Paclitaxel-Eluting Polymer Film Reduces Locoregional Recurrence and Improves Survival in a Recurrent Sarcoma Model: A Novel Investigational Therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-01

AUTHORS

Rong Liu, Jesse B. Wolinsky, Paul J. Catalano, Lucian R. Chirieac, Andrew J. Wagner, Mark W. Grinstaff, Yolonda L. Colson, Chandrajit P. Raut

ABSTRACT

BACKGROUND: Locoregional recurrences occur in up to 50% of patients after macroscopically complete (R0/R1) resections of abdominal, pelvic, and retroperitoneal sarcomas. Efficacy of a drug-eluting polymer film in reducing locoregional recurrence rates was assessed in a murine recurrent sarcoma model. METHODS: Poly(glycerol monostearate-co-caprolactone) polymer films were synthesized with and without 300 μg paclitaxel (Pax-film and unloaded film). Cytotoxicity was assessed against CS-1 (human chondrosarcoma) cells in vitro and in vivo in nude mice. Following R0/R1 resection of primary subcutaneous tumors, mice were blindly randomized to: (1) Pax-film implant, (2) unloaded film implant, (3) paclitaxel 300 μg IV (Pax IV), or (4) no other therapy ("untreated"). Locoregional recurrence, overall survival (OS), and tumor mitotic index were evaluated. RESULTS: Pax-films, but not unloaded films, reduced CS-1 viability in vitro for >50 days (P < 0.001). In vivo, locoregional recurrence was observed in 2 of 12 Pax-film mice (17%), 9 of 13 unloaded film mice (69%), 8 of 9 Pax IV mice (89%), and 7 of 8 untreated mice (88%) (P < 0.01). Median OS was 81, 64, 48, and 56 days, respectively. Paclitaxel levels in local tissues were 50- to 300-fold greater in Pax-film mice compared with Pax IV mice. Tumor mitotic index adjacent to Pax-films was significantly lower than adjacent to unloaded films. CONCLUSIONS: Tumor bed implantation of Pax-films after R0/R1 resection is superior to Pax IV as evidenced by reduced locoregional recurrence and improved OS in a murine recurrent sarcoma model. Continuous local drug exposure via polymer films represents a potentially novel approach for treatment of locally aggressive sarcomas. More... »

PAGES

199-206

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-011-1871-4

DOI

http://dx.doi.org/10.1245/s10434-011-1871-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010551047

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21769471


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Phytogenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chondrosarcoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanoparticles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paclitaxel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Therapies, Investigational", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Brigham and Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Department of Surgery, Brigham and Women\u2019s Hospital, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Rong", 
        "id": "sg:person.0611330536.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611330536.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University", 
          "id": "https://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Departments of Chemistry and Biomedical Engineering, Boston University, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolinsky", 
        "givenName": "Jesse B.", 
        "id": "sg:person.01107243137.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107243137.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Catalano", 
        "givenName": "Paul J.", 
        "id": "sg:person.07560202662.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07560202662.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brigham and Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chirieac", 
        "givenName": "Lucian R.", 
        "id": "sg:person.01341315327.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341315327.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wagner", 
        "givenName": "Andrew J.", 
        "id": "sg:person.0657204235.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657204235.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University", 
          "id": "https://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Departments of Chemistry and Biomedical Engineering, Boston University, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grinstaff", 
        "givenName": "Mark W.", 
        "id": "sg:person.0645076472.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645076472.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brigham and Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Department of Surgery, Brigham and Women\u2019s Hospital, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Colson", 
        "givenName": "Yolonda L.", 
        "id": "sg:person.0761325072.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761325072.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brigham and Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Department of Surgery, Brigham and Women\u2019s Hospital, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raut", 
        "givenName": "Chandrajit P.", 
        "id": "sg:person.0724431476.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724431476.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf02573869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001364133", 
          "https://doi.org/10.1007/bf02573869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02573869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001364133", 
          "https://doi.org/10.1007/bf02573869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5829.2009.00182.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002537953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/aso.2004.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004946783", 
          "https://doi.org/10.1245/aso.2004.10.008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/aso.2004.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004946783", 
          "https://doi.org/10.1245/aso.2004.10.008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005472227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2003.08.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005625095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2003.08.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005625095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0856-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006112700", 
          "https://doi.org/10.1245/s10434-009-0856-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0856-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006112700", 
          "https://doi.org/10.1245/s10434-009-0856-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.21.5467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006821566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)90755-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007598090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)90755-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007598090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra041866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008423872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra041866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008423872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011717958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(00)01589-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013074237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(97)08165-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014870691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)60500-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015024356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.18.0802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017397932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.10656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018069483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(94)90395-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019115434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(01)02595-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022468430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.b.30186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025655671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-007-9463-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025743805", 
          "https://doi.org/10.1245/s10434-007-9463-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199502000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026132319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199502000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026132319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1178-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030192673", 
          "https://doi.org/10.1245/s10434-010-1178-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1178-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030192673", 
          "https://doi.org/10.1245/s10434-010-1178-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1995.01430100082016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030909062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2005.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031124000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2007.03.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033849563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02305794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033959892", 
          "https://doi.org/10.1007/bf02305794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02305794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033959892", 
          "https://doi.org/10.1007/bf02305794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-005-4581-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035221843", 
          "https://doi.org/10.1007/s11095-005-4581-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-005-4581-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035221843", 
          "https://doi.org/10.1007/s11095-005-4581-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.20543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040244514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2008.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040593770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/5.2.79", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041423398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00276-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042682468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(94)00341-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045505455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.coc.0000158441.96455.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047812402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.coc.0000158441.96455.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047812402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.coc.0000158441.96455.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047812402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010715)92:2<359::aid-cncr1331>3.0.co;2-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052481310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199809000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199809000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199809000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199809000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.01.143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/030089169908500409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074559034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/030089169908500409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074559034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075250669", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0889-8588(18)30073-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082383417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jjco.a039757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082427984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083223906", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-01", 
    "datePublishedReg": "2012-01-01", 
    "description": "BACKGROUND: Locoregional recurrences occur in up to 50% of patients after macroscopically complete (R0/R1) resections of abdominal, pelvic, and retroperitoneal sarcomas. Efficacy of a drug-eluting polymer film in reducing locoregional recurrence rates was assessed in a murine recurrent sarcoma model.\nMETHODS: Poly(glycerol monostearate-co-caprolactone) polymer films were synthesized with and without 300\u00a0\u03bcg paclitaxel (Pax-film and unloaded film). Cytotoxicity was assessed against CS-1 (human chondrosarcoma) cells in vitro and in vivo in nude mice. Following R0/R1 resection of primary subcutaneous tumors, mice were blindly randomized to: (1) Pax-film implant, (2) unloaded film implant, (3) paclitaxel 300\u00a0\u03bcg IV (Pax IV), or (4) no other therapy (\"untreated\"). Locoregional recurrence, overall survival (OS), and tumor mitotic index were evaluated.\nRESULTS: Pax-films, but not unloaded films, reduced CS-1 viability in vitro for >50\u00a0days (P\u00a0<\u00a00.001). In vivo, locoregional recurrence was observed in 2 of 12 Pax-film mice (17%), 9 of 13 unloaded film mice (69%), 8 of 9 Pax IV mice (89%), and 7 of 8 untreated mice (88%) (P\u00a0<\u00a00.01). Median OS was 81, 64, 48, and 56\u00a0days, respectively. Paclitaxel levels in local tissues were 50- to 300-fold greater in Pax-film mice compared with Pax IV mice. Tumor mitotic index adjacent to Pax-films was significantly lower than adjacent to unloaded films.\nCONCLUSIONS: Tumor bed implantation of Pax-films after R0/R1 resection is superior to Pax IV as evidenced by reduced locoregional recurrence and improved OS in a murine recurrent sarcoma model. Continuous local drug exposure via polymer films represents a potentially novel approach for treatment of locally aggressive sarcomas.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-011-1871-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Paclitaxel-Eluting Polymer Film Reduces Locoregional Recurrence and Improves Survival in a Recurrent Sarcoma Model: A Novel Investigational Therapy", 
    "pagination": "199-206", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3243f09297e254c2c10aebe4c83ffeaf9ffcd2cd640e9d4c5e6d7854e3d040ab"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21769471"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-011-1871-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010551047"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-011-1871-4", 
      "https://app.dimensions.ai/details/publication/pub.1010551047"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000498.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1245/s10434-011-1871-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-1871-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-1871-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-1871-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-1871-4'


 

This table displays all metadata directly associated to this object as RDF triples.

315 TRIPLES      21 PREDICATES      85 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-011-1871-4 schema:about N198d34daa4e04e53b48687271280a4d4
2 N22ae4ef3d93749a18ce678f8b794e946
3 N27d0683469cd49e4ad72dbfc34896097
4 N2adb8b488a994b319aec90864d375454
5 N2cffe3df32484d378494b3eb3aa1e163
6 N38eb06e10edf4a9591e1f9993620c26d
7 N52ba561a9a3741eca1a413983d29b458
8 N707199f4bbb04d19bd2c0d18b100225f
9 Na6789812c92e482ba72435d722376ff0
10 Nc305928f7a86492e86720090cf563e5d
11 Nc8580557a19a4e96a65606194e6050d9
12 Nd098479a8c56468982c4e62601350af3
13 Ne071cfe96fc4409ca2636820e48de560
14 Ne38f8b3821f2439fa41f2ea5169d0e98
15 Ne73194a9cd9a4342b590eb142979d434
16 Nf49a44e0fc994a5fb67a2f80f76a4fec
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N5b283af2fc5d4746bfef25570a144cb9
20 schema:citation sg:pub.10.1007/bf02305794
21 sg:pub.10.1007/bf02573869
22 sg:pub.10.1007/s11095-005-4581-4
23 sg:pub.10.1245/aso.2004.10.008
24 sg:pub.10.1245/s10434-007-9463-z
25 sg:pub.10.1245/s10434-009-0856-z
26 sg:pub.10.1245/s10434-010-1178-x
27 https://app.dimensions.ai/details/publication/pub.1075250669
28 https://app.dimensions.ai/details/publication/pub.1083223906
29 https://doi.org/10.1001/archsurg.1995.01430100082016
30 https://doi.org/10.1002/1097-0142(20010715)92:2<359::aid-cncr1331>3.0.co;2-y
31 https://doi.org/10.1002/cncr.20192
32 https://doi.org/10.1002/cncr.23826
33 https://doi.org/10.1002/jbm.b.30186
34 https://doi.org/10.1002/jso.20543
35 https://doi.org/10.1002/mrm.10656
36 https://doi.org/10.1016/0360-3016(94)00341-h
37 https://doi.org/10.1016/0360-3016(94)90395-6
38 https://doi.org/10.1016/j.bcp.2003.08.033
39 https://doi.org/10.1016/j.biomaterials.2007.03.022
40 https://doi.org/10.1016/j.ejso.2005.04.010
41 https://doi.org/10.1016/j.ejso.2008.11.003
42 https://doi.org/10.1016/s0140-6736(09)60500-6
43 https://doi.org/10.1016/s0140-6736(95)90755-6
44 https://doi.org/10.1016/s0140-6736(97)08165-8
45 https://doi.org/10.1016/s0360-3016(00)01589-3
46 https://doi.org/10.1016/s0360-3016(01)02595-0
47 https://doi.org/10.1016/s0889-8588(18)30073-x
48 https://doi.org/10.1016/s1535-6108(03)00276-9
49 https://doi.org/10.1056/nejmra041866
50 https://doi.org/10.1093/neuonc/5.2.79
51 https://doi.org/10.1093/oxfordjournals.jjco.a039757
52 https://doi.org/10.1097/00000658-199502000-00009
53 https://doi.org/10.1097/00000658-199809000-00008
54 https://doi.org/10.1097/01.coc.0000158441.96455.31
55 https://doi.org/10.1111/j.1476-5829.2009.00182.x
56 https://doi.org/10.1177/030089169908500409
57 https://doi.org/10.1200/jco.2003.01.143
58 https://doi.org/10.1200/jco.2008.18.0802
59 https://doi.org/10.1200/jco.2008.21.5467
60 schema:datePublished 2012-01
61 schema:datePublishedReg 2012-01-01
62 schema:description BACKGROUND: Locoregional recurrences occur in up to 50% of patients after macroscopically complete (R0/R1) resections of abdominal, pelvic, and retroperitoneal sarcomas. Efficacy of a drug-eluting polymer film in reducing locoregional recurrence rates was assessed in a murine recurrent sarcoma model. METHODS: Poly(glycerol monostearate-co-caprolactone) polymer films were synthesized with and without 300 μg paclitaxel (Pax-film and unloaded film). Cytotoxicity was assessed against CS-1 (human chondrosarcoma) cells in vitro and in vivo in nude mice. Following R0/R1 resection of primary subcutaneous tumors, mice were blindly randomized to: (1) Pax-film implant, (2) unloaded film implant, (3) paclitaxel 300 μg IV (Pax IV), or (4) no other therapy ("untreated"). Locoregional recurrence, overall survival (OS), and tumor mitotic index were evaluated. RESULTS: Pax-films, but not unloaded films, reduced CS-1 viability in vitro for >50 days (P < 0.001). In vivo, locoregional recurrence was observed in 2 of 12 Pax-film mice (17%), 9 of 13 unloaded film mice (69%), 8 of 9 Pax IV mice (89%), and 7 of 8 untreated mice (88%) (P < 0.01). Median OS was 81, 64, 48, and 56 days, respectively. Paclitaxel levels in local tissues were 50- to 300-fold greater in Pax-film mice compared with Pax IV mice. Tumor mitotic index adjacent to Pax-films was significantly lower than adjacent to unloaded films. CONCLUSIONS: Tumor bed implantation of Pax-films after R0/R1 resection is superior to Pax IV as evidenced by reduced locoregional recurrence and improved OS in a murine recurrent sarcoma model. Continuous local drug exposure via polymer films represents a potentially novel approach for treatment of locally aggressive sarcomas.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree false
66 schema:isPartOf N11fb35603d9441c5a6d31ebd0ab63133
67 N587ad127a10543e0b9d8d0f60fc59392
68 sg:journal.1105545
69 schema:name Paclitaxel-Eluting Polymer Film Reduces Locoregional Recurrence and Improves Survival in a Recurrent Sarcoma Model: A Novel Investigational Therapy
70 schema:pagination 199-206
71 schema:productId N2e68c75e13c54a0ca398e99a33681f6c
72 N37fde6a550bf41c0897062bee3d556b9
73 N44eaacfbadd942c0bd89acc327062282
74 Nc6218cee7baa4793bd658d9b104eb229
75 Nce917c9262ed4ddaba51d8bad03cf1b2
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010551047
77 https://doi.org/10.1245/s10434-011-1871-4
78 schema:sdDatePublished 2019-04-11T00:13
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher N43862870906e4d6dbf85e14e7c6e17a0
81 schema:url http://link.springer.com/10.1245/s10434-011-1871-4
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N11fb35603d9441c5a6d31ebd0ab63133 schema:issueNumber 1
86 rdf:type schema:PublicationIssue
87 N198d34daa4e04e53b48687271280a4d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Animals
89 rdf:type schema:DefinedTerm
90 N22ae4ef3d93749a18ce678f8b794e946 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Xenograft Model Antitumor Assays
92 rdf:type schema:DefinedTerm
93 N27d0683469cd49e4ad72dbfc34896097 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Polymers
95 rdf:type schema:DefinedTerm
96 N2adb8b488a994b319aec90864d375454 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Chondrosarcoma
98 rdf:type schema:DefinedTerm
99 N2cffe3df32484d378494b3eb3aa1e163 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Survival Rate
101 rdf:type schema:DefinedTerm
102 N2e68c75e13c54a0ca398e99a33681f6c schema:name dimensions_id
103 schema:value pub.1010551047
104 rdf:type schema:PropertyValue
105 N37fde6a550bf41c0897062bee3d556b9 schema:name nlm_unique_id
106 schema:value 9420840
107 rdf:type schema:PropertyValue
108 N38eb06e10edf4a9591e1f9993620c26d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Female
110 rdf:type schema:DefinedTerm
111 N3b3911b7a71244a5bf33343cd0387a79 rdf:first sg:person.0645076472.31
112 rdf:rest Nde210c7b793f41af8b30716aa4a36b9c
113 N43862870906e4d6dbf85e14e7c6e17a0 schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 N44eaacfbadd942c0bd89acc327062282 schema:name readcube_id
116 schema:value 3243f09297e254c2c10aebe4c83ffeaf9ffcd2cd640e9d4c5e6d7854e3d040ab
117 rdf:type schema:PropertyValue
118 N52ba561a9a3741eca1a413983d29b458 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Mice
120 rdf:type schema:DefinedTerm
121 N587ad127a10543e0b9d8d0f60fc59392 schema:volumeNumber 19
122 rdf:type schema:PublicationVolume
123 N5b283af2fc5d4746bfef25570a144cb9 rdf:first sg:person.0611330536.26
124 rdf:rest Nebdc41c15650437cb5584fde12729bec
125 N707199f4bbb04d19bd2c0d18b100225f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Tumor Cells, Cultured
127 rdf:type schema:DefinedTerm
128 N984958e77a6e4c7196421b611639b8a4 rdf:first sg:person.01341315327.06
129 rdf:rest Nb09ce1c7e2cb431a8bf9a18881bc797d
130 Na6789812c92e482ba72435d722376ff0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 Nb09ce1c7e2cb431a8bf9a18881bc797d rdf:first sg:person.0657204235.11
134 rdf:rest N3b3911b7a71244a5bf33343cd0387a79
135 Nc0a97e6958e6440ca060e0ec83f12a62 rdf:first sg:person.0724431476.35
136 rdf:rest rdf:nil
137 Nc305928f7a86492e86720090cf563e5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Nanoparticles
139 rdf:type schema:DefinedTerm
140 Nc6218cee7baa4793bd658d9b104eb229 schema:name doi
141 schema:value 10.1245/s10434-011-1871-4
142 rdf:type schema:PropertyValue
143 Nc8580557a19a4e96a65606194e6050d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Disease Models, Animal
145 rdf:type schema:DefinedTerm
146 Nce70a079d9e143e4957261486d387ee5 rdf:first sg:person.07560202662.03
147 rdf:rest N984958e77a6e4c7196421b611639b8a4
148 Nce917c9262ed4ddaba51d8bad03cf1b2 schema:name pubmed_id
149 schema:value 21769471
150 rdf:type schema:PropertyValue
151 Nd098479a8c56468982c4e62601350af3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Paclitaxel
153 rdf:type schema:DefinedTerm
154 Nde210c7b793f41af8b30716aa4a36b9c rdf:first sg:person.0761325072.24
155 rdf:rest Nc0a97e6958e6440ca060e0ec83f12a62
156 Ne071cfe96fc4409ca2636820e48de560 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Antineoplastic Agents, Phytogenic
158 rdf:type schema:DefinedTerm
159 Ne38f8b3821f2439fa41f2ea5169d0e98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Neoplasm Recurrence, Local
161 rdf:type schema:DefinedTerm
162 Ne73194a9cd9a4342b590eb142979d434 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Therapies, Investigational
164 rdf:type schema:DefinedTerm
165 Nebdc41c15650437cb5584fde12729bec rdf:first sg:person.01107243137.95
166 rdf:rest Nce70a079d9e143e4957261486d387ee5
167 Nf49a44e0fc994a5fb67a2f80f76a4fec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Mice, Nude
169 rdf:type schema:DefinedTerm
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
174 schema:name Oncology and Carcinogenesis
175 rdf:type schema:DefinedTerm
176 sg:journal.1105545 schema:issn 1068-9265
177 1534-4681
178 schema:name Annals of Surgical Oncology
179 rdf:type schema:Periodical
180 sg:person.01107243137.95 schema:affiliation https://www.grid.ac/institutes/grid.189504.1
181 schema:familyName Wolinsky
182 schema:givenName Jesse B.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107243137.95
184 rdf:type schema:Person
185 sg:person.01341315327.06 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
186 schema:familyName Chirieac
187 schema:givenName Lucian R.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341315327.06
189 rdf:type schema:Person
190 sg:person.0611330536.26 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
191 schema:familyName Liu
192 schema:givenName Rong
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611330536.26
194 rdf:type schema:Person
195 sg:person.0645076472.31 schema:affiliation https://www.grid.ac/institutes/grid.189504.1
196 schema:familyName Grinstaff
197 schema:givenName Mark W.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645076472.31
199 rdf:type schema:Person
200 sg:person.0657204235.11 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
201 schema:familyName Wagner
202 schema:givenName Andrew J.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657204235.11
204 rdf:type schema:Person
205 sg:person.0724431476.35 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
206 schema:familyName Raut
207 schema:givenName Chandrajit P.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724431476.35
209 rdf:type schema:Person
210 sg:person.07560202662.03 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
211 schema:familyName Catalano
212 schema:givenName Paul J.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07560202662.03
214 rdf:type schema:Person
215 sg:person.0761325072.24 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
216 schema:familyName Colson
217 schema:givenName Yolonda L.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761325072.24
219 rdf:type schema:Person
220 sg:pub.10.1007/bf02305794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033959892
221 https://doi.org/10.1007/bf02305794
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/bf02573869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001364133
224 https://doi.org/10.1007/bf02573869
225 rdf:type schema:CreativeWork
226 sg:pub.10.1007/s11095-005-4581-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035221843
227 https://doi.org/10.1007/s11095-005-4581-4
228 rdf:type schema:CreativeWork
229 sg:pub.10.1245/aso.2004.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004946783
230 https://doi.org/10.1245/aso.2004.10.008
231 rdf:type schema:CreativeWork
232 sg:pub.10.1245/s10434-007-9463-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1025743805
233 https://doi.org/10.1245/s10434-007-9463-z
234 rdf:type schema:CreativeWork
235 sg:pub.10.1245/s10434-009-0856-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1006112700
236 https://doi.org/10.1245/s10434-009-0856-z
237 rdf:type schema:CreativeWork
238 sg:pub.10.1245/s10434-010-1178-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030192673
239 https://doi.org/10.1245/s10434-010-1178-x
240 rdf:type schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1075250669 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1083223906 schema:CreativeWork
243 https://doi.org/10.1001/archsurg.1995.01430100082016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030909062
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/1097-0142(20010715)92:2<359::aid-cncr1331>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1052481310
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/cncr.20192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011717958
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/cncr.23826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005472227
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/jbm.b.30186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025655671
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/jso.20543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040244514
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1002/mrm.10656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018069483
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/0360-3016(94)00341-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1045505455
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/0360-3016(94)90395-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019115434
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.bcp.2003.08.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005625095
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.biomaterials.2007.03.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033849563
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.ejso.2005.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031124000
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.ejso.2008.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040593770
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0140-6736(09)60500-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015024356
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0140-6736(95)90755-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007598090
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0140-6736(97)08165-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014870691
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0360-3016(00)01589-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013074237
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0360-3016(01)02595-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022468430
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0889-8588(18)30073-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082383417
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s1535-6108(03)00276-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042682468
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1056/nejmra041866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008423872
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1093/neuonc/5.2.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041423398
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1093/oxfordjournals.jjco.a039757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082427984
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1097/00000658-199502000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026132319
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1097/00000658-199809000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134859
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1097/01.coc.0000158441.96455.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047812402
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1111/j.1476-5829.2009.00182.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002537953
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1177/030089169908500409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074559034
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1200/jco.2003.01.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203301
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1200/jco.2008.18.0802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017397932
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1200/jco.2008.21.5467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006821566
304 rdf:type schema:CreativeWork
305 https://www.grid.ac/institutes/grid.189504.1 schema:alternateName Boston University
306 schema:name Departments of Chemistry and Biomedical Engineering, Boston University, Boston, MA, USA
307 rdf:type schema:Organization
308 https://www.grid.ac/institutes/grid.62560.37 schema:alternateName Brigham and Women's Hospital
309 schema:name Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA
310 Department of Surgery, Brigham and Women’s Hospital, Boston, MA, USA
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.65499.37 schema:alternateName Dana–Farber Cancer Institute
313 schema:name Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA
314 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
315 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...