Diagnosis, Management, and Outcome of Patients with Dedifferentiated Liposarcoma Systemic Metastasis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12

AUTHORS

Markus P. Ghadimi, Tariq Al-Zaid, John Madewell, Tingsheng Peng, Chiara Colombo, Aviad Hoffman, Chad J. Creighton, Yiqun Zhang, Anna Zhang, Alexander J. Lazar, Raphael E. Pollock, Dina Lev

ABSTRACT

BACKGROUND: Dedifferentiated liposarcomas (DDLPSs) result in worse patient outcomes than well-differentiated tumors despite shared molecular derangements. Prevalence and pattern of DDLPS systemic metastases have not been extensively reported; information regarding diagnosis, treatment, and outcomes of metastatic DDLPS patients is limited. Our study seeks to address this knowledge gap. METHODS: Metastatic patients were identified from a clinical database consisting of 277 DDLPS patients treated at the University of Texas M D Anderson Cancer Center (UTMDACC) (1993-2010). Only patients with radiologically demonstrable distant metastases were included. Patient, tumor, treatment, and outcome variables were recorded. Available imaging studies and tumor FFPE blocks were assessed. RESULTS: A total of 40 patients were identified, translating into a DDLPS metastatic rate of 14% (17% for de novo DDLPS and 9% for secondary dedifferentiation). The average patient age was 61 years with a male predilection. The retroperitoneum and lungs were the most common primary and metastatic tumor sites. Any of the 4 described DDLPS morphological subtypes harbored metastatic potential; MFH/UPS-like morphology was the most common. The median time from primary diagnosis to metastasis was 25 months; more than 50% of metastases developed without local failure. The median survival of metastatic patients was 11.5 months; the 5-year DSS was 5.2%. Patients amenable to complete surgical extirpation (n = 14) faired significantly better (P = .001; log rank). CONCLUSIONS: Metastatic spread is an ominous consequence of DDLPS, especially regarding de novo tumors. Occurring relatively early in the course of disease and exhibiting a pulmonary predilection, these lesions are highly aggressive and commonly fatal. Further studies to identify metastatic biomarkers are needed. More... »

PAGES

3762-3770

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-011-1794-0

DOI

http://dx.doi.org/10.1245/s10434-011-1794-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000475499

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21614627


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