Effects of Perioperative Red Blood Cell Transfusion on Disease Recurrence and Survival After Pancreaticoduodenectomy for Ductal Adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-05

AUTHORS

Peter J. Kneuertz, Sameer H. Patel, Carrie K. Chu, Shishir K. Maithel, Juan M. Sarmiento, Keith A. Delman, Charles A. Staley, David A. Kooby

ABSTRACT

BACKGROUND: The premise that allogeneic red blood cell transfusion (RBCT) contributes to adverse oncologic outcomes after surgery remains controversial. We examined the effects of RBCT during and after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC) on disease recurrence and survival. METHODS: A prospective database of 220 patients undergoing PD for PDAC from 2000 to 2008 was reviewed and transfusion data collected. Univariate and multivariate analyses were performed for factors influencing RBCT, recurrence-free survival (RFS), and overall survival (OS). The effect of amount and timing (intraoperative vs. postoperative) of RBCT was analyzed. RESULTS: One hundred forty-seven patients (67%) received RBCT: 70 (32%) received 1 to 2 units, and 77 (35%) received >2 units. Median RFS and OS for the entire cohort was 12 and 16 months, respectively. RBCT of >2 units was associated with reduced RFS (9 vs. 15 months; P = 0.033) and OS (14 vs. 20 months; P = 0.003). Stratified by timing of transfusion, postoperative RBCT was associated with shortened RFS and OS. Controlling for age, body mass index, comorbidities, tumor factors, and major complications, each incremental unit of postoperative RBCT was associated with reduced RFS (hazard ratio 1.10, 95% confidence interval 1.02-1.18) and OS (hazard ratio 1.08, 95% confidence interval 1.03-1.12). Low hemoglobin and presence of comorbidities were the only preoperative factors independently associated with RBCT. CONCLUSIONS: Allogeneic red blood cell transfusion after PD for PDAC is independently associated with earlier cancer recurrence and reduced survival, in particular when administered postoperatively and in larger quantities. Blood-conservation methods are especially indicated for patients with preoperative anemia and medical comorbidities. More... »

PAGES

1327-1334

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-010-1476-3

DOI

http://dx.doi.org/10.1245/s10434-010-1476-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020627798

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21369744


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Pancreatic Ductal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Erythrocyte Transfusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreaticoduodenectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Perioperative Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postoperative Complications", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kneuertz", 
        "givenName": "Peter J.", 
        "id": "sg:person.01057140757.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057140757.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "Sameer H.", 
        "id": "sg:person.01127711647.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127711647.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chu", 
        "givenName": "Carrie K.", 
        "id": "sg:person.01037254165.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037254165.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maithel", 
        "givenName": "Shishir K.", 
        "id": "sg:person.01006057677.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006057677.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarmiento", 
        "givenName": "Juan M.", 
        "id": "sg:person.01033565640.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033565640.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delman", 
        "givenName": "Keith A.", 
        "id": "sg:person.01147022643.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147022643.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Staley", 
        "givenName": "Charles A.", 
        "id": "sg:person.01073205115.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073205115.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA", 
            "Department of Surgery/Division of Surgical Oncology, Winship Cancer Institute-Emory University, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kooby", 
        "givenName": "David A.", 
        "id": "sg:person.0765452440.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765452440.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.suronc.2007.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001216694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199506000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001874243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199506000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001874243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1537-2995.2000.40070821.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002730517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9610(91)91134-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002784076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800830512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004088707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19950415)75:8<2069::aid-cncr2820750807>3.0.co;2-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007141077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(05)80406-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013617072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010215)91:4<771::aid-cncr1063>3.0.co;2-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014102237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-008-9807-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018732697", 
          "https://doi.org/10.1007/s00268-008-9807-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-008-9807-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018732697", 
          "https://doi.org/10.1007/s00268-008-9807-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19900701)66:1<56::aid-cncr2820660112>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019046908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9681(87)90171-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020988115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(82)92764-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022524237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(82)92764-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022524237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-007-9502-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023506774", 
          "https://doi.org/10.1245/s10434-007-9502-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9610(91)90371-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023735566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024049438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.4484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024648330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13651820701769693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025440479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02562122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025743607", 
          "https://doi.org/10.1007/bf02562122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02562122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025743607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1987.01400130062009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034260451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.5488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037420414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm197810122991503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038011178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.2009.282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038195201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s1091-255x(00)80105-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048529586", 
          "https://doi.org/10.1016/s1091-255x(00)80105-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-001-0254-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049775746", 
          "https://doi.org/10.1007/s00268-001-0254-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v13.i2.257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071365800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074254096", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074488962", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081635304", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-05", 
    "datePublishedReg": "2011-05-01", 
    "description": "BACKGROUND: The premise that allogeneic red blood cell transfusion (RBCT) contributes to adverse oncologic outcomes after surgery remains controversial. We examined the effects of RBCT during and after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC) on disease recurrence and survival.\nMETHODS: A prospective database of 220 patients undergoing PD for PDAC from 2000 to 2008 was reviewed and transfusion data collected. Univariate and multivariate analyses were performed for factors influencing RBCT, recurrence-free survival (RFS), and overall survival (OS). The effect of amount and timing (intraoperative vs. postoperative) of RBCT was analyzed.\nRESULTS: One hundred forty-seven patients (67%) received RBCT: 70 (32%) received 1 to 2 units, and 77 (35%) received >2 units. Median RFS and OS for the entire cohort was 12 and 16 months, respectively. RBCT of >2 units was associated with reduced RFS (9 vs. 15 months; P = 0.033) and OS (14 vs. 20 months; P = 0.003). Stratified by timing of transfusion, postoperative RBCT was associated with shortened RFS and OS. Controlling for age, body mass index, comorbidities, tumor factors, and major complications, each incremental unit of postoperative RBCT was associated with reduced RFS (hazard ratio 1.10, 95% confidence interval 1.02-1.18) and OS (hazard ratio 1.08, 95% confidence interval 1.03-1.12). Low hemoglobin and presence of comorbidities were the only preoperative factors independently associated with RBCT.\nCONCLUSIONS: Allogeneic red blood cell transfusion after PD for PDAC is independently associated with earlier cancer recurrence and reduced survival, in particular when administered postoperatively and in larger quantities. Blood-conservation methods are especially indicated for patients with preoperative anemia and medical comorbidities.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-010-1476-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Effects of Perioperative Red Blood Cell Transfusion on Disease Recurrence and Survival After Pancreaticoduodenectomy for Ductal Adenocarcinoma", 
    "pagination": "1327-1334", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6249a2b4296db479bf6f656f2168cb604be42dcf266e4fd512fc874d84c8f01a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21369744"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-010-1476-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020627798"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-010-1476-3", 
      "https://app.dimensions.ai/details/publication/pub.1020627798"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000499.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1245/s10434-010-1476-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1476-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1476-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1476-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1476-3'


 

This table displays all metadata directly associated to this object as RDF triples.

292 TRIPLES      21 PREDICATES      79 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-010-1476-3 schema:about N08148760e31c43f791e14480b6e5d198
2 N4564dfaaeceb4440a6e883d7cc531260
3 N4740b87e0b144c53835d35cd1381af56
4 N489057cf696443b9bc5fe6ce74a44412
5 N51c11ba474444b8b9e90483a77ed5e9b
6 N7774da7ceddd4262bf4092ec4accc897
7 N7fe94163b5cc4219a64953fbbce52ee2
8 N8c9eaed54c374c2ebd2ac9b0001c5aec
9 N8f4055452c2745cd85410d5cdcebdf2c
10 N92d8a1d7db224ade8c9689176bcb549d
11 N9d6f697725b64d87ba9297bcca29915d
12 Na13ff207e172499095185af18d1417f3
13 Naa26f656755048218f50f598747edd5a
14 Nc21f7865ddc44bbca0937935159575ca
15 Nccdd73dbdfed49628358d85a8464b80a
16 Nee369e390a774107a40ae4e4cdff1ebb
17 Nf18a98255e7d43549451393977e05566
18 Nf252e330fdf540d68002abe0eaa67d47
19 Nf7c82c5b78694e6db05da842bb6cdcb7
20 Nffa2b1283aab43a682068ed13477a035
21 Nffca2b42a460482c825a46c047a7a454
22 anzsrc-for:11
23 anzsrc-for:1103
24 schema:author N8b83b8cbffae4d5999b76f0f10deacb5
25 schema:citation sg:pub.10.1007/bf02562122
26 sg:pub.10.1007/s00268-001-0254-6
27 sg:pub.10.1007/s00268-008-9807-2
28 sg:pub.10.1016/s1091-255x(00)80105-5
29 sg:pub.10.1245/s10434-007-9502-9
30 https://app.dimensions.ai/details/publication/pub.1074254096
31 https://app.dimensions.ai/details/publication/pub.1074488962
32 https://app.dimensions.ai/details/publication/pub.1081635304
33 https://doi.org/10.1001/archsurg.1987.01400130062009
34 https://doi.org/10.1001/archsurg.2009.282
35 https://doi.org/10.1002/1097-0142(19900701)66:1<56::aid-cncr2820660112>3.0.co;2-6
36 https://doi.org/10.1002/1097-0142(19950415)75:8<2069::aid-cncr2820750807>3.0.co;2-7
37 https://doi.org/10.1002/1097-0142(20010215)91:4<771::aid-cncr1063>3.0.co;2-9
38 https://doi.org/10.1002/bjs.1800830512
39 https://doi.org/10.1002/bjs.4484
40 https://doi.org/10.1002/bjs.5488
41 https://doi.org/10.1007/bf02562122
42 https://doi.org/10.1016/0002-9610(91)90371-j
43 https://doi.org/10.1016/0002-9610(91)91134-5
44 https://doi.org/10.1016/0021-9681(87)90171-8
45 https://doi.org/10.1016/j.suronc.2007.10.016
46 https://doi.org/10.1016/s0002-9610(05)80406-4
47 https://doi.org/10.1016/s0140-6736(82)92764-7
48 https://doi.org/10.1046/j.1537-2995.2000.40070821.x
49 https://doi.org/10.1056/nejm197810122991503
50 https://doi.org/10.1080/13651820701769693
51 https://doi.org/10.1097/00000658-199506000-00011
52 https://doi.org/10.1097/01.sla.0000133083.54934.ae
53 https://doi.org/10.3748/wjg.v13.i2.257
54 schema:datePublished 2011-05
55 schema:datePublishedReg 2011-05-01
56 schema:description BACKGROUND: The premise that allogeneic red blood cell transfusion (RBCT) contributes to adverse oncologic outcomes after surgery remains controversial. We examined the effects of RBCT during and after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC) on disease recurrence and survival. METHODS: A prospective database of 220 patients undergoing PD for PDAC from 2000 to 2008 was reviewed and transfusion data collected. Univariate and multivariate analyses were performed for factors influencing RBCT, recurrence-free survival (RFS), and overall survival (OS). The effect of amount and timing (intraoperative vs. postoperative) of RBCT was analyzed. RESULTS: One hundred forty-seven patients (67%) received RBCT: 70 (32%) received 1 to 2 units, and 77 (35%) received >2 units. Median RFS and OS for the entire cohort was 12 and 16 months, respectively. RBCT of >2 units was associated with reduced RFS (9 vs. 15 months; P = 0.033) and OS (14 vs. 20 months; P = 0.003). Stratified by timing of transfusion, postoperative RBCT was associated with shortened RFS and OS. Controlling for age, body mass index, comorbidities, tumor factors, and major complications, each incremental unit of postoperative RBCT was associated with reduced RFS (hazard ratio 1.10, 95% confidence interval 1.02-1.18) and OS (hazard ratio 1.08, 95% confidence interval 1.03-1.12). Low hemoglobin and presence of comorbidities were the only preoperative factors independently associated with RBCT. CONCLUSIONS: Allogeneic red blood cell transfusion after PD for PDAC is independently associated with earlier cancer recurrence and reduced survival, in particular when administered postoperatively and in larger quantities. Blood-conservation methods are especially indicated for patients with preoperative anemia and medical comorbidities.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N5d3694fa2524413bb12960cad2ec20f0
61 Na3304379975d4537947d7870c3f6e2e6
62 sg:journal.1105545
63 schema:name Effects of Perioperative Red Blood Cell Transfusion on Disease Recurrence and Survival After Pancreaticoduodenectomy for Ductal Adenocarcinoma
64 schema:pagination 1327-1334
65 schema:productId N4bb25ba26997416f805558ff5de7d1ab
66 N764596ae2afe49cf98a6c2e5b25206ed
67 Na6c7fe85e2a54ecdaa3915a0d383f7b8
68 Nb3a85356ae5c4ce4ad0feb537bdebd8d
69 Nf0885f1be30e4929b4f14d6f98c52800
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020627798
71 https://doi.org/10.1245/s10434-010-1476-3
72 schema:sdDatePublished 2019-04-10T17:28
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N9deb02fa609b4d03a651b6e1e3e32440
75 schema:url http://link.springer.com/10.1245/s10434-010-1476-3
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N08148760e31c43f791e14480b6e5d198 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Humans
81 rdf:type schema:DefinedTerm
82 N19456665556f43e4b519093ba61c5343 rdf:first sg:person.01006057677.97
83 rdf:rest N211e17da55f54d2ca4e1561d531fd914
84 N1da5dc6a86c543f09677de24f17da1cd rdf:first sg:person.01127711647.40
85 rdf:rest N8279f7a0a4774f7f92b0bc944962ffd7
86 N211e17da55f54d2ca4e1561d531fd914 rdf:first sg:person.01033565640.92
87 rdf:rest Necaa2898a6b146c292f8fc3ecc126525
88 N4564dfaaeceb4440a6e883d7cc531260 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Pancreaticoduodenectomy
90 rdf:type schema:DefinedTerm
91 N4740b87e0b144c53835d35cd1381af56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Postoperative Complications
93 rdf:type schema:DefinedTerm
94 N489057cf696443b9bc5fe6ce74a44412 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Aged
96 rdf:type schema:DefinedTerm
97 N4bb25ba26997416f805558ff5de7d1ab schema:name doi
98 schema:value 10.1245/s10434-010-1476-3
99 rdf:type schema:PropertyValue
100 N51c11ba474444b8b9e90483a77ed5e9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Carcinoma, Pancreatic Ductal
102 rdf:type schema:DefinedTerm
103 N5a7bf8bb34044fd287acdd83c4e91f60 rdf:first sg:person.01073205115.34
104 rdf:rest Na44f4e926eb246e584a0b4eea7d44554
105 N5d3694fa2524413bb12960cad2ec20f0 schema:volumeNumber 18
106 rdf:type schema:PublicationVolume
107 N764596ae2afe49cf98a6c2e5b25206ed schema:name pubmed_id
108 schema:value 21369744
109 rdf:type schema:PropertyValue
110 N7774da7ceddd4262bf4092ec4accc897 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Female
112 rdf:type schema:DefinedTerm
113 N7fe94163b5cc4219a64953fbbce52ee2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Aged, 80 and over
115 rdf:type schema:DefinedTerm
116 N8279f7a0a4774f7f92b0bc944962ffd7 rdf:first sg:person.01037254165.13
117 rdf:rest N19456665556f43e4b519093ba61c5343
118 N8b83b8cbffae4d5999b76f0f10deacb5 rdf:first sg:person.01057140757.37
119 rdf:rest N1da5dc6a86c543f09677de24f17da1cd
120 N8c9eaed54c374c2ebd2ac9b0001c5aec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Pancreatic Neoplasms
122 rdf:type schema:DefinedTerm
123 N8f4055452c2745cd85410d5cdcebdf2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Survival Rate
125 rdf:type schema:DefinedTerm
126 N92d8a1d7db224ade8c9689176bcb549d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Middle Aged
128 rdf:type schema:DefinedTerm
129 N9d6f697725b64d87ba9297bcca29915d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Prospective Studies
131 rdf:type schema:DefinedTerm
132 N9deb02fa609b4d03a651b6e1e3e32440 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 Na13ff207e172499095185af18d1417f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Combined Modality Therapy
136 rdf:type schema:DefinedTerm
137 Na3304379975d4537947d7870c3f6e2e6 schema:issueNumber 5
138 rdf:type schema:PublicationIssue
139 Na44f4e926eb246e584a0b4eea7d44554 rdf:first sg:person.0765452440.23
140 rdf:rest rdf:nil
141 Na6c7fe85e2a54ecdaa3915a0d383f7b8 schema:name nlm_unique_id
142 schema:value 9420840
143 rdf:type schema:PropertyValue
144 Naa26f656755048218f50f598747edd5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Erythrocyte Transfusion
146 rdf:type schema:DefinedTerm
147 Nb3a85356ae5c4ce4ad0feb537bdebd8d schema:name readcube_id
148 schema:value 6249a2b4296db479bf6f656f2168cb604be42dcf266e4fd512fc874d84c8f01a
149 rdf:type schema:PropertyValue
150 Nc21f7865ddc44bbca0937935159575ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Follow-Up Studies
152 rdf:type schema:DefinedTerm
153 Nccdd73dbdfed49628358d85a8464b80a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Male
155 rdf:type schema:DefinedTerm
156 Necaa2898a6b146c292f8fc3ecc126525 rdf:first sg:person.01147022643.55
157 rdf:rest N5a7bf8bb34044fd287acdd83c4e91f60
158 Nee369e390a774107a40ae4e4cdff1ebb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Treatment Outcome
160 rdf:type schema:DefinedTerm
161 Nf0885f1be30e4929b4f14d6f98c52800 schema:name dimensions_id
162 schema:value pub.1020627798
163 rdf:type schema:PropertyValue
164 Nf18a98255e7d43549451393977e05566 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Adenocarcinoma
166 rdf:type schema:DefinedTerm
167 Nf252e330fdf540d68002abe0eaa67d47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Adult
169 rdf:type schema:DefinedTerm
170 Nf7c82c5b78694e6db05da842bb6cdcb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Cohort Studies
172 rdf:type schema:DefinedTerm
173 Nffa2b1283aab43a682068ed13477a035 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Neoplasm Recurrence, Local
175 rdf:type schema:DefinedTerm
176 Nffca2b42a460482c825a46c047a7a454 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Perioperative Care
178 rdf:type schema:DefinedTerm
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
183 schema:name Clinical Sciences
184 rdf:type schema:DefinedTerm
185 sg:journal.1105545 schema:issn 1068-9265
186 1534-4681
187 schema:name Annals of Surgical Oncology
188 rdf:type schema:Periodical
189 sg:person.01006057677.97 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
190 schema:familyName Maithel
191 schema:givenName Shishir K.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006057677.97
193 rdf:type schema:Person
194 sg:person.01033565640.92 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
195 schema:familyName Sarmiento
196 schema:givenName Juan M.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033565640.92
198 rdf:type schema:Person
199 sg:person.01037254165.13 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
200 schema:familyName Chu
201 schema:givenName Carrie K.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037254165.13
203 rdf:type schema:Person
204 sg:person.01057140757.37 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
205 schema:familyName Kneuertz
206 schema:givenName Peter J.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057140757.37
208 rdf:type schema:Person
209 sg:person.01073205115.34 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
210 schema:familyName Staley
211 schema:givenName Charles A.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073205115.34
213 rdf:type schema:Person
214 sg:person.01127711647.40 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
215 schema:familyName Patel
216 schema:givenName Sameer H.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127711647.40
218 rdf:type schema:Person
219 sg:person.01147022643.55 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
220 schema:familyName Delman
221 schema:givenName Keith A.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147022643.55
223 rdf:type schema:Person
224 sg:person.0765452440.23 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
225 schema:familyName Kooby
226 schema:givenName David A.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765452440.23
228 rdf:type schema:Person
229 sg:pub.10.1007/bf02562122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025743607
230 https://doi.org/10.1007/bf02562122
231 rdf:type schema:CreativeWork
232 sg:pub.10.1007/s00268-001-0254-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049775746
233 https://doi.org/10.1007/s00268-001-0254-6
234 rdf:type schema:CreativeWork
235 sg:pub.10.1007/s00268-008-9807-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018732697
236 https://doi.org/10.1007/s00268-008-9807-2
237 rdf:type schema:CreativeWork
238 sg:pub.10.1016/s1091-255x(00)80105-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048529586
239 https://doi.org/10.1016/s1091-255x(00)80105-5
240 rdf:type schema:CreativeWork
241 sg:pub.10.1245/s10434-007-9502-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023506774
242 https://doi.org/10.1245/s10434-007-9502-9
243 rdf:type schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1074254096 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1074488962 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1081635304 schema:CreativeWork
247 https://doi.org/10.1001/archsurg.1987.01400130062009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034260451
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1001/archsurg.2009.282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038195201
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/1097-0142(19900701)66:1<56::aid-cncr2820660112>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019046908
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/1097-0142(19950415)75:8<2069::aid-cncr2820750807>3.0.co;2-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007141077
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1002/1097-0142(20010215)91:4<771::aid-cncr1063>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014102237
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1002/bjs.1800830512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004088707
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/bjs.4484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024648330
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/bjs.5488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037420414
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1007/bf02562122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025743607
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/0002-9610(91)90371-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1023735566
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/0002-9610(91)91134-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002784076
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/0021-9681(87)90171-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020988115
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.suronc.2007.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001216694
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0002-9610(05)80406-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013617072
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0140-6736(82)92764-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022524237
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1046/j.1537-2995.2000.40070821.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002730517
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1056/nejm197810122991503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038011178
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1080/13651820701769693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025440479
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1097/00000658-199506000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001874243
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1097/01.sla.0000133083.54934.ae schema:sameAs https://app.dimensions.ai/details/publication/pub.1024049438
286 rdf:type schema:CreativeWork
287 https://doi.org/10.3748/wjg.v13.i2.257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071365800
288 rdf:type schema:CreativeWork
289 https://www.grid.ac/institutes/grid.189967.8 schema:alternateName Emory University
290 schema:name Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA
291 Department of Surgery/Division of Surgical Oncology, Winship Cancer Institute-Emory University, Atlanta, GA, USA
292 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...