Additive Lymph Node Dissection may be Necessary in Minute Submucosal Cancer of the Stomach after Endoscopic Resection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10-01

AUTHORS

Jie-Hyun Kim, Yong Chan Lee, Hyunki Kim, Sun Och Yoon, Hoguen Kim, Young Hoon Youn, Hyojin Park, Sang In Lee, Seung Ho Choi, Sung Hoon Noh

ABSTRACT

PurposeIn early gastric cancer (EGC), minute submucosal (SM1) invasion of the stomach has been regarded as an expanded indication for endoscopic resection (ER). The exact prediction of SM1 invasion before ER may be difficult. Thus, SM1 invasion may be important to decide additive treatment after ER. This study was designed to investigate the incidence of lymph node metastasis (LNM) in SM1-EGC based on surgical specimens and to evaluate the factors that indicate additional treatment after ER.MethodsFrom May 2005 to December 2008, 1,676 patients with EGC underwent surgery at Severance and Gangnam Severance Hospital, Seoul, Korea. Among them, 126 patients were diagnosed with differentiated SM1-EGC. The clinicopathologic characteristics were analyzed with respect to LNM and lymphovascular invasion (LVI), which is a known independent risk factor for LNM. Intratumoral marker immunohistochemistry was examined as a predictor of LVI.ResultsThe mean SM1 invasion depth was 621.3 ± 745.6 μm. The LNM rates did not differ significantly between differentiated SM1-EGC (6.3%) and SM1-EGC (4.1%) meeting the expanded indication for ER. Female gender, moderate differentiation, LVI, and LVI grade were positively correlated with LNM. Female gender and elevated lesion morphology were associated with LVI. The expression levels of VEGF-C and OPHN1 were higher in LVI-positive tissues.ConclusionsThe LNM rate in differentiated SM1-EGC meeting the expanded ER criteria was 4.1% in the present study, indicating that additional lymph node dissection may be necessary after ER in some cases of SM1-EGC. More... »

PAGES

779-785

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-011-2081-9

DOI

http://dx.doi.org/10.1245/s10434-011-2081-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027678142

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21964889


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GTPase-Activating Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Node Excision", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase 9", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor C", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jie-Hyun", 
        "id": "sg:person.014010425671.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014010425671.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Yong Chan", 
        "id": "sg:person.01350057705.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350057705.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Department of Pathology, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyunki", 
        "id": "sg:person.01061166771.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061166771.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea", 
            "Department of Pathology, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoon", 
        "givenName": "Sun Och", 
        "id": "sg:person.01203343502.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203343502.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Department of Pathology, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hoguen", 
        "id": "sg:person.01003376625.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003376625.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Youn", 
        "givenName": "Young Hoon", 
        "id": "sg:person.0703167664.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703167664.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Hyojin", 
        "id": "sg:person.0604225325.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604225325.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Sang In", 
        "id": "sg:person.0672573046.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672573046.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea", 
            "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Seung Ho", 
        "id": "sg:person.01053322044.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053322044.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Department of Surgery, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noh", 
        "givenName": "Sung Hoon", 
        "id": "sg:person.01120377020.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120377020.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00432-007-0264-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040629933", 
          "https://doi.org/10.1007/s00432-007-0264-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1023777013659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020945232", 
          "https://doi.org/10.1023/a:1023777013659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035885592", 
          "https://doi.org/10.1038/sj.onc.1203928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10529-009-0035-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025649336", 
          "https://doi.org/10.1007/s10529-009-0035-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-008-0476-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018920529", 
          "https://doi.org/10.1007/s10120-008-0476-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00011720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026415252", 
          "https://doi.org/10.1007/pl00011720"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-10-01", 
    "datePublishedReg": "2011-10-01", 
    "description": "PurposeIn early gastric cancer (EGC), minute submucosal (SM1) invasion of the stomach has been regarded as an expanded indication for endoscopic resection (ER). The exact prediction of SM1 invasion before ER may be difficult. Thus, SM1 invasion may be important to decide additive treatment after ER. This study was designed to investigate the incidence of lymph node metastasis (LNM) in SM1-EGC based on surgical specimens and to evaluate the factors that indicate additional treatment after ER.MethodsFrom May 2005 to December 2008, 1,676 patients with EGC underwent surgery at Severance and Gangnam Severance Hospital, Seoul, Korea. Among them, 126 patients were diagnosed with differentiated SM1-EGC. The clinicopathologic characteristics were analyzed with respect to LNM and lymphovascular invasion (LVI), which is a known independent risk factor for LNM. Intratumoral marker immunohistochemistry was examined as a predictor of LVI.ResultsThe mean SM1 invasion depth was 621.3\u00a0\u00b1\u00a0745.6\u00a0\u03bcm. The LNM rates did not differ significantly between differentiated SM1-EGC (6.3%) and SM1-EGC (4.1%) meeting the expanded indication for ER. Female gender, moderate differentiation, LVI, and LVI grade were positively correlated with LNM. Female gender and elevated lesion morphology were associated with LVI. The expression levels of VEGF-C and OPHN1 were higher in LVI-positive tissues.ConclusionsThe LNM rate in differentiated SM1-EGC meeting the expanded ER criteria was 4.1% in the present study, indicating that additional lymph node dissection may be necessary after ER in some cases of SM1-EGC.", 
    "genre": "article", 
    "id": "sg:pub.10.1245/s10434-011-2081-9", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "lymph node metastasis", 
      "lymph node dissection", 
      "endoscopic resection", 
      "lymphovascular invasion", 
      "early gastric cancer", 
      "SM1 invasion", 
      "node dissection", 
      "LNM rate", 
      "female gender", 
      "additional lymph node dissection", 
      "minute submucosal cancers", 
      "independent risk factor", 
      "Gangnam Severance Hospital", 
      "underwent surgery", 
      "submucosal cancer", 
      "submucosal invasion", 
      "clinicopathologic characteristics", 
      "node metastasis", 
      "Severance Hospital", 
      "risk factors", 
      "surgical specimens", 
      "gastric cancer", 
      "lesion morphology", 
      "invasion depth", 
      "additional treatment", 
      "ER criteria", 
      "resection", 
      "patients", 
      "minute submucosal invasion", 
      "expression levels", 
      "cancer", 
      "invasion", 
      "stomach", 
      "dissection", 
      "present study", 
      "treatment", 
      "moderate differentiation", 
      "indications", 
      "additive treatment", 
      "gender", 
      "surgery", 
      "metastasis", 
      "hospital", 
      "immunohistochemistry", 
      "incidence", 
      "VEGF", 
      "ResultsThe", 
      "factors", 
      "predictors", 
      "study", 
      "tissue", 
      "rate", 
      "grade", 
      "OPHN1", 
      "differentiation", 
      "severance", 
      "levels", 
      "criteria", 
      "cases", 
      "specimens", 
      "meeting", 
      "Seoul", 
      "characteristics", 
      "Korea", 
      "respect", 
      "morphology", 
      "prediction", 
      "depth", 
      "exact prediction", 
      "PurposeIn early gastric cancer", 
      "SM1-EGC", 
      "EGC underwent surgery", 
      "differentiated SM1-EGC", 
      "Intratumoral marker immunohistochemistry", 
      "marker immunohistochemistry", 
      "predictor of LVI", 
      "SM1 invasion depth", 
      "SM1-EGC (4.1%) meeting", 
      "LVI grade", 
      "elevated lesion morphology", 
      "LVI-positive tissues", 
      "ConclusionsThe LNM rate", 
      "cases of SM1-EGC", 
      "Additive Lymph Node Dissection"
    ], 
    "name": "Additive Lymph Node Dissection may be Necessary in Minute Submucosal Cancer of the Stomach after Endoscopic Resection", 
    "pagination": "779-785", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027678142"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-011-2081-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21964889"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-011-2081-9", 
      "https://app.dimensions.ai/details/publication/pub.1027678142"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1245/s10434-011-2081-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-2081-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-2081-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-2081-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-2081-9'


 

This table displays all metadata directly associated to this object as RDF triples.

312 TRIPLES      22 PREDICATES      134 URIs      120 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-011-2081-9 schema:about N03645854d77a42a8a0f7ff7d100a328a
2 N08c88b00c1ca49678ba38b19f873453b
3 N12c30eb8def24c5890880a849741240c
4 N15d3ec3a6ae14bd8bb47f9abd8d24ded
5 N1d06c4f504c34d18a301af485d6c4684
6 N2b0f1e44669a4961a804321ace137cc8
7 N369a81a4a87941b4b0d6f3d807f61e5c
8 N4eb6eccb56da47479cc635a87fc96d83
9 N5586d58e300f402bb9f6f1b159263ba5
10 N7202b5eae5ba454abc4747633c76e863
11 N815c2f70ab9840c78ddb68a463b85643
12 N9ca5bfb22e764d41bda08927ad845070
13 Na73ecbd34a4542d499fb23ce9e078fec
14 Na87c146724c449fc9f72383edc58bce0
15 Nd5b6379499fd42dbaf57dc3f6de9465d
16 Ndbd5db04bf534927927351e0b0e125a5
17 Ndc0aca40d5b24aba9a42c10fcf743b58
18 Ne695ef88781b455080184fe06b6a9c83
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author N4d471c92c5f246fca6783a1d651893a8
22 schema:citation sg:pub.10.1007/pl00011720
23 sg:pub.10.1007/s00432-007-0264-3
24 sg:pub.10.1007/s10120-008-0476-5
25 sg:pub.10.1007/s10529-009-0035-0
26 sg:pub.10.1023/a:1023777013659
27 sg:pub.10.1038/sj.onc.1203928
28 schema:datePublished 2011-10-01
29 schema:datePublishedReg 2011-10-01
30 schema:description PurposeIn early gastric cancer (EGC), minute submucosal (SM1) invasion of the stomach has been regarded as an expanded indication for endoscopic resection (ER). The exact prediction of SM1 invasion before ER may be difficult. Thus, SM1 invasion may be important to decide additive treatment after ER. This study was designed to investigate the incidence of lymph node metastasis (LNM) in SM1-EGC based on surgical specimens and to evaluate the factors that indicate additional treatment after ER.MethodsFrom May 2005 to December 2008, 1,676 patients with EGC underwent surgery at Severance and Gangnam Severance Hospital, Seoul, Korea. Among them, 126 patients were diagnosed with differentiated SM1-EGC. The clinicopathologic characteristics were analyzed with respect to LNM and lymphovascular invasion (LVI), which is a known independent risk factor for LNM. Intratumoral marker immunohistochemistry was examined as a predictor of LVI.ResultsThe mean SM1 invasion depth was 621.3 ± 745.6 μm. The LNM rates did not differ significantly between differentiated SM1-EGC (6.3%) and SM1-EGC (4.1%) meeting the expanded indication for ER. Female gender, moderate differentiation, LVI, and LVI grade were positively correlated with LNM. Female gender and elevated lesion morphology were associated with LVI. The expression levels of VEGF-C and OPHN1 were higher in LVI-positive tissues.ConclusionsThe LNM rate in differentiated SM1-EGC meeting the expanded ER criteria was 4.1% in the present study, indicating that additional lymph node dissection may be necessary after ER in some cases of SM1-EGC.
31 schema:genre article
32 schema:inLanguage en
33 schema:isAccessibleForFree false
34 schema:isPartOf N86d04de49e2d467a9ba0dd10e67e8f6a
35 Nbbc7b3fb153748b0900af7a02e306d31
36 sg:journal.1105545
37 schema:keywords Additive Lymph Node Dissection
38 ConclusionsThe LNM rate
39 EGC underwent surgery
40 ER criteria
41 Gangnam Severance Hospital
42 Intratumoral marker immunohistochemistry
43 Korea
44 LNM rate
45 LVI grade
46 LVI-positive tissues
47 OPHN1
48 PurposeIn early gastric cancer
49 ResultsThe
50 SM1 invasion
51 SM1 invasion depth
52 SM1-EGC
53 SM1-EGC (4.1%) meeting
54 Seoul
55 Severance Hospital
56 VEGF
57 additional lymph node dissection
58 additional treatment
59 additive treatment
60 cancer
61 cases
62 cases of SM1-EGC
63 characteristics
64 clinicopathologic characteristics
65 criteria
66 depth
67 differentiated SM1-EGC
68 differentiation
69 dissection
70 early gastric cancer
71 elevated lesion morphology
72 endoscopic resection
73 exact prediction
74 expression levels
75 factors
76 female gender
77 gastric cancer
78 gender
79 grade
80 hospital
81 immunohistochemistry
82 incidence
83 independent risk factor
84 indications
85 invasion
86 invasion depth
87 lesion morphology
88 levels
89 lymph node dissection
90 lymph node metastasis
91 lymphovascular invasion
92 marker immunohistochemistry
93 meeting
94 metastasis
95 minute submucosal cancers
96 minute submucosal invasion
97 moderate differentiation
98 morphology
99 node dissection
100 node metastasis
101 patients
102 prediction
103 predictor of LVI
104 predictors
105 present study
106 rate
107 resection
108 respect
109 risk factors
110 severance
111 specimens
112 stomach
113 study
114 submucosal cancer
115 submucosal invasion
116 surgery
117 surgical specimens
118 tissue
119 treatment
120 underwent surgery
121 schema:name Additive Lymph Node Dissection may be Necessary in Minute Submucosal Cancer of the Stomach after Endoscopic Resection
122 schema:pagination 779-785
123 schema:productId N317b6d6942464f9681a2ce5b8027c352
124 N5b7a573ad93b4a4cb42699d60fc93681
125 Naa6652748ba14ba484b980c2abf11fd4
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027678142
127 https://doi.org/10.1245/s10434-011-2081-9
128 schema:sdDatePublished 2022-01-01T18:26
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher N50c16e731c834e63b9c2c1300dd4ca5c
131 schema:url https://doi.org/10.1245/s10434-011-2081-9
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N03645854d77a42a8a0f7ff7d100a328a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Biomarkers, Tumor
137 rdf:type schema:DefinedTerm
138 N08c88b00c1ca49678ba38b19f873453b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Matrix Metalloproteinase 9
140 rdf:type schema:DefinedTerm
141 N12c30eb8def24c5890880a849741240c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Vascular Endothelial Growth Factor C
143 rdf:type schema:DefinedTerm
144 N15d3ec3a6ae14bd8bb47f9abd8d24ded schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Lymph Node Excision
146 rdf:type schema:DefinedTerm
147 N1d06c4f504c34d18a301af485d6c4684 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Adenocarcinoma
149 rdf:type schema:DefinedTerm
150 N1f932b7820f3468ea3715cb7ce864e34 rdf:first sg:person.01203343502.18
151 rdf:rest N671941da4edb41ee87159ba97321f6cf
152 N2b0f1e44669a4961a804321ace137cc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Male
154 rdf:type schema:DefinedTerm
155 N317b6d6942464f9681a2ce5b8027c352 schema:name doi
156 schema:value 10.1245/s10434-011-2081-9
157 rdf:type schema:PropertyValue
158 N369a81a4a87941b4b0d6f3d807f61e5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Risk Factors
160 rdf:type schema:DefinedTerm
161 N3835aeeb28d64d2d8db8f0b1c2e9810d rdf:first sg:person.0672573046.75
162 rdf:rest Naadd2238409a4943bc3790a99cd25b90
163 N4d471c92c5f246fca6783a1d651893a8 rdf:first sg:person.014010425671.78
164 rdf:rest N5eceb4e1a8a34dc5b4495afd9a424e4c
165 N4eb6eccb56da47479cc635a87fc96d83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Humans
167 rdf:type schema:DefinedTerm
168 N50c16e731c834e63b9c2c1300dd4ca5c schema:name Springer Nature - SN SciGraph project
169 rdf:type schema:Organization
170 N5586d58e300f402bb9f6f1b159263ba5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Immunohistochemistry
172 rdf:type schema:DefinedTerm
173 N5b7a573ad93b4a4cb42699d60fc93681 schema:name pubmed_id
174 schema:value 21964889
175 rdf:type schema:PropertyValue
176 N5eceb4e1a8a34dc5b4495afd9a424e4c rdf:first sg:person.01350057705.89
177 rdf:rest Nb8ae3306022a4f6aaad53ef508715093
178 N671941da4edb41ee87159ba97321f6cf rdf:first sg:person.01003376625.30
179 rdf:rest Nfc9fd61954d242e0803e8d26f205c686
180 N7202b5eae5ba454abc4747633c76e863 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Gastroscopy
182 rdf:type schema:DefinedTerm
183 N815c2f70ab9840c78ddb68a463b85643 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Nuclear Proteins
185 rdf:type schema:DefinedTerm
186 N86d04de49e2d467a9ba0dd10e67e8f6a schema:volumeNumber 19
187 rdf:type schema:PublicationVolume
188 N8a32caf766bc4a0c997e9c8675bbff08 rdf:first sg:person.0604225325.08
189 rdf:rest N3835aeeb28d64d2d8db8f0b1c2e9810d
190 N9b4b5854bed9499384d97978a8cb7827 rdf:first sg:person.01120377020.04
191 rdf:rest rdf:nil
192 N9ca5bfb22e764d41bda08927ad845070 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Stomach Neoplasms
194 rdf:type schema:DefinedTerm
195 Na73ecbd34a4542d499fb23ce9e078fec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Middle Aged
197 rdf:type schema:DefinedTerm
198 Na87c146724c449fc9f72383edc58bce0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Neoplasm Invasiveness
200 rdf:type schema:DefinedTerm
201 Naa6652748ba14ba484b980c2abf11fd4 schema:name dimensions_id
202 schema:value pub.1027678142
203 rdf:type schema:PropertyValue
204 Naadd2238409a4943bc3790a99cd25b90 rdf:first sg:person.01053322044.62
205 rdf:rest N9b4b5854bed9499384d97978a8cb7827
206 Nb8ae3306022a4f6aaad53ef508715093 rdf:first sg:person.01061166771.52
207 rdf:rest N1f932b7820f3468ea3715cb7ce864e34
208 Nbbc7b3fb153748b0900af7a02e306d31 schema:issueNumber 3
209 rdf:type schema:PublicationIssue
210 Nd5b6379499fd42dbaf57dc3f6de9465d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Cytoskeletal Proteins
212 rdf:type schema:DefinedTerm
213 Ndbd5db04bf534927927351e0b0e125a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Lymphatic Metastasis
215 rdf:type schema:DefinedTerm
216 Ndc0aca40d5b24aba9a42c10fcf743b58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Female
218 rdf:type schema:DefinedTerm
219 Ne695ef88781b455080184fe06b6a9c83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name GTPase-Activating Proteins
221 rdf:type schema:DefinedTerm
222 Nfc9fd61954d242e0803e8d26f205c686 rdf:first sg:person.0703167664.48
223 rdf:rest N8a32caf766bc4a0c997e9c8675bbff08
224 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
225 schema:name Medical and Health Sciences
226 rdf:type schema:DefinedTerm
227 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
228 schema:name Oncology and Carcinogenesis
229 rdf:type schema:DefinedTerm
230 sg:journal.1105545 schema:issn 1068-9265
231 1534-4681
232 schema:name Annals of Surgical Oncology
233 schema:publisher Springer Nature
234 rdf:type schema:Periodical
235 sg:person.01003376625.30 schema:affiliation grid-institutes:grid.15444.30
236 schema:familyName Kim
237 schema:givenName Hoguen
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003376625.30
239 rdf:type schema:Person
240 sg:person.01053322044.62 schema:affiliation grid-institutes:grid.15444.30
241 schema:familyName Choi
242 schema:givenName Seung Ho
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053322044.62
244 rdf:type schema:Person
245 sg:person.01061166771.52 schema:affiliation grid-institutes:grid.15444.30
246 schema:familyName Kim
247 schema:givenName Hyunki
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061166771.52
249 rdf:type schema:Person
250 sg:person.01120377020.04 schema:affiliation grid-institutes:grid.15444.30
251 schema:familyName Noh
252 schema:givenName Sung Hoon
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120377020.04
254 rdf:type schema:Person
255 sg:person.01203343502.18 schema:affiliation grid-institutes:grid.15444.30
256 schema:familyName Yoon
257 schema:givenName Sun Och
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203343502.18
259 rdf:type schema:Person
260 sg:person.01350057705.89 schema:affiliation grid-institutes:grid.15444.30
261 schema:familyName Lee
262 schema:givenName Yong Chan
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350057705.89
264 rdf:type schema:Person
265 sg:person.014010425671.78 schema:affiliation grid-institutes:grid.15444.30
266 schema:familyName Kim
267 schema:givenName Jie-Hyun
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014010425671.78
269 rdf:type schema:Person
270 sg:person.0604225325.08 schema:affiliation grid-institutes:grid.15444.30
271 schema:familyName Park
272 schema:givenName Hyojin
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604225325.08
274 rdf:type schema:Person
275 sg:person.0672573046.75 schema:affiliation grid-institutes:grid.15444.30
276 schema:familyName Lee
277 schema:givenName Sang In
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672573046.75
279 rdf:type schema:Person
280 sg:person.0703167664.48 schema:affiliation grid-institutes:grid.15444.30
281 schema:familyName Youn
282 schema:givenName Young Hoon
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703167664.48
284 rdf:type schema:Person
285 sg:pub.10.1007/pl00011720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026415252
286 https://doi.org/10.1007/pl00011720
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/s00432-007-0264-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040629933
289 https://doi.org/10.1007/s00432-007-0264-3
290 rdf:type schema:CreativeWork
291 sg:pub.10.1007/s10120-008-0476-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018920529
292 https://doi.org/10.1007/s10120-008-0476-5
293 rdf:type schema:CreativeWork
294 sg:pub.10.1007/s10529-009-0035-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025649336
295 https://doi.org/10.1007/s10529-009-0035-0
296 rdf:type schema:CreativeWork
297 sg:pub.10.1023/a:1023777013659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020945232
298 https://doi.org/10.1023/a:1023777013659
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/sj.onc.1203928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035885592
301 https://doi.org/10.1038/sj.onc.1203928
302 rdf:type schema:CreativeWork
303 grid-institutes:grid.15444.30 schema:alternateName Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
304 Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
305 Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
306 Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
307 schema:name Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
308 Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
309 Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
310 Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
311 Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
312 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...