Clinical Implications of Occult Metastases and Isolated Tumor Cells in Sentinel and Non-Sentinel Lymph Nodes in Early Breast Cancer Patients: ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10-12

AUTHORS

Takashi Takeshita, Hitoshi Tsuda, Tomoyuki Moriya, Tamio Yamasaki, Hideki Asakawa, Shigeto Ueda, Kazuhiko Sato, Shinsuke Aida, Seiichi Tamai, Osamu Matsubara, Kazuo Hase, Junji Yamamoto

ABSTRACT

BackgroundThis study was designed to clarify retrospectively the clinical significance of occult metastases in both sentinel lymph nodes (SLNs) and non-SLNs in patients with early breast cancer.MethodsA total of 109 (80.1%) of 136 women with breast cancer who had consecutively undergone SLN biopsy (176 lymph nodes) were intraoperatively diagnosed as being free of SLN involvement. SLNs were routinely examined by hematoxylin–eosin (HE) staining of one to four frozen sections per node. Sixty-four (58.7%) of these patients also underwent backup axillary dissection. For the 109 patients, all formalin-fixed, paraffin-embedded tissues of SLNs and non-SLNs were entirely cut into 5-μm-thick sections. All serial step sections at 85-μm intervals were stained with HE and immunohistochemistry with pancytokeratin.ResultsOccult metastases in SLNs and non-SLNs were detected in 25 (23%) and 10 (16%) patients, respectively. The presence of occult SLN metastasis was marginally correlated with T-factor (P = 0.06), and predictive factors for occult non-SLN metastases were tumor nuclear grade (P = 0.039). With a median follow-up of 86 months, disease-free survival (P = 0.3) or overall survival (P = 0.8) did not differ between the patients with and without occult SLN metastases, regardless of backup axillary lymph node dissection.ConclusionsSLN or non-SLN occult metastases detected by serial step sections at 85-μm intervals did not have significant prognostic implications. More... »

PAGES

1160-1166

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-011-2085-5

DOI

http://dx.doi.org/10.1245/s10434-011-2085-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034051278

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21989659


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