Compartmental Differences of Circulating Tumor Cells in Colorectal Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-07

AUTHORS

Nuh N. Rahbari, Ulrich Bork, Alexandra Kircher, Thomas Nimitz, Sebastian Schölch, Christoph Kahlert, Thomas Schmidt, Gunnar Steinert, Alexis B. Ulrich, Christoph Reissfelder, Markus W. Büchler, Moritz Koch, Jürgen Weitz

ABSTRACT

BACKGROUND: The prognostic role of circulating tumor cells (CTCs) has been established for colorectal cancer (CRC). We investigated the qualitative and quantitative detection of CTC in the central (CVBC) and mesenteric (MVBC) venous blood compartments to elucidate the patterns of hematogenous tumor cell dissemination in patients with CRC. METHODS: A total of 200 patients were enrolled prospectively. Blood samples were collected from the tumor-draining vein and via a central venous line. CTCs were detected and quantified by using the CellSearch system. Factors associated with CTC detection in both compartments were analyzed by using univariate and multivariate analyses. RESULTS: CTC analyses were performed in the CVBC and MVBC in 200 and 80 patients, respectively. CTCs were found at a higher rate (P=0.01) and at a higher count (P=0.006) in the MVBC compared with the CVBC. On multivariate analyses, stage IV disease (odds ratio, 3.83; 95% confidence interval, 1.42-10.35) and increased preoperative carbohydrate antigen 19-9 level (odds ratio, 3.57; 1.30-9.79) were associated with CTC detection in the CVBC. CTCs were detected more frequently (P=0.05) and at higher numbers (P=0.05) in the CVBC of patients with low compared with mid or high rectal tumors. CONCLUSIONS: The qualitative and quantitative detection of CTCs is higher in the MVBC compared with the CVBC of patients with CRC. More... »

PAGES

2195-2202

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-011-2178-1

DOI

http://dx.doi.org/10.1245/s10434-011-2178-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044751954

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22230943


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