The Clinical Outcome of Chemotherapy-Induced Amenorrhea in Premenopausal Young Patients with Breast Cancer with Long-Term Follow-up View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-06-19

AUTHORS

Minkyu Jung, Hyun Joon Shin, Sun Young Rha, Hei Cheul Jeung, Soojung Hong, Yong Wha Moon, Hyo Song Kim, Kyung Jin Oh, Woo Ick Yang, Jae Kyung Roh, Hyun Cheol Chung

ABSTRACT

BackgroundWe investigated the factors that predict chemotherapy-induced amenorrhea (CIA) and the prognostic significance of CIA after long-term follow-up.MethodsWe reviewed data from 241 premenopausal patients with breast cancer who underwent adjuvant CMF or FAC chemotherapy after breast cancer surgery between January 1995 and December 2000.ResultsThe median follow-up duration was 109.8 (range, 16.6–193.1) months. The age of CIA patients was older than non-CIA patients (median, 44 (range, 28–53) years and 36 (range, 25–49) years, respectively; P < 0.001). The addition of tamoxifen to the chemotherapy increased the incidence of CIA from 48% to 63.6% (P = 0.015). The 10-year disease-free survival (DFS) rate was higher in the CIA group compared with the non-CIA group in hormonal receptor-positive patients (78.4% vs. 67%, respectively; P = 0.022), and the 10-year overall survival (OS) rate also was higher in the CIA group compared with the non-CIA group (90.8% vs. 79.7%, respectively; P = 0.041).ConclusionsThe most important predictors of CIA are age and the addition of tamoxifen to the chemotherapy. CIA is likely to have an influence on DFS and OS in premenopausal patients with breast cancer with a positive hormone receptor, and it might be used as a surrogate marker for effective chemotherapy in these young Asian patients. More... »

PAGES

3259-3268

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-010-1172-3

DOI

http://dx.doi.org/10.1245/s10434-010-1172-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027772920

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20563656


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amenorrhea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Hormonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Ductal, Breast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Lobular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclophosphamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Doxorubicin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methotrexate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Premenopause", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tamoxifen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
            "Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Minkyu", 
        "id": "sg:person.01346136021.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346136021.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shin", 
        "givenName": "Hyun Joon", 
        "id": "sg:person.0623174642.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623174642.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
            "BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea", 
            "Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rha", 
        "givenName": "Sun Young", 
        "id": "sg:person.01036404665.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036404665.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeung", 
        "givenName": "Hei Cheul", 
        "id": "sg:person.01276364570.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276364570.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Soojung", 
        "id": "sg:person.01167435321.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167435321.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moon", 
        "givenName": "Yong Wha", 
        "id": "sg:person.0706167144.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706167144.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyo Song", 
        "id": "sg:person.015206504504.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015206504504.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Kyung Jin", 
        "id": "sg:person.0613644650.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613644650.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea", 
            "Department of Pathology, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Woo Ick", 
        "id": "sg:person.016025552634.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016025552634.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
            "BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea", 
            "Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roh", 
        "givenName": "Jae Kyung", 
        "id": "sg:person.0767622633.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767622633.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea", 
            "BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea", 
            "Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Hyun Cheol", 
        "id": "sg:person.016554426212.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016554426212.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10549-008-9937-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005214736", 
          "https://doi.org/10.1007/s10549-008-9937-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00570489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007459702", 
          "https://doi.org/10.1007/bf00570489"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-06-19", 
    "datePublishedReg": "2010-06-19", 
    "description": "BackgroundWe investigated the factors that predict chemotherapy-induced amenorrhea (CIA) and the prognostic significance of CIA after long-term follow-up.MethodsWe reviewed data from 241 premenopausal patients with breast cancer who underwent adjuvant CMF or FAC chemotherapy after breast cancer surgery between January 1995 and December 2000.ResultsThe median follow-up duration was 109.8 (range, 16.6\u2013193.1) months. The age of CIA patients was older than non-CIA patients (median, 44 (range, 28\u201353) years and 36 (range, 25\u201349) years, respectively; P\u00a0<\u00a00.001). The addition of tamoxifen to the chemotherapy increased the incidence of CIA from 48% to 63.6% (P\u00a0=\u00a00.015). The 10-year disease-free survival (DFS) rate was higher in the CIA group compared with the non-CIA group in hormonal receptor-positive patients (78.4% vs. 67%, respectively; P\u00a0=\u00a00.022), and the 10-year overall survival (OS) rate also was higher in the CIA group compared with the non-CIA group (90.8% vs. 79.7%, respectively; P\u00a0=\u00a00.041).ConclusionsThe most important predictors of CIA are age and the addition of tamoxifen to the chemotherapy. CIA is likely to have an influence on DFS and OS in premenopausal patients with breast cancer with a positive hormone receptor, and it might be used as a surrogate marker for effective chemotherapy in these young Asian patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1245/s10434-010-1172-3", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "keywords": [
      "chemotherapy-induced amenorrhea", 
      "CIA group", 
      "addition of tamoxifen", 
      "breast cancer", 
      "premenopausal patients", 
      "incidence of CIA", 
      "survival rate", 
      "disease-free survival rates", 
      "receptor-positive patients", 
      "positive hormone receptors", 
      "overall survival rate", 
      "breast cancer surgery", 
      "young Asian patients", 
      "adjuvant CMF", 
      "median follow", 
      "CIA patients", 
      "FAC chemotherapy", 
      "younger patients", 
      "cancer surgery", 
      "clinical outcomes", 
      "prognostic significance", 
      "Asian patients", 
      "surrogate marker", 
      "effective chemotherapy", 
      "patients", 
      "chemotherapy", 
      "hormone receptors", 
      "cancer", 
      "amenorrhea", 
      "tamoxifen", 
      "important predictor", 
      "age", 
      "group", 
      "long term", 
      "surgery", 
      "BackgroundWe", 
      "follow", 
      "MethodsWe", 
      "incidence", 
      "DFS", 
      "months", 
      "receptors", 
      "outcomes", 
      "predictors", 
      "CMF", 
      "markers", 
      "duration", 
      "rate", 
      "OS", 
      "factors", 
      "addition", 
      "significance", 
      "data", 
      "influence"
    ], 
    "name": "The Clinical Outcome of Chemotherapy-Induced Amenorrhea in Premenopausal Young Patients with Breast Cancer with Long-Term Follow-up", 
    "pagination": "3259-3268", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027772920"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-010-1172-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20563656"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-010-1172-3", 
      "https://app.dimensions.ai/details/publication/pub.1027772920"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_506.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1245/s10434-010-1172-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1172-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1172-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1172-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1172-3'


 

This table displays all metadata directly associated to this object as RDF triples.

281 TRIPLES      22 PREDICATES      102 URIs      92 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-010-1172-3 schema:about N0bb3d63fcfee4baca92e28179a8b0629
2 N0fbaaf6e71fa41458d277b12a4b83bbe
3 N1840f5a1e64545cdb2abdd9d0ece9a8e
4 N29153967267d479eb1d4beb45ff5afbb
5 N46bc44caf3a14e9badee8b8e3abcba44
6 N4b7ecf4c9bdc42228f7c887f17380e75
7 N4f12fdc1588d4c9996fbf49668f98d41
8 N6196ad5393f049178e618e704b48c7fa
9 N77f5c93df4c94f6ebfae4d4c4e4e6154
10 N7886909820534933856442e0bf5907ac
11 N7fda9fb9351140c684b56c277236cfae
12 N81a3add6835c43ef87720a2f63f128f7
13 N8d87538a2c474022967288702c1f09ec
14 N9da8a73402a349b8849f9f1b12e4f69f
15 Na1aa7dc3ae314a64a72bcc0d6958f82c
16 Nac21d0b969d241e3a1036af21c7321a7
17 Nb98075af2fed41a4bee15c315ddf0d07
18 Ndce2caf5df5040349765b144faf6fd52
19 Nea39c1ebca5f4732a44a8597f170ed63
20 Nf16a4843f7584b55b7f3a5997f25a7a7
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author N85930296da9d4b4b8f57f0615432bfb9
24 schema:citation sg:pub.10.1007/bf00570489
25 sg:pub.10.1007/s10549-008-9937-0
26 schema:datePublished 2010-06-19
27 schema:datePublishedReg 2010-06-19
28 schema:description BackgroundWe investigated the factors that predict chemotherapy-induced amenorrhea (CIA) and the prognostic significance of CIA after long-term follow-up.MethodsWe reviewed data from 241 premenopausal patients with breast cancer who underwent adjuvant CMF or FAC chemotherapy after breast cancer surgery between January 1995 and December 2000.ResultsThe median follow-up duration was 109.8 (range, 16.6–193.1) months. The age of CIA patients was older than non-CIA patients (median, 44 (range, 28–53) years and 36 (range, 25–49) years, respectively; P < 0.001). The addition of tamoxifen to the chemotherapy increased the incidence of CIA from 48% to 63.6% (P = 0.015). The 10-year disease-free survival (DFS) rate was higher in the CIA group compared with the non-CIA group in hormonal receptor-positive patients (78.4% vs. 67%, respectively; P = 0.022), and the 10-year overall survival (OS) rate also was higher in the CIA group compared with the non-CIA group (90.8% vs. 79.7%, respectively; P = 0.041).ConclusionsThe most important predictors of CIA are age and the addition of tamoxifen to the chemotherapy. CIA is likely to have an influence on DFS and OS in premenopausal patients with breast cancer with a positive hormone receptor, and it might be used as a surrogate marker for effective chemotherapy in these young Asian patients.
29 schema:genre article
30 schema:inLanguage en
31 schema:isAccessibleForFree false
32 schema:isPartOf N17a306765b0644139d4c0ab6edb5cc4d
33 Nd1e158fa00a34675bd66a47683fdcfaf
34 sg:journal.1105545
35 schema:keywords Asian patients
36 BackgroundWe
37 CIA group
38 CIA patients
39 CMF
40 DFS
41 FAC chemotherapy
42 MethodsWe
43 OS
44 addition
45 addition of tamoxifen
46 adjuvant CMF
47 age
48 amenorrhea
49 breast cancer
50 breast cancer surgery
51 cancer
52 cancer surgery
53 chemotherapy
54 chemotherapy-induced amenorrhea
55 clinical outcomes
56 data
57 disease-free survival rates
58 duration
59 effective chemotherapy
60 factors
61 follow
62 group
63 hormone receptors
64 important predictor
65 incidence
66 incidence of CIA
67 influence
68 long term
69 markers
70 median follow
71 months
72 outcomes
73 overall survival rate
74 patients
75 positive hormone receptors
76 predictors
77 premenopausal patients
78 prognostic significance
79 rate
80 receptor-positive patients
81 receptors
82 significance
83 surgery
84 surrogate marker
85 survival rate
86 tamoxifen
87 young Asian patients
88 younger patients
89 schema:name The Clinical Outcome of Chemotherapy-Induced Amenorrhea in Premenopausal Young Patients with Breast Cancer with Long-Term Follow-up
90 schema:pagination 3259-3268
91 schema:productId N425b47134a814671be67373e542da7ab
92 Nbab3aa02602a4f7485e6e9dcd19a858c
93 Nce345374fb6349639d735d7ca1fc9336
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027772920
95 https://doi.org/10.1245/s10434-010-1172-3
96 schema:sdDatePublished 2022-05-20T07:25
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher N0570faa3e3344e149c20a1efe0fc096e
99 schema:url https://doi.org/10.1245/s10434-010-1172-3
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N0570faa3e3344e149c20a1efe0fc096e schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 N0bb3d63fcfee4baca92e28179a8b0629 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Methotrexate
107 rdf:type schema:DefinedTerm
108 N0fbaaf6e71fa41458d277b12a4b83bbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Premenopause
110 rdf:type schema:DefinedTerm
111 N1701216cef054d82b04d074494c492c7 rdf:first sg:person.01167435321.38
112 rdf:rest N56635706b2e541e68f3e27b55e808ad8
113 N17a306765b0644139d4c0ab6edb5cc4d schema:volumeNumber 17
114 rdf:type schema:PublicationVolume
115 N1840f5a1e64545cdb2abdd9d0ece9a8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Neoplasm Recurrence, Local
117 rdf:type schema:DefinedTerm
118 N1cb3db74a95c4ddfb615bdfbf849b0a8 rdf:first sg:person.016025552634.33
119 rdf:rest N4b05a03cfecd48a1a52ed2bf865240f5
120 N29153967267d479eb1d4beb45ff5afbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Breast Neoplasms
122 rdf:type schema:DefinedTerm
123 N3b355e619052434c8a732aca380f0735 rdf:first sg:person.016554426212.74
124 rdf:rest rdf:nil
125 N425b47134a814671be67373e542da7ab schema:name dimensions_id
126 schema:value pub.1027772920
127 rdf:type schema:PropertyValue
128 N46bc44caf3a14e9badee8b8e3abcba44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Carcinoma, Lobular
130 rdf:type schema:DefinedTerm
131 N4b05a03cfecd48a1a52ed2bf865240f5 rdf:first sg:person.0767622633.82
132 rdf:rest N3b355e619052434c8a732aca380f0735
133 N4b7ecf4c9bdc42228f7c887f17380e75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Amenorrhea
135 rdf:type schema:DefinedTerm
136 N4f12fdc1588d4c9996fbf49668f98d41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Doxorubicin
138 rdf:type schema:DefinedTerm
139 N55e0980e6fb34d7cb64b99d4a91408ea rdf:first sg:person.01276364570.14
140 rdf:rest N1701216cef054d82b04d074494c492c7
141 N56635706b2e541e68f3e27b55e808ad8 rdf:first sg:person.0706167144.03
142 rdf:rest Na2050dd30db24eb49fce2fb18ddce44d
143 N6196ad5393f049178e618e704b48c7fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Cyclophosphamide
145 rdf:type schema:DefinedTerm
146 N6e563bf7f5ca445baf6ed07d8d5a614b rdf:first sg:person.0623174642.22
147 rdf:rest Nee258a11b5274dfa918d96fea320085b
148 N77f5c93df4c94f6ebfae4d4c4e4e6154 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Middle Aged
150 rdf:type schema:DefinedTerm
151 N7886909820534933856442e0bf5907ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Treatment Outcome
153 rdf:type schema:DefinedTerm
154 N7fda9fb9351140c684b56c277236cfae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 N81a3add6835c43ef87720a2f63f128f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Female
159 rdf:type schema:DefinedTerm
160 N85930296da9d4b4b8f57f0615432bfb9 rdf:first sg:person.01346136021.40
161 rdf:rest N6e563bf7f5ca445baf6ed07d8d5a614b
162 N8d87538a2c474022967288702c1f09ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Antineoplastic Combined Chemotherapy Protocols
164 rdf:type schema:DefinedTerm
165 N9da8a73402a349b8849f9f1b12e4f69f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Tamoxifen
167 rdf:type schema:DefinedTerm
168 Na1aa7dc3ae314a64a72bcc0d6958f82c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Antineoplastic Agents, Hormonal
170 rdf:type schema:DefinedTerm
171 Na2050dd30db24eb49fce2fb18ddce44d rdf:first sg:person.015206504504.94
172 rdf:rest Nd3964cd6818f49f6a7649019cd424c14
173 Nac21d0b969d241e3a1036af21c7321a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Carcinoma, Ductal, Breast
175 rdf:type schema:DefinedTerm
176 Nb98075af2fed41a4bee15c315ddf0d07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Fluorouracil
178 rdf:type schema:DefinedTerm
179 Nbab3aa02602a4f7485e6e9dcd19a858c schema:name pubmed_id
180 schema:value 20563656
181 rdf:type schema:PropertyValue
182 Nce345374fb6349639d735d7ca1fc9336 schema:name doi
183 schema:value 10.1245/s10434-010-1172-3
184 rdf:type schema:PropertyValue
185 Nd1e158fa00a34675bd66a47683fdcfaf schema:issueNumber 12
186 rdf:type schema:PublicationIssue
187 Nd3964cd6818f49f6a7649019cd424c14 rdf:first sg:person.0613644650.39
188 rdf:rest N1cb3db74a95c4ddfb615bdfbf849b0a8
189 Ndce2caf5df5040349765b144faf6fd52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Adult
191 rdf:type schema:DefinedTerm
192 Nea39c1ebca5f4732a44a8597f170ed63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Follow-Up Studies
194 rdf:type schema:DefinedTerm
195 Nee258a11b5274dfa918d96fea320085b rdf:first sg:person.01036404665.54
196 rdf:rest N55e0980e6fb34d7cb64b99d4a91408ea
197 Nf16a4843f7584b55b7f3a5997f25a7a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Survival Rate
199 rdf:type schema:DefinedTerm
200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
201 schema:name Medical and Health Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
204 schema:name Oncology and Carcinogenesis
205 rdf:type schema:DefinedTerm
206 sg:journal.1105545 schema:issn 1068-9265
207 1534-4681
208 schema:name Annals of Surgical Oncology
209 schema:publisher Springer Nature
210 rdf:type schema:Periodical
211 sg:person.01036404665.54 schema:affiliation grid-institutes:grid.15444.30
212 schema:familyName Rha
213 schema:givenName Sun Young
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036404665.54
215 rdf:type schema:Person
216 sg:person.01167435321.38 schema:affiliation grid-institutes:grid.15444.30
217 schema:familyName Hong
218 schema:givenName Soojung
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167435321.38
220 rdf:type schema:Person
221 sg:person.01276364570.14 schema:affiliation grid-institutes:grid.15444.30
222 schema:familyName Jeung
223 schema:givenName Hei Cheul
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276364570.14
225 rdf:type schema:Person
226 sg:person.01346136021.40 schema:affiliation grid-institutes:grid.15444.30
227 schema:familyName Jung
228 schema:givenName Minkyu
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346136021.40
230 rdf:type schema:Person
231 sg:person.015206504504.94 schema:affiliation grid-institutes:grid.15444.30
232 schema:familyName Kim
233 schema:givenName Hyo Song
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015206504504.94
235 rdf:type schema:Person
236 sg:person.016025552634.33 schema:affiliation grid-institutes:grid.15444.30
237 schema:familyName Yang
238 schema:givenName Woo Ick
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016025552634.33
240 rdf:type schema:Person
241 sg:person.016554426212.74 schema:affiliation grid-institutes:grid.15444.30
242 schema:familyName Chung
243 schema:givenName Hyun Cheol
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016554426212.74
245 rdf:type schema:Person
246 sg:person.0613644650.39 schema:affiliation grid-institutes:grid.15444.30
247 schema:familyName Oh
248 schema:givenName Kyung Jin
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613644650.39
250 rdf:type schema:Person
251 sg:person.0623174642.22 schema:affiliation grid-institutes:grid.15444.30
252 schema:familyName Shin
253 schema:givenName Hyun Joon
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623174642.22
255 rdf:type schema:Person
256 sg:person.0706167144.03 schema:affiliation grid-institutes:grid.15444.30
257 schema:familyName Moon
258 schema:givenName Yong Wha
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706167144.03
260 rdf:type schema:Person
261 sg:person.0767622633.82 schema:affiliation grid-institutes:grid.15444.30
262 schema:familyName Roh
263 schema:givenName Jae Kyung
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767622633.82
265 rdf:type schema:Person
266 sg:pub.10.1007/bf00570489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007459702
267 https://doi.org/10.1007/bf00570489
268 rdf:type schema:CreativeWork
269 sg:pub.10.1007/s10549-008-9937-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005214736
270 https://doi.org/10.1007/s10549-008-9937-0
271 rdf:type schema:CreativeWork
272 grid-institutes:grid.15444.30 schema:alternateName Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
273 Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
274 Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
275 Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
276 schema:name BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
277 Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
278 Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
279 Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
280 Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
281 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...