Presence of Pancreatic Intraepithelial Neoplasia in the Pancreatic Transection Margin does not Influence Outcome in Patients with R0 Resected Pancreatic ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-05-03

AUTHORS

Hanno Matthaei, Seung-Mo Hong, Skye C. Mayo, Marco dal Molin, Kelly Olino, Raghunandan Venkat, Michael Goggins, Joseph M. Herman, Barish H. Edil, Christopher L. Wolfgang, John L. Cameron, Richard D. Schulick, Anirban Maitra, Ralph H. Hruban

ABSTRACT

BackgroundMargin status is one of the strongest prognosticators after resection of pancreatic ductal adenocarcinoma (PDAC). The clinical significance of pancreatic intraepithelial neoplasia (PanIN) at a surgical margin has not been established.MethodsA total of 208 patients who underwent R0 resection for PDAC between 2004 and 2008 were selected. Intraoperative frozen section slides containing the final pancreatic parenchymal transection margin were evaluated for presence or absence, number, and grade of PanINs. Data were compared to clinicopathologic factors, including patient survival.ResultsPanIN lesions were present in margins in 107 of 208 patients (51.4%). Median number of PanINs per pancreatic resection margin was 1 (range, 1–11). A total of 72 patients had PanIN-1 (34.6%), 44 had PanIN-2 (21.1%), and 16 had PanIN-3 (7.2%) at their margin. Overall median survival was 17.9 (95% confidence interval, 14–21.9) months. Neither the presence nor absence of PanIN nor histological grade had any significant correlation with important clinicopathologic characteristics. There were no significant survival differences between patients with or without PanIN lesions at the resection margin or among patients with PanIN-3 (carcinoma in situ) versus lower PanIN grades. However, patients with R1 resection had a significantly worse outcome compared with patients without invasive cancer at a margin irrespective of the presence of PanIN (P = 0.02).ConclusionsThe presence of PanINs at a resection margin does not affect survival in patients who undergo R0 resection for PDAC. These results have significant clinical implications for surgeons, because no additional resection seems to be indicated when intraoperative frozen sections reveal even high-grade PanIN lesions. More... »

PAGES

3493-3499

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-011-1745-9

DOI

http://dx.doi.org/10.1245/s10434-011-1745-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009849820

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21537863


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma in Situ", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Pancreatic Ductal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Frozen Sections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, The Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Pathology, The Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matthaei", 
        "givenName": "Hanno", 
        "id": "sg:person.0716474325.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716474325.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, The Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Pathology, The Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Seung-Mo", 
        "id": "sg:person.013167714057.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013167714057.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayo", 
        "givenName": "Skye C.", 
        "id": "sg:person.01321030726.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321030726.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, The Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Pathology, The Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "dal Molin", 
        "givenName": "Marco", 
        "id": "sg:person.01175530044.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175530044.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olino", 
        "givenName": "Kelly", 
        "id": "sg:person.01127457063.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127457063.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Venkat", 
        "givenName": "Raghunandan", 
        "id": "sg:person.01036637517.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036637517.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, The Johns Hopkins University, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Pathology, The Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Department of Oncology, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Medicine, The Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goggins", 
        "givenName": "Michael", 
        "id": "sg:person.016071157737.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016071157737.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiation Oncology, The Johns Hopkins University, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Radiation Oncology, The Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herman", 
        "givenName": "Joseph M.", 
        "id": "sg:person.015567603732.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015567603732.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Edil", 
        "givenName": "Barish H.", 
        "id": "sg:person.01116422516.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116422516.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolfgang", 
        "givenName": "Christopher L.", 
        "id": "sg:person.013555514237.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013555514237.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cameron", 
        "givenName": "John L.", 
        "id": "sg:person.011317137122.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011317137122.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, The Johns Hopkins University, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Oncology, The Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schulick", 
        "givenName": "Richard D.", 
        "id": "sg:person.013701724657.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013701724657.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, The Johns Hopkins University, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Pathology, The Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Department of Oncology, The Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maitra", 
        "givenName": "Anirban", 
        "id": "sg:person.01246576774.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246576774.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, The Johns Hopkins University, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Pathology, The Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Department of Oncology, The Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hruban", 
        "givenName": "Ralph H.", 
        "id": "sg:person.07624111077.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07624111077.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1245/s10434-008-9839-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052637528", 
          "https://doi.org/10.1245/s10434-008-9839-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-009-0845-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028064850", 
          "https://doi.org/10.1007/s11605-009-0845-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029325111", 
          "https://doi.org/10.1038/nature09515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-6694-0_19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044030029", 
          "https://doi.org/10.1007/978-1-4419-6694-0_19"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-05-03", 
    "datePublishedReg": "2011-05-03", 
    "description": "BackgroundMargin status is one of the strongest prognosticators after resection of pancreatic ductal adenocarcinoma (PDAC). The clinical significance of pancreatic intraepithelial neoplasia (PanIN) at a surgical margin has not been established.MethodsA total of 208 patients who underwent R0 resection for PDAC between 2004 and 2008 were selected. Intraoperative frozen section slides containing the final pancreatic parenchymal transection margin were evaluated for presence or absence, number, and grade of PanINs. Data were compared to clinicopathologic factors, including patient survival.ResultsPanIN lesions were present in margins in 107 of 208 patients (51.4%). Median number of PanINs per pancreatic resection margin was 1 (range, 1\u201311). A total of 72 patients had PanIN-1 (34.6%), 44 had PanIN-2 (21.1%), and 16 had PanIN-3 (7.2%) at their margin. Overall median survival was 17.9 (95% confidence interval, 14\u201321.9) months. Neither the presence nor absence of PanIN nor histological grade had any significant correlation with important clinicopathologic characteristics. There were no significant survival differences between patients with or without PanIN lesions at the resection margin or among patients with PanIN-3 (carcinoma in situ) versus lower PanIN grades. However, patients with R1 resection had a significantly worse outcome compared with patients without invasive cancer at a margin irrespective of the presence of PanIN (P\u00a0=\u00a00.02).ConclusionsThe presence of PanINs at a resection margin does not affect survival in patients who undergo R0 resection for PDAC. These results have significant clinical implications for surgeons, because no additional resection seems to be indicated when intraoperative frozen sections reveal even high-grade PanIN lesions.", 
    "genre": "article", 
    "id": "sg:pub.10.1245/s10434-011-1745-9", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440141", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "pancreatic ductal adenocarcinoma", 
      "pancreatic intraepithelial neoplasia", 
      "resection margins", 
      "transection margin", 
      "R0 resection", 
      "intraepithelial neoplasia", 
      "PanIN lesions", 
      "PanIN-3", 
      "high-grade PanIN lesions", 
      "pancreatic resection margin", 
      "important clinicopathologic characteristics", 
      "presence of PanIN", 
      "pancreatic transection margin", 
      "overall median survival", 
      "significant survival difference", 
      "intraoperative frozen section", 
      "significant clinical implications", 
      "grades of PanINs", 
      "R1 resection", 
      "strong prognosticator", 
      "median survival", 
      "clinicopathologic factors", 
      "clinicopathologic characteristics", 
      "additional resection", 
      "surgical margins", 
      "patient survival", 
      "histological grade", 
      "invasive cancer", 
      "survival differences", 
      "worse outcomes", 
      "pancreatic cancer", 
      "ductal adenocarcinoma", 
      "frozen section slides", 
      "clinical significance", 
      "median number", 
      "PanIN-2", 
      "resection", 
      "patients", 
      "PanIN-1", 
      "PanIN grade", 
      "clinical implications", 
      "frozen sections", 
      "ConclusionsThe presence", 
      "PanIN", 
      "lesions", 
      "section slides", 
      "significant correlation", 
      "survival", 
      "neoplasia", 
      "cancer", 
      "outcomes", 
      "total", 
      "grade", 
      "prognosticator", 
      "adenocarcinoma", 
      "surgeons", 
      "months", 
      "absence", 
      "presence", 
      "status", 
      "margin", 
      "factors", 
      "differences", 
      "significance", 
      "number", 
      "slides", 
      "correlation", 
      "data", 
      "R0", 
      "implications", 
      "sections", 
      "results", 
      "characteristics"
    ], 
    "name": "Presence of Pancreatic Intraepithelial Neoplasia in the Pancreatic Transection Margin does not Influence Outcome in Patients with R0 Resected Pancreatic Cancer", 
    "pagination": "3493-3499", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009849820"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-011-1745-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21537863"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-011-1745-9", 
      "https://app.dimensions.ai/details/publication/pub.1009849820"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_548.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1245/s10434-011-1745-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-1745-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-1745-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-1745-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-011-1745-9'


 

This table displays all metadata directly associated to this object as RDF triples.

316 TRIPLES      21 PREDICATES      118 URIs      106 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-011-1745-9 schema:about N012982d85d3844f2a768f725fddf2944
2 N0530b1072b0a43cb888df085050632a8
3 N0b6f06565bd149ca9bda14e172757768
4 N20fc27ad93204e139b28d0e7089d7205
5 N2635d4e990ec438e81c016a46bda3bb5
6 N4861ee9bfbb5456b97795d9c6977aed8
7 N612a68cafb2640a2a01c360a5fbb0d21
8 N65e86d62a0b44c729acb4d00f6f1c43f
9 N8e4846f075ea4e6c82552db26bde1ad9
10 N9715372c021c4128977da55979c34d68
11 N979a1ff944974958ad77ace6d7aaf0d4
12 Nad076d20ae7849319e0891bdfe22c130
13 Ndeaa2444985d48e79d762a2e2b5368a1
14 Ne9457cc573ef4e5e9ed4e4dd08732233
15 Nfba4126ff4c1481a83f4110a7da33d9a
16 Nfdc86855978745c989d1db284ffa62d4
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N12b2461a616541478d0b991f7dac99f6
20 schema:citation sg:pub.10.1007/978-1-4419-6694-0_19
21 sg:pub.10.1007/s11605-009-0845-3
22 sg:pub.10.1038/nature09515
23 sg:pub.10.1245/s10434-008-9839-8
24 schema:datePublished 2011-05-03
25 schema:datePublishedReg 2011-05-03
26 schema:description BackgroundMargin status is one of the strongest prognosticators after resection of pancreatic ductal adenocarcinoma (PDAC). The clinical significance of pancreatic intraepithelial neoplasia (PanIN) at a surgical margin has not been established.MethodsA total of 208 patients who underwent R0 resection for PDAC between 2004 and 2008 were selected. Intraoperative frozen section slides containing the final pancreatic parenchymal transection margin were evaluated for presence or absence, number, and grade of PanINs. Data were compared to clinicopathologic factors, including patient survival.ResultsPanIN lesions were present in margins in 107 of 208 patients (51.4%). Median number of PanINs per pancreatic resection margin was 1 (range, 1–11). A total of 72 patients had PanIN-1 (34.6%), 44 had PanIN-2 (21.1%), and 16 had PanIN-3 (7.2%) at their margin. Overall median survival was 17.9 (95% confidence interval, 14–21.9) months. Neither the presence nor absence of PanIN nor histological grade had any significant correlation with important clinicopathologic characteristics. There were no significant survival differences between patients with or without PanIN lesions at the resection margin or among patients with PanIN-3 (carcinoma in situ) versus lower PanIN grades. However, patients with R1 resection had a significantly worse outcome compared with patients without invasive cancer at a margin irrespective of the presence of PanIN (P = 0.02).ConclusionsThe presence of PanINs at a resection margin does not affect survival in patients who undergo R0 resection for PDAC. These results have significant clinical implications for surgeons, because no additional resection seems to be indicated when intraoperative frozen sections reveal even high-grade PanIN lesions.
27 schema:genre article
28 schema:isAccessibleForFree true
29 schema:isPartOf N12c979c6f3f24503a47c8125fc1dec7e
30 N273dc2e262bc42f286f403c19413b399
31 sg:journal.1105545
32 schema:keywords ConclusionsThe presence
33 PanIN
34 PanIN grade
35 PanIN lesions
36 PanIN-1
37 PanIN-2
38 PanIN-3
39 R0
40 R0 resection
41 R1 resection
42 absence
43 additional resection
44 adenocarcinoma
45 cancer
46 characteristics
47 clinical implications
48 clinical significance
49 clinicopathologic characteristics
50 clinicopathologic factors
51 correlation
52 data
53 differences
54 ductal adenocarcinoma
55 factors
56 frozen section slides
57 frozen sections
58 grade
59 grades of PanINs
60 high-grade PanIN lesions
61 histological grade
62 implications
63 important clinicopathologic characteristics
64 intraepithelial neoplasia
65 intraoperative frozen section
66 invasive cancer
67 lesions
68 margin
69 median number
70 median survival
71 months
72 neoplasia
73 number
74 outcomes
75 overall median survival
76 pancreatic cancer
77 pancreatic ductal adenocarcinoma
78 pancreatic intraepithelial neoplasia
79 pancreatic resection margin
80 pancreatic transection margin
81 patient survival
82 patients
83 presence
84 presence of PanIN
85 prognosticator
86 resection
87 resection margins
88 results
89 section slides
90 sections
91 significance
92 significant clinical implications
93 significant correlation
94 significant survival difference
95 slides
96 status
97 strong prognosticator
98 surgeons
99 surgical margins
100 survival
101 survival differences
102 total
103 transection margin
104 worse outcomes
105 schema:name Presence of Pancreatic Intraepithelial Neoplasia in the Pancreatic Transection Margin does not Influence Outcome in Patients with R0 Resected Pancreatic Cancer
106 schema:pagination 3493-3499
107 schema:productId N6f6b130e262c4a45a34f9f4640372ff8
108 Ndf79da33c124497cb49e543cc089821c
109 Ndfd5d828fb7e4f958b173b38c5d87380
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009849820
111 https://doi.org/10.1245/s10434-011-1745-9
112 schema:sdDatePublished 2022-11-24T20:55
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher Ncec8d4c11d754a20b566f84a701c8ec7
115 schema:url https://doi.org/10.1245/s10434-011-1745-9
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N012982d85d3844f2a768f725fddf2944 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Pancreatic Neoplasms
121 rdf:type schema:DefinedTerm
122 N04e0bab3c8ab478884c8a22d6a968eb7 rdf:first sg:person.01246576774.91
123 rdf:rest N3de714c822fc4083a8a76c6c609c067d
124 N0530b1072b0a43cb888df085050632a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Male
126 rdf:type schema:DefinedTerm
127 N0b6f06565bd149ca9bda14e172757768 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Neoplasm Recurrence, Local
129 rdf:type schema:DefinedTerm
130 N0df9970a30a245e0bf616409177cf634 rdf:first sg:person.01127457063.99
131 rdf:rest N147997c121d04f67bc7b09fcea564385
132 N12b2461a616541478d0b991f7dac99f6 rdf:first sg:person.0716474325.38
133 rdf:rest Nfa842e11649c4377950c817c2d2a04b3
134 N12c979c6f3f24503a47c8125fc1dec7e schema:volumeNumber 18
135 rdf:type schema:PublicationVolume
136 N147997c121d04f67bc7b09fcea564385 rdf:first sg:person.01036637517.81
137 rdf:rest N9308167d99584e52b85d005d102e3dc8
138 N20fc27ad93204e139b28d0e7089d7205 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Frozen Sections
140 rdf:type schema:DefinedTerm
141 N2635d4e990ec438e81c016a46bda3bb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Carcinoma, Pancreatic Ductal
143 rdf:type schema:DefinedTerm
144 N273dc2e262bc42f286f403c19413b399 schema:issueNumber 12
145 rdf:type schema:PublicationIssue
146 N3cd1a3d72c944e18b6f017be176268d6 rdf:first sg:person.013555514237.73
147 rdf:rest N8ce5363ee1c5405b83c05e87d295c2d5
148 N3de714c822fc4083a8a76c6c609c067d rdf:first sg:person.07624111077.08
149 rdf:rest rdf:nil
150 N440c50f1b2254c7189ad35c87cfa9b55 rdf:first sg:person.013701724657.77
151 rdf:rest N04e0bab3c8ab478884c8a22d6a968eb7
152 N4861ee9bfbb5456b97795d9c6977aed8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Prognosis
154 rdf:type schema:DefinedTerm
155 N4a7cb2e93aeb48a9b01bf99197b3d3b7 rdf:first sg:person.015567603732.54
156 rdf:rest Nc131b584f41144f680bd190226a0d7fe
157 N612a68cafb2640a2a01c360a5fbb0d21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Middle Aged
159 rdf:type schema:DefinedTerm
160 N65e86d62a0b44c729acb4d00f6f1c43f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Carcinoma in Situ
162 rdf:type schema:DefinedTerm
163 N6f6b130e262c4a45a34f9f4640372ff8 schema:name doi
164 schema:value 10.1245/s10434-011-1745-9
165 rdf:type schema:PropertyValue
166 N8ce5363ee1c5405b83c05e87d295c2d5 rdf:first sg:person.011317137122.71
167 rdf:rest N440c50f1b2254c7189ad35c87cfa9b55
168 N8e4846f075ea4e6c82552db26bde1ad9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Neoplasm Staging
170 rdf:type schema:DefinedTerm
171 N9308167d99584e52b85d005d102e3dc8 rdf:first sg:person.016071157737.75
172 rdf:rest N4a7cb2e93aeb48a9b01bf99197b3d3b7
173 N9715372c021c4128977da55979c34d68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Follow-Up Studies
175 rdf:type schema:DefinedTerm
176 N979a1ff944974958ad77ace6d7aaf0d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Survival Rate
178 rdf:type schema:DefinedTerm
179 Nad076d20ae7849319e0891bdfe22c130 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Lymphatic Metastasis
181 rdf:type schema:DefinedTerm
182 Nc131b584f41144f680bd190226a0d7fe rdf:first sg:person.01116422516.18
183 rdf:rest N3cd1a3d72c944e18b6f017be176268d6
184 Ncec8d4c11d754a20b566f84a701c8ec7 schema:name Springer Nature - SN SciGraph project
185 rdf:type schema:Organization
186 Nde4a0fc805524abb86e3914ebadf81cf rdf:first sg:person.01321030726.16
187 rdf:rest Nf289e934e0314a978b7245ff8e89847e
188 Ndeaa2444985d48e79d762a2e2b5368a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Female
190 rdf:type schema:DefinedTerm
191 Ndf79da33c124497cb49e543cc089821c schema:name pubmed_id
192 schema:value 21537863
193 rdf:type schema:PropertyValue
194 Ndfd5d828fb7e4f958b173b38c5d87380 schema:name dimensions_id
195 schema:value pub.1009849820
196 rdf:type schema:PropertyValue
197 Ne9457cc573ef4e5e9ed4e4dd08732233 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Aged
199 rdf:type schema:DefinedTerm
200 Nf289e934e0314a978b7245ff8e89847e rdf:first sg:person.01175530044.51
201 rdf:rest N0df9970a30a245e0bf616409177cf634
202 Nfa842e11649c4377950c817c2d2a04b3 rdf:first sg:person.013167714057.20
203 rdf:rest Nde4a0fc805524abb86e3914ebadf81cf
204 Nfba4126ff4c1481a83f4110a7da33d9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Humans
206 rdf:type schema:DefinedTerm
207 Nfdc86855978745c989d1db284ffa62d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Prospective Studies
209 rdf:type schema:DefinedTerm
210 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
211 schema:name Medical and Health Sciences
212 rdf:type schema:DefinedTerm
213 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
214 schema:name Oncology and Carcinogenesis
215 rdf:type schema:DefinedTerm
216 sg:grant.2440141 http://pending.schema.org/fundedItem sg:pub.10.1245/s10434-011-1745-9
217 rdf:type schema:MonetaryGrant
218 sg:journal.1105545 schema:issn 1068-9265
219 1534-4681
220 schema:name Annals of Surgical Oncology
221 schema:publisher Springer Nature
222 rdf:type schema:Periodical
223 sg:person.01036637517.81 schema:affiliation grid-institutes:grid.21107.35
224 schema:familyName Venkat
225 schema:givenName Raghunandan
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036637517.81
227 rdf:type schema:Person
228 sg:person.01116422516.18 schema:affiliation grid-institutes:grid.21107.35
229 schema:familyName Edil
230 schema:givenName Barish H.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116422516.18
232 rdf:type schema:Person
233 sg:person.01127457063.99 schema:affiliation grid-institutes:grid.21107.35
234 schema:familyName Olino
235 schema:givenName Kelly
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127457063.99
237 rdf:type schema:Person
238 sg:person.011317137122.71 schema:affiliation grid-institutes:grid.21107.35
239 schema:familyName Cameron
240 schema:givenName John L.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011317137122.71
242 rdf:type schema:Person
243 sg:person.01175530044.51 schema:affiliation grid-institutes:grid.21107.35
244 schema:familyName dal Molin
245 schema:givenName Marco
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175530044.51
247 rdf:type schema:Person
248 sg:person.01246576774.91 schema:affiliation grid-institutes:grid.21107.35
249 schema:familyName Maitra
250 schema:givenName Anirban
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246576774.91
252 rdf:type schema:Person
253 sg:person.013167714057.20 schema:affiliation grid-institutes:grid.21107.35
254 schema:familyName Hong
255 schema:givenName Seung-Mo
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013167714057.20
257 rdf:type schema:Person
258 sg:person.01321030726.16 schema:affiliation grid-institutes:grid.21107.35
259 schema:familyName Mayo
260 schema:givenName Skye C.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321030726.16
262 rdf:type schema:Person
263 sg:person.013555514237.73 schema:affiliation grid-institutes:grid.21107.35
264 schema:familyName Wolfgang
265 schema:givenName Christopher L.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013555514237.73
267 rdf:type schema:Person
268 sg:person.013701724657.77 schema:affiliation grid-institutes:grid.21107.35
269 schema:familyName Schulick
270 schema:givenName Richard D.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013701724657.77
272 rdf:type schema:Person
273 sg:person.015567603732.54 schema:affiliation grid-institutes:grid.21107.35
274 schema:familyName Herman
275 schema:givenName Joseph M.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015567603732.54
277 rdf:type schema:Person
278 sg:person.016071157737.75 schema:affiliation grid-institutes:grid.21107.35
279 schema:familyName Goggins
280 schema:givenName Michael
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016071157737.75
282 rdf:type schema:Person
283 sg:person.0716474325.38 schema:affiliation grid-institutes:grid.21107.35
284 schema:familyName Matthaei
285 schema:givenName Hanno
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716474325.38
287 rdf:type schema:Person
288 sg:person.07624111077.08 schema:affiliation grid-institutes:grid.21107.35
289 schema:familyName Hruban
290 schema:givenName Ralph H.
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07624111077.08
292 rdf:type schema:Person
293 sg:pub.10.1007/978-1-4419-6694-0_19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044030029
294 https://doi.org/10.1007/978-1-4419-6694-0_19
295 rdf:type schema:CreativeWork
296 sg:pub.10.1007/s11605-009-0845-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028064850
297 https://doi.org/10.1007/s11605-009-0845-3
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/nature09515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029325111
300 https://doi.org/10.1038/nature09515
301 rdf:type schema:CreativeWork
302 sg:pub.10.1245/s10434-008-9839-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052637528
303 https://doi.org/10.1245/s10434-008-9839-8
304 rdf:type schema:CreativeWork
305 grid-institutes:grid.21107.35 schema:alternateName Department of Medicine, The Johns Hopkins University, Baltimore, MD, USA
306 Department of Oncology, The Johns Hopkins University, Baltimore, MD, USA
307 Department of Pathology, The Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA
308 Department of Radiation Oncology, The Johns Hopkins University, Baltimore, MD, USA
309 Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA
310 schema:name Department of Medicine, The Johns Hopkins University, Baltimore, MD, USA
311 Department of Oncology, The Johns Hopkins University, Baltimore, MD, USA
312 Department of Pathology, The Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, MD, USA
313 Department of Radiation Oncology, The Johns Hopkins University, Baltimore, MD, USA
314 Department of Surgery, The Johns Hopkins University, Baltimore, MD, USA
315 The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA
316 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...