The Relationship Between Tumor Inflammatory Cell Infiltrate and Outcome in Patients with Pancreatic Ductal Adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-10

AUTHORS

Nigel B. Jamieson, Mohamed Mohamed, Karin A. Oien, Alan K. Foulis, Euan J. Dickson, Clem W. Imrie, C. Ross Carter, Colin J. McKay, Donald C. McMillan

ABSTRACT

BACKGROUND: The tumor-associated inflammatory cell infiltrate is recognized to have prognostic value in various common solid tumors. However, the prognostic value of the tumor inflammatory cell infiltrate has not been established in pancreatic ductal adenocarcinoma (PDAC) nor has its relationship with the systemic inflammatory response. METHODS: Retrospective study was made of 173 patients who underwent surgery between 1997 and 2009. Routine pathology specimens were scored according to density of the tumor inflammatory cell infiltrate, and biochemical data were collected preoperatively. RESULTS: Low-grade tumor inflammatory cell infiltrate was associated with earlier tumor recurrence (P < 0.001) and particularly in the liver (P = 0.027). It was also associated with T3 tumors (P < 0.05), lymph node involvement (P < 0.05), and resection margin involvement (P < 0.05). On univariate survival analysis, age <65 years (P < 0.05), mGPS (P < 0.001), increased tumor stage (P < 0.01), nodal involvement (P < 0.01), size (P < 0.05), grade (P < 0.05), perineural invasion (P < 0.05), venous invasion (P < 0.01), resection margin involvement (P ≤ 0.001), vascular reconstruction (P < 0.05), and no adjuvant chemotherapy (P < 0.05) were associated with poor survival. In contrast, high-grade tumor inflammatory cell infiltrate was associated with better survival (P < 0.001). On multivariate survival analysis, mGPS [hazard ratio (HR): 1.77, 95% confidence interval (95% CI): 1.19-2.62, P = 0.005], tumor stage (HR: 2.21, 95% CI: 1.16-4.23, P = 0.016), resection margin involvement (HR: 2.19, 95% CI: 1.41-3.44, P = 0.001), venous invasion (HR: 1.79, 95% CI: 1.22-2.63, P = 0.003), tumor inflammatory cell infiltrate (HR: 0.37, 95% CI: 0.25-0.55, P = 0.0001), and adjuvant chemotherapy (P = 0.04) were independently prognostic. CONCLUSIONS: The results of the study show, for the first time, that the presence of a high-grade tumor inflammatory cell infiltrate is an independent predictor of prolonged overall survival following resection for PDAC. Furthermore, measures of the local and the systemic inflammatory response were inversely associated. More... »

PAGES

3581-3590

References to SciGraph publications

  • 2002. AJCC Cancer Staging Manual in NONE
  • 2011-04. Relationship Between Preoperative Comorbidity, Systemic Inflammatory Response, and Survival in Patients Undergoing Curative Resection for Colorectal Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2010-02. Immune infiltration in human tumors: a prognostic factor that should not be ignored in ONCOGENE
  • 2007-08. Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2004-11. C-reactive protein in IMMUNOLOGIC RESEARCH
  • 2006-09. 1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experience in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2007-11. Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer in BRITISH JOURNAL OF CANCER
  • 2003-09. Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer in BRITISH JOURNAL OF CANCER
  • 2008-07. Cancer-related inflammation in NATURE
  • 2002-11. Cancer immunoediting: from immunosurveillance to tumor escape in NATURE IMMUNOLOGY
  • 2005-01. Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas in BRITISH JOURNAL OF CANCER
  • 2006-10. Prognostic factors in patients with recently diagnosed incurable cancer: a systematic review in SUPPORTIVE CARE IN CANCER
  • 2011-08. A Prospective Comparison of the Prognostic Value of Tumor- and Patient-Related Factors in Patients Undergoing Potentially Curative Surgery for Pancreatic Ductal Adenocarcinoma in ANNALS OF SURGICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1245/s10434-012-2370-y

    DOI

    http://dx.doi.org/10.1245/s10434-012-2370-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033542688

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22555345


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenocarcinoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemotherapy, Adjuvant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kaplan-Meier Estimate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphatic Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multivariate Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Grading", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Invasiveness", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Observer Variation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreatectomy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreatic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Glasgow Royal Infirmary", 
              "id": "https://www.grid.ac/institutes/grid.411714.6", 
              "name": [
                "West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom", 
                "University Department of Surgery, Glasgow Royal Infirmary, Glasgow, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jamieson", 
            "givenName": "Nigel B.", 
            "id": "sg:person.0774007275.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774007275.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Glasgow Royal Infirmary", 
              "id": "https://www.grid.ac/institutes/grid.411714.6", 
              "name": [
                "University Department of Surgery, Glasgow Royal Infirmary, Glasgow, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mohamed", 
            "givenName": "Mohamed", 
            "id": "sg:person.01347065245.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347065245.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Glasgow Royal Infirmary", 
              "id": "https://www.grid.ac/institutes/grid.411714.6", 
              "name": [
                "University Department of Pathology, Glasgow Royal Infirmary, Glasgow, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oien", 
            "givenName": "Karin A.", 
            "id": "sg:person.01167262224.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167262224.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Glasgow Royal Infirmary", 
              "id": "https://www.grid.ac/institutes/grid.411714.6", 
              "name": [
                "University Department of Pathology, Glasgow Royal Infirmary, Glasgow, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Foulis", 
            "givenName": "Alan K.", 
            "id": "sg:person.01245331301.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245331301.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Glasgow Royal Infirmary", 
              "id": "https://www.grid.ac/institutes/grid.411714.6", 
              "name": [
                "West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dickson", 
            "givenName": "Euan J.", 
            "id": "sg:person.01122251345.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122251345.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Glasgow Royal Infirmary", 
              "id": "https://www.grid.ac/institutes/grid.411714.6", 
              "name": [
                "West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Imrie", 
            "givenName": "Clem W.", 
            "id": "sg:person.014305340264.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014305340264.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Glasgow Royal Infirmary", 
              "id": "https://www.grid.ac/institutes/grid.411714.6", 
              "name": [
                "West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carter", 
            "givenName": "C. Ross", 
            "id": "sg:person.0752311657.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752311657.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Glasgow Royal Infirmary", 
              "id": "https://www.grid.ac/institutes/grid.411714.6", 
              "name": [
                "West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McKay", 
            "givenName": "Colin J.", 
            "id": "sg:person.0627322245.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627322245.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Glasgow Royal Infirmary", 
              "id": "https://www.grid.ac/institutes/grid.411714.6", 
              "name": [
                "University Department of Surgery, Glasgow Royal Infirmary, Glasgow, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McMillan", 
            "givenName": "Donald C.", 
            "id": "sg:person.0636771507.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636771507.26"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(200006)191:2<154::aid-path603>3.0.co;2-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000434049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.22400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001602756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199912)189:4<487::aid-path484>3.0.co;2-i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003676834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-06-0686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006719266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.22.012703.104803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007787378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1198443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008077720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00520-006-0079-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008308000", 
              "https://doi.org/10.1007/s00520-006-0079-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00520-006-0079-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008308000", 
              "https://doi.org/10.1007/s00520-006-0079-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0029665108007131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008751837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.06.866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012047761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2006.113068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012563145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1102-991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013709887", 
              "https://doi.org/10.1038/ni1102-991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1102-991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013709887", 
              "https://doi.org/10.1038/ni1102-991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3181a3e738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017041087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3181a3e738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017041087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3181a3e738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017041087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3181a3e738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017041087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa020177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017266513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-0185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018420588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgp127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019816173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgp127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019816173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1129139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021857158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0215(19971021)74:5<492::aid-ijc3>3.0.co;2-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023878020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6601242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024195508", 
              "https://doi.org/10.1038/sj.bjc.6601242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6601242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024195508", 
              "https://doi.org/10.1038/sj.bjc.6601242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024729982", 
              "https://doi.org/10.1038/nature07205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/ir:30:3:261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029591810", 
              "https://doi.org/10.1385/ir:30:3:261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archinte.160.6.861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030016414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030793923", 
              "https://doi.org/10.1038/sj.bjc.6604027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2005.07.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031072703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2005.07.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031072703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.gassur.2006.08.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031265211", 
              "https://doi.org/10.1016/j.gassur.2006.08.018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mco.0b013e32832a7902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031475058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mco.0b013e32832a7902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031475058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mco.0b013e32832a7902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031475058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4757-3656-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032089040", 
              "https://doi.org/10.1007/978-1-4757-3656-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4757-3656-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032089040", 
              "https://doi.org/10.1007/978-1-4757-3656-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4757-3656-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032089040", 
              "https://doi.org/10.1007/978-1-4757-3656-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/cclm.2008.089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032985567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0959-8049(94)e0159-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033861474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(19960401)77:7<1303::aid-cncr12>3.0.co;2-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036127185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042063808", 
              "https://doi.org/10.1038/onc.2009.416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-011-1560-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043429292", 
              "https://doi.org/10.1245/s10434-011-1560-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043982539", 
              "https://doi.org/10.1038/sj.bjc.6602305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043982539", 
              "https://doi.org/10.1038/sj.bjc.6602305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-006-0259-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046118686", 
              "https://doi.org/10.1007/s00384-006-0259-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-006-0259-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046118686", 
              "https://doi.org/10.1007/s00384-006-0259-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-010-1410-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047723603", 
              "https://doi.org/10.1245/s10434-010-1410-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199707)182:3<318::aid-path862>3.0.co;2-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048209545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199707)182:3<318::aid-path862>3.0.co;2-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048209545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-0175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052274588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-200112000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053277218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-200112000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053277218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074546411", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/83.4.735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077219117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/83.6.1345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077253075"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-10", 
        "datePublishedReg": "2012-10-01", 
        "description": "BACKGROUND: The tumor-associated inflammatory cell infiltrate is recognized to have prognostic value in various common solid tumors. However, the prognostic value of the tumor inflammatory cell infiltrate has not been established in pancreatic ductal adenocarcinoma (PDAC) nor has its relationship with the systemic inflammatory response.\nMETHODS: Retrospective study was made of 173 patients who underwent surgery between 1997 and 2009. Routine pathology specimens were scored according to density of the tumor inflammatory cell infiltrate, and biochemical data were collected preoperatively.\nRESULTS: Low-grade tumor inflammatory cell infiltrate was associated with earlier tumor recurrence (P < 0.001) and particularly in the liver (P = 0.027). It was also associated with T3 tumors (P < 0.05), lymph node involvement (P < 0.05), and resection margin involvement (P < 0.05). On univariate survival analysis, age <65 years (P < 0.05), mGPS (P < 0.001), increased tumor stage (P < 0.01), nodal involvement (P < 0.01), size (P < 0.05), grade (P < 0.05), perineural invasion (P < 0.05), venous invasion (P < 0.01), resection margin involvement (P \u2264 0.001), vascular reconstruction (P < 0.05), and no adjuvant chemotherapy (P < 0.05) were associated with poor survival. In contrast, high-grade tumor inflammatory cell infiltrate was associated with better survival (P < 0.001). On multivariate survival analysis, mGPS [hazard ratio (HR): 1.77, 95% confidence interval (95% CI): 1.19-2.62, P = 0.005], tumor stage (HR: 2.21, 95% CI: 1.16-4.23, P = 0.016), resection margin involvement (HR: 2.19, 95% CI: 1.41-3.44, P = 0.001), venous invasion (HR: 1.79, 95% CI: 1.22-2.63, P = 0.003), tumor inflammatory cell infiltrate (HR: 0.37, 95% CI: 0.25-0.55, P = 0.0001), and adjuvant chemotherapy (P = 0.04) were independently prognostic.\nCONCLUSIONS: The results of the study show, for the first time, that the presence of a high-grade tumor inflammatory cell infiltrate is an independent predictor of prolonged overall survival following resection for PDAC. Furthermore, measures of the local and the systemic inflammatory response were inversely associated.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1245/s10434-012-2370-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5150594", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1105545", 
            "issn": [
              "1068-9265", 
              "1534-4681"
            ], 
            "name": "Annals of Surgical Oncology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "name": "The Relationship Between Tumor Inflammatory Cell Infiltrate and Outcome in Patients with Pancreatic Ductal Adenocarcinoma", 
        "pagination": "3581-3590", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "9fc9b5274d43e4876fd87828c105d690038e708689e6973d96dbfeb3b24b9020"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22555345"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9420840"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1245/s10434-012-2370-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1033542688"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1245/s10434-012-2370-y", 
          "https://app.dimensions.ai/details/publication/pub.1033542688"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T20:44", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000500.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1245/s10434-012-2370-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2370-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2370-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2370-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-012-2370-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    337 TRIPLES      21 PREDICATES      88 URIs      40 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1245/s10434-012-2370-y schema:about N16169a2dbc814c6ca022e6a7ecb6787c
    2 N24cefd8408034ea88d5da492b1da5e04
    3 N2fe26a1c601e41119b57f40cee55fb5a
    4 N308d1913a620448980ed3de74f6942a8
    5 N4ad02a01701d473aaf607d70c4a2e7d0
    6 N5c3cb1861f8345728f25c24fc93c0fb7
    7 N6ef57de79ce44f4cb7e7d16dd0ce149f
    8 N80ced70827ce4e1c9fbe4ea84c697059
    9 N8fe66aeda50d415f906245adef0b0bbe
    10 N9034bee0880f47fe9ec85a507ad10a24
    11 Nac9bd12494d441cc9539ebe6835ceb43
    12 Nb8d40fa0c2844fe1997046259bea42e3
    13 Nc3059c5f6a6448dcaeda688854aedf80
    14 Ncb897e0d6e3e45a88682fce4f277abb2
    15 Nd1d4a21a5664423480c1e764a1bf28a2
    16 Ne0a4e2f08a34488c9a5772483049044e
    17 Ne8ea4351552d44f4a525f10d3160a541
    18 Nf12b2dd6dc784473b42791fed6103db6
    19 Nf74a708d65e84dff88932e6878eb4a43
    20 anzsrc-for:11
    21 anzsrc-for:1112
    22 schema:author Nb9660533ef8f479ea35504901932a4ee
    23 schema:citation sg:pub.10.1007/978-1-4757-3656-4
    24 sg:pub.10.1007/s00384-006-0259-6
    25 sg:pub.10.1007/s00520-006-0079-9
    26 sg:pub.10.1016/j.gassur.2006.08.018
    27 sg:pub.10.1038/nature07205
    28 sg:pub.10.1038/ni1102-991
    29 sg:pub.10.1038/onc.2009.416
    30 sg:pub.10.1038/sj.bjc.6601242
    31 sg:pub.10.1038/sj.bjc.6602305
    32 sg:pub.10.1038/sj.bjc.6604027
    33 sg:pub.10.1245/s10434-010-1410-8
    34 sg:pub.10.1245/s10434-011-1560-3
    35 sg:pub.10.1385/ir:30:3:261
    36 https://app.dimensions.ai/details/publication/pub.1074546411
    37 https://doi.org/10.1001/archinte.160.6.861
    38 https://doi.org/10.1002/(sici)1096-9896(199707)182:3<318::aid-path862>3.0.co;2-6
    39 https://doi.org/10.1002/(sici)1096-9896(199912)189:4<487::aid-path484>3.0.co;2-i
    40 https://doi.org/10.1002/(sici)1096-9896(200006)191:2<154::aid-path603>3.0.co;2-c
    41 https://doi.org/10.1002/(sici)1097-0142(19960401)77:7<1303::aid-cncr12>3.0.co;2-5
    42 https://doi.org/10.1002/(sici)1097-0215(19971021)74:5<492::aid-ijc3>3.0.co;2-z
    43 https://doi.org/10.1002/cncr.22400
    44 https://doi.org/10.1016/0959-8049(94)e0159-2
    45 https://doi.org/10.1016/j.ejca.2005.07.017
    46 https://doi.org/10.1017/s0029665108007131
    47 https://doi.org/10.1056/nejmoa020177
    48 https://doi.org/10.1093/ajcn/83.4.735
    49 https://doi.org/10.1093/ajcn/83.6.1345
    50 https://doi.org/10.1093/carcin/bgp127
    51 https://doi.org/10.1097/00000658-200112000-00007
    52 https://doi.org/10.1097/mco.0b013e32832a7902
    53 https://doi.org/10.1097/sla.0b013e3181a3e738
    54 https://doi.org/10.1126/science.1129139
    55 https://doi.org/10.1126/science.1198443
    56 https://doi.org/10.1136/gut.2006.113068
    57 https://doi.org/10.1146/annurev.immunol.22.012703.104803
    58 https://doi.org/10.1158/0008-5472.can-07-0175
    59 https://doi.org/10.1158/1078-0432.ccr-05-0185
    60 https://doi.org/10.1158/1535-7163.mct-06-0686
    61 https://doi.org/10.1200/jco.2005.06.866
    62 https://doi.org/10.1515/cclm.2008.089
    63 schema:datePublished 2012-10
    64 schema:datePublishedReg 2012-10-01
    65 schema:description BACKGROUND: The tumor-associated inflammatory cell infiltrate is recognized to have prognostic value in various common solid tumors. However, the prognostic value of the tumor inflammatory cell infiltrate has not been established in pancreatic ductal adenocarcinoma (PDAC) nor has its relationship with the systemic inflammatory response. METHODS: Retrospective study was made of 173 patients who underwent surgery between 1997 and 2009. Routine pathology specimens were scored according to density of the tumor inflammatory cell infiltrate, and biochemical data were collected preoperatively. RESULTS: Low-grade tumor inflammatory cell infiltrate was associated with earlier tumor recurrence (P < 0.001) and particularly in the liver (P = 0.027). It was also associated with T3 tumors (P < 0.05), lymph node involvement (P < 0.05), and resection margin involvement (P < 0.05). On univariate survival analysis, age <65 years (P < 0.05), mGPS (P < 0.001), increased tumor stage (P < 0.01), nodal involvement (P < 0.01), size (P < 0.05), grade (P < 0.05), perineural invasion (P < 0.05), venous invasion (P < 0.01), resection margin involvement (P ≤ 0.001), vascular reconstruction (P < 0.05), and no adjuvant chemotherapy (P < 0.05) were associated with poor survival. In contrast, high-grade tumor inflammatory cell infiltrate was associated with better survival (P < 0.001). On multivariate survival analysis, mGPS [hazard ratio (HR): 1.77, 95% confidence interval (95% CI): 1.19-2.62, P = 0.005], tumor stage (HR: 2.21, 95% CI: 1.16-4.23, P = 0.016), resection margin involvement (HR: 2.19, 95% CI: 1.41-3.44, P = 0.001), venous invasion (HR: 1.79, 95% CI: 1.22-2.63, P = 0.003), tumor inflammatory cell infiltrate (HR: 0.37, 95% CI: 0.25-0.55, P = 0.0001), and adjuvant chemotherapy (P = 0.04) were independently prognostic. CONCLUSIONS: The results of the study show, for the first time, that the presence of a high-grade tumor inflammatory cell infiltrate is an independent predictor of prolonged overall survival following resection for PDAC. Furthermore, measures of the local and the systemic inflammatory response were inversely associated.
    66 schema:genre research_article
    67 schema:inLanguage en
    68 schema:isAccessibleForFree false
    69 schema:isPartOf N7ee74d6969b74f9f825ff85221814315
    70 Nff83b2a519f04b12b9588fea2e170598
    71 sg:journal.1105545
    72 schema:name The Relationship Between Tumor Inflammatory Cell Infiltrate and Outcome in Patients with Pancreatic Ductal Adenocarcinoma
    73 schema:pagination 3581-3590
    74 schema:productId N0ed389d0c1434505be7a02431d3c521d
    75 N587cd43c74584cb79b8e66bb729a5d4e
    76 Nb99bb2fe434b4afcaf9f3a2b927bf4d0
    77 Nd4b56d8b530a4f6e918d8701bd2b7402
    78 Nd929b16ffa9b43d883406767e825673d
    79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033542688
    80 https://doi.org/10.1245/s10434-012-2370-y
    81 schema:sdDatePublished 2019-04-10T20:44
    82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    83 schema:sdPublisher N3bf86b9d0f0b418ca34ae494f14b1397
    84 schema:url http://link.springer.com/10.1245/s10434-012-2370-y
    85 sgo:license sg:explorer/license/
    86 sgo:sdDataset articles
    87 rdf:type schema:ScholarlyArticle
    88 N097a5ff188284eeda95008eb8857b73c rdf:first sg:person.0636771507.26
    89 rdf:rest rdf:nil
    90 N0ed389d0c1434505be7a02431d3c521d schema:name pubmed_id
    91 schema:value 22555345
    92 rdf:type schema:PropertyValue
    93 N16169a2dbc814c6ca022e6a7ecb6787c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Lymphatic Metastasis
    95 rdf:type schema:DefinedTerm
    96 N24cefd8408034ea88d5da492b1da5e04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Middle Aged
    98 rdf:type schema:DefinedTerm
    99 N2fe26a1c601e41119b57f40cee55fb5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Humans
    101 rdf:type schema:DefinedTerm
    102 N308d1913a620448980ed3de74f6942a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Adenocarcinoma
    104 rdf:type schema:DefinedTerm
    105 N3bf86b9d0f0b418ca34ae494f14b1397 schema:name Springer Nature - SN SciGraph project
    106 rdf:type schema:Organization
    107 N4ad02a01701d473aaf607d70c4a2e7d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Kaplan-Meier Estimate
    109 rdf:type schema:DefinedTerm
    110 N587cd43c74584cb79b8e66bb729a5d4e schema:name doi
    111 schema:value 10.1245/s10434-012-2370-y
    112 rdf:type schema:PropertyValue
    113 N5c3cb1861f8345728f25c24fc93c0fb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Pancreatic Neoplasms
    115 rdf:type schema:DefinedTerm
    116 N6ef57de79ce44f4cb7e7d16dd0ce149f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Neoplasm Invasiveness
    118 rdf:type schema:DefinedTerm
    119 N74e8e2208328448399434c4e9b0642dc rdf:first sg:person.014305340264.13
    120 rdf:rest N89bce332ad284695828732197b500402
    121 N7c64bf86b5db4cbc972c9e7a51ef8eb0 rdf:first sg:person.01245331301.44
    122 rdf:rest Nedfd478eea984119b50dcce89979003b
    123 N7ee74d6969b74f9f825ff85221814315 schema:volumeNumber 19
    124 rdf:type schema:PublicationVolume
    125 N80ced70827ce4e1c9fbe4ea84c697059 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Aged
    127 rdf:type schema:DefinedTerm
    128 N89bce332ad284695828732197b500402 rdf:first sg:person.0752311657.15
    129 rdf:rest Nd731586ca82246ddb3381cf8f4d0369a
    130 N8fe66aeda50d415f906245adef0b0bbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Pancreatectomy
    132 rdf:type schema:DefinedTerm
    133 N9034bee0880f47fe9ec85a507ad10a24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Treatment Outcome
    135 rdf:type schema:DefinedTerm
    136 N9654b038f78144dfa99d4ed4cdd260d3 rdf:first sg:person.01347065245.56
    137 rdf:rest Nb9648198fe924a5c9e7a15b5b9b7414d
    138 Nac9bd12494d441cc9539ebe6835ceb43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Male
    140 rdf:type schema:DefinedTerm
    141 Nb8d40fa0c2844fe1997046259bea42e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Neoplasm Staging
    143 rdf:type schema:DefinedTerm
    144 Nb9648198fe924a5c9e7a15b5b9b7414d rdf:first sg:person.01167262224.50
    145 rdf:rest N7c64bf86b5db4cbc972c9e7a51ef8eb0
    146 Nb9660533ef8f479ea35504901932a4ee rdf:first sg:person.0774007275.43
    147 rdf:rest N9654b038f78144dfa99d4ed4cdd260d3
    148 Nb99bb2fe434b4afcaf9f3a2b927bf4d0 schema:name nlm_unique_id
    149 schema:value 9420840
    150 rdf:type schema:PropertyValue
    151 Nc3059c5f6a6448dcaeda688854aedf80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Retrospective Studies
    153 rdf:type schema:DefinedTerm
    154 Ncb897e0d6e3e45a88682fce4f277abb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Observer Variation
    156 rdf:type schema:DefinedTerm
    157 Nd1d4a21a5664423480c1e764a1bf28a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Multivariate Analysis
    159 rdf:type schema:DefinedTerm
    160 Nd4b56d8b530a4f6e918d8701bd2b7402 schema:name readcube_id
    161 schema:value 9fc9b5274d43e4876fd87828c105d690038e708689e6973d96dbfeb3b24b9020
    162 rdf:type schema:PropertyValue
    163 Nd731586ca82246ddb3381cf8f4d0369a rdf:first sg:person.0627322245.66
    164 rdf:rest N097a5ff188284eeda95008eb8857b73c
    165 Nd929b16ffa9b43d883406767e825673d schema:name dimensions_id
    166 schema:value pub.1033542688
    167 rdf:type schema:PropertyValue
    168 Ne0a4e2f08a34488c9a5772483049044e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Female
    170 rdf:type schema:DefinedTerm
    171 Ne8ea4351552d44f4a525f10d3160a541 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Neoplasm Grading
    173 rdf:type schema:DefinedTerm
    174 Nedfd478eea984119b50dcce89979003b rdf:first sg:person.01122251345.36
    175 rdf:rest N74e8e2208328448399434c4e9b0642dc
    176 Nf12b2dd6dc784473b42791fed6103db6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Chemotherapy, Adjuvant
    178 rdf:type schema:DefinedTerm
    179 Nf74a708d65e84dff88932e6878eb4a43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Inflammation
    181 rdf:type schema:DefinedTerm
    182 Nff83b2a519f04b12b9588fea2e170598 schema:issueNumber 11
    183 rdf:type schema:PublicationIssue
    184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    185 schema:name Medical and Health Sciences
    186 rdf:type schema:DefinedTerm
    187 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    188 schema:name Oncology and Carcinogenesis
    189 rdf:type schema:DefinedTerm
    190 sg:grant.5150594 http://pending.schema.org/fundedItem sg:pub.10.1245/s10434-012-2370-y
    191 rdf:type schema:MonetaryGrant
    192 sg:journal.1105545 schema:issn 1068-9265
    193 1534-4681
    194 schema:name Annals of Surgical Oncology
    195 rdf:type schema:Periodical
    196 sg:person.01122251345.36 schema:affiliation https://www.grid.ac/institutes/grid.411714.6
    197 schema:familyName Dickson
    198 schema:givenName Euan J.
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122251345.36
    200 rdf:type schema:Person
    201 sg:person.01167262224.50 schema:affiliation https://www.grid.ac/institutes/grid.411714.6
    202 schema:familyName Oien
    203 schema:givenName Karin A.
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167262224.50
    205 rdf:type schema:Person
    206 sg:person.01245331301.44 schema:affiliation https://www.grid.ac/institutes/grid.411714.6
    207 schema:familyName Foulis
    208 schema:givenName Alan K.
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245331301.44
    210 rdf:type schema:Person
    211 sg:person.01347065245.56 schema:affiliation https://www.grid.ac/institutes/grid.411714.6
    212 schema:familyName Mohamed
    213 schema:givenName Mohamed
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347065245.56
    215 rdf:type schema:Person
    216 sg:person.014305340264.13 schema:affiliation https://www.grid.ac/institutes/grid.411714.6
    217 schema:familyName Imrie
    218 schema:givenName Clem W.
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014305340264.13
    220 rdf:type schema:Person
    221 sg:person.0627322245.66 schema:affiliation https://www.grid.ac/institutes/grid.411714.6
    222 schema:familyName McKay
    223 schema:givenName Colin J.
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627322245.66
    225 rdf:type schema:Person
    226 sg:person.0636771507.26 schema:affiliation https://www.grid.ac/institutes/grid.411714.6
    227 schema:familyName McMillan
    228 schema:givenName Donald C.
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636771507.26
    230 rdf:type schema:Person
    231 sg:person.0752311657.15 schema:affiliation https://www.grid.ac/institutes/grid.411714.6
    232 schema:familyName Carter
    233 schema:givenName C. Ross
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752311657.15
    235 rdf:type schema:Person
    236 sg:person.0774007275.43 schema:affiliation https://www.grid.ac/institutes/grid.411714.6
    237 schema:familyName Jamieson
    238 schema:givenName Nigel B.
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774007275.43
    240 rdf:type schema:Person
    241 sg:pub.10.1007/978-1-4757-3656-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032089040
    242 https://doi.org/10.1007/978-1-4757-3656-4
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1007/s00384-006-0259-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046118686
    245 https://doi.org/10.1007/s00384-006-0259-6
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1007/s00520-006-0079-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008308000
    248 https://doi.org/10.1007/s00520-006-0079-9
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1016/j.gassur.2006.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031265211
    251 https://doi.org/10.1016/j.gassur.2006.08.018
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nature07205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024729982
    254 https://doi.org/10.1038/nature07205
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/ni1102-991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013709887
    257 https://doi.org/10.1038/ni1102-991
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/onc.2009.416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042063808
    260 https://doi.org/10.1038/onc.2009.416
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/sj.bjc.6601242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024195508
    263 https://doi.org/10.1038/sj.bjc.6601242
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/sj.bjc.6602305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043982539
    266 https://doi.org/10.1038/sj.bjc.6602305
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/sj.bjc.6604027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030793923
    269 https://doi.org/10.1038/sj.bjc.6604027
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1245/s10434-010-1410-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047723603
    272 https://doi.org/10.1245/s10434-010-1410-8
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1245/s10434-011-1560-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043429292
    275 https://doi.org/10.1245/s10434-011-1560-3
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1385/ir:30:3:261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029591810
    278 https://doi.org/10.1385/ir:30:3:261
    279 rdf:type schema:CreativeWork
    280 https://app.dimensions.ai/details/publication/pub.1074546411 schema:CreativeWork
    281 https://doi.org/10.1001/archinte.160.6.861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030016414
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1002/(sici)1096-9896(199707)182:3<318::aid-path862>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048209545
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1002/(sici)1096-9896(199912)189:4<487::aid-path484>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1003676834
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1002/(sici)1096-9896(200006)191:2<154::aid-path603>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1000434049
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1002/(sici)1097-0142(19960401)77:7<1303::aid-cncr12>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036127185
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1002/(sici)1097-0215(19971021)74:5<492::aid-ijc3>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1023878020
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1002/cncr.22400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001602756
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/0959-8049(94)e0159-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033861474
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.ejca.2005.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031072703
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1017/s0029665108007131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008751837
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1056/nejmoa020177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017266513
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1093/ajcn/83.4.735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077219117
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1093/ajcn/83.6.1345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077253075
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1093/carcin/bgp127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019816173
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1097/00000658-200112000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053277218
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1097/mco.0b013e32832a7902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031475058
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1097/sla.0b013e3181a3e738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017041087
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1126/science.1129139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021857158
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1126/science.1198443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008077720
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1136/gut.2006.113068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012563145
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1146/annurev.immunol.22.012703.104803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007787378
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1158/0008-5472.can-07-0175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052274588
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1158/1078-0432.ccr-05-0185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018420588
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1158/1535-7163.mct-06-0686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006719266
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1200/jco.2005.06.866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012047761
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1515/cclm.2008.089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032985567
    332 rdf:type schema:CreativeWork
    333 https://www.grid.ac/institutes/grid.411714.6 schema:alternateName Glasgow Royal Infirmary
    334 schema:name University Department of Pathology, Glasgow Royal Infirmary, Glasgow, United Kingdom
    335 University Department of Surgery, Glasgow Royal Infirmary, Glasgow, United Kingdom
    336 West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom
    337 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...