Adjuvant PEFG (Cisplatin, Epirubicin, 5-Fluorouracil, Gemcitabine) or Gemcitabine Followed by Chemoradiation in Pancreatic Cancer: A Randomized Phase II Trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-07

AUTHORS

Michele Reni, Gianpaolo Balzano, Giuseppe Aprile, Stefano Cereda, Paolo Passoni, Alessandro Zerbi, Maria Chiara Tronconi, Carlo Milandri, Piercarlo Saletti, Alessia Rognone, Clara Fugazza, Alessandro Magli, Nadia Di Muzio, Valerio Di Carlo, Eugenio Villa

ABSTRACT

BACKGROUND: Information from randomized trials on the role of combination chemotherapy in the adjuvant treatment of pancreatic adenocarcinoma is limited. This randomized phase II trial aimed to identify the most promising regimen warranting phase III evaluation. METHODS: Therapy-naive patients, age 18-75 years, Karnofsky Performance Status (KPS)>60, gross total resection of stage IB-III pancreatic adenocarcinoma, stratified for center and surgical margins, were randomly assigned to receive either gemcitabine 1 g/m2 weekly on days 1, 8, and 15 (arm A) or the PEFG regimen (cisplatin and epirubicin 40 mg/m2, day 1; gemcitabine 600 mg/m2, days 1, 8; 5-fluorouracil 200 mg/m2 daily, days 1-28) (arm B). Chemotherapy was administered every 4 weeks for 3 months and followed by irradiation concurrent to continuous infusion of 5-fluorouracil 250 mg/m2 daily. Primary endpoint was the probability of being disease-free at 1 year from surgery. Assuming P0=35% and P1=55%, α=.05 and β=.10, the study was to enroll 51 patients per arm. RESULTS: A total of 102 patients were randomized; 100 were eligible (arm A: 51; arm B: 49). Baseline characteristic (A/B) were: Median age was 61/60 years; 75% had KPS>80 75/76%; 36% grade 3 tumor 29/43%, 79% stage IIB/III 75/84%, 31% R1 resection 35/29%. Survival figures (A/B) were: Median disease-free survival was 11.7 and 15.2 months; 1-year disease-free survival 49.0% (95% confidence interval [95% CI] 35-63%) and 69.4% (95% CI 56-83%); median survival 24.8 and 28.9 months. Combination chemotherapy produced more hematological toxicity without relevant differences in nonhematological toxicities. CONCLUSIONS: The 4-drug regimen deserves further assessment in resectable pancreatic cancer. More... »

PAGES

2256-2263

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-011-2205-2

DOI

http://dx.doi.org/10.1245/s10434-011-2205-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040445038

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22237835


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoradiotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxycytidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epirubicin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Oncology, S. Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reni", 
        "givenName": "Michele", 
        "id": "sg:person.01164712517.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164712517.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Surgery, S. Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balzano", 
        "givenName": "Gianpaolo", 
        "id": "sg:person.01301141117.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301141117.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Santa Maria della Misericordia di Udine", 
          "id": "https://www.grid.ac/institutes/grid.411492.b", 
          "name": [
            "Department of Oncology, University Hospital, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aprile", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01150115462.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150115462.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Oncology, S. Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cereda", 
        "givenName": "Stefano", 
        "id": "sg:person.01210713123.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210713123.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Radiotherapy, S. Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Passoni", 
        "givenName": "Paolo", 
        "id": "sg:person.01134654171.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134654171.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Pancreatic Surgery Section, Humanitas Scientific Institute, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zerbi", 
        "givenName": "Alessandro", 
        "id": "sg:person.0736672032.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736672032.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Medical Oncology and Hematology, Humanitas Scientific Institute, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tronconi", 
        "givenName": "Maria Chiara", 
        "id": "sg:person.0742036640.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742036640.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.419563.c", 
          "name": [
            "Medical Oncology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Forl\u00ec, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milandri", 
        "givenName": "Carlo", 
        "id": "sg:person.01036655036.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036655036.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Divisions of Medical Oncology, Oncology Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saletti", 
        "givenName": "Piercarlo", 
        "id": "sg:person.0635044562.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635044562.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Oncology, S. Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rognone", 
        "givenName": "Alessia", 
        "id": "sg:person.01257026323.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257026323.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Oncology, S. Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fugazza", 
        "givenName": "Clara", 
        "id": "sg:person.01174414717.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174414717.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Santa Maria della Misericordia di Udine", 
          "id": "https://www.grid.ac/institutes/grid.411492.b", 
          "name": [
            "Department of Radiotherapy, University Hospital, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magli", 
        "givenName": "Alessandro", 
        "id": "sg:person.0746006425.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746006425.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Radiotherapy, S. Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muzio", 
        "givenName": "Nadia Di", 
        "id": "sg:person.0653510157.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653510157.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Surgery, S. Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carlo", 
        "givenName": "Valerio Di", 
        "id": "sg:person.0613402062.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613402062.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Oncology, S. Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Villa", 
        "givenName": "Eugenio", 
        "id": "sg:person.01064027417.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064027417.78"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2009.24.2446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004259551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.07.9525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005176755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.30.3446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005314802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/07357900701359932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007988690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.297.3.267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010434617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa073149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014019609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015676534", 
          "https://doi.org/10.1038/sj.bjc.6602513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015676534", 
          "https://doi.org/10.1038/sj.bjc.6602513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000086780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016938291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000086780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016938291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2010.1275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017077374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000094563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018012713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.0886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019676980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.12.082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022163283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1011923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022967950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-011-1680-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024770282", 
          "https://doi.org/10.1007/s00280-011-1680-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdi309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024868281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdi309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024868281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(05)70175-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026335507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07357909009017560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031573606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034324223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.20.9007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035245959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1985.01390320023003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039164497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-006-0277-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040836963", 
          "https://doi.org/10.1007/s00280-006-0277-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-006-0277-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040836963", 
          "https://doi.org/10.1007/s00280-006-0277-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043189393", 
          "https://doi.org/10.1038/sj.bjc.6605256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043189393", 
          "https://doi.org/10.1038/sj.bjc.6605256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.299.9.1019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046928841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.25.4433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047521785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048680038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.06.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048830818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.05.1490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049817200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199912000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060135163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199912000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060135163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199912000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060135163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.11.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.08.072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v16.i39.4883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071367122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.10.2679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074814012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.6.2403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083106816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.18_suppl.lba4012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083946809"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-07", 
    "datePublishedReg": "2012-07-01", 
    "description": "BACKGROUND: Information from randomized trials on the role of combination chemotherapy in the adjuvant treatment of pancreatic adenocarcinoma is limited. This randomized phase II trial aimed to identify the most promising regimen warranting phase III evaluation.\nMETHODS: Therapy-naive patients, age 18-75 years, Karnofsky Performance Status (KPS)>60, gross total resection of stage IB-III pancreatic adenocarcinoma, stratified for center and surgical margins, were randomly assigned to receive either gemcitabine 1 g/m2 weekly on days 1, 8, and 15 (arm A) or the PEFG regimen (cisplatin and epirubicin 40 mg/m2, day 1; gemcitabine 600 mg/m2, days 1, 8; 5-fluorouracil 200 mg/m2 daily, days 1-28) (arm B). Chemotherapy was administered every 4 weeks for 3 months and followed by irradiation concurrent to continuous infusion of 5-fluorouracil 250 mg/m2 daily. Primary endpoint was the probability of being disease-free at 1 year from surgery. Assuming P0=35% and P1=55%, \u03b1=.05 and \u03b2=.10, the study was to enroll 51 patients per arm.\nRESULTS: A total of 102 patients were randomized; 100 were eligible (arm A: 51; arm B: 49). Baseline characteristic (A/B) were: Median age was 61/60 years; 75% had KPS>80 75/76%; 36% grade 3 tumor 29/43%, 79% stage IIB/III 75/84%, 31% R1 resection 35/29%. Survival figures (A/B) were: Median disease-free survival was 11.7 and 15.2 months; 1-year disease-free survival 49.0% (95% confidence interval [95% CI] 35-63%) and 69.4% (95% CI 56-83%); median survival 24.8 and 28.9 months. Combination chemotherapy produced more hematological toxicity without relevant differences in nonhematological toxicities.\nCONCLUSIONS: The 4-drug regimen deserves further assessment in resectable pancreatic cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-011-2205-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Adjuvant PEFG (Cisplatin, Epirubicin, 5-Fluorouracil, Gemcitabine) or Gemcitabine Followed by Chemoradiation in Pancreatic Cancer: A Randomized Phase II Trial", 
    "pagination": "2256-2263", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c0a9b5617024378cd8ae773ccc7c422e2afe3f7a0f9bf35f7f458780876f13e5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22237835"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-011-2205-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040445038"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-011-2205-2", 
      "https://app.dimensions.ai/details/publication/pub.1040445038"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000500.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1245/s10434-011-2205-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-2205-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-2205-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-2205-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-2205-2'


 

This table displays all metadata directly associated to this object as RDF triples.

380 TRIPLES      21 PREDICATES      86 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-011-2205-2 schema:about N000640252b6c4d20b38760953598fb3e
2 N0b360d24b99a4f4cacd4227543ceb37c
3 N1190278db39c4d2eada6affa6ffe2412
4 N14cfbc0409c5430cbedcdb40af53be64
5 N215aeb44514a43deb4d344e80478e546
6 N26ea40d176cd437a886a7fe3da5a8de3
7 N282990f0bb904b58b05cb98b7981309e
8 N2b363d1e6c2b45f0973224a28070b47d
9 N3a169098f7a84f0283ce499beb25ba0f
10 N5258178dd2dc41f19fab30e413e9d442
11 N586b9b361d034f46960f0a88344d4e68
12 N84fba1317ed849c3b6ec9efe7c9a822a
13 N87a0375aa4844ee980a144fd6c5ff30a
14 N8bb29c0f46fb4da4ac66de552c85fe18
15 N9459c7b8f408471196bef8f056153459
16 N97691bccae9842d88ae94af315d9bab3
17 Na0cf92739095453b837c8bd2575d1df9
18 Nacfe0fb6416848208578d61f80dce498
19 Nb2da0d5213f6427d948cef7a0c638ea4
20 Nc3789130b18b47a9b6a6aee92cb42ad1
21 Nc9dd18364a934910a69314ac900799d0
22 Ne80f88c2784341ed8e4112fbd29b0d8b
23 Nf9159dbeb24944b6a5573383e8e1d8a2
24 anzsrc-for:11
25 anzsrc-for:1112
26 schema:author Na0e6293cc3bd41049efb6fb7f8589e1c
27 schema:citation sg:pub.10.1007/s00280-006-0277-7
28 sg:pub.10.1007/s00280-011-1680-2
29 sg:pub.10.1038/sj.bjc.6602513
30 sg:pub.10.1038/sj.bjc.6605256
31 https://doi.org/10.1001/archsurg.1985.01390320023003
32 https://doi.org/10.1001/jama.2010.1275
33 https://doi.org/10.1001/jama.297.3.267
34 https://doi.org/10.1001/jama.299.9.1019
35 https://doi.org/10.1016/s1470-2045(05)70175-3
36 https://doi.org/10.1056/nejmoa032295
37 https://doi.org/10.1056/nejmoa073149
38 https://doi.org/10.1056/nejmoa1011923
39 https://doi.org/10.1080/07357900701359932
40 https://doi.org/10.1093/annonc/mdi309
41 https://doi.org/10.1093/annonc/mdq384
42 https://doi.org/10.1097/00000658-199912000-00006
43 https://doi.org/10.1159/000086780
44 https://doi.org/10.1159/000094563
45 https://doi.org/10.1200/jco.1997.15.6.2403
46 https://doi.org/10.1200/jco.2001.19.10.2679
47 https://doi.org/10.1200/jco.2002.11.149
48 https://doi.org/10.1200/jco.2003.08.072
49 https://doi.org/10.1200/jco.2004.12.082
50 https://doi.org/10.1200/jco.2005.05.1490
51 https://doi.org/10.1200/jco.2005.06.023
52 https://doi.org/10.1200/jco.2006.07.9525
53 https://doi.org/10.1200/jco.2006.09.0886
54 https://doi.org/10.1200/jco.2008.20.9007
55 https://doi.org/10.1200/jco.2009.24.2446
56 https://doi.org/10.1200/jco.2009.25.4433
57 https://doi.org/10.1200/jco.2010.28.18_suppl.lba4012
58 https://doi.org/10.1200/jco.2010.30.3446
59 https://doi.org/10.3109/07357909009017560
60 https://doi.org/10.3748/wjg.v16.i39.4883
61 schema:datePublished 2012-07
62 schema:datePublishedReg 2012-07-01
63 schema:description BACKGROUND: Information from randomized trials on the role of combination chemotherapy in the adjuvant treatment of pancreatic adenocarcinoma is limited. This randomized phase II trial aimed to identify the most promising regimen warranting phase III evaluation. METHODS: Therapy-naive patients, age 18-75 years, Karnofsky Performance Status (KPS)>60, gross total resection of stage IB-III pancreatic adenocarcinoma, stratified for center and surgical margins, were randomly assigned to receive either gemcitabine 1 g/m2 weekly on days 1, 8, and 15 (arm A) or the PEFG regimen (cisplatin and epirubicin 40 mg/m2, day 1; gemcitabine 600 mg/m2, days 1, 8; 5-fluorouracil 200 mg/m2 daily, days 1-28) (arm B). Chemotherapy was administered every 4 weeks for 3 months and followed by irradiation concurrent to continuous infusion of 5-fluorouracil 250 mg/m2 daily. Primary endpoint was the probability of being disease-free at 1 year from surgery. Assuming P0=35% and P1=55%, α=.05 and β=.10, the study was to enroll 51 patients per arm. RESULTS: A total of 102 patients were randomized; 100 were eligible (arm A: 51; arm B: 49). Baseline characteristic (A/B) were: Median age was 61/60 years; 75% had KPS>80 75/76%; 36% grade 3 tumor 29/43%, 79% stage IIB/III 75/84%, 31% R1 resection 35/29%. Survival figures (A/B) were: Median disease-free survival was 11.7 and 15.2 months; 1-year disease-free survival 49.0% (95% confidence interval [95% CI] 35-63%) and 69.4% (95% CI 56-83%); median survival 24.8 and 28.9 months. Combination chemotherapy produced more hematological toxicity without relevant differences in nonhematological toxicities. CONCLUSIONS: The 4-drug regimen deserves further assessment in resectable pancreatic cancer.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree false
67 schema:isPartOf N7ab49bd9ffb74bfe9612fc6723fb98d7
68 Nb251c48469e84508bd9e95e59ee5f0a0
69 sg:journal.1105545
70 schema:name Adjuvant PEFG (Cisplatin, Epirubicin, 5-Fluorouracil, Gemcitabine) or Gemcitabine Followed by Chemoradiation in Pancreatic Cancer: A Randomized Phase II Trial
71 schema:pagination 2256-2263
72 schema:productId N4f5a3d8058b847a1b334b44536ae7f69
73 N6203319cda7c4adbb290a39cebde71a7
74 N7bc3d297a3f94bfdac8a5c859b773cc2
75 N8173c547ae984b8c9f8174daccc15e5e
76 Ne0bc9e3468754526b244ee08f985a82e
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040445038
78 https://doi.org/10.1245/s10434-011-2205-2
79 schema:sdDatePublished 2019-04-10T17:29
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N0eee3733d2f94f9d94631e67291c6598
82 schema:url http://link.springer.com/10.1245/s10434-011-2205-2
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N000640252b6c4d20b38760953598fb3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Male
88 rdf:type schema:DefinedTerm
89 N079d362b734046119f2626c643fdd288 rdf:first sg:person.01036655036.33
90 rdf:rest Nc7e6ea478b44499192449df840baf3cf
91 N0b0c1133634d40e2ad931bd35068bac0 rdf:first sg:person.0746006425.58
92 rdf:rest Ncc22892daf3a4b829b02a0ded1b3cdce
93 N0b360d24b99a4f4cacd4227543ceb37c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Young Adult
95 rdf:type schema:DefinedTerm
96 N0eee3733d2f94f9d94631e67291c6598 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N1190278db39c4d2eada6affa6ffe2412 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Humans
100 rdf:type schema:DefinedTerm
101 N14cfbc0409c5430cbedcdb40af53be64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Prognosis
103 rdf:type schema:DefinedTerm
104 N1a57b88456c94271a008fc19bfaf9247 rdf:first sg:person.01174414717.99
105 rdf:rest N0b0c1133634d40e2ad931bd35068bac0
106 N215aeb44514a43deb4d344e80478e546 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Adenocarcinoma
108 rdf:type schema:DefinedTerm
109 N22516eea59684737b60905987f12a697 rdf:first sg:person.01064027417.78
110 rdf:rest rdf:nil
111 N23bc5b95909e44eab63e8f4131c580d3 rdf:first sg:person.01257026323.26
112 rdf:rest N1a57b88456c94271a008fc19bfaf9247
113 N26ea40d176cd437a886a7fe3da5a8de3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Cisplatin
115 rdf:type schema:DefinedTerm
116 N282990f0bb904b58b05cb98b7981309e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Deoxycytidine
118 rdf:type schema:DefinedTerm
119 N2b363d1e6c2b45f0973224a28070b47d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Adolescent
121 rdf:type schema:DefinedTerm
122 N33236f7c2fea44c6a3b887afcc195f68 rdf:first sg:person.0742036640.91
123 rdf:rest N079d362b734046119f2626c643fdd288
124 N3a169098f7a84f0283ce499beb25ba0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Chemoradiotherapy
126 rdf:type schema:DefinedTerm
127 N3c1a023c4989458082d5c846629e25e6 schema:name Pancreatic Surgery Section, Humanitas Scientific Institute, Rozzano, Italy
128 rdf:type schema:Organization
129 N4f5a3d8058b847a1b334b44536ae7f69 schema:name doi
130 schema:value 10.1245/s10434-011-2205-2
131 rdf:type schema:PropertyValue
132 N5258178dd2dc41f19fab30e413e9d442 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Neoplasm Recurrence, Local
134 rdf:type schema:DefinedTerm
135 N584a7a4f851b4f018647de3bbcb31f11 rdf:first sg:person.01150115462.24
136 rdf:rest Nbdbf10c3b4c8450d9b7a56533bc2129c
137 N586b9b361d034f46960f0a88344d4e68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Fluorouracil
139 rdf:type schema:DefinedTerm
140 N6203319cda7c4adbb290a39cebde71a7 schema:name pubmed_id
141 schema:value 22237835
142 rdf:type schema:PropertyValue
143 N67b9b2e87928447e9aba94f584301108 rdf:first sg:person.01301141117.22
144 rdf:rest N584a7a4f851b4f018647de3bbcb31f11
145 N7ab49bd9ffb74bfe9612fc6723fb98d7 schema:issueNumber 7
146 rdf:type schema:PublicationIssue
147 N7bc3d297a3f94bfdac8a5c859b773cc2 schema:name dimensions_id
148 schema:value pub.1040445038
149 rdf:type schema:PropertyValue
150 N8173c547ae984b8c9f8174daccc15e5e schema:name nlm_unique_id
151 schema:value 9420840
152 rdf:type schema:PropertyValue
153 N84fba1317ed849c3b6ec9efe7c9a822a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Neoplasm Grading
155 rdf:type schema:DefinedTerm
156 N87a0375aa4844ee980a144fd6c5ff30a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Antineoplastic Combined Chemotherapy Protocols
158 rdf:type schema:DefinedTerm
159 N8bb29c0f46fb4da4ac66de552c85fe18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Pancreatic Neoplasms
161 rdf:type schema:DefinedTerm
162 N9459c7b8f408471196bef8f056153459 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Epirubicin
164 rdf:type schema:DefinedTerm
165 N97691bccae9842d88ae94af315d9bab3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Chemotherapy, Adjuvant
167 rdf:type schema:DefinedTerm
168 Na0cf92739095453b837c8bd2575d1df9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Neoplasm Staging
170 rdf:type schema:DefinedTerm
171 Na0e6293cc3bd41049efb6fb7f8589e1c rdf:first sg:person.01164712517.20
172 rdf:rest N67b9b2e87928447e9aba94f584301108
173 Nacfe0fb6416848208578d61f80dce498 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Survival Rate
175 rdf:type schema:DefinedTerm
176 Nb251c48469e84508bd9e95e59ee5f0a0 schema:volumeNumber 19
177 rdf:type schema:PublicationVolume
178 Nb2da0d5213f6427d948cef7a0c638ea4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Adult
180 rdf:type schema:DefinedTerm
181 Nbdbf10c3b4c8450d9b7a56533bc2129c rdf:first sg:person.01210713123.27
182 rdf:rest Nc9039032ae194606bc0d39e1d20bb98c
183 Nc3789130b18b47a9b6a6aee92cb42ad1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Aged
185 rdf:type schema:DefinedTerm
186 Nc7e6ea478b44499192449df840baf3cf rdf:first sg:person.0635044562.28
187 rdf:rest N23bc5b95909e44eab63e8f4131c580d3
188 Nc9039032ae194606bc0d39e1d20bb98c rdf:first sg:person.01134654171.43
189 rdf:rest Nd5807e4519564bc69d8f257909b4fa54
190 Nc9dd18364a934910a69314ac900799d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Female
192 rdf:type schema:DefinedTerm
193 Nca2734b4532746a3ade1c57a4169825a rdf:first sg:person.0613402062.26
194 rdf:rest N22516eea59684737b60905987f12a697
195 Ncc22892daf3a4b829b02a0ded1b3cdce rdf:first sg:person.0653510157.51
196 rdf:rest Nca2734b4532746a3ade1c57a4169825a
197 Ncf3da6378b174c74a3db4de9ddc28a70 schema:name Medical Oncology and Hematology, Humanitas Scientific Institute, Rozzano, Italy
198 rdf:type schema:Organization
199 Nd5807e4519564bc69d8f257909b4fa54 rdf:first sg:person.0736672032.67
200 rdf:rest N33236f7c2fea44c6a3b887afcc195f68
201 Ne0bc9e3468754526b244ee08f985a82e schema:name readcube_id
202 schema:value c0a9b5617024378cd8ae773ccc7c422e2afe3f7a0f9bf35f7f458780876f13e5
203 rdf:type schema:PropertyValue
204 Ne288a303adad4b808129f5daf2f619e7 schema:name Divisions of Medical Oncology, Oncology Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland
205 rdf:type schema:Organization
206 Ne80f88c2784341ed8e4112fbd29b0d8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Follow-Up Studies
208 rdf:type schema:DefinedTerm
209 Nf9159dbeb24944b6a5573383e8e1d8a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Middle Aged
211 rdf:type schema:DefinedTerm
212 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
213 schema:name Medical and Health Sciences
214 rdf:type schema:DefinedTerm
215 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
216 schema:name Oncology and Carcinogenesis
217 rdf:type schema:DefinedTerm
218 sg:journal.1105545 schema:issn 1068-9265
219 1534-4681
220 schema:name Annals of Surgical Oncology
221 rdf:type schema:Periodical
222 sg:person.01036655036.33 schema:affiliation https://www.grid.ac/institutes/grid.419563.c
223 schema:familyName Milandri
224 schema:givenName Carlo
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036655036.33
226 rdf:type schema:Person
227 sg:person.01064027417.78 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
228 schema:familyName Villa
229 schema:givenName Eugenio
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064027417.78
231 rdf:type schema:Person
232 sg:person.01134654171.43 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
233 schema:familyName Passoni
234 schema:givenName Paolo
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134654171.43
236 rdf:type schema:Person
237 sg:person.01150115462.24 schema:affiliation https://www.grid.ac/institutes/grid.411492.b
238 schema:familyName Aprile
239 schema:givenName Giuseppe
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150115462.24
241 rdf:type schema:Person
242 sg:person.01164712517.20 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
243 schema:familyName Reni
244 schema:givenName Michele
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164712517.20
246 rdf:type schema:Person
247 sg:person.01174414717.99 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
248 schema:familyName Fugazza
249 schema:givenName Clara
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174414717.99
251 rdf:type schema:Person
252 sg:person.01210713123.27 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
253 schema:familyName Cereda
254 schema:givenName Stefano
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210713123.27
256 rdf:type schema:Person
257 sg:person.01257026323.26 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
258 schema:familyName Rognone
259 schema:givenName Alessia
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257026323.26
261 rdf:type schema:Person
262 sg:person.01301141117.22 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
263 schema:familyName Balzano
264 schema:givenName Gianpaolo
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301141117.22
266 rdf:type schema:Person
267 sg:person.0613402062.26 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
268 schema:familyName Carlo
269 schema:givenName Valerio Di
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613402062.26
271 rdf:type schema:Person
272 sg:person.0635044562.28 schema:affiliation Ne288a303adad4b808129f5daf2f619e7
273 schema:familyName Saletti
274 schema:givenName Piercarlo
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635044562.28
276 rdf:type schema:Person
277 sg:person.0653510157.51 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
278 schema:familyName Muzio
279 schema:givenName Nadia Di
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653510157.51
281 rdf:type schema:Person
282 sg:person.0736672032.67 schema:affiliation N3c1a023c4989458082d5c846629e25e6
283 schema:familyName Zerbi
284 schema:givenName Alessandro
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736672032.67
286 rdf:type schema:Person
287 sg:person.0742036640.91 schema:affiliation Ncf3da6378b174c74a3db4de9ddc28a70
288 schema:familyName Tronconi
289 schema:givenName Maria Chiara
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742036640.91
291 rdf:type schema:Person
292 sg:person.0746006425.58 schema:affiliation https://www.grid.ac/institutes/grid.411492.b
293 schema:familyName Magli
294 schema:givenName Alessandro
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746006425.58
296 rdf:type schema:Person
297 sg:pub.10.1007/s00280-006-0277-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040836963
298 https://doi.org/10.1007/s00280-006-0277-7
299 rdf:type schema:CreativeWork
300 sg:pub.10.1007/s00280-011-1680-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024770282
301 https://doi.org/10.1007/s00280-011-1680-2
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/sj.bjc.6602513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015676534
304 https://doi.org/10.1038/sj.bjc.6602513
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/sj.bjc.6605256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043189393
307 https://doi.org/10.1038/sj.bjc.6605256
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1001/archsurg.1985.01390320023003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039164497
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1001/jama.2010.1275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017077374
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1001/jama.297.3.267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010434617
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1001/jama.299.9.1019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046928841
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s1470-2045(05)70175-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026335507
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1056/nejmoa032295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048680038
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1056/nejmoa073149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014019609
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1056/nejmoa1011923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022967950
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1080/07357900701359932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007988690
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1093/annonc/mdi309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024868281
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1093/annonc/mdq384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034324223
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1097/00000658-199912000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060135163
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1159/000086780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016938291
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1159/000094563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018012713
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1200/jco.1997.15.6.2403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083106816
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1200/jco.2001.19.10.2679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074814012
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1200/jco.2002.11.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203191
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1200/jco.2003.08.072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203794
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1200/jco.2004.12.082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022163283
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1200/jco.2005.05.1490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049817200
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1200/jco.2005.06.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048830818
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1200/jco.2006.07.9525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005176755
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1200/jco.2006.09.0886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019676980
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1200/jco.2008.20.9007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035245959
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1200/jco.2009.24.2446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004259551
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1200/jco.2009.25.4433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047521785
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1200/jco.2010.28.18_suppl.lba4012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083946809
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1200/jco.2010.30.3446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005314802
364 rdf:type schema:CreativeWork
365 https://doi.org/10.3109/07357909009017560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031573606
366 rdf:type schema:CreativeWork
367 https://doi.org/10.3748/wjg.v16.i39.4883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071367122
368 rdf:type schema:CreativeWork
369 https://www.grid.ac/institutes/grid.18887.3e schema:alternateName San Raffaele Hospital
370 schema:name Department of Oncology, S. Raffaele Scientific Institute, Milan, Italy
371 Department of Radiotherapy, S. Raffaele Scientific Institute, Milan, Italy
372 Department of Surgery, S. Raffaele Scientific Institute, Milan, Italy
373 rdf:type schema:Organization
374 https://www.grid.ac/institutes/grid.411492.b schema:alternateName Ospedale Santa Maria della Misericordia di Udine
375 schema:name Department of Oncology, University Hospital, Udine, Italy
376 Department of Radiotherapy, University Hospital, Udine, Italy
377 rdf:type schema:Organization
378 https://www.grid.ac/institutes/grid.419563.c schema:alternateName Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
379 schema:name Medical Oncology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Forlì, Italy
380 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...