64
186 rdf:rest N3fb0085913544ce395593dfdad32f823
187 Nb418650b42b044c8b9cd9f3fcf0b30fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Contraindications
189 rdf:type schema:DefinedTerm
190 Nb77a521385f7433f94566f6d3a36fd7e schema:name readcube_id
191 schema:value 97a080a8a08a8a2d7c4ae7ad758b56ca4f55f31676ee36a9d740afdfe059d89b
192 rdf:type schema:PropertyValue
193 Nbb0569f9f6cf41f6b417c9d88e75d01c schema:name dimensions_id
194 schema:value pub.1031829239
195 rdf:type schema:PropertyValue
196 Nc3a7cd5e079f430ca867d23c0c2c89e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Female
198 rdf:type schema:DefinedTerm
199 Ncb051804e1ee4e5b89f1351667a0b16e schema:name Department of Surgery, “Josep Trueta” Hospital, Girona, Spain
200 rdf:type schema:Organization
201 Nd013388f29c94a4baa8ff6d40846f2ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Hepatectomy
203 rdf:type schema:DefinedTerm
204 Nd5eb9e4efc2e46aebdaf341c83bfcaab rdf:first sg:person.011172561042.20
205 rdf:rest N2cac90fc244b4aedba8fe0f15a48635a
206 Ndafe8c962e45446b9e474db6bde6bbbf schema:name Department of Digestive and Emergency Surgery, University Hospital, University Joseph Fourier, Grenoble, France
207 rdf:type schema:Organization
208 Ndb416b28a5b3427c8e3b2f1ae04ef18e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Male
210 rdf:type schema:DefinedTerm
211 Ndb7743e1378b4d4d9e973c4d965c560d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Retrospective Studies
213 rdf:type schema:DefinedTerm
214 Ndc3e8be977924ecfabd9954c770d31eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Multivariate Analysis
216 rdf:type schema:DefinedTerm
217 Ndd958a6ba40f4ebd965a35ebeeb370ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Risk Factors
219 rdf:type schema:DefinedTerm
220 Nf1d4c3e754c9414b9bce7981d15ad76a rdf:first sg:person.01371206063.43
221 rdf:rest Nd5eb9e4efc2e46aebdaf341c83bfcaab
222 Nf245203fa38c4908ab744d12453e01c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Cetuximab
224 rdf:type schema:DefinedTerm
225 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
226 schema:name Medical and Health Sciences
227 rdf:type schema:DefinedTerm
228 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
229 schema:name Oncology and Carcinogenesis
230 rdf:type schema:DefinedTerm
231 sg:journal.1105545 schema:issn 1068-9265
232 1534-4681
233 schema:name Annals of Surgical Oncology
234 rdf:type schema:Periodical
235 sg:person.01016066143.92 schema:affiliation N60415bc11adc4a668183f97a89c98273
236 schema:familyName Herrera
237 schema:givenName Javier
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016066143.92
239 rdf:type schema:Person
240 sg:person.01042754411.09 schema:affiliation https://www.grid.ac/institutes/grid.413362.1
241 schema:familyName Barroso
242 schema:givenName Eduardo
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042754411.09
244 rdf:type schema:Person
245 sg:person.01064605320.06 schema:affiliation https://www.grid.ac/institutes/grid.415490.d
246 schema:familyName Mirza
247 schema:givenName Darius F.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064605320.06
249 rdf:type schema:Person
250 sg:person.01110043213.64 schema:affiliation https://www.grid.ac/institutes/grid.414700.6
251 schema:familyName Viganò
252 schema:givenName Luca
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110043213.64
254 rdf:type schema:Person
255 sg:person.011172561042.20 schema:affiliation Ncb051804e1ee4e5b89f1351667a0b16e
256 schema:familyName Figueras
257 schema:givenName Joan
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011172561042.20
259 rdf:type schema:Person
260 sg:person.01127700373.79 schema:affiliation https://www.grid.ac/institutes/grid.28911.33
261 schema:familyName Castro Sousa
262 schema:givenName Francisco
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127700373.79
264 rdf:type schema:Person
265 sg:person.01133764026.15 schema:affiliation https://www.grid.ac/institutes/grid.8142.f
266 schema:familyName Nuzzo
267 schema:givenName Gennaro
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133764026.15
269 rdf:type schema:Person
270 sg:person.01153120500.12 schema:affiliation https://www.grid.ac/institutes/grid.413133.7
271 schema:familyName Adam
272 schema:givenName René
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153120500.12
274 rdf:type schema:Person
275 sg:person.01153410535.93 schema:affiliation Ndafe8c962e45446b9e474db6bde6bbbf
276 schema:familyName Letoublon
277 schema:givenName Christian
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153410535.93
279 rdf:type schema:Person
280 sg:person.01156246422.84 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
281 schema:familyName Gruenberger
282 schema:givenName Thomas
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156246422.84
284 rdf:type schema:Person
285 sg:person.01260460625.42 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
286 schema:familyName Elias
287 schema:givenName Dominique
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260460625.42
289 rdf:type schema:Person
290 sg:person.01275745276.40 schema:affiliation https://www.grid.ac/institutes/grid.414339.8
291 schema:familyName Laurent
292 schema:givenName Christophe
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275745276.40
294 rdf:type schema:Person
295 sg:person.01371206063.43 schema:affiliation https://www.grid.ac/institutes/grid.48769.34
296 schema:familyName Gigot
297 schema:givenName Jean-François
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371206063.43
299 rdf:type schema:Person
300 sg:person.014376165757.48 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
301 schema:familyName Ijzermans
302 schema:givenName Jan N. M.
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014376165757.48
304 rdf:type schema:Person
305 sg:person.0605432266.18 schema:affiliation https://www.grid.ac/institutes/grid.414700.6
306 schema:familyName Capussotti
307 schema:givenName Lorenzo
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605432266.18
309 rdf:type schema:Person
310 sg:person.0607370647.42 schema:affiliation https://www.grid.ac/institutes/grid.411255.6
311 schema:familyName Poston
312 schema:givenName Graeme
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607370647.42
314 rdf:type schema:Person
315 sg:person.0660433203.71 schema:affiliation https://www.grid.ac/institutes/grid.415180.9
316 schema:familyName Popescu
317 schema:givenName Irinel
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660433203.71
319 rdf:type schema:Person
320 sg:person.0726062650.45 schema:affiliation Na3558a49472f42a89b78bb3d2d005c33
321 schema:familyName Lucidi
322 schema:givenName Valerio
323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726062650.45
324 rdf:type schema:Person
325 sg:person.0734706372.03 schema:affiliation https://www.grid.ac/institutes/grid.411730.0
326 schema:familyName Pardo
327 schema:givenName Fernando
328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734706372.03
329 rdf:type schema:Person
330 sg:person.0746463325.19 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
331 schema:familyName Isoniemi
332 schema:givenName Helena
333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746463325.19
334 rdf:type schema:Person
335 sg:pub.10.1016/s1091-255x(02)00121-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009452701
336 https://doi.org/10.1016/s1091-255x(02)00121-x
337 rdf:type schema:CreativeWork
338 sg:pub.10.1245/s10434-006-9068-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1034768212
339 https://doi.org/10.1245/s10434-006-9068-y
340 rdf:type schema:CreativeWork
341 sg:pub.10.1245/s10434-006-9284-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041426567
342 https://doi.org/10.1245/s10434-006-9284-5
343 rdf:type schema:CreativeWork
344 sg:pub.10.1245/s10434-009-0348-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028630724
345 https://doi.org/10.1245/s10434-009-0348-1
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1002/bjs.4160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045165820
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1002/bjs.5386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027975622
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/j.surg.2009.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046409701
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1016/s0140-6736(08)60455-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038419533
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1093/annonc/mdl386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036275458
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1093/jnci/92.3.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032301848
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1097/00000658-199610000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134371
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1097/01.sla.0000145964.08365.01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022055193
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1097/sla.0b013e3181b4539b schema:sameAs https://app.dimensions.ai/details/publication/pub.1077952929
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1097/sla.0b013e3181fcf3e3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018330460
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1200/jco.2005.05.3074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043576224
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1200/jco.2006.05.8727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010256912
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1200/jco.2007.13.7471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011463806
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1200/jco.2007.13.7679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041363961
374 rdf:type schema:CreativeWork
375 https://doi.org/10.2307/2529620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069975249
376 rdf:type schema:CreativeWork
377 https://www.grid.ac/institutes/grid.14925.3b schema:alternateName Institut Gustave Roussy
378 schema:name Department of Surgery, Institute Gustave Roussy, Villejuif, France
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.15485.3d schema:alternateName Helsinki University Central Hospital
381 schema:name Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.22937.3d schema:alternateName Medical University of Vienna
384 schema:name Department of Surgery, Medical University of Vienna, Vienna, Austria
385 rdf:type schema:Organization
386 https://www.grid.ac/institutes/grid.28911.33 schema:alternateName Hospitais da Universidade de Coimbra
387 schema:name Department of Surgery, Surgery 3, Coimbra University Hospital, Coimbra, Portugal
388 rdf:type schema:Organization
389 https://www.grid.ac/institutes/grid.411255.6 schema:alternateName Aintree University Hospital
390 schema:name Department of Surgery, University Hospital Aintree, Liverpool, UK
391 rdf:type schema:Organization
392 https://www.grid.ac/institutes/grid.411730.0 schema:alternateName Clinica Universidad de Navarra
393 schema:name Department of General Surgery, Clínica Universidad de Navarra, Pamplona, Spain
394 rdf:type schema:Organization
395 https://www.grid.ac/institutes/grid.413133.7 schema:alternateName Hospital Paul Brousse
396 schema:name AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire, Université Paris-Sud, Villejuif, France
397 rdf:type schema:Organization
398 https://www.grid.ac/institutes/grid.413362.1 schema:alternateName Hospital Curry Cabral
399 schema:name Department of HPB Surgery and Transplantation, Curry Cabral Hospital, Lisbon, Portugal
400 rdf:type schema:Organization
401 https://www.grid.ac/institutes/grid.414339.8 schema:alternateName Hôpital Saint-André
402 schema:name Department of Surgery, Hôpital Saint André, Bordeaux, France
403 rdf:type schema:Organization
404 https://www.grid.ac/institutes/grid.414700.6 schema:alternateName A. O. Ordine Mauriziano di Torino
405 schema:name Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy
406 rdf:type schema:Organization
407 https://www.grid.ac/institutes/grid.415180.9 schema:alternateName Institutul Clinic Fundeni
408 schema:name Department of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.415490.d schema:alternateName Queen Elizabeth Hospital Birmingham
411 schema:name Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
412 rdf:type schema:Organization
413 https://www.grid.ac/institutes/grid.48769.34 schema:alternateName Cliniques Universitaires Saint-Luc
414 schema:name Unit of HPB Surgery, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCL), Brussels, Belgium
415 rdf:type schema:Organization
416 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
417 schema:name Department of Transplantation and Hepato-biliary Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
418 rdf:type schema:Organization
419 https://www.grid.ac/institutes/grid.8142.f schema:alternateName Catholic University of the Sacred Heart
420 schema:name Hepatobiliary Unit, Department of Surgery, Catholic University of the Sacred Heart School of Medicine, Rome, Italy
421 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...