Overexpression of Endothelial Cell Specific Molecule-1 (ESM-1) in Gastric Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10

AUTHORS

Ni Liu, Lian-hai Zhang, Hong Du, Ying Hu, Gui-guo Zhang, Xiao-hong Wang, Ji-you Li, Jia-fu Ji

ABSTRACT

BACKGROUND: The endothelial cell-specific molecule-1 (ESM-1) gene is involved in various biological events. This study was designed to clarify its clinical significance and explore its biological behavior in gastric cancer (GC). METHODS: ESM-1 mRNA expression was evaluated by real-time PCR in GC (n = 34) and matched adjacent normal tissues (n = 14). The expression of ESM-1 protein was investigated by immunohistochemistry in GC (n = 159) and matched normal tissues (n = 40), and its correlation with the clinicopathological features and overall survival of patients was analyzed. Microvessel density (MVD) in GC was assessed by anti-CD34 and the pattern of ESM-1 expression in tumor-related vascular was evaluated. The effect of ESM-1 promotion of proliferation in the GC MKN28 cell line and human microvascular endothelial cell line HMEC-1 were tested using the MTT assay. RESULTS: ESM-1 mRNA was significantly overexpressed in GC compared with adjacent noncarcinoma controls (P < 0.01). ESM-1 protein was predominantly expressed in GC. ESM-1 expression was associated with distant metastasis and Borrmann type IV (P < 0.05) and was strongly associated with vascular invasion (P = 0.0057). Patients with ESM-1 expression showed lower 5-year survival rate (P = 0.0339). Multivariate analysis revealed that ESM-1 was an independent prognostic factor. In GC, CD34-MVD of GC vessels positively expressing ESM-1 was higher than that of GC with negative vessels expression of ESM-1 (P < 0.05). Besides, ESM-1 antibody dose-dependently impaired MKN28 and HMEC-1 growth. CONCLUSIONS: ESM-1 is overexpressed in GC and can serve as a tumor biomarker to predict survival of GC patients, and it might promote tumor angiogenesis and growth in GC and, hence, may represent a potential therapeutic target. More... »

PAGES

2628-2639

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-010-1037-9

DOI

http://dx.doi.org/10.1245/s10434-010-1037-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022280686

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20383661


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Signet Ring Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microcirculation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peritoneal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteoglycans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Peking University Cancer Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412474.0", 
          "name": [
            "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Surgery, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Ni", 
        "id": "sg:person.01064017701.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064017701.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Cancer Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412474.0", 
          "name": [
            "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Surgery, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Lian-hai", 
        "id": "sg:person.0626755231.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626755231.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Cancer Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412474.0", 
          "name": [
            "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Tissue Bank, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Du", 
        "givenName": "Hong", 
        "id": "sg:person.01203470464.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203470464.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Cancer Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412474.0", 
          "name": [
            "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Tissue Bank, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Ying", 
        "id": "sg:person.01204037144.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204037144.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Cancer Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412474.0", 
          "name": [
            "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Tissue Bank, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Gui-guo", 
        "id": "sg:person.01204727330.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204727330.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Cancer Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412474.0", 
          "name": [
            "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Surgery, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Xiao-hong", 
        "id": "sg:person.01051527074.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051527074.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Cancer Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412474.0", 
          "name": [
            "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Ji-you", 
        "id": "sg:person.012255174444.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012255174444.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Cancer Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412474.0", 
          "name": [
            "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Surgery, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ji", 
        "givenName": "Jia-fu", 
        "id": "sg:person.01022571576.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022571576.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1164/rccm.200401-066oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004031794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2001.2177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007616002", 
          "https://doi.org/10.1054/bjoc.2001.2177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008676548", 
          "https://doi.org/10.1007/bf00666038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008676548", 
          "https://doi.org/10.1007/bf00666038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2009.03458.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008825916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2009.03458.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008825916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mvr.2006.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009434653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.34.20458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010789203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(95)00004-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011327157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/283139a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014668798", 
          "https://doi.org/10.1038/283139a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-3-31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020861401", 
          "https://doi.org/10.1186/1471-2407-3-31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022080605", 
          "https://doi.org/10.1038/nrc1627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022080605", 
          "https://doi.org/10.1038/nrc1627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022080605", 
          "https://doi.org/10.1038/nrc1627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-2361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022233639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000025758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026843710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03032579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029576921", 
          "https://doi.org/10.1007/bf03032579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03032579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029576921", 
          "https://doi.org/10.1007/bf03032579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-0185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030175261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000011896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032690046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mvre.2001.2380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033410587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-005-0320-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034635641", 
          "https://doi.org/10.1007/s10120-005-0320-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1040-8428(01)00199-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035224939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036099121", 
          "https://doi.org/10.1186/bcr562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdg726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039372472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(00)00529-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042568382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000198525.82124.74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044668368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000198525.82124.74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044668368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/canjclin.55.2.74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048020321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1026529222845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048028741", 
          "https://doi.org/10.1023/a:1026529222845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2005.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048153181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2005.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048153181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v12.i1.17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071364239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v8.i4.591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071375263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.4.1.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071508941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m108395200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074890756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082895740", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-10", 
    "datePublishedReg": "2010-10-01", 
    "description": "BACKGROUND: The endothelial cell-specific molecule-1 (ESM-1) gene is involved in various biological events. This study was designed to clarify its clinical significance and explore its biological behavior in gastric cancer (GC).\nMETHODS: ESM-1 mRNA expression was evaluated by real-time PCR in GC (n\u00a0=\u00a034) and matched adjacent normal tissues (n\u00a0=\u00a014). The expression of ESM-1 protein was investigated by immunohistochemistry in GC (n\u00a0=\u00a0159) and matched normal tissues (n\u00a0=\u00a040), and its correlation with the clinicopathological features and overall survival of patients was analyzed. Microvessel density (MVD) in GC was assessed by anti-CD34 and the pattern of ESM-1 expression in tumor-related vascular was evaluated. The effect of ESM-1 promotion of proliferation in the GC MKN28 cell line and human microvascular endothelial cell line HMEC-1 were tested using the MTT assay.\nRESULTS: ESM-1 mRNA was significantly overexpressed in GC compared with adjacent noncarcinoma controls (P\u00a0<\u00a00.01). ESM-1 protein was predominantly expressed in GC. ESM-1 expression was associated with distant metastasis and Borrmann type IV (P\u00a0<\u00a00.05) and was strongly associated with vascular invasion (P\u00a0=\u00a00.0057). Patients with ESM-1 expression showed lower 5-year survival rate (P\u00a0=\u00a00.0339). Multivariate analysis revealed that ESM-1 was an independent prognostic factor. In GC, CD34-MVD of GC vessels positively expressing ESM-1 was higher than that of GC with negative vessels expression of ESM-1 (P\u00a0<\u00a00.05). Besides, ESM-1 antibody dose-dependently impaired MKN28 and HMEC-1 growth.\nCONCLUSIONS: ESM-1 is overexpressed in GC and can serve as a tumor biomarker to predict survival of GC patients, and it might promote tumor angiogenesis and growth in GC and, hence, may represent a potential therapeutic target.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-010-1037-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Overexpression of Endothelial Cell Specific Molecule-1 (ESM-1) in Gastric Cancer", 
    "pagination": "2628-2639", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6a2654c88fe35d7e912758fe93c8b72dc748bc42eb347ce906033f5b02e78185"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20383661"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-010-1037-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022280686"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-010-1037-9", 
      "https://app.dimensions.ai/details/publication/pub.1022280686"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54297_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1245/s10434-010-1037-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1037-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1037-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1037-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-1037-9'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      89 URIs      51 LITERALS      39 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-010-1037-9 schema:about N009d7db9cf9a4f45b8d048540547435f
2 N065c358da7454cd7910f4e5c0b7253d7
3 N06a31156e0cb4aad826601dda8719c9d
4 N06a61dfba5c5404cbec2f721e989bbb1
5 N0717500ea12e44ef857170330fc02646
6 N0a713002e8af4ad9aa02bf44705c0089
7 N10c0cb1349f746b280685446a82b8784
8 N10fa569cef5e4ddaa2b155353ab0de7d
9 N1b2cf1117c164265970a71cc59c289fd
10 N202a56b2515347ff996860fa09c85a56
11 N4066845a5bd741319d810b0caf12988c
12 N44a146a537094801bc8e3e72b188fe96
13 N470906988d214c8eafae2cbeec96c564
14 N51b71d9bf4df4b54a0c18baf0cf91025
15 N5664defdb9d440108c7b63edb6b00d45
16 N5d5f2bfb9ee741b7b389f0daa9407e9b
17 N6a5b64d0a2c44128b584ce8bc0bd7df2
18 N6b81d299041b4f9696cb2bafecb96aab
19 N75029be1bfd9401a97c808fa199c3370
20 N7992acd2c490479c8a6b36f644b6a927
21 N8e2c77985f01416f89eee9b385b69806
22 N90e9da75a4074c69975b17960c0c0aaa
23 N94e5532c1bfc4f9997c49a0b5c311b58
24 Na06593ef43234ae0a8a110c6925aaa6d
25 Na9b269e39b5c4eeabea4a5ff2b7fe716
26 Nad030c829ccd4d368fb8e95dd27bf118
27 Nb6d0ae7add834aaf9cad9fd50ceceb3a
28 Nc677ba4cb5334f58b08ab679fd821351
29 Nca4ca44ce5c44896a1494394a504377a
30 Nd70a6a9ceaf94b719f25694269ddcaa1
31 anzsrc-for:11
32 anzsrc-for:1112
33 schema:author Ncbbaacbd604e4981aeab1165b11599f1
34 schema:citation sg:pub.10.1007/bf00666038
35 sg:pub.10.1007/bf03032579
36 sg:pub.10.1007/s10120-005-0320-0
37 sg:pub.10.1023/a:1026529222845
38 sg:pub.10.1038/283139a0
39 sg:pub.10.1038/nrc1627
40 sg:pub.10.1054/bjoc.2001.2177
41 sg:pub.10.1186/1471-2407-3-31
42 sg:pub.10.1186/bcr562
43 https://app.dimensions.ai/details/publication/pub.1082895740
44 https://doi.org/10.1006/mvre.2001.2380
45 https://doi.org/10.1016/j.bbcan.2005.08.004
46 https://doi.org/10.1016/j.mvr.2006.05.010
47 https://doi.org/10.1016/s0006-2952(00)00529-3
48 https://doi.org/10.1016/s0960-9822(95)00004-2
49 https://doi.org/10.1016/s1040-8428(01)00199-8
50 https://doi.org/10.1074/jbc.271.34.20458
51 https://doi.org/10.1074/jbc.m108395200
52 https://doi.org/10.1093/annonc/mdg726
53 https://doi.org/10.1097/01.ccm.0000198525.82124.74
54 https://doi.org/10.1111/j.1365-2559.2009.03458.x
55 https://doi.org/10.1158/0008-5472.can-03-2361
56 https://doi.org/10.1158/1078-0432.ccr-06-0185
57 https://doi.org/10.1159/000011896
58 https://doi.org/10.1159/000025758
59 https://doi.org/10.1164/rccm.200401-066oc
60 https://doi.org/10.3322/canjclin.55.2.74
61 https://doi.org/10.3748/wjg.v12.i1.17
62 https://doi.org/10.3748/wjg.v8.i4.591
63 https://doi.org/10.3892/ijmm.4.1.39
64 schema:datePublished 2010-10
65 schema:datePublishedReg 2010-10-01
66 schema:description BACKGROUND: The endothelial cell-specific molecule-1 (ESM-1) gene is involved in various biological events. This study was designed to clarify its clinical significance and explore its biological behavior in gastric cancer (GC). METHODS: ESM-1 mRNA expression was evaluated by real-time PCR in GC (n = 34) and matched adjacent normal tissues (n = 14). The expression of ESM-1 protein was investigated by immunohistochemistry in GC (n = 159) and matched normal tissues (n = 40), and its correlation with the clinicopathological features and overall survival of patients was analyzed. Microvessel density (MVD) in GC was assessed by anti-CD34 and the pattern of ESM-1 expression in tumor-related vascular was evaluated. The effect of ESM-1 promotion of proliferation in the GC MKN28 cell line and human microvascular endothelial cell line HMEC-1 were tested using the MTT assay. RESULTS: ESM-1 mRNA was significantly overexpressed in GC compared with adjacent noncarcinoma controls (P < 0.01). ESM-1 protein was predominantly expressed in GC. ESM-1 expression was associated with distant metastasis and Borrmann type IV (P < 0.05) and was strongly associated with vascular invasion (P = 0.0057). Patients with ESM-1 expression showed lower 5-year survival rate (P = 0.0339). Multivariate analysis revealed that ESM-1 was an independent prognostic factor. In GC, CD34-MVD of GC vessels positively expressing ESM-1 was higher than that of GC with negative vessels expression of ESM-1 (P < 0.05). Besides, ESM-1 antibody dose-dependently impaired MKN28 and HMEC-1 growth. CONCLUSIONS: ESM-1 is overexpressed in GC and can serve as a tumor biomarker to predict survival of GC patients, and it might promote tumor angiogenesis and growth in GC and, hence, may represent a potential therapeutic target.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree false
70 schema:isPartOf N274b3aba95544b5eb4d3032db83c834e
71 N9b646f9e354b4662828664ca50276706
72 sg:journal.1105545
73 schema:name Overexpression of Endothelial Cell Specific Molecule-1 (ESM-1) in Gastric Cancer
74 schema:pagination 2628-2639
75 schema:productId N1de06f95f3cd457fa7b4bf537e628a8c
76 N1de2c7f7b976495698c68dbc27a45cf8
77 N26c0661bce704c41bd3e213d50457407
78 N5678fe28a32b4ca5bd898d4258807256
79 Nf0059ed38bdd4ee98630af1717834826
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022280686
81 https://doi.org/10.1245/s10434-010-1037-9
82 schema:sdDatePublished 2019-04-11T10:15
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N9a87a9477f72494f9257007b73b41c40
85 schema:url http://link.springer.com/10.1245/s10434-010-1037-9
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N009d7db9cf9a4f45b8d048540547435f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Up-Regulation
91 rdf:type schema:DefinedTerm
92 N065c358da7454cd7910f4e5c0b7253d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Survival Rate
94 rdf:type schema:DefinedTerm
95 N06a31156e0cb4aad826601dda8719c9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Female
97 rdf:type schema:DefinedTerm
98 N06a61dfba5c5404cbec2f721e989bbb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Adult
100 rdf:type schema:DefinedTerm
101 N0717500ea12e44ef857170330fc02646 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Follow-Up Studies
103 rdf:type schema:DefinedTerm
104 N0a713002e8af4ad9aa02bf44705c0089 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Lymphatic Metastasis
106 rdf:type schema:DefinedTerm
107 N10c0cb1349f746b280685446a82b8784 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Immunoenzyme Techniques
109 rdf:type schema:DefinedTerm
110 N10d75afbfbc046ef8186c540194febb6 rdf:first sg:person.01203470464.12
111 rdf:rest Ncfb43380d96943b6bcf5715848a3a6b0
112 N10fa569cef5e4ddaa2b155353ab0de7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Carcinoma, Signet Ring Cell
114 rdf:type schema:DefinedTerm
115 N1b2cf1117c164265970a71cc59c289fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name RNA, Small Interfering
117 rdf:type schema:DefinedTerm
118 N1de06f95f3cd457fa7b4bf537e628a8c schema:name readcube_id
119 schema:value 6a2654c88fe35d7e912758fe93c8b72dc748bc42eb347ce906033f5b02e78185
120 rdf:type schema:PropertyValue
121 N1de2c7f7b976495698c68dbc27a45cf8 schema:name pubmed_id
122 schema:value 20383661
123 rdf:type schema:PropertyValue
124 N202a56b2515347ff996860fa09c85a56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Adenocarcinoma
126 rdf:type schema:DefinedTerm
127 N26c0661bce704c41bd3e213d50457407 schema:name nlm_unique_id
128 schema:value 9420840
129 rdf:type schema:PropertyValue
130 N274b3aba95544b5eb4d3032db83c834e schema:issueNumber 10
131 rdf:type schema:PublicationIssue
132 N4066845a5bd741319d810b0caf12988c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Prognosis
134 rdf:type schema:DefinedTerm
135 N44a146a537094801bc8e3e72b188fe96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Aged
137 rdf:type schema:DefinedTerm
138 N470906988d214c8eafae2cbeec96c564 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Middle Aged
140 rdf:type schema:DefinedTerm
141 N51b71d9bf4df4b54a0c18baf0cf91025 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Cell Proliferation
143 rdf:type schema:DefinedTerm
144 N5664defdb9d440108c7b63edb6b00d45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Liver Neoplasms
146 rdf:type schema:DefinedTerm
147 N5678fe28a32b4ca5bd898d4258807256 schema:name doi
148 schema:value 10.1245/s10434-010-1037-9
149 rdf:type schema:PropertyValue
150 N5d5f2bfb9ee741b7b389f0daa9407e9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name RNA, Messenger
152 rdf:type schema:DefinedTerm
153 N6a5b64d0a2c44128b584ce8bc0bd7df2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Stomach Neoplasms
155 rdf:type schema:DefinedTerm
156 N6b81d299041b4f9696cb2bafecb96aab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Reverse Transcriptase Polymerase Chain Reaction
158 rdf:type schema:DefinedTerm
159 N75029be1bfd9401a97c808fa199c3370 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Proteoglycans
161 rdf:type schema:DefinedTerm
162 N7992acd2c490479c8a6b36f644b6a927 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Peritoneal Neoplasms
164 rdf:type schema:DefinedTerm
165 N86f3ec21e09a44efaccc0d3b3c241304 rdf:first sg:person.0626755231.70
166 rdf:rest N10d75afbfbc046ef8186c540194febb6
167 N8e2c77985f01416f89eee9b385b69806 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Neoplasm Proteins
169 rdf:type schema:DefinedTerm
170 N90e9da75a4074c69975b17960c0c0aaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Male
172 rdf:type schema:DefinedTerm
173 N94e5532c1bfc4f9997c49a0b5c311b58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Microcirculation
175 rdf:type schema:DefinedTerm
176 N9a87a9477f72494f9257007b73b41c40 schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 N9b646f9e354b4662828664ca50276706 schema:volumeNumber 17
179 rdf:type schema:PublicationVolume
180 Na06593ef43234ae0a8a110c6925aaa6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Disease Progression
182 rdf:type schema:DefinedTerm
183 Na9b269e39b5c4eeabea4a5ff2b7fe716 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Neovascularization, Pathologic
185 rdf:type schema:DefinedTerm
186 Nad030c829ccd4d368fb8e95dd27bf118 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Neoplasm Invasiveness
188 rdf:type schema:DefinedTerm
189 Nb2d5d11e90d44acb93c2b73d6a4f56d2 rdf:first sg:person.01051527074.05
190 rdf:rest Nf3ba113ea7d34229a5ff304a569c70b3
191 Nb6d0ae7add834aaf9cad9fd50ceceb3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Blotting, Western
193 rdf:type schema:DefinedTerm
194 Nc677ba4cb5334f58b08ab679fd821351 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Humans
196 rdf:type schema:DefinedTerm
197 Nca4ca44ce5c44896a1494394a504377a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Aged, 80 and over
199 rdf:type schema:DefinedTerm
200 Ncbbaacbd604e4981aeab1165b11599f1 rdf:first sg:person.01064017701.47
201 rdf:rest N86f3ec21e09a44efaccc0d3b3c241304
202 Nccb13dd538f24adea753e8519cc5704a rdf:first sg:person.01204727330.73
203 rdf:rest Nb2d5d11e90d44acb93c2b73d6a4f56d2
204 Ncfb43380d96943b6bcf5715848a3a6b0 rdf:first sg:person.01204037144.69
205 rdf:rest Nccb13dd538f24adea753e8519cc5704a
206 Nd70a6a9ceaf94b719f25694269ddcaa1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Cells, Cultured
208 rdf:type schema:DefinedTerm
209 Nee66098b36204c55af37ee96b1a305e5 rdf:first sg:person.01022571576.54
210 rdf:rest rdf:nil
211 Nf0059ed38bdd4ee98630af1717834826 schema:name dimensions_id
212 schema:value pub.1022280686
213 rdf:type schema:PropertyValue
214 Nf3ba113ea7d34229a5ff304a569c70b3 rdf:first sg:person.012255174444.65
215 rdf:rest Nee66098b36204c55af37ee96b1a305e5
216 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
217 schema:name Medical and Health Sciences
218 rdf:type schema:DefinedTerm
219 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
220 schema:name Oncology and Carcinogenesis
221 rdf:type schema:DefinedTerm
222 sg:journal.1105545 schema:issn 1068-9265
223 1534-4681
224 schema:name Annals of Surgical Oncology
225 rdf:type schema:Periodical
226 sg:person.01022571576.54 schema:affiliation https://www.grid.ac/institutes/grid.412474.0
227 schema:familyName Ji
228 schema:givenName Jia-fu
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022571576.54
230 rdf:type schema:Person
231 sg:person.01051527074.05 schema:affiliation https://www.grid.ac/institutes/grid.412474.0
232 schema:familyName Wang
233 schema:givenName Xiao-hong
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051527074.05
235 rdf:type schema:Person
236 sg:person.01064017701.47 schema:affiliation https://www.grid.ac/institutes/grid.412474.0
237 schema:familyName Liu
238 schema:givenName Ni
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064017701.47
240 rdf:type schema:Person
241 sg:person.01203470464.12 schema:affiliation https://www.grid.ac/institutes/grid.412474.0
242 schema:familyName Du
243 schema:givenName Hong
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203470464.12
245 rdf:type schema:Person
246 sg:person.01204037144.69 schema:affiliation https://www.grid.ac/institutes/grid.412474.0
247 schema:familyName Hu
248 schema:givenName Ying
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204037144.69
250 rdf:type schema:Person
251 sg:person.01204727330.73 schema:affiliation https://www.grid.ac/institutes/grid.412474.0
252 schema:familyName Zhang
253 schema:givenName Gui-guo
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204727330.73
255 rdf:type schema:Person
256 sg:person.012255174444.65 schema:affiliation https://www.grid.ac/institutes/grid.412474.0
257 schema:familyName Li
258 schema:givenName Ji-you
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012255174444.65
260 rdf:type schema:Person
261 sg:person.0626755231.70 schema:affiliation https://www.grid.ac/institutes/grid.412474.0
262 schema:familyName Zhang
263 schema:givenName Lian-hai
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626755231.70
265 rdf:type schema:Person
266 sg:pub.10.1007/bf00666038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008676548
267 https://doi.org/10.1007/bf00666038
268 rdf:type schema:CreativeWork
269 sg:pub.10.1007/bf03032579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029576921
270 https://doi.org/10.1007/bf03032579
271 rdf:type schema:CreativeWork
272 sg:pub.10.1007/s10120-005-0320-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034635641
273 https://doi.org/10.1007/s10120-005-0320-0
274 rdf:type schema:CreativeWork
275 sg:pub.10.1023/a:1026529222845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048028741
276 https://doi.org/10.1023/a:1026529222845
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/283139a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014668798
279 https://doi.org/10.1038/283139a0
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/nrc1627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022080605
282 https://doi.org/10.1038/nrc1627
283 rdf:type schema:CreativeWork
284 sg:pub.10.1054/bjoc.2001.2177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007616002
285 https://doi.org/10.1054/bjoc.2001.2177
286 rdf:type schema:CreativeWork
287 sg:pub.10.1186/1471-2407-3-31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020861401
288 https://doi.org/10.1186/1471-2407-3-31
289 rdf:type schema:CreativeWork
290 sg:pub.10.1186/bcr562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036099121
291 https://doi.org/10.1186/bcr562
292 rdf:type schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1082895740 schema:CreativeWork
294 https://doi.org/10.1006/mvre.2001.2380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033410587
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.bbcan.2005.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048153181
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.mvr.2006.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009434653
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s0006-2952(00)00529-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042568382
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/s0960-9822(95)00004-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011327157
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/s1040-8428(01)00199-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035224939
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1074/jbc.271.34.20458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010789203
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1074/jbc.m108395200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074890756
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1093/annonc/mdg726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039372472
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1097/01.ccm.0000198525.82124.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044668368
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1111/j.1365-2559.2009.03458.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008825916
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1158/0008-5472.can-03-2361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022233639
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1158/1078-0432.ccr-06-0185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030175261
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1159/000011896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032690046
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1159/000025758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026843710
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1164/rccm.200401-066oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1004031794
325 rdf:type schema:CreativeWork
326 https://doi.org/10.3322/canjclin.55.2.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048020321
327 rdf:type schema:CreativeWork
328 https://doi.org/10.3748/wjg.v12.i1.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071364239
329 rdf:type schema:CreativeWork
330 https://doi.org/10.3748/wjg.v8.i4.591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071375263
331 rdf:type schema:CreativeWork
332 https://doi.org/10.3892/ijmm.4.1.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071508941
333 rdf:type schema:CreativeWork
334 https://www.grid.ac/institutes/grid.412474.0 schema:alternateName Peking University Cancer Hospital
335 schema:name Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China
336 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Surgery, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China
337 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Tissue Bank, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...