Comparison between Preoperative Versus Intraoperative Injection of Technetium-99 m Neomannosyl Human Serum Albumin for Sentinel Lymph Node Identification in Early ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12-06

AUTHORS

Hyun Koo Kim, Sungeun Kim, Ho Kyung Sung, Yun-Sang Lee, Jae Min Jeong, Young Ho Choi

ABSTRACT

PurposeWe aimed to evaluate the results of sentinel lymph node mapping according to injection time (preoperative vs. intraoperative) of technetium-99m neomannosyl human serum albumin (99mTc-MSA) in patients with lung cancer.MethodsData of 82 patients (55 men; mean age 62.9 ± 9.3 years) who were candidates for lobectomy with mediastinal lymph node dissection for clinical stage I non–small cell lung cancer were retrospectively reviewed. 99mTc-MSA was administered at the peritumoral region under chest computed tomographic guidance, 1 to 2 h before surgery (preoperation group, n = 48) or soon after thoracotomy (intraoperation group, n = 34).ResultsPatients’ demographic data, except type of operation, did not differ between the two groups. Sentinel lymph nodes were detected in 46 patients (95.8%) in the preoperation group and 33 patients (97.1%) in the intraoperation group (P = .243). The mean number of sentinel nodes per patient was 2.1 in the preoperation group and 2.6 in the intraoperation group (P = .068). No falsely negative sentinel nodes were detected in any of the 17 patients with N1 or N2 disease (0%) in either group. Administration of the intraoperative injection could save additional cost (US$607) and time (70 min) in each patient.ConclusionsSentinel node identification using 99mTc-MSA appears to provide similar excellent results in both preoperative and intraoperative injection. Therefore, intraoperative injection of 99mTc-MSA may be preferred as a result of lower cost and less waste of time. More... »

PAGES

1343-1349

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URI

http://scigraph.springernature.com/pub.10.1245/s10434-011-2130-4

DOI

http://dx.doi.org/10.1245/s10434-011-2130-4

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https://app.dimensions.ai/details/publication/pub.1047177560

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22143575


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