Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q24 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-03-21

AUTHORS

Shinya Ishimaru, Koshi Mimori, Ken Yamamoto, Hiroshi Inoue, Seiya Imoto, Shuichi Kawano, Rui Yamaguchi, Tetsuya Sato, Hiroyuki Toh, Hisae Iinuma, Toyoki Maeda, Hideshi Ishii, Sadao Suzuki, Shinkan Tokudome, Masahiko Watanabe, Jun-ichi Tanaka, Shin-ei Kudo, Ken-ichi Sugihara, Kazuo Hase, Hidetaka Mochizuki, Masato Kusunoki, Kazutaka Yamada, Yasuhiro Shimada, Yoshihiro Moriya, Graham F. Barnard, Satoru Miyano, Masaki Mori

ABSTRACT

BackgroundColorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated.MethodsA multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures.ResultsVariants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06–1.27, P = 0.0015). Non-insulin-dependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM.ConclusionsWe confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present. More... »

PAGES

2853-2858

Journal

TITLE

Annals of Surgical Oncology

ISSUE

9

VOLUME

19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-012-2278-6

DOI

http://dx.doi.org/10.1245/s10434-012-2278-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032068652

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22434246


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